Obesity Inflammation And Cancer
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Obesity Inflammation And Cancer
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Author : Andrew J. Dannenberg
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-05-21
Obesity Inflammation And Cancer written by Andrew J. Dannenberg and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-05-21 with Medical categories.
In addition to its metabolic and endocrinologic effects, obesity and adipose tissue have now been shown to be associated with low grade inflammation resulting in cellular and humoral inflammatory factors of which the latter may act by endocrine, paracrine and autocrine mechanisms. These inflammatory mediators have increasingly been suggested as contributing to the obesity link to carcinogenesis and cancer promotion. This volume of Energy Balance and Cancer will focus on recent developments and cutting edge research pointing to inflammation and inflammatory factors as key mediators of this linkage. The volume first provides information on inflammation as an important link between obesity and insulin resistance, which is in itself linked to promotion of cancer through hyperinsulinemia. The volume then covers some of the most important mechanisms by which obesity leads to inflammation, including the novel inflammasome concept, alterations in chromatin structure, circulating inflammatory factors, unique cellular interactions between adipocytes and macrophages and the direct link of dietary fat to inflammation and cancer. Overall, this volume will provide important insight to help understand how inflammation may help modulate the linkage between obesity and cancer and serve as a platform for developing future research in this area.
Adipose Tissue And Cancer
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Author : Mikhail G. Kolonin
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-07-17
Adipose Tissue And Cancer written by Mikhail G. Kolonin and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-07-17 with Medical categories.
Recent studies have shown that cells from adipose tissue are capable of trafficking to tumors, thus enabling paracrine action of adipokines from within the tumor microenvironment. Increased tumor vascularization, immune system suppression and direct effects on malignant cell survival and proliferation have been investigated as mechanisms regulated by adipokines. The goal of this book is to discuss data pointing to the role of adipose tissue in cancer and to dissect individual mechanisms through which adipose tissue excess or restriction could influence cancer progression.
Obesity And Cancer
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Author : Shashank Kumar
language : en
Publisher: Springer Nature
Release Date : 2021-07-18
Obesity And Cancer written by Shashank Kumar and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-07-18 with Medical categories.
This book highlights the concordance between signaling pathways that are involved in obesity and cancer cross-talks. It describes the role of cytokines, chemokines, growth factors, insulin, and adipokines in the development of obesity-associated cancers. The book reviews the role of inflammatory signaling pathways such as estrogen-mediated signaling, mTOR and AMP-activated protein kinase pathway and the involvement of adaptive and innate immunity, oxidative stress, gene polymorphism, dietary phytochemicals, and miRNAs in obesity and cancer. In addition, it covers the latest research on the drugs and natural therapeutic agents that target obesity-induced cancers and discusses various in vivo models for studying obesity and obesity-associated cancer. Lastly, it analyses the role of genetic polymorphisms in the obesity-related genes that influence cancer development. The book is a useful resource for researchers in the field of cancer, pharmacology, food chemistry, and clinical biochemistry.
T Cell Alterations In Adipose Tissue During Obesity Hiv And Cancer
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Author : Dorothy Ellen Lewis
language : en
Publisher: Frontiers Media SA
Release Date : 2019-09-25
T Cell Alterations In Adipose Tissue During Obesity Hiv And Cancer written by Dorothy Ellen Lewis and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-09-25 with categories.
The Link Between Obesity And Cancer
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Author : Raman Mehrzad
language : en
Publisher: Academic Press
Release Date : 2022-09-22
The Link Between Obesity And Cancer written by Raman Mehrzad and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-09-22 with Science categories.
The Link between Obesity and Cancer provides a comprehensive review on the relationship between obesity and cancer, presenting global perspectives on obesity and cancer incidence that are followed by in-depth discussions on cancers for which we have new evidence of a causal relationship with obesity. Readers will gain fundamental knowledge on which cancer types are related to obesity. In addition, this updated resource provides significant knowledge for clinicians on when to act, along with specific management guidelines for patients, as well as how to understand potential risk factors and how to directly or indirectly minimize these risks. The book also provides never-before-published scientific data for any researcher in the field, identifying molecular mechanisms and links behind the development of malignancy and promoting research in new and effective target pathways in developing therapeutic strategies. Provides essential knowledge on how to understand the link between obesity and cancer and why and how this occurs Presents a significant knowledge base for clinicians on when to act, along with patient management guidelines for patients with obesity and potential risk factors Contains new scientific data and findings for researchers that identify the molecular mechanisms and links behind the development of malignancy
Adipose Tissue And Inflammation
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Author : Atif B. Awad
language : en
Publisher: CRC Press
Release Date : 2009-10-08
Adipose Tissue And Inflammation written by Atif B. Awad and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-10-08 with Medical categories.
