Opioid Analgesics
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Opioid Analgesics
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Author : A.F. Casy
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-06-29
Opioid Analgesics written by A.F. Casy and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-06-29 with Medical categories.
The rapidly burgeoning research of the past two decades on agonist-antagonist analgesics and opioid receptors makes this exhaustive review of opioid anal gesics particularly relevant and timely. After an introductory chapter the additional 12 chapters begin logically with morphine and congeners (4- epoxymorphinans) and end with opioid receptors. All principal chemical types of centrally acting analgesics (including endogenous opioid-like substances) and their antagonists as well as the mixed agonist-antagonists are treated thoroughly, although not always (and for good reason) in historical (chrono logical) order. A chapter on miscellaneous types (atypical structures for the most part) includes the benzimidazoles (etonitazene), aminotetralins (dezocine), tetrahydroisoquinolines (methopholine), and so on. Important aspects and correlations of chemistry, pharmacology, and biochemistry are discussed in depth. Literature citations are numerous. For educators, practicing laboratory scientists, and physicians, this scholarly review by two authors well of opioid analgesics versed in the chemistry, pharmacology, and biochemistry will be informative, stimulating, and thought-provoking. Everette L. May Medical College of Virginia Richmond, VA 23298 v Preface The history of opium predates the written word, although knowledge of its constituents dates back less than 200 years. Over the centuries its popularity for the relief of pain has waxed and waned, until today the opiates are widely recognized as excellent analgesics but with disadvantages that have impaired their use seriously. There is a clear need for a potent analgesic with minimal effects on the respiratory centers and gastrointestinal tract and preferably devoid of dependence liability.
The Essence Of Analgesia And Analgesics
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Author : Raymond S. Sinatra
language : en
Publisher: Cambridge University Press
Release Date : 2010-10-14
The Essence Of Analgesia And Analgesics written by Raymond S. Sinatra and has been published by Cambridge University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-10-14 with Medical categories.
The Essence of Analgesia and Analgesics is an invaluable practical resource for clinicians giving pain relief in any clinical setting, describing the pharmacologic principles and clinical use of all available pain medications. As well as detailed overviews of pain processing and analgesic theory, sections are dedicated to oral and panteral opioid analgesics, neuraxial opioids, NSAIDs, local anesthetics, anticonvulsant type analgesics, NMDA antagonists, alpha adrenergic analgesics, antidepressant analgesics, muscle relaxants, adjuvant medications, and new and emerging analgesics. The concise format of the chapters allows for quick and easy reading and assimilation of information. Enhanced by summary tables and figures, each chapter provides an overview of a particular drug, covering chemical structure, mode of activity, indications, contraindications, common doses and uses, advantages and disadvantages, and drug related adverse events. Key references are also provided. Edited by leading experts in pain management, this is essential reading for any clinician involved in pain management.
Opioids In Non Cancer Pain
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Author : Cathy Stannard
language : en
Publisher: OUP Oxford
Release Date : 2013-03-21
Opioids In Non Cancer Pain written by Cathy Stannard and has been published by OUP Oxford this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-03-21 with Medical categories.
Opioids have been used as analgesics for many years, and their use in the management of acute pain related to trauma and surgery is well established. However, patients with persisting pain need a pain management plan that brings relief of symptoms without adverse effects in both the short and longer terms. The prescribing of opioids for chronic non-cancer pain has increased substantially since the first edition of this pocketbook was published, prompting considerable debate regarding the appropriateness of prescribing for this indication and the potential harms to individuals and to society that may result from this trend. This second edition of Opioids in Non-Cancer Pain brings clinicians up to date on the current use of opioid drugs in patients with non-cancer pain, and highlights the potential benefits of therapy as well as the problems that can occur. The edition includes new chapters on the history of opioids to help contextualize the following discussions, and a new chapter covering the emerging field of pharmacogenomics which provides explanations for differing responsiveness to opioids and propensity to adverse effects. An international perspective on opioid prescribing trends is also a valuable new addition.
Opioid Therapy In The 21st Century
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Author : Howard S. Smith
language : en
Publisher: Oxford University Press
Release Date : 2013-02-21
Opioid Therapy In The 21st Century written by Howard S. Smith and has been published by Oxford University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-02-21 with Medical categories.
Over the last thirty years, the concern of Pain Medicine practitioners about the potential for their patients to develop a dependence on opioids has left opioid therapy as a largely underutilized treatment. While there is no simple answer to chronic pain, opioids remain the only class of drugs capable of providing relief to patients experiencing serious pain. Opioid Therapy in the 21st Century, Second Edition fills a dearth of clinical knowledge about analgesics to aid practitioners in weighing the risks versus the benefits of opioid therapy for their chronic pain patients. Part of the Oxford American Pain Library, this concise guide serves as a practical, user-friendly reference for physicians across the range of primary care and medical specialties. It includes an overview of appropriate clinical applications of opioids, covering such topics as opioid pharmacology, route selection, and individualization of therapy, as well as strategies for managing and mitigating the risk of abuse, addiction, and diversion. There are also special sections dedicated to the unique needs of pediatric, geriatric, and palliative care patient populations. This second edition discusses opioids approved for use since publication of the first edition, such as Butrans (buprenorphine patch); fentanyl patch and nasal spray; abuse resistant version of Oxycontin; and Embeda (morphine sulfate). Approved indications for older opioids as well as clinical trial information have also been updated.
