Oecd Guidelines For The Testing Of Chemicals Section 4 Test No 442b Skin Sensitization Local Lymph Node Assay Brdu Elisa Or Fcm
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Oecd Guidelines For The Testing Of Chemicals Section 4 Test No 442b Skin Sensitization Local Lymph Node Assay Brdu Elisa Or Fcm
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Author : OECD
language : en
Publisher: OECD Publishing
Release Date : 2025-06-25
Oecd Guidelines For The Testing Of Chemicals Section 4 Test No 442b Skin Sensitization Local Lymph Node Assay Brdu Elisa Or Fcm written by OECD and has been published by OECD Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 2025-06-25 with categories.
The Local Lymph Node Assay: BrdU-ELISA (LLNA:BrdU-ELISA) is a non-radioactive modification to the LLNA method for identifying potential skin sensitizing test substances and measuring the proliferation of lymphocytes they induce in the auricular ...
Oecd Guidelines For The Testing Of Chemicals Section 4 Test No 442c In Chemico Skin Sensitisation Assays Addressing The Adverse Outcome Pathway Key Event On Covalent Binding To Proteins
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Author : OECD
language : en
Publisher: OECD Publishing
Release Date : 2025-06-25
Oecd Guidelines For The Testing Of Chemicals Section 4 Test No 442c In Chemico Skin Sensitisation Assays Addressing The Adverse Outcome Pathway Key Event On Covalent Binding To Proteins written by OECD and has been published by OECD Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 2025-06-25 with categories.
The present Key Event based Test Guideline addresses the human health hazard endpoint skin sensitisation, following exposure to a test chemical. Skin sensitisation refers to an allergic response following skin contact with the tested chemical, as defined by the United Nations Globally Harmonized System of Classification and Labelling of Chemicals (UN GHS). This Test Guideline is proposed to address the Molecular Initiating Event leading to skin sensitisation, namely protein reactivity, by quantifying the reactivity of test chemicals towards model synthetic peptides or amino acid derivatives containing either lysine or cysteine. This Test Guideline provides three in chemico test methods addressing the same Key Event on the Adverse Outcome Pathway for Skin Sensitisation: (i) the Direct Peptide Reactivity Assay – DPRA, (ii) the Amino Acid Derivative Reactivity Assay – ADRA and (iii) the kinetic Direct Peptide Reactivity Assay – kDPRA. The DPRA and ADRA are used for supporting the discrimination between skin sensitisers and non-sensitisers in accordance with the UN GHS. In contrast, the kDPRA allows discrimination of UN GHS subcategory 1A skin sensitisers from those not categorised as subcategory 1A, i.e. subcategory 1B or no category but does not allow to distinguish sensitisers from non-sensitisers.
Oecd Guidelines For The Testing Of Chemicals Section 4 Guideline No 497 Defined Approaches On Skin Sensitisation
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Author : OECD
language : en
Publisher: OECD Publishing
Release Date : 2025-06-25
Oecd Guidelines For The Testing Of Chemicals Section 4 Guideline No 497 Defined Approaches On Skin Sensitisation written by OECD and has been published by OECD Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 2025-06-25 with categories.
A Defined Approach (DA) consists of a selection of information sources (e.g in silico predictions, in chemico, in vitro data) used in a specific combination, and resulting data are interpreted using a fixed data interpretation procedure (DIP) (e.g. a mathematical, rule-based model). DAs use methods in combination and are intended to overcome some limitations of the individual, stand-alone methods.
Skin Allergy An Issue Of Immunology And Allergy Clinics Of North America E Book
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Author : Susan Nedorost
language : en
Publisher: Elsevier Health Sciences
Release Date : 2021-07-08
Skin Allergy An Issue Of Immunology And Allergy Clinics Of North America E Book written by Susan Nedorost and has been published by Elsevier Health Sciences this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-07-08 with Medical categories.
Skin Allergy, An Issue of Immunology and Allergy Clinics of North America, E-Book
Toxicity Mechanisms Exposure Toxicokinetic And Risk Assessment Aspects Of Metals Toxic For Animals And Humans
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Author : Yanzhu Zhu
language : en
Publisher: Frontiers Media SA
Release Date : 2022-03-10
Toxicity Mechanisms Exposure Toxicokinetic And Risk Assessment Aspects Of Metals Toxic For Animals And Humans written by Yanzhu Zhu and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-03-10 with Science categories.
European Partnership On The Assessment Of Risks From Chemicals Parc Focus On New Approach Methodologies Nams In Risk Assessment
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Author : Terje Svingen
language : en
Publisher: Frontiers Media SA
Release Date : 2024-08-21
European Partnership On The Assessment Of Risks From Chemicals Parc Focus On New Approach Methodologies Nams In Risk Assessment written by Terje Svingen and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-08-21 with Medical categories.
