Oral Delivery Of Macromolecular Drugs
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Oral Delivery Of Macromolecular Drugs
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Author : Andreas Bernkop-Schnürch
language : en
Publisher: Springer Science & Business Media
Release Date : 2009-08-04
Oral Delivery Of Macromolecular Drugs written by Andreas Bernkop-Schnürch and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-08-04 with Medical categories.
Recent and rapid progress in the field of biotechnology has resulted in an increasing number of novel macromolecular drugs with great promise for further advanced research and clinical application. However, the delivery of these macromolecular drugs by routes other than the parenteral route is difficult. The pipeline of macromolecular drugs derived from biotechnology presents a challenging opportunity to develop practical dosage forms that could be dosed via the oral route. Given this, the successful oral delivery of macromolecular drugs presents an enormous opportunity. Oral Delivery of Macromolecular Drugs will provide an overview of the innovative oral delivery technologies that have demonstrated success in human testing and will go on to cite the challenges, strategies, and future trends that are to be expected.
Oral Delivery Of Macromolecular Drugs
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Author : Andreas Bernkop-Schnürch
language : en
Publisher: Springer
Release Date : 2009
Oral Delivery Of Macromolecular Drugs written by Andreas Bernkop-Schnürch and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009 with Electronic books categories.
Macromolecular Drug Delivery
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Author : Mattias Belting
language : en
Publisher: Humana Press
Release Date : 2014-10-30
Macromolecular Drug Delivery written by Mattias Belting and has been published by Humana Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-10-30 with Medical categories.
Macromolecular drugs hold the promise of becoming new therapeutics for several major disorders, including cancer and cardiovascular disease. This incredible potential is explored in Macromolecular Drug Delivery, a volume which gives a wide-ranging overview of contemporary methods used in the field, and which addresses the limitations presented by a lack of safe and efficient drug delivery strategies. Chapters offer information on both in vitro and in vivo methods of macromolecular delivery, thus appealing to a broad scientific audience. Composed in the highly successful Methods in Molecular BiologyTM series format, each chapter contains a brief introduction, step-by-step methods, a list of necessary materials, and a Notes section which shares tips on troubleshooting and avoiding known pitfalls. Comprehensive and cutting-edge, Macromolecular Drug Delivery offers a platform for interdisciplinary collaboration, which should provide opportunities for new discoveries at the interface between disciplines. Ultimately, this cooperation will lead to the use of macromolecular drugs as novel diagnostic tools and, even more importantly, as a means to revolutionize the way we view and treat diseases.
Targeted Delivery Of Small And Macromolecular Drugs
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Author : Ajit S. Narang
language : en
Publisher: CRC Press
Release Date : 2010-05-12
Targeted Delivery Of Small And Macromolecular Drugs written by Ajit S. Narang and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-05-12 with Medical categories.
Site-specific drug delivery and targeting attracts much research interest from both academia and industry, but because of the many challenges faced in the development of these systems, only a handful of targeted therapies have successfully made it into clinical practice. Focusing on the delivery technologies that utilize both systemic and local rou
Drug Delivery
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Author : Binghe Wang
language : en
Publisher: John Wiley & Sons
Release Date : 2016-04-18
Drug Delivery written by Binghe Wang and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-04-18 with Science categories.
Following its successful predecessor, this book covers the fundamentals, delivery routes and vehicles, and practical applications of drug delivery. In the 2nd edition, almost all chapters from the previous are retained and updated and several new chapters added to make a more complete resource and reference. • Helps readers understand progress in drug delivery research and applications • Updates and expands coverage to reflect advances in materials for delivery vehicles, drug delivery approaches, and therapeutics • Covers recent developments including transdermal and mucosal delivery, lymphatic system delivery, theranostics • Adds new chapters on nanoparticles, controlled drug release systems, theranostics, protein and peptide drugs, and biologics delivery
Controlled Release In Oral Drug Delivery
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Author : Clive G. Wilson
language : en
Publisher: Springer Science & Business Media
Release Date : 2011-09-22
Controlled Release In Oral Drug Delivery written by Clive G. Wilson and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-09-22 with Medical categories.
