Nuclear Pore Complexes And Nucleocytoplasmic Transport Methods
DOWNLOAD
Download Nuclear Pore Complexes And Nucleocytoplasmic Transport Methods PDF/ePub or read online books in Mobi eBooks. Click Download or Read Online button to get Nuclear Pore Complexes And Nucleocytoplasmic Transport Methods book now. This website allows unlimited access to, at the time of writing, more than 1.5 million titles, including hundreds of thousands of titles in various foreign languages. If the content not found or just blank you must refresh this page
Nuclear Pore Complexes And Nucleocytoplasmic Transport Methods
DOWNLOAD
Author :
language : en
Publisher: Elsevier
Release Date : 2014-05-20
Nuclear Pore Complexes And Nucleocytoplasmic Transport Methods written by and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-05-20 with Science categories.
Volume 122 of Methods in Cell Biology describes modern tools and techniques used to study nuclear pore complexes and nucleocytoplasmic transport in diverse eukaryotic model systems (including mammalian cells, Xenopus, C. elegans, yeast). The volume enables investigators to analyze nuclear pore complex structure, assembly, and dynamics; to evaluate protein and RNA trafficking through the nuclear envelope; and to design in vivo or in vitro assays appropriate to their research needs. Beyond the study of nuclear pores and transport as such, these protocols will also be helpful to scientists characterizing gene regulation, signal transduction, cell cycle, viral infections, or aging. The NPC being one of the largest multiprotein complexes in the cell, some protocols will also be of interest for people currently characterizing other macromolecular assemblies. This book is thus designed for laboratory use by graduate students, technicians, and researchers in many molecular and cellular disciplines. Describes modern tools and techniques used to study nuclear pore complexes and nucleocytoplasmic transport in diverse eukaryotic model systems (mammalian cells, Xenopus, C. elegans, yeast) Chapters are written by experts in the field Cutting-edge material
Nuclear Transport
DOWNLOAD
Author : Karsten Weis
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Nuclear Transport written by Karsten Weis and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Science categories.
Bidirectional traffic of macromolecules across the nuclear envelope is an active and essential transport process in all eukaryotic cells. Work on various model systems has led to a tremendous increase in our understanding of nuclear transport in recent years. This volume summarizes our current knowledge of protein and RNA transport into and out of the nucleus. It contains nine up-to-date reviews which cover various aspects of nucleocytoplasmic transport, including the structure and function of the nuclear pore complex, the role of soluble transport factors in protein and RNA transport, and the regulation of protein transport through the nuclear pore.
Nuclear Export Of Viral Rnas
DOWNLOAD
Author : J. Hauber
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Nuclear Export Of Viral Rnas written by J. Hauber and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Science categories.
In eukaryotic cells, the nuclear genome and its transcriptional apparatus is separated from the site of protein synthesis by the nuclear envelope. Thus, a constant flow of proteins and nucleic acids has to cross the nuclear envelope in both directions. This transport in and out of the nucleus is mediated by nuclear pore complexes (NPCs) and occurs in an energy and signal-dependent manner. Thus, nucleocytoplasmic translocation of macro molecules across the nuclear envelope appears to be a highly specific and regulated process. Viruses that replicate their genome in the cell nucleus are therefore forced to develop efficient ways to deal with the intracellulZlr host cell transport machinery. Historically, investigation of Polyomavirus replication allowed identification ofsequences that mediate nuclear import, which led subsequently to our detailed understanding of the cellular factors that are involved in nuclear import. Transport ofmacromolecules in the opposite direction, however, is less well understood. The investigation of retroviral gene expression in recent years pro vided the first insights into the cellular mechanisms that regulate nuclear export. In particular, the detailed dissection of the function of the human immunodeficiency virus type I (HIV-I) Rev trans-activator protein identified CRMI, as a hona fide nuclear export receptor. CRM I appears to be involved in the nucleocytoplasmic translocation of the vast majority of viral and cellular proteins that have subsequently been found to contain a Rev-type leucine-rich nuclear export signal (NES).
Nuclear Cytoplasmic Transport
DOWNLOAD
Author : Weidong Yang
language : en
Publisher: Springer
Release Date : 2018-07-27
Nuclear Cytoplasmic Transport written by Weidong Yang and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-07-27 with Science categories.