The European Partnership on the Assessment of Risks from Chemicals (PARC) project was launched in 2022. The overarching aim of this partnership is to enhance our knowledge about chemical substances to better safeguard human health and the environment against harmful effects. The project will run for seven years under Horizon Europe. PARC is subdivided into several work packages (WPs). WP5 is focused on hazard assessment for human and environmental health and includes more than 80 partners across Europe. WP5 aims to fill data gaps for specified chemical substances of concern (e.g, bisphenol alternatives) and to develop or improve new approach methodologies (NAMs) for chemical hazard assessment. This is in order to progress towards a risk assessment paradigm relying less on animal toxicity data, both with respect to human health and environmental safety. As the PARC initiative will evolve over time with respect to both projects and activities, presenting early initiatives will foster an increased awareness of ongoing activities and potential incorporation of new activities going forward.
Biocompatibility And Performance Of Medical Devices
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Author : Jean-Pierre Boutrand
language : en
Publisher: Woodhead Publishing
Release Date : 2019-11-21
Biocompatibility And Performance Of Medical Devices written by Jean-Pierre Boutrand and has been published by Woodhead Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-11-21 with Technology & Engineering categories.
Biocompatibility and Performance of Medical Devices, Second Edition, provides an understanding of the biocompatibility and performance tests for ensuring that biomaterials and medical devices are safe and will perform as expected in the biological environment. Sections cover key concepts and challenges faced in relation to biocompatibility in medical devices, discuss the evaluation and characterization of biocompatibility in medical devices, describe preclinical performance studies for bone, dental and soft tissue implants, and provide information on the regulation of medical devices in the European Union, Japan and China. The book concludes with a review of histopathology principles for biocompatibility and performance studies. - Presents diverse insights from experts in government, industry and academia - Delivers a comprehensive overview of testing and interpreting medical device performance - Expanded to include new information, including sections on managing extractables, accelerating and simplifying medical device development through screening and alternative biocompatibility methods, and quality strategies which fasten device access to market
Lignes Directrices De L Ocde Pour Les Essais De Produits Chimiques Section 4 Ligne Directrice N 497 Approches D Finies Pour La Sensibilisation Cutan E
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Author : OECD
language : fr
Publisher: OECD Publishing
Release Date : 2025-06-25
Lignes Directrices De L Ocde Pour Les Essais De Produits Chimiques Section 4 Ligne Directrice N 497 Approches D Finies Pour La Sensibilisation Cutan E written by OECD and has been published by OECD Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 2025-06-25 with categories.
Une approche définie (AD) est un ensemble défini de sources d’information (p. ex. prédiction in silico, des données in chemico ou in vitro) utilisées en une combinaison spécifique, dont les résultats sont interprétés selon une procédure établie d’interprétation des données (modèle mathématique ou approche fondée sur des règles, par exemple). Les ADs utilisent des combinaisons de méthodes dans le but de compenser certaines des limites de chacune de ces méthodes lorsqu’elles sont appliquées seules.
Lignes Directrices De L Ocde Pour Les Essais De Produits Chimiques Section 4 Essai N 442b Sensibilisation Cutan E Essai De Stimulation Locale Des Ganglions Lymphatiques Brdu Elisa
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Author : OECD
language : fr
Publisher: OECD Publishing
Release Date : 2025-06-25
Lignes Directrices De L Ocde Pour Les Essais De Produits Chimiques Section 4 Essai N 442b Sensibilisation Cutan E Essai De Stimulation Locale Des Ganglions Lymphatiques Brdu Elisa written by OECD and has been published by OECD Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 2025-06-25 with categories.
L’Essai de stimulation locale des ganglions lymphatiques: BrdU-ELISA (ELGL: BrdU-ELISA) est une variante non radioactive de la méthode ELGL qui vise à identifier les substances chimiques sensibilisantes et à mesurer la prolifération lymphocytaire ...
Oecd Guidelines For The Testing Of Chemicals Section 4 Test No 442a Skin Sensitization Local Lymph Node Assay Da
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Author : OECD
language : en
Publisher: OECD Publishing
Release Date : 2010-07-23
Oecd Guidelines For The Testing Of Chemicals Section 4 Test No 442a Skin Sensitization Local Lymph Node Assay Da written by OECD and has been published by OECD Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-07-23 with categories.
The Local Lymph Node Assay: DA (LLNA: DA) is a non-radioactive modification to the LLNA method for identifying potential skin sensitizing test substances and measuring the proliferation of lymphocytes they induce in the auricular lymph nodes. The ...