Open Channel Microfluidics Second Edihb
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Open Channel Microfluidics
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Author : Jean Berthier
language : en
Publisher: Morgan & Claypool Publishers
Release Date : 2019-09-04
Open Channel Microfluidics written by Jean Berthier and has been published by Morgan & Claypool Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-09-04 with Technology & Engineering categories.
Open microfluidics, the study of microflows having a boundary with surrounding air, encompasses different aspects such as paper or thread-based microfluidics, droplet microfluidics and open-channel microfluidics. Open-channel microflow is a flow at the micro-scale, guided by solid structures, and having at least a free boundary (with air or vapor) other than the advancing meniscus. This book is devoted to the study of open-channel microfluidics which (contrary to paper or thread or droplet microfluidics) is still very sparsely documented, but bears many new applications in biology, biotechnology, medicine, material and space sciences. Capillarity being the principal force triggering an open microflow, the principles of capillarity are first recalled. The onset of open-channel microflow is next analyzed and the fundamental notion of generalized Cassie angle (the apparent contact angle which accounts for the presence of air) is presented. The theory of the dynamics of open-channel microflows is then developed, using the notion of averaged friction length which accounts for the presence of air along the boundaries of the flow domain. Different channel morphologies are studied and geometrical features such as valves and capillary pumps are examined. An introduction to two-phase open-channel microflows is also presented showing that immiscible plugs can be transported by an open-channel flow. Finally, a selection of interesting applications in the domains of space, materials, medicine and biology is presented, showing the potentialities of open-channel microfluidics.
Open Channel Microfluidics
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Author : Berthier Jean
language : en
Publisher:
Release Date : 1901
Open Channel Microfluidics written by Berthier Jean and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1901 with categories.
Open Microfluidics
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Author : Jean Berthier
language : en
Publisher: John Wiley & Sons
Release Date : 2016-07-20
Open Microfluidics written by Jean Berthier and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-07-20 with Science categories.
Open microfluidics or open-surface is becoming fundamental in scientific domains such as biotechnology, biology and space. First, such systems and devices based on open microfluidics make use of capillary forces to move fluids, without any need for external energy. Second, the "openness" of the flow facilitates the accessibility to the liquid in biotechnology and biology, and reduces the weight in space applications. This book has been conceived to give the reader the fundamental basis of open microfluidics. It covers successively The theory of spontaneous capillary flow, with the general conditions for spontaneous capillary flow, and the dynamic aspects of such flows. The formation of capillary filaments which are associated to small contact angles and sharp grooves. The study of capillary flow in open rectangular, pseudo-rectangular and trapezoidal open microchannels. The dynamics of open capillary flows in grooves with a focus on capillary resistors. The case of very viscous liquids is analyzed. An analysis of suspended capillary flows: such flows move in suspended channels devoid of top cover and bottom plate. Their accessibility is reinforced, and such systems are becoming fundamental in biology. An analysis of “rails” microfluidics, which are flows that move in channels devoid of side walls. This geometry has the advantage to be compatible with capillary networks, which are now of great interest in biotechnology, for molecular detection for example. Paper-based microfluidics where liquids wick flat paper matrix. Applications concern bioassays such as point of care devices (POC). Thread-based microfluidics is a new domain of investigation. It is seeing presently many new developments in the domain of separation and filtration, and opens the way to smart bandages and tissue engineering. The book is intended to cover the theoretical aspects of open microfluidics, experimental approaches, and examples of application.
Introduction To Microfluidics
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Author : Patrick Tabeling
language : en
Publisher: Oxford University Press
Release Date : 2023-06-26
Introduction To Microfluidics written by Patrick Tabeling and has been published by Oxford University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-06-26 with Science categories.
The second edition of Introduction to Microfluidics captures all the new exciting developments in the field of microfluidics over the last twenty years. While maintaining the same clear structure, and accessible explanations of the basic theory, this new edition is a complete revision of the first edition and makes use of the considerable data collected in the field over the last two decades. The book describes the applications, the market, and attempts to envision the future of microfluidics. It covers the physics of miniaturization, the hydrodynamics of microfluidics in channels and with droplets, transport phenomena in microsystems, electrokinetic phenomena, and an introduction to microfabrication. The basic principles are explored in depth and with rigor, and their main applications are clearly presented. Many examples are provided and discussed simply, most often from a physical perspective, and the book includes 415 figures and 600 references. Offering a cross-disciplinary view of the field embracing biological, chemical, physical and engineering perspectives, this book is an ideal resource for students and researchers at any level.
Studying Droplet Behavior And Capillary Flow In Open Microfluidic Channels
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Author : Jing Jei Lee
language : en
Publisher:
Release Date : 2021
Studying Droplet Behavior And Capillary Flow In Open Microfluidic Channels written by Jing Jei Lee and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021 with categories.
