Oecd Guidelines For The Testing Of Chemicals Section 2 Test No 248 Xenopus Eleutheroembryonic Thyroid Assay Xeta
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Oecd Guidelines For The Testing Of Chemicals Section 2 Test No 248 Xenopus Eleutheroembryonic Thyroid Assay Xeta
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Author : OECD
language : en
Publisher: OECD Publishing
Release Date : 2019-06-18
Oecd Guidelines For The Testing Of Chemicals Section 2 Test No 248 Xenopus Eleutheroembryonic Thyroid Assay Xeta written by OECD and has been published by OECD Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-06-18 with categories.
The purpose of the test is to measure the capacity of a chemical to activate or inhibit the transcription of a genetic construct (THb/ZIP-GFP X. laevis eleutheroembryos) either by binding to the thyroid hormone receptor or by modifying the amount of thyroid hormone available for transcription. The test is based on the use of a transgenic frog (possessing the genetic construction THb/ZIP-GFP) of the species X. laevis. GFP is a fluorescent protein that can be used to affirm the presence of the substance and to follow its action. This test is based on the quantification of fluorescence, and thus of the GFP protein, throughout the eleutheroembryo exposed to a test chemical. Indeed, if the fluorescence is > 12% by including the highest concentration of the test, the test is considered positive. Organisms are exposed in chemically inert cell culture plates (6 wells). Each well contains ten organisms in solution. In a run, 20 organisms are exposed to each test concentration. Tadpoles are exposed to the test chemical at NF stage 45 for a duration of 72 hours. A positive result of the XETA test indicates in vivo that a substance induces damage to the receptor and metabolization of the thyroid hormone. A negative result indicates that, under test conditions, the test substance does not induce detectable damage to the thyroid and its functioning.
Oecd Guidelines For The Testing Of Chemicals Section 2 Test No 231 Amphibian Metamorphosis Assay
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Author : OECD
language : en
Publisher: OECD Publishing
Release Date : 2009-09-08
Oecd Guidelines For The Testing Of Chemicals Section 2 Test No 231 Amphibian Metamorphosis Assay written by OECD and has been published by OECD Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-09-08 with categories.
This Test Guideline describes an amphibian metamorphosis assay intended to screen substances which may interfere with the normal functioning of the hypothalamo-pituitary-thyroid axis. The assay was validated with the species Xenopus laevis, which is ...
Lignes Directrices De L Ocde Pour Les Essais De Produits Chimiques Section 2 Essai No 248 Essai Thyro Dien Sur Leuth Ro Embryons De X Nope Xeta
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Author : OECD
language : fr
Publisher: OECD Publishing
Release Date : 2019-06-18
Lignes Directrices De L Ocde Pour Les Essais De Produits Chimiques Section 2 Essai No 248 Essai Thyro Dien Sur Leuth Ro Embryons De X Nope Xeta written by OECD and has been published by OECD Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-06-18 with categories.
Le but de l’essai est de mesurer la capacité d’un produit chimique pour activer ou inhiber la transcription d’une construction génétique (THb/ZIP-GFP X. laevis eleutheroembryos) soit par liaison au récepteur de l’hormone thyroïdienne soit en modifiant la quantité de l’hormone thyroïdienne disponible pour la transcription. L’essai est basé sur l’utilisation d’une grenouille transgénique (possédant la construction génétique THb/ZIP-GFP) de l’espèce X. laevis. La GFP est une protéine fluorescente qui permet d’affirmer la présence de la substance et de suivre son action. Ce test repose sur la quantification de la fluorescence, et donc de la protéine GFP, dans l’ensemble de l’eleutheroembryon exposé au produit chimique testé. En effet, si la flurorescence est > 12% en incluant la plus forte concentration du test, le test est considéré comme positif. Les organismes sont exposés dans des plaques de culture cellulaire chimiquement inertes (6 puits). Chaque puits doit contenir dix organismes en solution. Dans une épreuve, 20 organismes sont exposés à chaque concentration d’essai. Les grenouilles sont exposées aux produits chimiques au stade NF45. La durée d’exposition est de 72H. Un résultat positif de l'essai XETA indique in vivo qu'une substance induit des dommages sur le récepteur et la métabolisation de l’hormone thyroïdienne. Un résultat négatif indique que, dans les conditions d'essai, le produit chimiques testé n'induit pas des dommages discernables sur la thyroïde et son fonctionnement.
Oecd Guidelines For The Testing Of Chemicals Section 2 Test No 251 Rapid Androgen Disruption Activity Reporter Radar Assay
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Author : OECD
language : en
Publisher: OECD Publishing
Release Date : 2022-06-30
Oecd Guidelines For The Testing Of Chemicals Section 2 Test No 251 Rapid Androgen Disruption Activity Reporter Radar Assay written by OECD and has been published by OECD Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-06-30 with categories.
The Rapid Androgen Disruption Activity Reporter (RADAR) Test Guideline describes an aquatic assay that utilizes transgenic Oryzias latipes (O. latipes, Japanese medaka) eleutheroembryos at day post hatch zero, in a multi-well format to detect chemicals active on the androgen axis.
Bioanalytical Tools In Water Quality Assessment
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Author : Beate Escher
language : en
Publisher: IWA Publishing
Release Date : 2011-12-15
Bioanalytical Tools In Water Quality Assessment written by Beate Escher and has been published by IWA Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-12-15 with Science categories.
