Optimization Of Ambient Ionization Methodologies For Field Investigations Utilizing Portable Mass Spectrometric Instrumentation
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Optimization Of Ambient Ionization Methodologies For Field Investigations Utilizing Portable Mass Spectrometric Instrumentation
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Author : Shahnaz Mukta
language : en
Publisher:
Release Date : 2018
Optimization Of Ambient Ionization Methodologies For Field Investigations Utilizing Portable Mass Spectrometric Instrumentation written by Shahnaz Mukta and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018 with categories.
In the late nineteenth century, Sir J.J. Thompson’s experiment on cathode ray tubes led to the ultimate invention of the mass spectrometer. Mass spectrometry (MS) is now recognized as a highly selective and sensitive analytical tool with a myriad of applications. To date, most MS systems are better suited for laboratory usage. However, much effort is being place in developing instrumentation and methodologies for field applications. Correspondingly, studies must be conducted to assess the suitability of instrument usage in the field. In recent years, a relatively new class of ionization techniques, ambient ionization, is gaining much popularity. In conjugation with portable mass spectrometry, these techniques have the potential for rapid, on-site analyte detection from samples in their native states. The objective of this research is to investigate the ruggedness of a portable mass spectrometer, the FLIR Systems AI-MS 1.2, and optimization of ambient ionization sources to determine their combined reliability for field applications. Instrument ruggedness was demonstrated by subjecting it to changes in temperature and relative humidity while observing its response to analyte detection. The robust instrument, coupled with ambient ionization sources, was employed for on-site forensic and environmental analysis. Paper spray ionization (PSI) was explored for rapid detection of synthetic cannabinoids but prompted an optimization study involving the employed spray solvent system to enhance reliability of use. Paper cone spray ionization (PCSI) was investigated for qualitative analysis of agrochemical contaminants in soil, an application area that has not been successfully reported via ambient MS methods. Proof-of-principle investigations into temporal profiling of agrochemical degradation was also examined.
Development And Characterization Of Robust Methods For Field Investigations With Portable Mass Spectrometry
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Author : Ashley Rose Stelmack
language : en
Publisher:
Release Date : 2020
Development And Characterization Of Robust Methods For Field Investigations With Portable Mass Spectrometry written by Ashley Rose Stelmack and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020 with categories.
Portable mass spectrometry (MS) has become an area of interest due to the ability to conduct chemical analyses in native environments. These instruments have the potential to increase efficiency and analytical throughput via real-time experimentation, minimizing the need for sample transportation. One drive towards the development of fieldable mass spectrometers is the potential for coupling to novel ambient ionization methods (or "ambient MS"), which can generate spectral data at ambient conditions from unprepared or minimally prepared samples of interest. Since the first introduction of the desorption electrospray ionization (DESI) technique in 2004, a myriad of novel techniques have been reported and applied, such as paper spray ionization (PSI), direct analysis in real time (DART), filter cone spray ionization (FCSI), etc. These methods allow for diverse sample types to be processed, opening the door to a variety of impactful applications.Forensics and homeland security are fields that can benefit from portable instrumentation, creating quick analytical capabilities during a criminal investigation or public safety events. Though it has been observed that portable MS systems can identify samples such as drugs of abuse, chemical warfare agents (CWAs), and explosives in a range of sample matrices, other factors/criteria must be considered before implementing into standard procedural methods of evidence collection. A factor to consider, however, is the instrumentals performance during exposure to common environmental conditions. The effect of temperature, relative humidity and windspeed were tested on the FLIR Systems Griffin Atmospheric Inlet-Mass Spectrometer (AI-MS) 1.2, observing target detection, signal intensity and signal duration while implementing PSI-MS, a newer ambient MS method that employs disposable paper substrates for sample collection and processing. Trends were interpreted to determine optimal conditions for high instrument performance, as well as potential conditions that yield a negative impact on sample processing. Other criteria are of note, such as the recommendations provided by the Scientific Working Group for the Analysis of Seized Drugs (SWGDRUG) for generating instrumental methods for forensic evidence confirmation; these recommendations center on the need for a multi-method analytical scheme for producing a definitive identification with prosecutorial ramifications. Towards this, a platform for combining surface enhanced Raman spectroscopy (SERS) and PSI-MS was developed to characterize the processing of authentic illicit drug analytes. A validation study was then performed, testing the overall reliability and accuracy of the dual methodology through a user blinded error rate study. Further, the potential admissibility of forensic drug evidentiary data produced from portable MS systems was examined, using the constraints of the Daubert or Frye standards for forensic evidence testimony as a guide. Overall, the efforts contained in this thesis seek to demonstrate the potential of portable mass spectrometry towards forensic/homeland security investigations.