This dissertation discusses advancements in open channel microfluidics, the design and fabrication of open channels and capillary pumps, and methods to manipulate open channels. An open droplet-based microfluidics platform is demonstrated with promising future applications. Additionally, an expression to measure the velocity of capillary flow in an open channel and design guidelines for an efficient capillary pump are presented.Chapter 1 discusses the field of microfluidics and the advantages of such platforms. The fundamentals of open microfluidics is presented along with the benefits of open channel systems. Capillary flow is discussed, and the necessary considerations for fabrication of channels to ensure that the fluid in the system is driven by capillary means is provided. Droplet-based microfluidics is a large subfield of microfluidics, which is briefly reviewed, and a need for further fundamental and applied work using droplet-based systems which are completely driven by capillary flow is discussed. Finally, capillary pumps provide a solution to the inherent decrease of velocity (and flow rate) observed in channels driven by capillary flow. Chapter 2 introduces droplet-based microfluidics where droplets are formed in an open channel that is completely driven by capillary means. Our work represents the first time that this phenomenon was observed and studied. The interaction that exists between a droplet and the surrounding phase is described in detail. Chapter 3 explores fundamental microfluidic features in open channels: droplet splitting, multiple droplets, and droplet merging. An example of an open platform that enables users to manipulate droplets on the same chip is presented. Chapter 4 investigates capillary flow in an open channel, and an expression to measure velocity derived from the Lucas-Washburn-Rideal law is presented. The capillary flow in bifurcations and networks of open channels are studied. Chapter 5 investigates the theory of open capillary pumps to alleviate the inherent decrease of velocity and flow rate during capillary flow. Design guidelines of an efficient open capillary pump are discussed. Chapter 6 concludes the thesis with an overall perspective of the field and other experimental proposals to improve the overall design of open channels and capillary pumps and to enable applications with the platform.
Applied Mechanics And Bio Microfluidic Applications For Open Microfluidic Systems
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Author : Jue Nee Tan
language : en
Publisher:
Release Date : 2014
Applied Mechanics And Bio Microfluidic Applications For Open Microfluidic Systems written by Jue Nee Tan and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014 with categories.
Microfluidics is attractive in many aspects and advancement of technology on these micron-scales have led to the development of devices often used in industries such as clinical and forensic analysis; micro-reaction engineering; surface patterning; and optical engineering. Despite its popularity, traditional microfluidic applications however, are known to have large dead volume; awkward chip-to-world interfaces; difficulty in exchanging solutions; and limited parallelization. Recent progresses in open microfluidic systems have shown great potential in addressing the aforementioned limitations.The aim of this thesis is to expand our understanding regarding fluid behaviour and interaction in the micro-domain scale of an open environment. Knowledge obtained through these studies could then be implemented in developing systems involving microfluidic components and bio-microfluidic applications. As a prelude to the main body of work, a basic theoretical framework on the background of microfluidics and the physics of the micro-scale is presented. The research can be divided into two major components, Part I: Open Microchannels and Part II: Microdroplets. These components were then further sub-categorized according to their applications including microfluidic pumping; mixing; liquid transfer; cell lysis; and concentration gradient generation. In all these, an open environment allowing for external interaction and manipulation was implemented. In Part I, flows on open channels and films was investigated. The open structures include a straight open channel defined by a narrow strip of solid surface and a wider structure allowing for multiple inputs and outputs. Computational models were also developed for fluid flow and the findings used to describe the factors affecting the stability of the system in both structures. The system can be seen as either a self-contained open fluidic device, or an open section in an otherwise enclosed system. Following on, the mixing mechanism of a Y-junction open raised channel was examined. The open nature of the channel employed allowed introduction of external shear stresses on the interfacial surface to aid in the mixing process, while maintaining the simplicity of the system as a whole. This mode of mixing provides a versatile platform where alterations can be made to the open system to accommodate mixing without the added complexities. In Part II, investigation was first carried out on two different mechanisms of vertical liquid transfer. The first is through the formation and detachment of a liquid bridge and the second is through the liquid jet formed upon rupture of an encapsulated bubble within a microdroplet. Both mechanisms demonstrated selective transfer of discrete volumes of fluid, a process that will prove useful in many droplet-based microfluidic applications. From the results gathered, the role of the bubble in inducing cell lysis in a controlled and repeatable environment was explored. The fluid jet was then presented as a method capable of causing effective 100% cell lysis of a droplet of suspended cells. Apart from that, a method using microdroplets administered on a planar surface to produce a gradient of droplet concentrations over an array of open wells is presented. The system was tailored to generate concentration gradients in a close quantitative agreement to a two-fold dilution system akin to routine pipetting operations. The findings presented in this thesis are unique in their nature as the methods and applications demonstrated were able to extract the advantages of open microfluidics. Benefits include and are not limited to minimal fabrication and consequently lower production costs involved; small sample volume requirements; selectivity; rapid operation time; and greater control. It is hoped that these results would promote the use of open microfluidics and encourage further exploration of this topic in the future.
Open Space Microfluidics
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Author : Emmanuel Delamarche
language : en
Publisher: John Wiley & Sons
Release Date : 2018-01-18
Open Space Microfluidics written by Emmanuel Delamarche and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-01-18 with Technology & Engineering categories.
Summarizing the latest trends and the current state of this research field, this up-to-date book discusses in detail techniques to perform localized alterations on surfaces with great flexibility, including microfluidic probes, multifunctional nanopipettes and various surface patterning techniques, such as dip pen nanolithography. These techniques are also put in perspective in terms of applications and how they can be transformative of numerous (bio)chemical processes involving surfaces. The editors are from IBM Zurich, the pioneers and pacesetters in the field at the forefront of research in this new and rapidly expanding area.
Fundamentals And Applications Of Microfluidics
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Author : Nam-Trung Nguyen
language : en
Publisher: Integrated Microsystems
Release Date : 2006
Fundamentals And Applications Of Microfluidics written by Nam-Trung Nguyen and has been published by Integrated Microsystems this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006 with Science categories.
This revised second edition provides electrical and mechanical engineers with complete and current coverage of microfluidics--an emerging field involving fluid flow and devices in microscale and nanoscale. This volume offers a greatly expanded treatment of nanotechnology, electrokinetics, and flow theory.