Optogenetics

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Optogenetics

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Author : Hiromu Yawo
language : en
Publisher: Springer Nature
Release Date : 2021-01-05

Optogenetics written by Hiromu Yawo and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-01-05 with Medical categories.

This book, now in a thoroughly revised second edition, offers a comprehensive review of the rapidly growing field of optogenetics, in which light-sensing proteins are genetically engineered into cells in order to acquire information on cellular physiology in optical form or to enable control of specific network in the brain upon activation by light. Light-sensing proteins of various living organisms are now available to be exogenously expressed in neurons and other target cells both in vivo and in vitro. Cellular functions can thus be manipulated or probed by light. The new edition documents fully the extensive progress since publication of the first edition to provide an up-to-date overview of the physical, chemical, and biological properties of light-sensing proteins and their application in biological systems, particularly in neuroscience but also in medicine and the optical sciences. Underlying principles are explained and detailed information provided on a wide range of optogenetic tools for the observation and control of cellular signaling and physiology, gene targeting technologies, and optical methods for biological applications. In presenting the current status of optogenetics and emerging directions, this milestone publication will be a “must read” for all involved in research in any way related to optogenetics.

Optogenetics

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Author : Thomas Knopfel
language : en
Publisher: Elsevier
Release Date : 2012-04-19

Optogenetics written by Thomas Knopfel and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-04-19 with Medical categories.

Optogenetics is a fast-growing field concerning the invention, and use, of molecules that are genetically expressed in cells, and then either report on cellular physiology in optical form, or enable control of specific pathways in cells when actuated by light. This book reviews the current state, as well as the underlying principles and future directions, of a diversity of optogenetic tools of importance for observing and controlling cellular signaling and physiology. These tools are already revolutionizing neuroscience, and are starting to have impact on fields ranging from metabolism to development to cardiology. The book contains a dozen chapters written by world experts on these topics, half focusing on the optogenetic molecular tools themselves, and half on the genetic and hardware approaches that make them powerfully useful in intact tissues and organisms. Leading authors review the state-of-the-art in their field of investigation and provide their views and perspectives for future research Chapters are extensively referenced to provide readers with a comprehensive list of resources on the topics covered All chapters include comprehensive background information and are written in a clear form that is also accessible to the non-specialist

Optogenetics

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Author : Armin Baumschlager
language : en
Publisher: Springer Nature
Release Date : 2024-12-26

Optogenetics written by Armin Baumschlager and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-12-26 with Technology & Engineering categories.

This volume explores the latest advancements in the field of optogenetics and how it uses cellular light-sensing components and genetic engineering to control proteins and biological processes. The book chapters are organized into four parts. Part One focuses on intracellular optogenetic components for control of specific cell functions; Part Two looks at externally supplied light regulators that do not require genetic manipulation of target cells; Part Three highlights optogenetic control of organelles, and Part Four introduces technical tools required for light induction in optogenetic experiments, as well as a method for performing and analyzing optogenetic cell-cell adhesion. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and practical, Optogenetics: Methods and Protocols is a valuable resource to help researchers understand and apply the concepts of optogenetics and the underlying bioengineering principles, and establish the required technical light-illumination setups for administering light inputs and analysis of experimental outcomes.

Optogenetics

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Author : Krishnarao Appasani
language : en
Publisher: Cambridge University Press
Release Date : 2017-04-27

Optogenetics written by Krishnarao Appasani and has been published by Cambridge University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-04-27 with Medical categories.

This book provides applications for the revolutionary technique of optogenetics, which combines genetic and optical methods to observe the function of neurons.

Optogenetics

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Author : Peter Hegemann
language : en
Publisher: Walter de Gruyter
Release Date : 2013-08-28

Optogenetics written by Peter Hegemann and has been published by Walter de Gruyter this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-08-28 with Science categories.

Optogenetics combines genetic engineering with optics to observe and control the function of cells using light, with clinical implications for restoration of vision and treatment of neurological diseases. As a new discipline much of the basic science and methods are currently under investigation and active development, thus there is a strong need for introductory literature in this field. This graduate level textbook provides an overview of the field of optogenetics in 5 concise chapters: Optogenetic tools, Applications in cellular systems, Mapping neuronal networks, Clinical applications and Restoration of vision and hearing. The concept and content was developed with top international researchers and students at a prestigious Dahlem Conference workshop.

Optogenetics

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Author : Sophie Vriz
language : en
Publisher: Royal Society of Chemistry
Release Date : 2019

Optogenetics written by Sophie Vriz and has been published by Royal Society of Chemistry this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019 with Science categories.

