Oecd Series On Testing And Assessment Revised Guidance Document 150 On Standardised Test Guidelines For Evaluating Chemicals For Endocrine Disruption
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Oecd Series On Testing And Assessment Revised Guidance Document 150 On Standardised Test Guidelines For Evaluating Chemicals For Endocrine Disruption
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Author : OECD
language : en
Publisher: OECD Publishing
Release Date : 2018-09-03
Oecd Series On Testing And Assessment Revised Guidance Document 150 On Standardised Test Guidelines For Evaluating Chemicals For Endocrine Disruption written by OECD and has been published by OECD Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-09-03 with categories.
This guidance document was originally published in 2012 and updated in 2018 to reflect new and updated OECD test guidelines, as well as reflect on scientific advances in the use of test methods and assessment of the endocrine activity of chemicals.
Oecd Studies On Water Endocrine Disrupting Chemicals In Freshwater Monitoring And Regulating Water Quality
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Author : OECD
language : en
Publisher: OECD Publishing
Release Date : 2023-10-12
Oecd Studies On Water Endocrine Disrupting Chemicals In Freshwater Monitoring And Regulating Water Quality written by OECD and has been published by OECD Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-10-12 with categories.
Endocrine disrupting chemicals (EDCs) are contaminants of emerging environmental and health concern that have been detected in freshwater, wastewater and drinking water. They interfere with the endocrine system in humans and wildlife, and produce adverse effects such as developmental, reproductive, neurological and immune effects.
Oecd Guidelines For The Testing Of Chemicals Section 2 Test No 251 Rapid Androgen Disruption Activity Reporter Radar Assay
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Author : OECD
language : en
Publisher: OECD Publishing
Release Date : 2022-06-30
Oecd Guidelines For The Testing Of Chemicals Section 2 Test No 251 Rapid Androgen Disruption Activity Reporter Radar Assay written by OECD and has been published by OECD Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-06-30 with categories.
The Rapid Androgen Disruption Activity Reporter (RADAR) Test Guideline describes an aquatic assay that utilizes transgenic Oryzias latipes (O. latipes, Japanese medaka) eleutheroembryos at day post hatch zero, in a multi-well format to detect chemicals active on the androgen axis.
Food Safety Assessment Of Pesticide Residues
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Author : Arpad Ambrus
language : en
Publisher: World Scientific
Release Date : 2017-01-05
Food Safety Assessment Of Pesticide Residues written by Arpad Ambrus and has been published by World Scientific this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-01-05 with Technology & Engineering categories.
Pesticides are now accepted as an integral part of modern agricultural production. This book provides analysis of the steps taken by national and international bodies working towards a cohesive global strategy for evaluating the safety of residues in food that result from approved pesticide uses. Also described is the role of the UN Food and Agriculture Organization (FAO), World Health Organization (WHO) and Codex Alimentarius in developing standards that protect the health of the consumers and ensure fair practices in the food trade. It goes on to look at the promotion of good agricultural practice in the use of pesticides and the need for control in their practical use. These include sampling, testing the compliance of marketed products against legal limits and verifying the effectiveness of the safety-based regulatory measures. This is a specialist book for those looking to go into the field of international food safety, for students and lecturers studying the topic, for policy makers working on public health and agricultural issues, and personnel responsible for taking samples and performing the analysis of pesticide formulations and residues.
Saving Costs In Chemicals Management How The Oecd Ensures Benefits To Society
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Author : OECD
language : en
Publisher: OECD Publishing
Release Date : 2019-01-28
Saving Costs In Chemicals Management How The Oecd Ensures Benefits To Society written by OECD and has been published by OECD Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-01-28 with categories.
The chemical industry is one of the largest industrial sectors in the world and is expected to grow fourfold by 2060. Indeed modern life without chemicals would be inconceivable. Given the potential environmental and human health risks from exposure to chemicals, governments and industry have a ...
Oecd Guidelines For The Testing Of Chemicals Section 2 Test No 248 Xenopus Eleutheroembryonic Thyroid Assay Xeta
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Author : OECD
language : en
Publisher: OECD Publishing
Release Date : 2019-06-18
Oecd Guidelines For The Testing Of Chemicals Section 2 Test No 248 Xenopus Eleutheroembryonic Thyroid Assay Xeta written by OECD and has been published by OECD Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-06-18 with categories.
The purpose of the test is to measure the capacity of a chemical to activate or inhibit the transcription of a genetic construct (THb/ZIP-GFP X. laevis eleutheroembryos) either by binding to the thyroid hormone receptor or by modifying the amount of thyroid hormone available for transcription. The test is based on the use of a transgenic frog (possessing the genetic construction THb/ZIP-GFP) of the species X. laevis. GFP is a fluorescent protein that can be used to affirm the presence of the substance and to follow its action. This test is based on the quantification of fluorescence, and thus of the GFP protein, throughout the eleutheroembryo exposed to a test chemical. Indeed, if the fluorescence is > 12% by including the highest concentration of the test, the test is considered positive. Organisms are exposed in chemically inert cell culture plates (6 wells). Each well contains ten organisms in solution. In a run, 20 organisms are exposed to each test concentration. Tadpoles are exposed to the test chemical at NF stage 45 for a duration of 72 hours. A positive result of the XETA test indicates in vivo that a substance induces damage to the receptor and metabolization of the thyroid hormone. A negative result indicates that, under test conditions, the test substance does not induce detectable damage to the thyroid and its functioning.
