The Potential Of Polymeric Nanoparticles For Oral Delivery Of Insulin
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The Potential Of Polymeric Nanoparticles For Oral Delivery Of Insulin
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Author : Gaurav Sharma
language : en
Publisher:
Release Date : 2010
The Potential Of Polymeric Nanoparticles For Oral Delivery Of Insulin written by Gaurav Sharma and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010 with categories.
Development Of Nanoparticles For Oral Delivery Of Insulin
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Author : Sunandini Chopra
language : en
Publisher:
Release Date : 2017
Development Of Nanoparticles For Oral Delivery Of Insulin written by Sunandini Chopra and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017 with categories.
Parenteral administration remains the mainstay of drug administration for protein therapeutics. However, for diseases that require frequent drug dose over long periods of time, injections can result in patient incompliance and poor treatment outcomes. For such diseases, oral drug delivery is the most non-invasive and patient-compliant method of drug administration. Although oral delivery of many small molecule drugs is routine, oral delivery of protein drugs - e.g. insulin presents several challenges including oral bioavailability of the protein therapeutic because of degradation in the stomach, inactivation and digestion of the therapeutics by the proteolytic enzymes in the luminal cavity, and poor permeability of drugs across the intestinal epithelium. Polymeric nanoparticle (NP) carriers provide new opportunities for controlled delivery of drugs, and have the potential to address challenges associated with effective oral delivery of insulin. NPs can protect the protein therapeutic from degradation in the GI tract as well as allow targeted transport across the epithelial lining. An efficient NP based oral insulin delivery solution that can enable targeted transport of insulin across the GI tract must have (1) high insulin loading, (2) sub-100 nm size, (3) ability to release insulin before opsonization by macrophages and (4) the ability to be surface-functionalized with ligands that facilitate transport across the epithelium. This work presents a detailed study on mechanistic understanding of polymeric insulin NP formation with a focus on the effect of synthesis parameters on insulin loading and NP size. We report how buffer conditions, ionic chelation, and NP preparation methods influence insulin loading in poly (lactic-co-glycolic acid)-b-poly(ethylene glycol) (PLGA-PEG) NPs. We report a 10-fold increase in insulin loading with the use of chelating zinc ions and by the optimization of the pH during nanoprecipitation. Next, we report the development of novel insulin Eudragit-PLGA-PEG blended NPs (Ins-Eud-NPs) with high insulin loading (13.1%) and sub-100 nm size. These NPs enable rapid release of insulin when triggered by a change in pH that occurs when the NPs cross the duodenal epithelium and go from acidic to neutral pH. The NPs are formed by successfully blending Eudragit S100, a commercially available polymer which dissolves at pH greater than 7 with a non-pH responsive polymer, PLGA-PEG. To enable effective transport of these NPs across the epithelial lining, NPs were designed to use the FcRn transport pathway that mediates IgG antibody transport across epithelial barriers. We report the successful chemical conjugation of the Fc fragment on the surface of Ins-Eud- NPs by overcoming the presence of non-ideal conjugation parameters owing to the pH restrictions of the system. This dissertation provides mechanistic insights and helps to understand fundamental concepts about polymeric NP formation and protein encapsulation. The modular NP system developed in this work can be extended to other protein drug delivery systems that are subject to limited drug loading and restricted transport across epithelial barriers.
Oral Delivery Of Insulin
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Author : T.A. Sonia
language : en
Publisher: Elsevier
Release Date : 2014-12-11
Oral Delivery Of Insulin written by T.A. Sonia and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-12-11 with Medical categories.
Diabetes Mellitus, a syndrome of disordered metabolism, characterised by abnormal elevation in blood glucose level, has become a life-threatening condition for many people. Current means of therapy for Diabetes Mellitus do not mimic the normal physiological pattern of insulin release. Oral delivery is the preferred route of administration due to its non-invasive nature. Oral delivery of insulin presents an overview of Diabetes Mellitus, and discusses the strategies and techniques adopted for oral delivery of insulin. This title begins with an introductory chapter on symptoms, complications and therapy for Diabetes Mellitus. Subsequent chapters cover the various routes for administering insulin; the challenges and strategies of oral delivery; experimental techniques in the development of an oral insulin carrier; lipids; inorganic nanoparticles and polymers in oral insulin delivery; and a summary and presentation of future perspectives on oral delivery of insulin. Presents an overview of Diabetes Mellitus Includes a discussion of various strategies and techniques adopted for oral delivery of insulin Presents an update of research in the field
Nanoscience In Medicine Vol 1
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Author : Hemant Kumar Daima
language : en
Publisher: Springer Nature
Release Date : 2020-01-10
Nanoscience In Medicine Vol 1 written by Hemant Kumar Daima and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-01-10 with Medical categories.