The American Obesity Association identifies obesity's link to numerous medical conditions, including hypertension, type 2 diabetes, cardiovascular disease, several cancers, and a host of inflammatory disorders. Evidence indicates that inflammation has more than a corollary relation with obesity; that in fact, obesity itself manifests a low-grade, m
Inflammation Lifestyle And Chronic Diseases
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Author : Bharat B. Aggarwal
language : en
Publisher: CRC Press
Release Date : 2016-04-19
Inflammation Lifestyle And Chronic Diseases written by Bharat B. Aggarwal and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-04-19 with Medical categories.
Oxidative stress and inflammation are among the most important factors of disease. Chronic infections, obesity, alcohol and tobacco usage, radiation, environmental pollutants, and high-calorie diets have been recognized as major risk factors for a variety of chronic diseases from cancer to metabolic diseases. All these risk factors are linked to ch
Inflammation And Obesity
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Author : Raman Mehrzad
language : en
Publisher: Academic Press
Release Date : 2022-09-24
Inflammation And Obesity written by Raman Mehrzad and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-09-24 with Medical categories.
Inflammation and Obesity: A New and Novel Approach to Manage Obesity and its Consequences is a comprehensive and up-to-date exploration of the correlation between obesity and inflammation. From the pathophysiology of obesity and inflammation, to the molecular mechanisms of obesity induced chronic inflammation, the book discusses how obesity and inflammation interact with other diseases. It highlights the hidden risk factors of obesity induced chronic inflammation, provides specific patient management guidelines regarding the higher inflammatory response in patients, and concludes with new therapeutic strategies to address inflammation in obese patients. Identifies the hidden physiological changes that accompany obesity, while also highlighting the challenge of managing obesity with a higher inflammatory response Discusses major hidden health risks of inflammation that accompany obesity, as well as management guidelines for obese patients Links the pathophysiology of inflammation and obesity to the therapeutic strategies that minimizes risk factors, thus opening new areas of research
Exploring Pancreatic Metabolism And Malignancy
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Author : Ganji Purnachandra Nagaraju
language : en
Publisher: Springer Nature
Release Date : 2019-11-23
Exploring Pancreatic Metabolism And Malignancy written by Ganji Purnachandra Nagaraju and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-11-23 with Medical categories.
This book comprehensively describes the association between metabolic syndrome and pancreatic cancer progression, and the mechanism of action and target definition with a view to drug discovery. Metabolic syndrome, which includes adnominal obesity, hypertension, dyslipidemia, and hyperglycemia, has recently been shown to play an important role in the etiology and progression of various cancers. Further, obesity and diabetes have been associated with an increased incidence of gastric cancers. The book reviews the key biological mechanisms underlying the association between metabolic dysregulation, including obesity-associated enhancement of growth factor signaling, inflammation, and perturbation in pancreatic cancer cell growth and metastasis. It also illustrates the role of the inflammatory signaling pathway in metabolic diseases as well as tumor growth and explores the potential of these pathways as the rational targets for pancreatic cancer therapy. Lastly, the book offers a comprehensive description of the challenges associated with diabetes and pancreatic cancer therapy.
Inflammation Oxidative Stress And Cancer
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Author : Ah-Ng Tony Kong
language : en
Publisher: CRC Press
Release Date : 2013-08-07
Inflammation Oxidative Stress And Cancer written by Ah-Ng Tony Kong and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-08-07 with Medical categories.
Increasing scientific evidence suggests that the majority of diseases including cancer are driven by oxidative stress and inflammation, attributed to environmental factors. These factors either drive genetic mutations or epigenetically modify expression of key regulatory genes. These changes can occur as early as gestational fetal development, and major questions remain as to how dietary/nutritional phytochemical factors biochemically interact with such genetic and epigenetic events. With chapters written by international experts, Inflammation, Oxidative Stress, and Cancer: Dietary Approaches for Cancer Prevention examines the latest developments on the effects of various dietary phytochemicals. Divided into nine sections, the book begins with the basic mechanisms of inflammation/oxidative stress-driven cancer, including an overview of the topic and how to prevent carcinogenesis, the role of obesity in inflammation and cancer, and antioxidant properties of some common dietary phytochemicals. Subsequent sections cover cellular signal transduction, molecular targets, and biomarkers of dietary cancer-preventive phytochemicals, as well as their potential challenges with in vivo absorption and pharmacokinetics. The chapters also examine the cancer-preventive properties of various classes of phytochemicals, including vitamins A, D, and E; omega-3 and omega-6 fatty acids; flavanoids and polyphenols; garlic organosulfur compounds and cruciferous glucosinolates; and selenium, traditional Chinese herbal medicines, and alpha lipoic acid. The final section of the book explores the latest developments on the interactions of dietary phytochemicals through epigenetics and the management of chronic inflammation with nutritional phytochemicals.