Ambient Ionization Mass Spectrometry In Life Sciences
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Author : Kei Zaitsu
language : en
Publisher: Elsevier
Release Date : 2019-11-06
Ambient Ionization Mass Spectrometry In Life Sciences written by Kei Zaitsu and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-11-06 with Science categories.
Ambient Ionization Mass Spectrometry in Life Sciences: Principles and Applications is a systematic introduction to this rapidly expanding area of study. Underlying principles of each technique are explained in detail, along with discussions on their applications across life science disciplines. Ambient ionization has recently emerged as one of the hottest and fastest growing topics in mass spectrometry, hence this book is not just for analysts and researchers who use and study mass spectrometry. This volume would be of interest to anyone who works in or studies analytical chemistry, omics sciences (including metabolomics), pharmacokinetics, forensic science or drug analysis. Covers the most up-to-date techniques, including DART, DCBI, DESI, PESI, PSI, REIMS and laser-based ambient ionization Includes easy-to-understand pros and cons of each ionization technique to aid in decision-making Provides plentiful examples of life science applications
Modified Ambient Mass Spectrometric Methods For Field Screening And Confirmation Of Forensic Evidence
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Author : William Lee Fatigante
language : en
Publisher:
Release Date : 2019
Modified Ambient Mass Spectrometric Methods For Field Screening And Confirmation Of Forensic Evidence written by William Lee Fatigante and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019 with categories.
The utility of field-portable analytical instrumentation has the potential to revolutionize many fields of science, particularly for forensic science and law enforcement. While colorimetric testing can be employed for drug evidence screening, the influx of novel psychoactive substances has significantly decreased the effectiveness of this investigation strategy. One approach to meeting the needs of today's practitioner is coupling flexible, ambient ionization techniques with portable mass spectrometric (MS) instrumentation. Ambient ionization techniques have a rich history of being amendable to the sample at hand. Since their inception in 2005, numerous techniques saturate the field. The main drive for this development is to allow the analysis of wider sample classes with doing as minimal sample preparation required. Herein, the efforts to develop and perform a selection of simplified, rapidly-interchangeable, ambient ionization sources will be discussed, including paper spray ionization (PSI) and paper cone spray ionization (PCSI).First reported by Cha and Kim, PCSI has been shown adept at bulk analyte analysis. Here, a modified PCSI source that allows for real-time extraction and filtration of forensic samples known to hinder screening or compromise hygiene on MS systems is investigated. Also, studies will be included that evaluates an inter-source comparison of ionization methods that have already shown broad utility within the forensic community, PSI and direct analysis in real time (DART), in order to discern analytical performance and usability in forensic evidence processing.While portable MS systems have been shown capable of assisting investigative decision-making, this single technology does not fulfill the two-tiered identification guidelines suggested by the Scientific Working Group for the Analysis of Seized Drugs (SWGDRUG) for generating prosecutorial data. By integrating surface-enhanced Raman spectroscopy (SERS) with a portable MS system, a rapid, yet robust, method for drug evidence identification is discussed, while looking at the development and characterization of this instrumental strategy.
Ambient Ionization Mass Spectrometry
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Author : Marek Domin
language : en
Publisher: Royal Society of Chemistry
Release Date : 2014-11-25
Ambient Ionization Mass Spectrometry written by Marek Domin and has been published by Royal Society of Chemistry this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-11-25 with Science categories.
Ambient ionization has emerged as one of the hottest and fastest growing topics in mass spectrometry enabling sample analysis with minimal sample preparation. Introducing the subject and explaining the basic concepts and terminology, this book will provide a comprehensive, unique treatise devoted to the subject. Written by acknowledged experts, there are full descriptions on how new ionization techniques work, with an overview of their strengths, weaknesses and applications. This title will bring the reader right up to date, with both applications and theory, and will be suitable as a tutorial text for those starting in the field from a variety of disciplines.
Advances In Ion Mobility Mass Spectrometry Fundamentals Instrumentation And Applications
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Author :
language : en
Publisher: Elsevier
Release Date : 2019-01-10
Advances In Ion Mobility Mass Spectrometry Fundamentals Instrumentation And Applications written by and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-01-10 with Science categories.
Ion Mobility Spectrometry, Volume 83 will focuses on new trends, methods and instrumentation in the field, starting from the innovations of each technique, to the most progressive challenges of IM-MS. Chapters includes section on Recent advances in IM-MS, IM-MS Principles and Theory, IM-MS Applications and Instrumentation, and the Future of IM-MS. Presents the latest advancements in IM-MS that are essential for new applications Helps readers understand the state-of-the-art in the currently available IM-MS interfaces and their principle uses Provides information on different IM-MS instrumentation Delves into key applications of IM-MS
Ion Mobility Spectrometry Mass Spectrometry
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Author : Charles L. Wilkins
language : en
Publisher: CRC Press
Release Date : 2010-12-14
Ion Mobility Spectrometry Mass Spectrometry written by Charles L. Wilkins and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-12-14 with House & Home categories.