Opioids In Cancer Pain
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Author : Mellar P. Davis
language : en
Publisher: Oxford University Press, USA
Release Date : 2009-05-28
Opioids In Cancer Pain written by Mellar P. Davis and has been published by Oxford University Press, USA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-05-28 with Medical categories.
Opioids can be effective in relieving pain in more than 90% of cancer patients. However, often irrational fears from both patients and clinicians persist about the potential for addiction, meaning treatable pain continues to be tolerated. This book offers clear guidelines on the use of opioids when managing cancer pain.
Regional Opioid Analgesia
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Author : J. de Castro
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Regional Opioid Analgesia written by J. de Castro and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
by E.K. ZSIGMOND, M.D. Department of Anesthesiology University of Illinois Chicago U.S.A. It is, indeed, a distinct honor and privilege to be invited by the authors to write a preface to this monumental monograph, Regional Opioid Analgesia. Regional Opioid Analgesia is a colossal undertaking by Drs. De Castro, Meynadier and Zenz shortly after the introduction of this revolutionary approach to pain relief which opened a new epoch in analgesiology. This is, indeed, the first authentic and comprehensive textbook encompassing the current knowl edge on this novel approach to pain relief. We are indebted to the authors for introducing the new opioids to regional analgesia with the scientists, who de veloped the potent short and ultrashort acting opioids with high therapeutic indices, which many researchers dreamt about but never before materialized. The side effect liabilities of these new opioids are minute as compared to morphine and meperidine. Regional Opioid Analgesia could not have been more authentically written than by Drs. De Castro,Zenz and Meynadier,who have conducted daily clinical investigations on all known opioids for regional analgesia as well as for neurolept analgesia. Therein lies the great value of this monograph: it is the most authentic work on this topic.
Non Opioid Analgesics In The Treatment Of Acute Pain
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Author : Michael J Parnham
language : en
Publisher: Springer
Release Date : 2012-12-06
Non Opioid Analgesics In The Treatment Of Acute Pain written by Michael J Parnham and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
Dipyrone is widely acknowledged to be an effective antipyretic analgesic with an additional intrinsic spasmolytic activity. It has stood the test of time over the last 75 years in many clinical settings throughout the world. Some 20 years ago, however, concern arose over the implications of isolat ed reports of agranulocytosis following use of dipyrone. Based on these initial cases the Swedish authorities ordered the withdrawal of the drug from the market. Subsequently, dipyrone has been subjected to extensive comparative epidemiological and clinical studies. The results of these in vestigations have allayed the earlier concerns and have shown dipyrone to be a versatile analgesic drug with an overall risk of serious adverse events lower than most other non-opioid analgesics. Based on these results, the Swedish authorities (Lakemedelsverket) have approved the reintroduc tion of dipyrone to clinical use as a valuable contribution to pain treat ment. In connection with this further milestone in the story of the drug, a symposium was held in Stockholm on March 14, 1996, under the chairman ship of Professor N. Rawal to review the current understanding of the ac tion, efficacy and safety of dipyrone. The highlights of this Hoechst symposium emphasize particularly the therapeutic basis for the use of dipyrone in the modern treatment of acute post-operative pain. 9 Mode of action of dipyrone Professor K. Brune, M. D. Erlangen, Germany Most non-opioid analgesic drugs are inhibitors of cydo-oxygenase, the en zyme catalysing the formation of prostaglandins (PGs).
Increase In Fatal Poisonings Involving Opioid Analgesics In The United States 1999 2006
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Author : Margaret Warner
language : en
Publisher:
Release Date : 2009
Increase In Fatal Poisonings Involving Opioid Analgesics In The United States 1999 2006 written by Margaret Warner and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009 with Accidental poisoning categories.
New Non Opioid Analgesics Understanding Molecular Mechanisms On The Basis Of Patch Clamp And Chemical Studies
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Author : Boris V. Krylov
language : en
Publisher: Bentham Science Publishers
Release Date : 2017-06-12
New Non Opioid Analgesics Understanding Molecular Mechanisms On The Basis Of Patch Clamp And Chemical Studies written by Boris V. Krylov and has been published by Bentham Science Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-06-12 with Science categories.
The monograph is a summary of methods used to study pain receptors and the results obtained in some experiments designed to study the effect of non-opioid analgesics. The molecular mechanisms of nociceptive information control in primary sensory nociceptive neurons are described based on investigations of the membrane signaling cascade (opioid-like receptor → Na+,K+-ATPase → NaV1.8 channel) observed by the authors. Based on this data, the authors conclude that the modulation of NaV1.8 channels responsible for the coding of noxious signals can be carried out due to two novel targeting mechanisms. The first of these is the activation of opioid-like receptors; the second is the activation of Na+/K+-ATPase as a signal transducer. The development of a novel class of analgesics that trigger these mechanisms should lead to a successful solution to the problem of chronic pain relief. Chapters of the monograph cover the general methods used in studying nociceptive pain (including the patch-clamp method), and the mechanism behind the binding of different ligands to these receptors such gamma-pyrones, gamma-pyridines and cardiotonic steroids. This monograph is a valuable reference for neuroscientists, pharmacologists and allied researchers studying pain receptors for the development of safe and effective analgesics.
Opioids In Pain Control
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Author : Christoph Stein
language : en
Publisher: Cambridge University Press
Release Date : 1999
Opioids In Pain Control written by Christoph Stein and has been published by Cambridge University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1999 with Medical categories.
This book offers a comprehensive overview of scientific developments and clinical implications surrounding the use of opioids in pain control.