Organic Bioelectronics For Neurotransmitter Release At The Speed Of Life
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Organic Bioelectronics For Neurotransmitter Release At The Speed Of Life
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Author : Theresia Arbring Sjöström
language : en
Publisher: Linköping University Electronic Press
Release Date : 2020-12-07
Organic Bioelectronics For Neurotransmitter Release At The Speed Of Life written by Theresia Arbring Sjöström and has been published by Linköping University Electronic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-12-07 with Electronic books categories.
The signaling dynamics in neuronal networks includes processes ranging from lifelong neuromodulation to direct synaptic neurotransmission. In chemical synapses, the time delay it takes to pass a signal from one neuron to the next lasts for less than a millisecond. At the post-synaptic neuron, further signaling is either up- or down-regulated, dependent on the specific neurotransmitter and receptor. While this up- and down-regulation of signals usually runs perfectly well and enables complex performance, even a minor dysfunction of this signaling system can cause major complications, in the shape of neurological disorders. The field of organic bioelectronics has the ability to interface neurons with high spatiotemporal recording and stimulation techniques. Local chemical stimulation, i.e. local release of neurotransmitters, enables the possibility of artificially altering the chemical environment in dysfunctional signaling pathways to regain or restore neural function. To successfully interface the biological nervous system with electronics, a range of demands must be met. Organic bioelectronic techniques and materials are capable of reaching the demands on the biological as well as the electronic side of the interface. These demands span from high performance biocompatible materials, to miniaturized and specific device architectures, and high dose control on demand within milliseconds. The content of this thesis is a continuation of the development of organic bioelectronic devices for neurotransmitter delivery. Organic materials are utilized to electrically control the dose of charged neurotransmitters by translating electric charge into controlled artificial release. The first part of the thesis, Papers 1 and 2, includes further development of the resistor-type release device called the organic electronic ion pump. This part includes material evaluation, microfluidic incorporation, and device design considerations. The aim for the second part of this thesis, Papers 3 and 4, is to enhance temporal performance, i.e. reduce the delay between electrical signal and neurotransmitter delivery to corresponding delay in biological neural signaling, while retaining tight dosage control. Diffusion of neurotransmitters between nerve cells is a slow process, but since it is restricted to short distances, the total time delay is short. In our organic bioelectronic devices, several orders of magnitude in speed can be gained by switching from lateral to vertical delivery geometries. This is realized by two different types of vertical diodes combined with a lateral preload and waste configuration. The vertical diode assembly was further expanded with a control electrode that enables individual addressing in each of several combined release sites. These integrated circuits allow for release of neurotransmitters with high on/off release ratios, approaching delivery times on par with biological neurotransmission.
Wearable Bioelectronics
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Author : Anthony P.F. Turner
language : en
Publisher: Elsevier
Release Date : 2019-11-26
Wearable Bioelectronics written by Anthony P.F. Turner and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-11-26 with Technology & Engineering categories.
Wearable Bioelectronics presents the latest on physical and (bio)chemical sensing for wearable electronics. It covers the miniaturization of bioelectrodes and high-throughput biosensing platforms while also presenting a systemic approach for the development of electrochemical biosensors and bioelectronics for biomedical applications. The book addresses the fundamentals, materials, processes and devices for wearable bioelectronics, showcasing key applications, including device fabrication, manufacturing, and healthcare applications. Topics covered include self-powering wearable bioelectronics, electrochemical transducers, textile-based biosensors, epidermal electronics and other exciting applications. - Includes comprehensive and systematic coverage of the most exciting and promising bioelectronics, processes for their fabrication, and their applications in healthcare - Reviews innovative applications, such as self-powering wearable bioelectronics, electrochemical transducers, textile-based biosensors and electronic skin - Examines and discusses the future of wearable bioelectronics - Addresses the wearable electronics market as a development of the healthcare industry
Electrochemical Biosensors
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Author : Serge Cosnier
language : en
Publisher: CRC Press
Release Date : 2015-01-26
Electrochemical Biosensors written by Serge Cosnier and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-01-26 with Science categories.
Since four decades, rapid detection and monitoring in clinical and food diagnostics and in environmental and biodefense have paved the way for the elaboration of electrochemical biosensors. Thanks to their adaptability, ease of use in relatively complex samples, and their portability, electrochemical biosensors now are one of the mainstays of analy
The Neuron
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Author : Irwin B. Levitan
language : en
Publisher: Oxford University Press, USA
Release Date : 2002
The Neuron written by Irwin B. Levitan and has been published by Oxford University Press, USA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2002 with Language Arts & Disciplines categories.
