Oral Delivery Of Insulin
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Oral Delivery Of Insulin
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Author : T.A. Sonia
language : en
Publisher: Elsevier
Release Date : 2014-12-11
Oral Delivery Of Insulin written by T.A. Sonia and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-12-11 with Medical categories.
Diabetes Mellitus, a syndrome of disordered metabolism, characterised by abnormal elevation in blood glucose level, has become a life-threatening condition for many people. Current means of therapy for Diabetes Mellitus do not mimic the normal physiological pattern of insulin release. Oral delivery is the preferred route of administration due to its non-invasive nature. Oral delivery of insulin presents an overview of Diabetes Mellitus, and discusses the strategies and techniques adopted for oral delivery of insulin. This title begins with an introductory chapter on symptoms, complications and therapy for Diabetes Mellitus. Subsequent chapters cover the various routes for administering insulin; the challenges and strategies of oral delivery; experimental techniques in the development of an oral insulin carrier; lipids; inorganic nanoparticles and polymers in oral insulin delivery; and a summary and presentation of future perspectives on oral delivery of insulin. Presents an overview of Diabetes Mellitus Includes a discussion of various strategies and techniques adopted for oral delivery of insulin Presents an update of research in the field
Development Of Nanoparticles For Oral Delivery Of Insulin
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Author : Sunandini Chopra
language : en
Publisher:
Release Date : 2017
Development Of Nanoparticles For Oral Delivery Of Insulin written by Sunandini Chopra and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017 with categories.
Parenteral administration remains the mainstay of drug administration for protein therapeutics. However, for diseases that require frequent drug dose over long periods of time, injections can result in patient incompliance and poor treatment outcomes. For such diseases, oral drug delivery is the most non-invasive and patient-compliant method of drug administration. Although oral delivery of many small molecule drugs is routine, oral delivery of protein drugs - e.g. insulin presents several challenges including oral bioavailability of the protein therapeutic because of degradation in the stomach, inactivation and digestion of the therapeutics by the proteolytic enzymes in the luminal cavity, and poor permeability of drugs across the intestinal epithelium. Polymeric nanoparticle (NP) carriers provide new opportunities for controlled delivery of drugs, and have the potential to address challenges associated with effective oral delivery of insulin. NPs can protect the protein therapeutic from degradation in the GI tract as well as allow targeted transport across the epithelial lining. An efficient NP based oral insulin delivery solution that can enable targeted transport of insulin across the GI tract must have (1) high insulin loading, (2) sub-100 nm size, (3) ability to release insulin before opsonization by macrophages and (4) the ability to be surface-functionalized with ligands that facilitate transport across the epithelium. This work presents a detailed study on mechanistic understanding of polymeric insulin NP formation with a focus on the effect of synthesis parameters on insulin loading and NP size. We report how buffer conditions, ionic chelation, and NP preparation methods influence insulin loading in poly (lactic-co-glycolic acid)-b-poly(ethylene glycol) (PLGA-PEG) NPs. We report a 10-fold increase in insulin loading with the use of chelating zinc ions and by the optimization of the pH during nanoprecipitation. Next, we report the development of novel insulin Eudragit-PLGA-PEG blended NPs (Ins-Eud-NPs) with high insulin loading (13.1%) and sub-100 nm size. These NPs enable rapid release of insulin when triggered by a change in pH that occurs when the NPs cross the duodenal epithelium and go from acidic to neutral pH. The NPs are formed by successfully blending Eudragit S100, a commercially available polymer which dissolves at pH greater than 7 with a non-pH responsive polymer, PLGA-PEG. To enable effective transport of these NPs across the epithelial lining, NPs were designed to use the FcRn transport pathway that mediates IgG antibody transport across epithelial barriers. We report the successful chemical conjugation of the Fc fragment on the surface of Ins-Eud- NPs by overcoming the presence of non-ideal conjugation parameters owing to the pH restrictions of the system. This dissertation provides mechanistic insights and helps to understand fundamental concepts about polymeric NP formation and protein encapsulation. The modular NP system developed in this work can be extended to other protein drug delivery systems that are subject to limited drug loading and restricted transport across epithelial barriers.
Subcutaneous And Oral Delivery Of Insulin
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Author : Zakieh Al Kurdi
language : en
Publisher:
Release Date : 2015
Subcutaneous And Oral Delivery Of Insulin written by Zakieh Al Kurdi and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015 with categories.
Nanoparticle Mediated Oral Delivery Of Insulin
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Author : Etienne Cabane
language : en
Publisher:
Release Date : 2007
Nanoparticle Mediated Oral Delivery Of Insulin written by Etienne Cabane and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007 with categories.
Oral Delivery Of Insulin By Polymer Coated Liposomes
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Author : Majid Tabbakhian
language : en
Publisher:
Release Date : 1998
Oral Delivery Of Insulin By Polymer Coated Liposomes written by Majid Tabbakhian and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1998 with Insulin categories.
Recent Advances In Novel Drug Carrier Systems
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Author : Ali Demir Sezer
language : en
Publisher: IntechOpen
Release Date : 2012-10-31
Recent Advances In Novel Drug Carrier Systems written by Ali Demir Sezer and has been published by IntechOpen this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-10-31 with Medical categories.
This contribution book collects reviews and original articles from eminent experts working in the interdisciplinary arena of novel drug delivery systems and their uses. From their direct and recent experience, the readers can achieve a wide vision on the new and ongoing potentialities of different drug delivery systems. Since the advent of analytical techniques and capabilities to measure particle sizes in nanometer ranges, there has been tremendous interest in the use of nanoparticles for more efficient methods of drug delivery. On the other hand, this reference discusses advances in the design, optimization, and adaptation of gene delivery systems for the treatment of cancer, cardiovascular, pulmonary, genetic, and infectious diseases, and considers assessment and review procedures involved in the development of gene-based pharmaceuticals.
Oral Delivery Of Insulin For Diabetes Therapy
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Author : Revanth Rayasam
language : en
Publisher:
Release Date : 2017
Oral Delivery Of Insulin For Diabetes Therapy written by Revanth Rayasam and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017 with categories.
Oral Delivery Of Insulin By Polymer Coated Liposomes
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Author : Majid Tabbakhian
language : en
Publisher:
Release Date : 1998
Oral Delivery Of Insulin By Polymer Coated Liposomes written by Majid Tabbakhian and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1998 with Insulin categories.
Design Development And Evaluation Of An Oral Delivery System For Insulin
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Author : Mukur Gupta
language : en
Publisher:
Release Date : 2004
Design Development And Evaluation Of An Oral Delivery System For Insulin written by Mukur Gupta and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2004 with Diabetes categories.
The Potential Of Polymeric Nanoparticles For Oral Delivery Of Insulin
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Author : Gaurav Sharma
language : en
Publisher:
Release Date : 2010
The Potential Of Polymeric Nanoparticles For Oral Delivery Of Insulin written by Gaurav Sharma and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010 with categories.