The analytical power of ion mobility spectrometry-mass spectrometry (IMS-MS) instruments is poised to advance this technology from research to analytical laboratories. Exploring these developments at this critical juncture, Ion Mobility Spectrometry-Mass Spectrometry: Theory and Applications covers the tools, techniques, and applications involved w
Electrospray Ionization Mass Spectrometry
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Author : Richard B. Cole
language : en
Publisher: Wiley-Interscience
Release Date : 1997-05-06
Electrospray Ionization Mass Spectrometry written by Richard B. Cole and has been published by Wiley-Interscience this book supported file pdf, txt, epub, kindle and other format this book has been release on 1997-05-06 with Science categories.
Comprehensive, up-to-date coverage of a revolutionary technique Electrospray ionization mass spectrometry (ESI-MS) has completely changed the way physicists, chemists, and biologists view the study of large molecules. The technique derives detailed information about molecular weights and structures from extremely small sample quantities. ESI-MS can create highly charged forms of very high molecular weight compounds, it is naturally compatible with many types of separation techniques, and it allows noncovalent interactions between molecules in solution to be preserved in the gas phase. But many researchers may not use the technique to its full potential because they are unfamiliar with the different perspectives of its underlying processes, the varied approaches to implementation, and the wide-ranging utility of the technique. In this book, Richard B. Cole and an assemblage of leading researchers present a single-volume compilation of different approaches to the understanding and exploitation of ESI-MS. This comprehensive guide: * Examines the physical and chemical aspects of the electrospray process and describes the events involved in ion formation as well as the electro-chemical phenomena that are central to charged droplet formation during the process * Explores the coupling of electrospray ionization to various mass spectrometers, including quadrupole, magnetic, time-of-flight, quadrupole ion trap, and Fourier transform ion cyclotron resonance instruments * Describes recent progress in interfacing ESI with solution-based separation techniques, including liquid chromatography and capillary electrophoresis * Charts the rapid development of ESI applications and categorizes them by compound type: peptides and proteins, nucleic acids and their constituents, carbohydrates and lipids, small molecules related to pharmacology and drug metabolism, and organometallics and inorganic compounds Electrospray Ionization Mass Spectrometry is the indispensable handbook and reference for anyone who wishes to understand, implement, or apply this technique, including researchers in chemistry, metallochemistry, biochemistry, biology, pharmacology, and physics.
Field Ionization Mass Spectrometry
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Author : Hans-D. Beckey
language : en
Publisher: Elsevier
Release Date : 2017-02-22
Field Ionization Mass Spectrometry written by Hans-D. Beckey and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-02-22 with Science categories.
Field Ionization Mass Spectrometry focuses on developments in field ionization (FI) mass spectrometry and describes its applications in physical chemistry, with emphasis on mass spectrometric problems. Physico-chemical problems as well as problems of chemical analysis are considered based on issues such as the probability of field ionization; field dissociation and charge distribution; kinetics of ion decomposition in high fields; negative ions; surface diffusion; activation of FI emitters; and elucidation of the structures of organic compounds. This book is comprised of four chapters and begins with a short review on some of the most important directions of research in FI mass spectrometry. Two main fields of research are discussed: physico-chemical investigations and quantitative analysis or structural determination of organic substances. The next chapter is devoted to focusing and non-focusing sources of FI and covers topics such as methods for production of FI tips and thin wires, together with the use of tips and carbon filaments as FI emitters. The last two chapters focus on the application of the FI mass spectrometer to physico-chemical problems and to quantitative analysis of homologous series of organic substances such as alkanes, alkenes, alkynes, amines, and alcohols. This monograph is intended primarily for chemists and mass spectrometrists.
Analytical Validation Of A Portable Mass Spectrometer System For High Throughput Forensic Screening
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Author : Zachary Earl Lawton
language : en
Publisher:
Release Date : 2016
Analytical Validation Of A Portable Mass Spectrometer System For High Throughput Forensic Screening written by Zachary Earl Lawton and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016 with categories.
The creation and proliferation of new psychoactive substances (NPS) over the last decade has shown that current forensic evidentiary screening methods are ineffective at identifying new compounds entering the market. The frequency and complexity of new drug evidence points to the need for robust screening methods, particularly portable instrument-based technologies that could expedite legal investigations and reduce the burden on the crime laboratory system. Direct sampling, field portable mass spectrometers (MS) coupled with ambient ionization methods have the potential to combat the NPS problem and alleviate the current evidentiary backlog by employing high-throughput, on-site analysis via automated identification.