Oecd Guidelines For The Testing Of Chemicals Section 4 Test No 490 In Vitro Mammalian Cell Gene Mutation Tests Using The Thymidine Kinase Gene
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Oecd Guidelines For The Testing Of Chemicals Section 4 Test No 490 In Vitro Mammalian Cell Gene Mutation Tests Using The Thymidine Kinase Gene
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Author : OECD
language : en
Publisher: OECD Publishing
Release Date : 2016-07-29
Oecd Guidelines For The Testing Of Chemicals Section 4 Test No 490 In Vitro Mammalian Cell Gene Mutation Tests Using The Thymidine Kinase Gene written by OECD and has been published by OECD Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-07-29 with categories.
This TG includes two distinct in vitro mammalian gene mutation assays requiring two specific tk heterozygous cells lines: L5178Y tk+/-3.7.2C cells for the mouse lymphoma assay (MLA) and TK6 tk+/- cells for the TK6 assay.
Test No 490 In Vitro Mammalian Cell Gene Mutation Tests Using The Thymidine Kinase Gene
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Author : OECD
language : en
Publisher: OECD Publishing
Release Date : 2015-07-28
Test No 490 In Vitro Mammalian Cell Gene Mutation Tests Using The Thymidine Kinase Gene written by OECD and has been published by OECD Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-07-28 with categories.
This TG includes two distinct in vitro mammalian gene mutation assays requiring two specific tk heterozygous cells lines: L5178Y tk+/-3.7.2C cells for the mouse lymphoma assay (MLA) and TK6 tk+/- cells for the TK6 assay.
Oecd Guidelines For The Testing Of Chemicals Section 4 Test No 476 In Vitro Mammalian Cell Gene Mutation Tests Using The Hprt And Xprt Genes
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Author : OECD
language : en
Publisher: OECD Publishing
Release Date : 2016-07-29
Oecd Guidelines For The Testing Of Chemicals Section 4 Test No 476 In Vitro Mammalian Cell Gene Mutation Tests Using The Hprt And Xprt Genes written by OECD and has been published by OECD Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-07-29 with categories.
The in vitro mammalian cell gene mutation test can be used to detect gene mutations induced by chemical substances. In this test, the used genetic endpoints measure mutation at hypoxanthine-guanine phosphoribosyl transferase (HPRT), and at a transgene of xanthineguanine phosphoribosyl transferase...
Test No 476 In Vitro Mammalian Cell Gene Mutation Test
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Author : OECD
language : en
Publisher: OECD Publishing
Release Date : 1997-07-21
Test No 476 In Vitro Mammalian Cell Gene Mutation Test written by OECD and has been published by OECD Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 1997-07-21 with categories.
The in vitro mammalian cell gene mutation test can be used to detect gene mutations induced by chemical substances. In the cell lines the most commonly-used genetic endpoints measure mutation at thymidine kinase (TK) and hypoxanthine-guanine ...
Oecd Guidelines For The Testing Of Chemicals Section 4 Test No 470 Mammalian Erythrocyte Pig A Gene Mutation Assay
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Author : OECD
language : en
Publisher: OECD Publishing
Release Date : 2022-06-30
Oecd Guidelines For The Testing Of Chemicals Section 4 Test No 470 Mammalian Erythrocyte Pig A Gene Mutation Assay written by OECD and has been published by OECD Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-06-30 with categories.
This Test Guideline describes an in vivo erythrocyte Pig-a gene mutation assay (hereafter called the Pig-a assay) which uses an endogenous mammalian gene, the phosphatidylinositol glycan class A gene (Pig-a), as a reporter of somatic-cell gene mutation. In vivo gene mutation tests, such as the Pig-a assay, are especially relevant for assessing mutagenicity because physiological factors, such as absorption of the test chemical from the site of exposure, distribution of the test chemical throughout the test system via systemic circulation, and in vivo metabolism and DNA repair processes, all contribute to the mutagenic responses.
Test No 476 In Vitro Mammalian Cell Gene Mutation Tests Using The Hprt And Xprt Genes
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Author : OECD
language : en
Publisher: OECD Publishing
Release Date : 2015-07-28
Test No 476 In Vitro Mammalian Cell Gene Mutation Tests Using The Hprt And Xprt Genes written by OECD and has been published by OECD Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-07-28 with categories.