This book takes a systematic approach to address the gaps relating to nanomedicine and bring together fragmented knowledge on the advances on nanomaterials and their biomedical applicability. In particular, it demonstrates an exclusive compilation of state of the art research with a focus on fundamental concepts, current trends, limitations, and future directions of nanomedicine.
Drug Delivery
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Author : Yitzhak Rosen
language : en
Publisher: CRC Press
Release Date : 2017-09-19
Drug Delivery written by Yitzhak Rosen and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-09-19 with Medical categories.
Integrating the clinical and engineering aspects of drug delivery, this book offers a much needed comprehensive overview and patient-oriented approach for enhanced drug delivery optimization and advancement. Starting with an introduction to the subject and pharmacokinetics, it explores advances for such topics as oral, gastroretentive, intravitreal, and intrathecal drug delivery, as well as insulin delivery, gene delivery, and biomaterials-based delivery systems. It also describes drug delivery in cancer, cardiac, infectious diseases, airway diseases, and obstetrics and gynecology applications. Examining special clinical states requiring innovative drug delivery modifications, such as hypercoagulability often seen in pregnancy, cancer, and autoimmune diseases, the book also discusses methods for improved drug delivery in clinical settings using clinical end points, clinical trials, simulations, and other venues. It also describes the latest drug delivery advances involving nanomaterials, NEMS and MEMS devices, hydrogels, microencapsulation, lipids, stem cells, patches, and ultrasound. The book is rounded out by a chapter on the FDA regulatory and bioethical challenges involved in advancing drug delivery.
Pharmaceutical Applications Of Polymers For Drug Delivery
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Author : David Jones
language : en
Publisher: iSmithers Rapra Publishing
Release Date : 2004
Pharmaceutical Applications Of Polymers For Drug Delivery written by David Jones and has been published by iSmithers Rapra Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 2004 with Medical categories.
Annotation The review focuses on the use of pharmaceutical polymer for controlled drug delivery applications. Examples of pharmaceutical polymers and the principles of controlled drug delivery are outlined and applications of polymers for controlled drug delivery are described. The field of controlled drug delivery is vast therefore this review aims to provide an overview of the applications of pharmaceutical polymers. The review is accompanied by approximately 250 abstracts taken from papers and books in the Rapra Polymer Library database, to facilitate further reading on this subject.
Novel Drug Delivery Systems For The Delivery Of Insulin
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Author : Radhika Narain
language : en
Publisher:
Release Date : 2016-09-15
Novel Drug Delivery Systems For The Delivery Of Insulin written by Radhika Narain and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-09-15 with categories.
Scientific Study from the year 2014 in the subject Medicine - Pharmacology, grade: A, language: English, abstract: The delivery of proteins is challenging due to their high molecular weight and hydrophilic structures, making them difficult to cross the ubiquitous lipidic membranes. Proteins have a unique structure which makes them suited to a unique function, therefore, maintenance of the structural integrity and stability of these macromolecules is also of a high concern as they can easily be denatured by temperature, pH and other physiochemical changes. The protein and peptide delivery systems have to be designed in a way such that the drug carriers can protect the protein from proteases, increase its permeability through membranes, increase its absorption and bioavailability, sustain its release, with low dosage requirements and, increase its systemic circulation. The study presents the delivery of insulin through various routes: buccal, transdermal, oral and pulmonary, utilizing different novel carriers like polymeric nanoparticles, solid lipid nanoparticles, liposomes, nanoshells, nanospheres and nanoparticles encapsulated in microparticles, along with drug surface modification either by attaching peptide ligands or conjugating with polymers to enhance absorption and targeting capacity of the drug.