Controlled Release in Oral Drug Delivery provides focus on specific topics, complementing other books in the initial CRS series. Each chapter sets the context for the inventions described and describe the latitude that the inventions allow. In order to provide some similar look to each chapter, the coverage includes the historical overview, candidate drugs, factors influencing design and development, formulation and manufacturing and delivery system design. This volume was written along three main sections: the relevant anatomy and physiology, a discussion on candidates for oral drug delivery and the major three groups of controlled release systems: diffusion control (swelling and inert matrices); environmental control (pH sensitive coatings, time control, enzymatic control, pressure control) and finally lipidic systems.
Polymers For Controlled Drug Delivery
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Author : Peter J. Tarcha
language : en
Publisher: CRC Press
Release Date : 1990-11-21
Polymers For Controlled Drug Delivery written by Peter J. Tarcha and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1990-11-21 with Medical categories.
Polymers for Controlled Drug Delivery addresses the challenges of designing macromolecules that deliver therapeutic agents that function safely and in concert with living organisms. The book primarily discusses classes of polymers and polymeric vehicles, including particulates, such as latexes, coacervates, ion-exchange resins, and liposomes, as well as non-particulate vehicles such as enteric coatings, mediators, and bioadhesives. Other topics discussed include diffusion; biodegradation-controlled delivery; animal model studies for toxicity, metabolism, and elimination testing; and FDA requirements for clinical studies. Drug delivery researchers will find this book to be an invaluable reference tool.
Safe And Effective Methods For Improving The Oral Delivery Of Macromolecules
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Author : Kathryn Ann Whitehead
language : en
Publisher: ProQuest
Release Date : 2007
Safe And Effective Methods For Improving The Oral Delivery Of Macromolecules written by Kathryn Ann Whitehead and has been published by ProQuest this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007 with categories.
Oral delivery is a convenient and patient-friendly route of drug administration compared to injections. Unfortunately, the oral route cannot be utilized for macromolecules due to their low oral bioavailability. This limitation is particularly aggravated for proteins and peptides because of their susceptibility to enzymatic degradation in the gastrointestinal tract and low permeability across the intestinal epithelium. In order to overcome such challenges, a novel method has been developed that utilizes mucoadhesive intestinal patches to deliver therapeutic doses of drug into systemic circulation. Intestinal patches were capable of securely adhering to the intestinal epithelium, localizing a drug near the mucosa, protecting it from proteolytic degradation, and releasing drug in a unidirectional manner. In vivo experiments performed via jejunal administration demonstrated that intestinal patches loaded with insulin were able to achieve therapeutic results comparable to those obtained by subcutaneous injection.
Controlled Drug Delivery
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Author : M A Mateescu
language : en
Publisher: Elsevier
Release Date : 2014-12-09
Controlled Drug Delivery written by M A Mateescu and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-12-09 with Medical categories.
In complex macromolecules, minor modifications can generate major changes, due to self-assembling capacities of macromolecular or supramolecular networks. Controlled Drug Delivery highlights how the multifunctionality of several materials can be achieved and valorized for pharmaceutical and biopharmaceutical applications. Topics covered in this comprehensive book include: the concept of self-assembling; starch and derivatives as pharmaceutical excipients; and chitosan and derivatives as biomaterials and as pharmaceutical excipients. Later chapters discuss polyelectrolyte complexes as excipients for oral administration; and natural semi-synthetic and synthetic materials. Closing chapters cover protein-protein associative interactions and their involvement in bioformulations; self-assembling materials, implants and xenografts; and provide conclusions and perspectives. Offers novel perspectives of a new concept: how minor alterations can induce major self-stabilization by cumulative forces exerted at short and long distances Gives guidance on how to approach modifications of biopolymers for drug delivery systems and materials for implants Describes structure-properties relationships in proposed excipients, drug delivery systems and biomedical materials
Polymers For Controlled Drug Delivery
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Author : Peter J. Tarcha
language : en
Publisher: CRC Press
Release Date : 2023-06-14
Polymers For Controlled Drug Delivery written by Peter J. Tarcha and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-06-14 with Medical categories.
Polymers for Controlled Drug Delivery addresses the challenges of designing macromolecules that deliver therapeutic agents that function safely and in concert with living organisms. The book primarily discusses classes of polymers and polymeric vehicles, including particulates, such as latexes, coacervates, ion-exchange resins, and liposomes, as well as non-particulate vehicles such as enteric coatings, mediators, and bioadhesives. Other topics discussed include diffusion; biodegradation-controlled delivery; animal model studies for toxicity, metabolism, and elimination testing; and FDA requirements for clinical studies. Drug delivery researchers will find this book to be an invaluable reference tool.