Part of Water Quality Set - Buy all four books and save over 30% on buying separately! Bioanalytical Tools in Water Quality Assessment reviews the application of bioanalytical tools to the assessment of water quality including surveillance monitoring. The types of water included range from wastewater to drinking water, including recycled water, as well as treatment processes and advanced water treatment. Bioanalytical Tools in Water Quality Assessment not only demonstrates applications but also fills in the background knowledge in toxicology/ecotoxicology needed to appreciate these applications. Each chapter summarises fundamental material in a targeted way so that information can be applied to better understand the use of bioanalytical tools in water quality assessment. Bioanalytical tools in Water Quality Assessment can be used by lecturers teaching academic and professional courses and also by risk assessors, regulators, experts, consultants, researchers and managers working in the water sector. It can also be a reference manual for environmental engineers, analytical chemists, and toxicologists. Authors: Beate Escher, National Research Centre for Environmental Toxicology (EnTox), The University of Queensland, Australia, Frederic Leusch, Smart Water Research Facility (G51), Griffith University Gold Coast Campus, Australia. With contributions by Heather Chapman and Anita Poulsen
Oecd Guidelines For Testing Of Chemicals
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Author : Organisation for Economic Co-operation and Development
language : en
Publisher: Organisation for Economic Co-operation and Development ; [Montréal : Renouf]
Release Date : 1981
Oecd Guidelines For Testing Of Chemicals written by Organisation for Economic Co-operation and Development and has been published by Organisation for Economic Co-operation and Development ; [Montréal : Renouf] this book supported file pdf, txt, epub, kindle and other format this book has been release on 1981 with Chemical industry categories.
Clinical Safety And Efficacy Testing Of Cosmetics
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Author : William Waggoner
language : en
Publisher: CRC Press
Release Date : 1989-11-27
Clinical Safety And Efficacy Testing Of Cosmetics written by William Waggoner and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1989-11-27 with Medical categories.
Oecd Guidelines For The Testing Of Chemicals Section 2 Test No 243 Lymnaea Stagnalis Reproduction Test
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Author : OECD
language : en
Publisher: OECD Publishing
Release Date : 2016-07-29
Oecd Guidelines For The Testing Of Chemicals Section 2 Test No 243 Lymnaea Stagnalis Reproduction Test written by OECD and has been published by OECD Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-07-29 with categories.
This Test Guideline is designed to assess effects of prolonged exposure to chemicals on the reproduction and survival of the hermaphrodite freshwater snail Lymnaea stagnalis (the Great Pond Snail).
Statistical Analysis Of Ecotoxicity Studies
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Author : John W. Green
language : en
Publisher: John Wiley & Sons
Release Date : 2018-08-14
Statistical Analysis Of Ecotoxicity Studies written by John W. Green and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-08-14 with Science categories.
A guide to the issues relevant to the design, analysis, and interpretation of toxicity studies that examine chemicals for use in the environment Statistical Analysis of Ecotoxicity Studies offers a guide to the design, analysis, and interpretation of a range of experiments that are used to assess the toxicity of chemicals. While the book highlights ecotoxicity studies, the methods presented are applicable to the broad range of toxicity studies. The text contains myriad datasets (from laboratory and field research) that clearly illustrate the book's topics. The datasets reveal the techniques, pitfalls, and precautions derived from these studies. The text includes information on recently developed methods for the analysis of severity scores and other ordered responses, as well as extensive power studies of competing tests and computer simulation studies of regression models that offer an understanding of the sensitivity (or lack thereof) of various methods and the quality of parameter estimates from regression models. The authors also discuss the regulatory process indicating how test guidelines are developed and review the statistical methodology in current or pending OECD and USEPA ecotoxicity guidelines. This important guide: Offers the information needed for the design and analysis to a wide array of ecotoxicity experiments and to the development of international test guidelines used to assess the toxicity of chemicals Contains a thorough examination of the statistical issues that arise in toxicity studies, especially ecotoxicity Includes an introduction to toxicity experiments and statistical analysis basics Includes programs in R and excel Covers the analysis of continuous and Quantal data, analysis of data as well as Regulatory Issues Presents additional topics (Mesocosm and Microplate experiments, mixtures of chemicals, benchmark dose models, and limit tests) as well as software Written for directors, scientists, regulators, and technicians, Statistical Analysis of Ecotoxicity Studies provides a sound understanding of the technical and practical issues in designing, analyzing, and interpreting toxicity studies to support or challenge chemicals for use in the environment.
Threatened Amphibians Of The World
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Author : S. N. Stuart
language : en
Publisher:
Release Date : 2008
Threatened Amphibians Of The World written by S. N. Stuart and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008 with Amphibians categories.
"Amphibians are facing an extinction crisis, but getting to the facts has been difficult. "Threatened Amphibians of the World" is a visual journey through the first-ever comprehensive assessment of the conservation status of the world's 6,000 known species of frogs, toads, salamanders, and caecilians. All 1,900 species known to be threatened with extinction are covered, including a description of threats to each species and an evaluation of conservation measures in place or needed. Each entry includes a photograph or illustration of the species where available, a distribution map, and detailed information on range, population and habitat and ecology. Introductory chapters present a detailed analysis of the results, complemented by a series of short essays written by many of the world's leading herpetologists. Appendices include annoted lists of lower risk species and a country-by-country listing of threatened amphibians."--pub. desc.