Oecd Guidelines For The Testing Of Chemicals Section 2 Test No 241 The Larval Amphibian Growth And Development Assay Lagda
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Oecd Guidelines For The Testing Of Chemicals Section 2 Test No 241 The Larval Amphibian Growth And Development Assay Lagda
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Author : OECD
language : en
Publisher: OECD Publishing
Release Date : 2015-07-28
Oecd Guidelines For The Testing Of Chemicals Section 2 Test No 241 The Larval Amphibian Growth And Development Assay Lagda written by OECD and has been published by OECD Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-07-28 with categories.
This Test Guideline describes the Medaka Extended One Generation Test (MEOGRT), which exposes fish over multiple generations to give data relevant to ecological hazard and risk assessment of chemicals, including suspected endocrine disrupting chemicals (EDCs). Exposure in the MEOGRT starts with ...
Oecd Guidelines For The Testing Of Chemicals Section 2 Test No 248 Xenopus Eleutheroembryonic Thyroid Assay Xeta
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Author : OECD
language : en
Publisher: OECD Publishing
Release Date : 2019-06-18
Oecd Guidelines For The Testing Of Chemicals Section 2 Test No 248 Xenopus Eleutheroembryonic Thyroid Assay Xeta written by OECD and has been published by OECD Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-06-18 with categories.
The purpose of the test is to measure the capacity of a chemical to activate or inhibit the transcription of a genetic construct (THb/ZIP-GFP X. laevis eleutheroembryos) either by binding to the thyroid hormone receptor or by modifying the amount of thyroid hormone available for transcription. The test is based on the use of a transgenic frog (possessing the genetic construction THb/ZIP-GFP) of the species X. laevis. GFP is a fluorescent protein that can be used to affirm the presence of the substance and to follow its action. This test is based on the quantification of fluorescence, and thus of the GFP protein, throughout the eleutheroembryo exposed to a test chemical. Indeed, if the fluorescence is > 12% by including the highest concentration of the test, the test is considered positive. Organisms are exposed in chemically inert cell culture plates (6 wells). Each well contains ten organisms in solution. In a run, 20 organisms are exposed to each test concentration. Tadpoles are exposed to the test chemical at NF stage 45 for a duration of 72 hours. A positive result of the XETA test indicates in vivo that a substance induces damage to the receptor and metabolization of the thyroid hormone. A negative result indicates that, under test conditions, the test substance does not induce detectable damage to the thyroid and its functioning.
Oecd Guidelines For The Testing Of Chemicals Section 2 Test No 231 Amphibian Metamorphosis Assay
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Author : OECD
language : en
Publisher: OECD Publishing
Release Date : 2009-09-08
Oecd Guidelines For The Testing Of Chemicals Section 2 Test No 231 Amphibian Metamorphosis Assay written by OECD and has been published by OECD Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-09-08 with categories.
This Test Guideline describes an amphibian metamorphosis assay intended to screen substances which may interfere with the normal functioning of the hypothalamo-pituitary-thyroid axis. The assay was validated with the species Xenopus laevis, which is ...
Oecd Guidelines For The Testing Of Chemicals Section 2 Test No 249 Fish Cell Line Acute Toxicity The Rtgill W1 Cell Line Assay
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Author : OECD
language : en
Publisher: OECD Publishing
Release Date : 2021-06-18
Oecd Guidelines For The Testing Of Chemicals Section 2 Test No 249 Fish Cell Line Acute Toxicity The Rtgill W1 Cell Line Assay written by OECD and has been published by OECD Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-06-18 with categories.
The RTgill-W1 cell line assay describes a 24-well plate format fish cell line acute toxicity test using the permanent cell line from rainbow trout (Oncorhynchus mykiss) gill, RTgill-W1. After 24 h of exposure to the test chemical, cell viability is assessed based on three fluorescent cell viability indicator dyes, measured on the same set of cells. Resazurin enters the cells in its non-fluorescent form and is converted to the fluorescent product, resorufin, by mitochondrial, microsomal or cytoplasmic oxidoreductases.