Intended for use by advanced undergraduate, graduate and medical students, this book presents a study of the unique biochemical and physiological properties of neurons, emphasising the molecular mechanisms that generate and regulate their activity.
Bioelectromagnetism
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Author : Jaakko Malmivuo
language : en
Publisher:
Release Date : 1995
Bioelectromagnetism written by Jaakko Malmivuo and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1995 with Language Arts & Disciplines categories.
This text applies engineering science and technology to biological cells and tissues that are electrically conducting and excitable. It describes the theory and a wide range of applications in both electric and magnetic fields.
Integrative Biophysics
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Author : Fritz-Albert Popp
language : en
Publisher: Springer Science & Business Media
Release Date : 2003-02-28
Integrative Biophysics written by Fritz-Albert Popp and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2003-02-28 with Language Arts & Disciplines categories.
Biophotonics is a rapidly increasing field of current scientific research and applications, based on the discovery of biophotons, a permanent, weak photon current emanating from all living systems. The biophoton emission reflects some, if not all, of the essential biological and physiological activities in biological systems. Biophotonics provides a powerful tool for investigating these electromagnetic interactions. The theoretical approach requires holistic models of living systems, rather than local analytical models. Consequently, these new insights into living matter create a new basis of "integrative biophysics" that is concerned with the questions of regulation, communication and organization of biological systems. Most of the specialists working in this interdisciplinary field of physics, biology, biophysics and medicine are associated with "The International Institute of Biophysics" (IIB), in Neuss, Germany, where basic research and possibilities for applications are coordinated. The growth in this field is indicated by the increase in financial support, interest from the scientific community and frequency of publications. Audience: The scientists of IIB have presented the most essential background and applications of biophotonics in these lecture notes in biophysics, based on the summer school lectures by this group. This book is devoted to questions of elementary biophysics, as well as current developments and applications. It will be of interest to graduate and postgraduate students, life scientists, and the responsible officials of industries and governments looking for non-invasive methods of investigating biological tissues.
Materials Nanoarchitectonics
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Author : Katsuhiko Ariga
language : en
Publisher: Elsevier
Release Date : 2023-12-07
Materials Nanoarchitectonics written by Katsuhiko Ariga and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-12-07 with Technology & Engineering categories.
Materials Nanoarchitectonics: From Integrated Molecular Systems to Advanced Devices provides the latest information on the design and molecular manipulation of self‐organized hierarchically structured systems using tailor-made nanoscale materials as structural and functional units. The book is organized into three main sections that focus on molecular design of building blocks and hybrid materials, formation of nanostructures, and applications and devices. Bringing together emerging materials, synthetic aspects, nanostructure strategies, and applications, the book aims to support further progress, by offering different perspectives and a strong interdisciplinary approach to this rapidly growing area of innovation. This is an extremely valuable resource for researchers, advanced students, and scientists in industry, with an interest in nanoarchitectonics, nanostructures, and nanomaterials, or across the areas of nanotechnology, chemistry, surface science, polymer science, electrical engineering, physics, chemical engineering, and materials science. - Offers a nanoarchitectonic perspective on emerging fields, such as metal-organic frameworks, porous polymer materials, or biomimetic nanostructures - Discusses different approaches to utilizing "soft chemistry" as a source for hierarchically organized materials - Offers an interdisciplinary approach to the design and construction of integrated chemical nano systems - Discusses novel approaches towards the creation of complex multiscale architectures
Biomedical Sensors
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Author : Deric P. Jones
language : en
Publisher: Momentum Press
Release Date : 2010
Biomedical Sensors written by Deric P. Jones and has been published by Momentum Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010 with Medical categories.
Sensors are the eyes, ears, and more, of the modern engineered product or system- including the living human organism. This authoritative reference work, part of Momentum Press's new Sensors Technology series, edited by noted sensors expert, Dr. Joe Watson, will offer a complete review of all sensors and their associated instrumentation systems now commonly used in modern medicine. Readers will find invaluable data and guidance on a wide variety of sensors used in biomedical applications, from fluid flow sensors, to pressure sensors, to chemical analysis sensors. New developments in biomaterials- based sensors that mimic natural bio-systems will be covered as well. Also featured will be ample references throughout, along with a useful Glossary and symbols list, as well as convenient conversion tables.
Biosensors
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Author : Anthony P. F. Turner
language : en
Publisher: Oxford University Press, USA
Release Date : 1989
Biosensors written by Anthony P. F. Turner and has been published by Oxford University Press, USA this book supported file pdf, txt, epub, kindle and other format this book has been release on 1989 with Language Arts & Disciplines categories.
The first comprehensive book to be published in this field. It has many contributors, chosen to reflect the spread of disciplines from which the new techniques have emerged.