The in vitro mammalian cell gene mutation test can be used to detect gene mutations induced by chemical substances. In this test, the used genetic endpoints measure mutation at hypoxanthine-guanine phosphoribosyl transferase (HPRT), and at a transgene of xanthineguanine phosphoribosyl ...
Oecd Guidelines For The Testing Of Chemicals Section 4 Test No 488 Transgenic Rodent Somatic And Germ Cell Gene Mutation Assays
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Author : OECD
language : en
Publisher: OECD Publishing
Release Date : 2022-06-30
Oecd Guidelines For The Testing Of Chemicals Section 4 Test No 488 Transgenic Rodent Somatic And Germ Cell Gene Mutation Assays written by OECD and has been published by OECD Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-06-30 with categories.
This Test Guideline describes an in vivo assay that detects chemicals that may induce gene mutations in somatic and germ cells. In this assay, transgenic rats or mice that contain multiple copies of chromosomally integrated plasmid or phage shuttle vectors are used. The transgenes contain reporter genes for the detection of various types of mutations induced by test chemicals.
Oecd Guidelines For The Testing Of Chemicals Section 4 Test No 482 Genetic Toxicology Dna Damage And Repair Unscheduled Dna Synthesis In Mammalian Cells In Vitro
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Author : OECD
language : en
Publisher: OECD Publishing
Release Date : 1986-10-23
Oecd Guidelines For The Testing Of Chemicals Section 4 Test No 482 Genetic Toxicology Dna Damage And Repair Unscheduled Dna Synthesis In Mammalian Cells In Vitro written by OECD and has been published by OECD Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 1986-10-23 with categories.
The Test Guideline for Unscheduled DNA Synthesis (UDS) in mammalian cells in vitro describes procedures utilizing primary cultures, human lymphocytes or established cell lines, to detect DNA repair synthesis after excision and removal of a stretch ...
Oecd Guidelines For The Testing Of Chemicals Section 4 Test No 487 In Vitro Mammalian Cell Micronucleus Test
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Author : OECD
language : en
Publisher: OECD Publishing
Release Date : 2023-07-04
Oecd Guidelines For The Testing Of Chemicals Section 4 Test No 487 In Vitro Mammalian Cell Micronucleus Test written by OECD and has been published by OECD Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-07-04 with categories.
The in vitro micronucleus test is a genotoxicity test for the detection of micronuclei in the cytoplasm of interphase cells.
Nanocosmetics
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Author : Arun Nanda
language : en
Publisher: Elsevier
Release Date : 2020-05-06
Nanocosmetics written by Arun Nanda and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-05-06 with Technology & Engineering categories.
Nanotechnology is key to the design and manufacture of the new generation of cosmetics. Nanotechnology can enhance the performance and properties of cosmetics, including colour, transparency, solubility, texture, and durability. Sunscreen products, such as UV nano-filters, nano-TiO2 and nano-ZnO particles, can offer an advantage over their traditional counterparts due to their broad UV-protection and non-cutaneous side effects. For perfumes, nano-droplets can be found in cosmetic products including Eau de Toilette and Eau de Parfum. Nanomaterials can also be used in cosmetics as transdermal drug delivery systems. By using smart nanocontainers, active compounds such as vitamins, antioxidants, nutrients, and anti-inflammatory, anti-infective agents, can be delivered effectively. These smart nanocontainers are typically related with the smart releasing property for their embedded active substances. These smart releases could be obtained by using the smart coatings as their outer nano-shells. These nano-shells could prevent the direct contact between these active agents and the adjacent local environments. Nanocosmetics: Fundamentals, Applications and Toxicity explores the formulation design concepts and emerging applications of nanocosmetics. The book also focuses on the mitigation or prevention of their potential nanotoxicity, potential global regulatory challenges, and the technical challenges of mass implementation. It is an important reference source for materials scientists and pharmaceutical scientists looking to further their understanding of how nanotechnology is being used for the new generation of cosmetics. Outlines the major fabrication and formulation design concepts of nanoscale products for cosmetic applications Explores how nanomaterials can safely be used for various applications in cosmetic products Assesses the major challenges of using nanomaterials for cosmetic applications on a large scale