The Nuclear Pore Complex
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Nuclear Pore Complexes And Nucleocytoplasmic Transport Methods
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Author :
language : en
Publisher: Elsevier
Release Date : 2014-05-20
Nuclear Pore Complexes And Nucleocytoplasmic Transport Methods written by and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-05-20 with Science categories.
Volume 122 of Methods in Cell Biology describes modern tools and techniques used to study nuclear pore complexes and nucleocytoplasmic transport in diverse eukaryotic model systems (including mammalian cells, Xenopus, C. elegans, yeast). The volume enables investigators to analyze nuclear pore complex structure, assembly, and dynamics; to evaluate protein and RNA trafficking through the nuclear envelope; and to design in vivo or in vitro assays appropriate to their research needs. Beyond the study of nuclear pores and transport as such, these protocols will also be helpful to scientists characterizing gene regulation, signal transduction, cell cycle, viral infections, or aging. The NPC being one of the largest multiprotein complexes in the cell, some protocols will also be of interest for people currently characterizing other macromolecular assemblies. This book is thus designed for laboratory use by graduate students, technicians, and researchers in many molecular and cellular disciplines. Describes modern tools and techniques used to study nuclear pore complexes and nucleocytoplasmic transport in diverse eukaryotic model systems (mammalian cells, Xenopus, C. elegans, yeast) Chapters are written by experts in the field Cutting-edge material
The Nuclear Pore Complex
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Author : Martin W. Goldberg
language : en
Publisher: Humana
Release Date : 2023-04-27
The Nuclear Pore Complex written by Martin W. Goldberg and has been published by Humana this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-04-27 with Science categories.
This volume covers all methods used to discover the composition, structure, and dynamics of the nuclear pore complex (NPC), as well as the soluble transport factors involved in the transport process. Chapters detail structural biology methods, biophysical, transport factors , and a wide range of model organisms that have been used over the years. Written in the format of the highly successful Methods in Molecular Biology series, each chapter includes an introduction to the topic, lists necessary materials and reagents, includes tips on troubleshooting and known pitfalls, and step-by-step, readily reproducible protocols. Authoritative and cutting-edge, The Nuclear Pore Complex: Methods and Protocols: Methods and Protocols aims to be a useful and practical guide to new researchers and experts looking to expand their knowledge.
Nuclear Pore Complexes In Genome Organization Function And Maintenance
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Author : Maximiliano D’Angelo
language : en
Publisher: Springer
Release Date : 2018-02-02
Nuclear Pore Complexes In Genome Organization Function And Maintenance written by Maximiliano D’Angelo and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-02-02 with Medical categories.
The three-dimensional organization of the DNA inside the eukaryotic cell nucleus has emerged a critical regulator of genome integrity and function. Increasing evidence indicates that nuclear pore complexes (NPCs), the large protein channels that connect the nucleus to the cytoplasm, play a critical role in the establishment and maintenance of chromatin organization and in the regulation of gene activity. These findings, which oppose the traditional view of NPCs as channels with only one: the facilitation of nucleocytoplasmic molecule exchange, have completely transformed our understanding of these structures. This book describes our current knowledge of the role of NPCs in genome organization and gene expression regulation. It starts by providing an overview of the different compartments and structures of the nucleus and how they contribute to organizing the genome, then moves to examine the direct roles of NPCs and their components in gene expression regulation in different organisms, and ends by describing the function of nuclear pores in the infection and genome integration of HIV, in DNA repair and telomere maintenance, and in the regulation of chromosome segregation and mitosis. This book provides an intellectual backdrop for anyone interested in understanding how the gatekeepers of the nucleus contribute to safeguarding the integrity and function of the eukaryotic genome.
Nuclear Transport
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Author : Karsten Weis
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Nuclear Transport written by Karsten Weis and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Science categories.
Bidirectional traffic of macromolecules across the nuclear envelope is an active and essential transport process in all eukaryotic cells. Work on various model systems has led to a tremendous increase in our understanding of nuclear transport in recent years. This volume summarizes our current knowledge of protein and RNA transport into and out of the nucleus. It contains nine up-to-date reviews which cover various aspects of nucleocytoplasmic transport, including the structure and function of the nuclear pore complex, the role of soluble transport factors in protein and RNA transport, and the regulation of protein transport through the nuclear pore.
Nucleocytoplasmic Transport
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Author : Reiner Peters
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Nucleocytoplasmic Transport written by Reiner Peters and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Science categories.
Nuclear Transport
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Author : Karsten Weis
language : en
Publisher:
Release Date : 2001-11-20
Nuclear Transport written by Karsten Weis and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2001-11-20 with categories.
Molecular Biology Of The Cell
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Author : Bruce Alberts
language : en
Publisher:
Release Date : 2002
Molecular Biology Of The Cell written by Bruce Alberts and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2002 with Cytology categories.
Networks Of Protein Interactions At The Nuclear Pore Complex In Saccharomyces Cerevisiae
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Author : Nadia P. C. Allen
language : en
Publisher:
Release Date : 2003
Networks Of Protein Interactions At The Nuclear Pore Complex In Saccharomyces Cerevisiae written by Nadia P. C. Allen and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2003 with categories.
Nuclear Cytoplasmic Transport
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Author : Weidong Yang
language : en
Publisher: Springer
Release Date : 2018-07-27
Nuclear Cytoplasmic Transport written by Weidong Yang and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-07-27 with Science categories.
Dysfunction of nuclear-cytoplasmic transport systems has been associated with many human diseases. Thus, understanding of how functional this transport system maintains, or through dysfunction fails to maintain remains the core question in cell biology. In eukaryotic cells, the nuclear envelope (NE) separates the genetic transcription in the nucleus from the translational machinery in the cytoplasm. Thousands of nuclear pore complexes (NPCs) embedded on the NE selectively mediate the bidirectional trafficking of macromolecules such as RNAs and proteins between these two cellular compartments. In this book, the authors integrate recent progress on the structure of NPC and the mechanism of nuclear-cytoplasmic transport system in vitro and in vivo.
Nup98 And The Transcription Dependent Dynamics Of The Metazoan Nuclear Pore Complex
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Author : Eric Ross Griffis
language : en
Publisher:
Release Date : 2004
Nup98 And The Transcription Dependent Dynamics Of The Metazoan Nuclear Pore Complex written by Eric Ross Griffis and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2004 with categories.