Toxicological Risk Assessment And Multi System Health Impacts From Exposure
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Author : Aristidis M. Tsatsakis
language : en
Publisher: Elsevier
Release Date : 2021-08-01
Toxicological Risk Assessment And Multi System Health Impacts From Exposure written by Aristidis M. Tsatsakis and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-08-01 with Medical categories.
Toxicological Risk Assessment and Multisystem Health Impacts From Exposure highlights the emerging problems of human and environmental health attributable to cumulative and multiple sources of long-term exposure to environmental toxicants. The book describes the cellular, biological, immunological, endocrinologic, genetic, and epigenetic effects of long-term exposure. It examines how the combined exposure to nanomaterials, metals, pharmaceuticals, multifrequency radiation, dietary mycotoxins, and pesticides accelerates ecotoxicity in humans, animals, plants, and the larger environment. The book goes on to also offer insights into mixture risk assessments, protocols for evaluating the risks, and how this information can serve the regulatory agencies in setting safer exposure limits. The book is a go-to resource for scientists and professionals in the field tackling the current and emerging trends in modern toxicology and risk assessment. - Bridges basic research with clinical, epidemiological, regulatory, and translational research, conveying both an introductory understanding and the latest developments in the field - Evaluates real-life human health risk assessment for long-term exposures to xenobiotic mixtures and the role they play in contributing to chronic disease - Discusses advances in predictive (in silico) toxicology tools and the benefits of using omics technologies in toxicology research
Oecd Guidelines For The Testing Of Chemicals Section 2 Test No 250 Easzy Assay Detection Of Endocrine Active Substances Acting Through Estrogen Receptors Using Transgenic Tg Cyp19a1b Gfp Zebrafish Embryos
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Author : OECD
language : en
Publisher: OECD Publishing
Release Date : 2021-06-17
Oecd Guidelines For The Testing Of Chemicals Section 2 Test No 250 Easzy Assay Detection Of Endocrine Active Substances Acting Through Estrogen Receptors Using Transgenic Tg Cyp19a1b Gfp Zebrafish Embryos written by OECD and has been published by OECD Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-06-17 with categories.
The EASZY assay is a mechanism-based in vivo screening assay designed to detect endocrine active chemicals acting as agonist through estrogen receptors (ERs), by inducing the expression of the green fluorescent protein (GFP) driven by the cyp19a1b promoter. The EASZY assay allows for the detection of estrogenic activity of chemicals on transgenic tg(cyp19a1b:GFP) Zebrafish embryos exposed for 96 hours during the embryonic stages of development.
Oecd Guidelines For The Testing Of Chemicals Section 4 Test No 458 Stably Transfected Human Androgen Receptor Transcriptional Activation Assay For Detection Of Androgenic Agonist And Antagonist Activity Of Chemicals
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Author : OECD
language : en
Publisher: OECD Publishing
Release Date : 2023-07-04
Oecd Guidelines For The Testing Of Chemicals Section 4 Test No 458 Stably Transfected Human Androgen Receptor Transcriptional Activation Assay For Detection Of Androgenic Agonist And Antagonist Activity Of Chemicals written by OECD and has been published by OECD Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-07-04 with categories.
This Test Guideline describes in vitro assays, which use Androgen Receptor TransActivation (ARTA) to detect Androgen Receptor Agonists and Antagonists. The ARTA assay methods are mechanistically and functionally similar test methods that provide information on the transcription and translation of a reporter gene following the binding of a chemical to the androgen receptor and subsequent transactivation.
Haschek And Rousseaux S Handbook Of Toxicologic Pathology Volume 2 Safety Assessment And Toxicologic Pathology
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Author : Wanda M. Haschek
language : en
Publisher: Academic Press
Release Date : 2023-02-18
Haschek And Rousseaux S Handbook Of Toxicologic Pathology Volume 2 Safety Assessment And Toxicologic Pathology written by Wanda M. Haschek and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-02-18 with Medical categories.
Haschek and Rousseaux's Handbook of Toxicologic Pathology, recognized by many as the most authoritative single source of information in the field of toxicologic pathology, has been extensively updated to continue its comprehensive and timely coverage. The fourth edition has been expanded to five separate volumes due to an explosion of information in this field requiring new and updated chapters. Completely revised with a number of new chapters, Volume 2: Toxicologic Pathology in Safety Assessment is an essential part of the most authoritative reference on toxicologic pathology principles and techniques for assessing product safety and human risk. Volume 2 describes the integration of product-induced structural and functional changes in tissues and the interpretation of their biological implications. Completely revised with many new chapters, Volume 2 of the Fourth Edition covers product safety assessment from many angles including current and emerging issues in toxicologic pathology for many product classes. Volume 2 of the Handbook of Toxicologic Pathology is a key resource for pathologists, toxicologists, research scientists, and regulators who use toxicologic pathology methods to study and make decisions on product safety. - Previous chapters on such topics as drug discovery and development, toxicity and carcinogenicity testing, report preparation, and risk assessment and communication have undergone extensive revision that includes in-depth discussion of new developments in the field - New chapters consider fundamental attributes for additional product classes including protein therapeutics, nucleic acid pharmaceutical agents, gene therapy and gene editing, stem cell and other cell therapies, vaccines, agricultural and bulk chemicals, and assigning adversity - Chapters dealing with product-specific practices address pathology and regulatory issues - Chapters offer high-quality and up-to-date content in a trusted work written by the collaborative efforts of many leading international subject matter experts - Hundreds of full-color images and diagrams are featured in both the print and electronic versions of this book to illustrate classic examples and highlight difficult concepts