Organelle And Molecular Targeting
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Organelle And Molecular Targeting
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Author : Lara Scheherazade Milane
language : en
Publisher: CRC Press
Release Date : 2021-12-27
Organelle And Molecular Targeting written by Lara Scheherazade Milane and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-12-27 with Science categories.
We have surpassed the omics era and are truly in the Age of Molecular Therapeutics. The fast-paced development of SARS-CoV-2 vaccines, such as the mRNA vaccines encoding the viral spike protein, demonstrated the need for and capability of molecular therapy and nanotechnology-based solutions for drug delivery. In record speed, the SARS-CoV-2 viral RNA genome was sequenced and shared with the scientific community, allowing the rapid design of molecular therapeutics. The mRNA vaccines exploit the host cell endoplasmic reticulum to produce viral spike proteins for antigen presentation and recognition by the innate and adaptive immune system. Lipid nanoparticles enable the delivery of the fragile, degradation-sensitive nucleic acid payloads. Molecular-based therapeutics and nanotechnology solutions continue to drive the scientific and medical response to the COVID-19 pandemic as new mRNA, DNA, and protein-based vaccines are developed and approved and the emergency use approved vaccines are rapidly manufactured and distributed throughout the globe. The need for molecular therapies and drug delivery solutions is clear, and as these therapies progress and become more specialized there will be important advancements in organelle targeting. For example, using organelle targeting to direct lipid nanoparticles with mRNA payloads to the endoplasmic reticulum would increase the efficacy of mRNA vaccines, reducing the required dose and therefore the biomanufacturing demand. Likewise, improving the delivery of DNA therapeutics to the nucleus would improve efficacy. Organelles and molecules have always been drug targets, but until recently we have not had the tools or capability to design and develop such highly specific therapeutics. Organelle targeting has far-reaching implications. For example, mitochondria are central to both energy production and intrinsic apoptosis. Effectively targeting and manipulating mitochondria has therapeutic applications for diseases such as myopathies, cancer, neurodegeneration, progerias, diabetes, and the natural aging process. The SARS-CoV-2 vaccines that exploit the endoplasmic reticulum (for mRNA vaccines) and the nucleic translational process (DNA vaccines) attest to the need for organelle and molecular therapeutics. This book covers the status, demand, and future of organelle- and molecularly targeted therapeutics that are critical to the advancement of modern medicine. Organelle and molecular targeting is the drug design and drug delivery approach of today and the future; understanding this approach is essential for students, scientists, and clinicians contributing to modern medicine.
Molecular Biology Of The Cell
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Author :
language : en
Publisher:
Release Date : 2004
Molecular Biology Of The Cell written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2004 with Cells categories.
Protein Targeting Transport And Translocation
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Author : Ross Dalbey
language : en
Publisher: Elsevier
Release Date : 2002-04-09
Protein Targeting Transport And Translocation written by Ross Dalbey and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2002-04-09 with Science categories.
Protein Targeting, Transport, and Translocation presents an in-depth overview on the topic of protein synthesis, covering all areas of protein science, including protein targeting, secretion, folding, assembly, structure, localization, quality control, degradation, and antigen presentation. Chapters also include sections on the history of the field as well as summary panels for quick reference. Numerous color illustrations complement the presentation of material. This book is an essential reference for anyone in biochemistry and protein science, as well as an excellent textbook for advanced students in these and related fields. - Basic principles and techniques - Targeting adn sorting sequences - Protein export in bacteria - Membrane protein integration into ER and bacterial membranes - Protein translocation across the ER - Disulfide bond formation in prokaryotes and eukaryotes - Quality control in the export pathway - Import of proteins into organelles - The secretory pathway - Vesicular transport - Spectacular color throughout
Organelle Specific Pharmaceutical Nanotechnology
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Author : Volkmar Weissig
language : en
Publisher: John Wiley & Sons
Release Date : 2011-03-01
Organelle Specific Pharmaceutical Nanotechnology written by Volkmar Weissig and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-03-01 with Science categories.
