Oecd Guidelines For The Testing Of Chemicals Section 2 Test No 250 Easzy Assay Detection Of Endocrine Active Substances Acting Through Estrogen Receptors Using Transgenic Tg Cyp19a1b Gfp Zebrafish Embryos
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Oecd Guidelines For The Testing Of Chemicals Section 2 Test No 250 Easzy Assay Detection Of Endocrine Active Substances Acting Through Estrogen Receptors Using Transgenic Tg Cyp19a1b Gfp Zebrafish Embryos
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Author : OECD
language : en
Publisher: OECD Publishing
Release Date : 2021-06-17
Oecd Guidelines For The Testing Of Chemicals Section 2 Test No 250 Easzy Assay Detection Of Endocrine Active Substances Acting Through Estrogen Receptors Using Transgenic Tg Cyp19a1b Gfp Zebrafish Embryos written by OECD and has been published by OECD Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-06-17 with categories.
The EASZY assay is a mechanism-based in vivo screening assay designed to detect endocrine active chemicals acting as agonist through estrogen receptors (ERs), by inducing the expression of the green fluorescent protein (GFP) driven by the cyp19a1b promoter. The EASZY assay allows for the detection of estrogenic activity of chemicals on transgenic tg(cyp19a1b:GFP) Zebrafish embryos exposed for 96 hours during the embryonic stages of development.
Lignes Directrices De L Ocde Pour Les Essais De Produits Chimiques Section 2 Essai N 250 D Tection Sur Des Embryons De Poisson Z Bre Transg Nique Tg Cyp19a1b Gfp Des Perturbateurs Endocriniens Agissant Via Les R Cepteurs Des Strog Nes Essai Easzy
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Author : OECD
language : fr
Publisher: OECD Publishing
Release Date : 2021-06-17
Lignes Directrices De L Ocde Pour Les Essais De Produits Chimiques Section 2 Essai N 250 D Tection Sur Des Embryons De Poisson Z Bre Transg Nique Tg Cyp19a1b Gfp Des Perturbateurs Endocriniens Agissant Via Les R Cepteurs Des Strog Nes Essai Easzy written by OECD and has been published by OECD Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-06-17 with categories.
La méthode d’essai EASZY (Endocrine Active Substances using Zebrafish embrYos) est une méthode de dépistage in vivo de type mécanistique, conçue pour détecter les perturbateurs endocriniens agissant comme agonistes des récepteurs des œstrogènes (estrogen receptors, ER), en induisant l’expression de la protéine fluorescente verte (Green Fluorescent Protein, GFP) sous le contrôle du promoteur du gène cyp19a1b.
Clinical Safety And Efficacy Testing Of Cosmetics
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Author : William Waggoner
language : en
Publisher: CRC Press
Release Date : 1989-11-27
Clinical Safety And Efficacy Testing Of Cosmetics written by William Waggoner and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1989-11-27 with Medical categories.
Produced Water
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Author : Kenneth Lee
language : en
Publisher: Springer Science & Business Media
Release Date : 2011-09-18
Produced Water written by Kenneth Lee and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-09-18 with Technology & Engineering categories.
A state-of-the-art review of scientific knowledge on the environmental risk of ocean discharge of produced water and advances in mitigation technologies. In offshore oil and gas operations, produced water (the water produced with oil or gas from a well) accounts for the largest waste stream (in terms of volume discharged). Its discharge is continuous during oil and gas production and typically increases in volume over the lifetime of an offshore production platform. Produced water discharge as waste into the ocean has become an environmental concern because of its potential contaminant content. Environmental risk assessments of ocean discharge of produced water have yielded different results. For example, several laboratory and field studies have shown that significant acute toxic effects cannot be detected beyond the "point of discharge" due to rapid dilution in the receiving waters. However, there is some preliminary evidence of chronic sub-lethal impacts in biota associated with the discharge of produced water from oil and gas fields within the North Sea. As the composition and concentration of potential produced water contaminants may vary from one geologic formation to another, this conference also highlights the results of recent studies in Atlantic Canada.
Oecd Guidelines For The Testing Of Chemicals Section 2 Test No 231 Amphibian Metamorphosis Assay
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Author : OECD
language : en
Publisher: OECD Publishing
Release Date : 2009-09-08
Oecd Guidelines For The Testing Of Chemicals Section 2 Test No 231 Amphibian Metamorphosis Assay written by OECD and has been published by OECD Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-09-08 with categories.
This Test Guideline describes an amphibian metamorphosis assay intended to screen substances which may interfere with the normal functioning of the hypothalamo-pituitary-thyroid axis. The assay was validated with the species Xenopus laevis, which is ...
Vertebrate Development
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Author : Francisco Pelegri
language : en
Publisher: Springer
Release Date : 2016-12-13
Vertebrate Development written by Francisco Pelegri and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-12-13 with Science categories.