Dysfunction of nuclear-cytoplasmic transport systems has been associated with many human diseases. Thus, understanding of how functional this transport system maintains, or through dysfunction fails to maintain remains the core question in cell biology. In eukaryotic cells, the nuclear envelope (NE) separates the genetic transcription in the nucleus from the translational machinery in the cytoplasm. Thousands of nuclear pore complexes (NPCs) embedded on the NE selectively mediate the bidirectional trafficking of macromolecules such as RNAs and proteins between these two cellular compartments. In this book, the authors integrate recent progress on the structure of NPC and the mechanism of nuclear-cytoplasmic transport system in vitro and in vivo.
Nuclear Transport
DOWNLOAD
Author : Karsten Weis
language : en
Publisher:
Release Date : 2001-11-20
Nuclear Transport written by Karsten Weis and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2001-11-20 with categories.
Challenges In Delivery Of Therapeutic Genomics And Proteomics
DOWNLOAD
Author : Ambikanandan Misra
language : en
Publisher: Elsevier
Release Date : 2010-09-09
Challenges In Delivery Of Therapeutic Genomics And Proteomics written by Ambikanandan Misra and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-09-09 with Science categories.
Delivery of therapeutic proteomics and genomics represent an important area of drug delivery research. Genomics and proteomics approaches could be used to direct drug development processes by unearthing pathways involved in disease pathogenesis where intervention may be most successful. This book describes the basics of genomics and proteomics and highlights the various chemical, physical and biological approaches to protein and gene delivery. Covers a diverse array of topics from basic sciences to therapeutic applications of proteomics and genomics delivery Of interest to researchers in both academia and industry Highlights what’s currently known and where further research is needed
The Meaning Of Nucleocytoplasmic Transport
DOWNLOAD
Author : Paul S. Agutter
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-06-29
The Meaning Of Nucleocytoplasmic Transport written by Paul S. Agutter and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-06-29 with Science categories.
The means by which proteins and RNAs are exchanged between cytoplasm and nucleus have interested cell biologists for many years, and the field has seen a number of exciting recent advances. Much has been learned about the intricate architecture of the nuclear pore-complex, the mechanisms by which transport substrates are sorted, and the supply of energy for exchange processes. This book attempts a general review of the growing body of knowledge. However, the authors challenge the presumptions implicit in some interpretations of the evidence, re-examining the concept of "transport" within cells, and suggesting that lessons learned from nucleocytoplasmic transport studies can elucidate wider aspects of cell biology.
Nucleocytoplasmic Transport
DOWNLOAD
Author : Reiner Peters
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Nucleocytoplasmic Transport written by Reiner Peters and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Science categories.
Nuclear Transport
DOWNLOAD
Author : Karsten Weis
language : en
Publisher: Springer
Release Date : 2001-11-20
Nuclear Transport written by Karsten Weis and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2001-11-20 with Science categories.
Bidirectional traffic of macromolecules across the nuclear envelope is an active and essential transport process in all eukaryotic cells. Work on various model systems has led to a tremendous increase in our understanding of nuclear transport in recent years. This volume summarizes our current knowledge of protein and RNA transport into and out of the nucleus. It contains nine up-to-date reviews which cover various aspects of nucleocytoplasmic transport, including the structure and function of the nuclear pore complex, the role of soluble transport factors in protein and RNA transport, and the regulation of protein transport through the nuclear pore.
The Nuclear Pore Complex
DOWNLOAD
Author : Martin W. Goldberg
language : en
Publisher: Humana
Release Date : 2023-04-27
The Nuclear Pore Complex written by Martin W. Goldberg and has been published by Humana this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-04-27 with Science categories.
This volume covers all methods used to discover the composition, structure, and dynamics of the nuclear pore complex (NPC), as well as the soluble transport factors involved in the transport process. Chapters detail structural biology methods, biophysical, transport factors , and a wide range of model organisms that have been used over the years. Written in the format of the highly successful Methods in Molecular Biology series, each chapter includes an introduction to the topic, lists necessary materials and reagents, includes tips on troubleshooting and known pitfalls, and step-by-step, readily reproducible protocols. Authoritative and cutting-edge, The Nuclear Pore Complex: Methods and Protocols: Methods and Protocols aims to be a useful and practical guide to new researchers and experts looking to expand their knowledge.