This book introduces and discusses the latest in biomedical research--Pharmaceutical Nanotechnology applied at the sub-cellular level.
Molecular Mechanisms And Physiological Significance Of Organelle Interactions And Cooperation Volume Ii
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Author : Michael Schrader
language : en
Publisher: Frontiers Media SA
Release Date : 2022-12-02
Molecular Mechanisms And Physiological Significance Of Organelle Interactions And Cooperation Volume Ii written by Michael Schrader and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-12-02 with Science categories.
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Organelle Targeting Focus On Drug Discovery And Theranostics
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Author : Qixin Chen
language : en
Publisher: Frontiers Media SA
Release Date : 2022-11-10
Organelle Targeting Focus On Drug Discovery And Theranostics written by Qixin Chen and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-11-10 with Science categories.
Molecular Cell Biology Of The Growth And Differentiation Of Plant Cells
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Author : Ray J. Rose
language : en
Publisher: Lulu.com
Release Date :
Molecular Cell Biology Of The Growth And Differentiation Of Plant Cells written by Ray J. Rose and has been published by Lulu.com this book supported file pdf, txt, epub, kindle and other format this book has been release on with categories.
Molecular Imaging And Targeted Therapy
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Author : Shankar Vallabhajosula
language : en
Publisher: Springer Nature
Release Date : 2023-03-31
Molecular Imaging And Targeted Therapy written by Shankar Vallabhajosula and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-03-31 with Medical categories.
This book, now published in its second edition, covers a wide range of topics relating to the use of radiopharmaceuticals. The basics of nuclear chemistry, radiochemistry, and radiopharmacology are considered in detail, regulatory issues are reviewed, and potential applications in drug development, translational medicine, clinical diagnostics, and targeted therapy are discussed. Compared with the first edition, the chapters on targeted therapy with alpha- and beta-emitting radiopharmaceuticals and theranostics are completely new. Other chapters have been updated and revised as necessary. Radioisotope-based molecular imaging probes (radiopharmaceuticals) provide unprecedented insights into biochemistry and function in both normal and diseased states of living systems, with unbiased in vivo measurements of regional radiotracer activities offering very high specificity and sensitivity. No other molecular imaging technology, including functional magnetic resonance imaging, can provide such high sensitivity and specificity at a tracer level. This book, written by an experienced radiochemist and scientist, offers valuable insights into the full range of applications of this technology.
Versatile Roles Of Organelle Outer Membranes In Intracellular Communication
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Author : Kentaro Inoue
language : en
Publisher: Frontiers Media SA
Release Date : 2015-07-09
Versatile Roles Of Organelle Outer Membranes In Intracellular Communication written by Kentaro Inoue and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-07-09 with Botany categories.
This topic covers emerging knowledge about the properties and functions of the outer membranes of chloroplasts and mitochondria. These outer membranes house various processes necessary for efficient communication and thus integration of the organelles with and into their surroundings in the cytoplasm. Such processes include, but are not limited to, protein import, organelle division, organelle movement, metabolism, and metabolite/ion transport. Recent molecular genetic, biochemical and cell biological studies have revealed functions of various outer membrane proteins. These findings have helped address and generate diverse biological and evolutionary questions at molecular, cellular and whole organism levels. The topic should encourage contributions of scientists from various disciplines and thus would provide the field with opportunities to "think outside the box" and to develop potential collaborations. The topic is also aimed to stimulate interests of general audience in the outer membranes of chloroplasts and mitochondria.
10000 German Azerbaijani Azerbaijani German Vocabulary
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Author : Gilad Soffer
language : az
Publisher: Soffer Publishing
Release Date :
10000 German Azerbaijani Azerbaijani German Vocabulary written by Gilad Soffer and has been published by Soffer Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on with Foreign Language Study categories.
10000+ German - Azerbaijani Azerbaijani - German Vocabulary - is a list of more than 10000 words translated from German to Azerbaijani, as well as translated from Azerbaijani to German. Easy to use- great for tourists and German speakers interested in learning Azerbaijani. As well as Azerbaijani speakers interested in learning German.