This book provides a comprehensive overview of topics describing the earliest steps of fertilization, from egg activation and fertilization to the activation of the zygotic genome, in various studied vertebrate model systems. The contribution of maternal and paternal factors and their role in the early embryo as parental DNA becomes modified and embryonic genes become activated is fundamental to the initiation of embryogenesis in all animal systems. It can be argued that this is a unique developmental period, when information from the parents is compressed to direct the development of the body plan of the entire organism, a process of astounding simplicity, elegance and beauty. In addition to their fundamental scientific interest, many frontiers of biomedicine, such as reproductive biology, stem cells and reprogramming, and the understanding of intergenerational diseases, depend on advances in our knowledge of these early processes. Vertebrate Development: Maternal to Zygotic Control brings together chapters from experts in various disciplines describing the latest advances related to this important developmental transition. Each chapter is a synthesis of knowledge relevant to all vertebrates, with details on specific systems as well as comparisons between the various studied vertebrate models. The editorial expertise encompasses the fields of major vertebrate model systems (mammalian, amphibian and teleost) ensuring a balanced approach to various topics. This unique book—with its combination of in-depth and up-to-date basic research, inter-species comprehensiveness and emphasis on the very early stages of animal development—is essential for research scientists studying vertebrate development, as well as being a valuable resource for college educators teaching advanced courses in developmental biology.
Oecd Guidelines For The Testing Of Chemicals Oecd Series On Testing And Assessment Detailed Review Paper On Fish Screening Assays For The Detection Of Endocrine Active Substances
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Author : OECD
language : en
Publisher: OECD Publishing
Release Date : 2004-11-01
Oecd Guidelines For The Testing Of Chemicals Oecd Series On Testing And Assessment Detailed Review Paper On Fish Screening Assays For The Detection Of Endocrine Active Substances written by OECD and has been published by OECD Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 2004-11-01 with categories.
This Detailed Review Paper (DRP) is intended to provide the current state-of-the-knowledge in the area of fish screening assays for chemicals active at the endocrine level on the reproductive system of test animals.
Oecd Guidelines For The Testing Of Chemicals Section 4 Test No 455 Performance Based Test Guideline For Stably Transfected Transactivation In Vitro Assays To Detect Estrogen Receptor Agonists And Antagonists
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Author : OECD
language : en
Publisher: OECD Publishing
Release Date : 2021-06-17
Oecd Guidelines For The Testing Of Chemicals Section 4 Test No 455 Performance Based Test Guideline For Stably Transfected Transactivation In Vitro Assays To Detect Estrogen Receptor Agonists And Antagonists written by OECD and has been published by OECD Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-06-17 with categories.
This Performance-Based Test Guideline (PBTG) describes in vitro assays, which provide the methodology of Stably Transfected Transactivation to detect Estrogen Receptor Agonists and Antagonists (ER TA assays).
Oecd Guidelines For The Testing Of Chemicals Section 2 Test No 248 Xenopus Eleutheroembryonic Thyroid Assay Xeta
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Author : OECD
language : en
Publisher: OECD Publishing
Release Date : 2019-06-18
Oecd Guidelines For The Testing Of Chemicals Section 2 Test No 248 Xenopus Eleutheroembryonic Thyroid Assay Xeta written by OECD and has been published by OECD Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-06-18 with categories.
The purpose of the test is to measure the capacity of a chemical to activate or inhibit the transcription of a genetic construct (THb/ZIP-GFP X. laevis eleutheroembryos) either by binding to the thyroid hormone receptor or by modifying the amount of thyroid hormone available for transcription. The test is based on the use of a transgenic frog (possessing the genetic construction THb/ZIP-GFP) of the species X. laevis. GFP is a fluorescent protein that can be used to affirm the presence of the substance and to follow its action. This test is based on the quantification of fluorescence, and thus of the GFP protein, throughout the eleutheroembryo exposed to a test chemical. Indeed, if the fluorescence is > 12% by including the highest concentration of the test, the test is considered positive. Organisms are exposed in chemically inert cell culture plates (6 wells). Each well contains ten organisms in solution. In a run, 20 organisms are exposed to each test concentration. Tadpoles are exposed to the test chemical at NF stage 45 for a duration of 72 hours. A positive result of the XETA test indicates in vivo that a substance induces damage to the receptor and metabolization of the thyroid hormone. A negative result indicates that, under test conditions, the test substance does not induce detectable damage to the thyroid and its functioning.
Oecd Guidelines For The Testing Of Chemicals Oecd Series On Testing And Assessment Detailed Review Paper On Amphibian Metamorphosis Assay For The Detection Of Thyroid Active Substances
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Author : OECD
language : en
Publisher: OECD Publishing
Release Date : 2004-11-01
Oecd Guidelines For The Testing Of Chemicals Oecd Series On Testing And Assessment Detailed Review Paper On Amphibian Metamorphosis Assay For The Detection Of Thyroid Active Substances written by OECD and has been published by OECD Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 2004-11-01 with categories.
This Detailed Review Paper (DRP) provides the current state-of-the-knowledge in the area of amphibian metamorphosis with the view to use amphibian metamorphosis as a model for the detection of chemicals affecting the thyroid axis in vertebrates.