Environmental Risk Analysis For Asian Oriented Risk Based Watershed Management
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Author : Minoru Yoneda
language : en
Publisher: Springer
Release Date : 2018-05-07
Environmental Risk Analysis For Asian Oriented Risk Based Watershed Management written by Minoru Yoneda and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-05-07 with Technology & Engineering categories.
This publication is a practical guidebook on environmental risk assessment, especially for watershed-scale management. It highlights case studies of watershed environmental risk in Malaysia, including the potential health risks as well as screening methods and management in practice. In order to apply environmental risk assessment methods for the management of toxic chemicals, it is necessary to consider the geological and climate features of each country as well as their cultural characteristics. Focusing on Malaysia as a representative country, the book also discusses studies in other Asian countries. The insights provided can be applied to advanced and developing countries alike. A suitable textbook for graduate students, it is also a valuable reference source for researchers, practitioners and policymakers.
Guidance Document On Standardised Test Guidelines For Evaluating Chemicals For Endocrine Disruption
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Author : OECD
language : en
Publisher: OECD Publishing
Release Date : 2014-09-03
Guidance Document On Standardised Test Guidelines For Evaluating Chemicals For Endocrine Disruption written by OECD and has been published by OECD Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-09-03 with categories.
This document is a tool to support regulatory authorities’ decisions on the hazard of specific chemicals when they receive test results from a Test Guideline (TG) or draft TG for the screening/testing of chemicals for endocrine disrupting properties.
Oecd Guidelines For The Testing Of Chemicals Section 2 Test No 232 Collembolan Reproduction Test In Soil
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Author : OECD
language : en
Publisher: OECD Publishing
Release Date : 2016-07-29
Oecd Guidelines For The Testing Of Chemicals Section 2 Test No 232 Collembolan Reproduction Test In Soil written by OECD and has been published by OECD Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-07-29 with categories.
This Test Guideline is designed for assessing the effects of chemicals on the reproduction of collembolans in soil.
Oecd Guidelines For The Testing Of Chemicals Section 2 Test No 237 Honey Bee Apis Mellifera Larval Toxicity Test Single Exposure
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Author : OECD
language : en
Publisher: OECD Publishing
Release Date : 2013-07-26
Oecd Guidelines For The Testing Of Chemicals Section 2 Test No 237 Honey Bee Apis Mellifera Larval Toxicity Test Single Exposure written by OECD and has been published by OECD Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-07-26 with categories.
This Test Guideline (TG) describes a honey bee brood acute toxicity test under laboratory conditions. The method aims at the determination of the lethal dose (72-h LD50) following single exposure of larvae to a chemical. On day 1 (D1) of the study ...
Oecd Guidelines For The Testing Of Chemicals Section 2 Test No 221 Lemna Sp Growth Inhibition Test
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Author : OECD
language : en
Publisher: OECD Publishing
Release Date : 2006-07-11
Oecd Guidelines For The Testing Of Chemicals Section 2 Test No 221 Lemna Sp Growth Inhibition Test written by OECD and has been published by OECD Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006-07-11 with categories.
This Test Guideline is designed to assess the toxicity of substances to freshwater aquatic plants of the genus Lemna (duckweed). Exponentially growing plant cultures of the genus Lemna (Lemna gibba and Lemna minor usually) are allowed to grow as ...
Oecd Series On Testing And Assessment Revised Guidance Document 150 On Standardised Test Guidelines For Evaluating Chemicals For Endocrine Disruption
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Author : OECD
language : en
Publisher: OECD Publishing
Release Date : 2018-09-03
Oecd Series On Testing And Assessment Revised Guidance Document 150 On Standardised Test Guidelines For Evaluating Chemicals For Endocrine Disruption written by OECD and has been published by OECD Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-09-03 with categories.
This guidance document was originally published in 2012 and updated in 2018 to reflect new and updated OECD test guidelines, as well as reflect on scientific advances in the use of test methods and assessment of the endocrine activity of chemicals.