Seaweed Polysaccharides
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Author : Jayachandran Venkatesan
language : en
Publisher: Elsevier
Release Date : 2017-05-30
Seaweed Polysaccharides written by Jayachandran Venkatesan and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-05-30 with Technology & Engineering categories.
Seaweed Polysaccharides: Isolation, Biological, and Biomedical Applications examines the isolation and characterization of algal biopolymers, including a range of new biological and biomedical applications. In recent years, significant developments have been made in algae-based polymers (commonly called polysaccharides), and in biomedical applications such as drug delivery, wound dressings, and tissue engineering. Demand for algae-based polymers is increasing and represent a potential—very inexpensive—resource for these applications. The structure and chemical modification of algal polymers are covered, as well as the biological properties of these materials – including antithrombic, anti-inflammatory, anticoagulant, and antiviral aspects. Toxicity of algal biopolymers is also covered. Finally, the book introduces and explains real world applications of algal-based biopolymers in biomedical applications, including tissue engineering, drug delivery, and biosensors. This is the first book to cover the extraction techniques, biomedical applications, and the economic perspective of seaweed polysaccharides. It is an essential text for researchers and industry professionals looking to work with this renewable resource. Provides comprehensive coverage of the research currently taking place in biomedical applications of algae biopolymers Includes practical guidance on the isolation, extraction, and characterization of polysaccharides from sustainable marine sources Covers the extraction techniques, biomedical applications, and economic outlook of seaweed polysaccharides
Smart Drug Delivery System
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Author : Ali Demir Sezer
language : en
Publisher: BoD – Books on Demand
Release Date : 2016-02-10
Smart Drug Delivery System written by Ali Demir Sezer and has been published by BoD – Books on Demand this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-02-10 with Medical categories.
This contribution book collects reviews and original articles from eminent experts working in the interdisciplinary arena of novel drug delivery systems and their uses. From their direct and recent experience, the readers can achieve a wide vision on the new and ongoing potentialities of different smart drug delivery systems. Since the advent of analytical techniques and capabilities to measure particle sizes in nanometer ranges, there has been tremendous interest in the use of nanoparticles for more efficient methods of drug delivery. On the other hand, this reference discusses advances in the design, optimization, and adaptation of gene delivery systems for the treatment of cancer, cardiovascular, diabetic, genetic, and infectious diseases, and considers assessment and review procedures involved in the development of gene-based pharmaceuticals.
Nanoengineering Of Biomaterials
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Author : Sougata Jana
language : de
Publisher: John Wiley & Sons
Release Date : 2022-04-18
Nanoengineering Of Biomaterials written by Sougata Jana and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-04-18 with Science categories.
A comprehensive discussion of various types of nanoengineered biomaterials and their applications In Nanoengineering of Biomaterials: Drug Delivery & Biomedical Applications, an expert team of chemists delivers a succinct exploration of the synthesis, characterization, in-vitro and in-vivo drug molecule release, pharmacokinetic activity, pharmacodynamic activity, and the biomedical applications of several types of nanoengineered biomaterials. The editors have also included resources to highlight the most current developments in the field. The book is a collection of valuable and accessible reference sources for researchers in materials chemistry and related disciplines. It uses a functions-directed approach to using organic and inorganic source compounds that translate into biological systems as scaffolds, micelles, dendrimers, and other delivery systems. Nanoengineering of Biomaterials offers readers up-to-date chemistry and material science insights that are readily transferrable to biomedical systems. The book also includes: Thorough introductions to alginate nanoparticle delivery of therapeutics and chitosan-based nanomaterials in biological applications Comprehensive explorations of nanostructured carrageenan as a drug carrier, gellan gum nanoparticles in drug delivery, and guar-gum nanoparticles in the delivery of bioactive molecules Practical discussions of protein-based nanoparticles for drug delivery, solid lipid nanoparticles as drug carriers, and pH-responsive nanoparticles in therapy In-depth examinations of stimuli-responsive nano carriers in drug targeting Perfect for pharmaceutical chemists, materials scientists, polymer chemists, life scientists, and medicinal chemists, Nanoengineering of Biomaterials: Drug Delivery and Biomedical Applications is also an indispensable resource for biologists and bioengineers seeking a one-stop reference on the transferability of materials chemistry and nanotechnology to biomedicine.