Optogenetic tools have allowed significant advances in the understanding of biological problems, particularly in the neurosciences field. Biological tools as well as optical set-ups have evolved and a wide range of probes and light-controllable modules are now available. The aim of this book is to give a flavour of illumination strategies and imaging with an overview of the different optogenetic tools and their main applications in cell biology. Based on examples covering the different aspects of cell biology, this book provides a practical approach for using light-emitting sensors and light-driven actuators.

The Advances And Applications Of Optogenetics

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Author : Elena G. Govorunova
language : en
Publisher: MDPI
Release Date : 2020-12-28

The Advances And Applications Of Optogenetics written by Elena G. Govorunova and has been published by MDPI this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-12-28 with Science categories.

This book provides an update for the rapidly developing technology known as “optogenetics”, which is the use of genetically encoded light-sensitive molecular elements (usually derived from lower organisms) to control or report various physiological and biochemical processes within the cell. Two ongoing clinical trials use optogenetic tools for vision restoration, and optogenetic strategies have been suggested as novel therapies for several neurological, psychiatric and cardiac disorders. This Special Issue comprises two reviews and seven experimental papers on different types of light-sensitive modules widely used in optogenetic studies. These papers demonstrate the efficiency and versatility of optogenetics and are expected to be equally relevant for advanced users and beginners considering using optogenetic tools in their research.

Optogenetics An Emerging Approach In Cardiac Electrophysiology

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Author : Ming Lei
language : en
Publisher: Frontiers Media SA
Release Date : 2020-06-25

Optogenetics An Emerging Approach In Cardiac Electrophysiology written by Ming Lei and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-06-25 with categories.

Cardiac Optogenetics Using Light To Observe And Excite The Heart

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Author : Tobias Bruegmann
language : en
Publisher: Frontiers Media SA
Release Date : 2022-11-15

Cardiac Optogenetics Using Light To Observe And Excite The Heart written by Tobias Bruegmann and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-11-15 with Science categories.

Topic Editor Godfrey Smith is the founder, director and honorary Chief Scientific Officer of Clyde Biosciences Ltd (UK). The other Topic Editors declare no competing interests with regard to the Research Topic subject.

Neural Circuits Underlying Emotion And Motivation Insights From Optogenetics And Pharmacogenetics

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Author : Anton Ilango
language : en
Publisher: Frontiers Media SA
Release Date : 2015-06-04

Neural Circuits Underlying Emotion And Motivation Insights From Optogenetics And Pharmacogenetics written by Anton Ilango and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-06-04 with Neural circuitry categories.

Application of optogenetic and pharmacogenetic tools to study the neural circuits underlying emotional valence, feeding, arousal and motivated behaviors has provided crucial insights into brain function. Expression of light sensitive proteins into specific neurons and subsequent stimulation by light (optogenetics) to control neuronal activity or expression of designer receptors exclusively activated by designer drugs (DREADD) in specific neuronal populations with subsequent activation or suppression of neuronal activity by an otherwise inert ligand (pharmacogenetics) provides control over defined elements of neural circuits. These novel tools have provided a more in depth understanding into several questions about brain function. These include: • Regulation of sleep-wake transition by the interaction of hypocretin neurons of lateral hypothalamus and nor adrenergic neurons of the locus coruleaus • Regulation of feeding by AGRP and POMC neurons in arcuate nucleus of the hypothalamus • Place preference and positive reinforcement by activation of DA neuron of VTA • Place aversion by activation of VTA GABA and lateral habenula neurons • Opposing influences on reinforcement by activation of D1 and D2 expressing medium spiny neurons of dorsal striatum and nucleus accumbens The list still grows... From cell type specific manipulations to signaling properties in the cell (Dietz et al 2012) with unprecedented temporal resolution, these tools revolutionize the exploration of pathways/connectivity. Recent years also witnessed the extension of applying these tools from studying emotional valence and motivated behavior to reactivation of memory. c-fos based genetic approaches allowed us to integrate light sensitive opsins or DREADD receptor into specific neurons that are activated by certain learning events (for example fear) (Garner et al 2012; Liu et al 2012). In this Research Topic, we welcome researchers to contribute original research articles, review articles, methods and commentary on topics utilizing optogenetic and pharmacogenetic tools to study the neural circuits underlying emotional valence, motivation, reinforcement and memory. We believe the Research Topic will shine light on various questions we have about brain function by using novel optogenetic and pharmacogenetic tools and will hopefully inspire ongoing research to overcome the hurdles of using these tools to advance clinical applications.