Organoids
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Organoids And Mini Organs
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Author : Jamie Davies
language : en
Publisher: Academic Press
Release Date : 2018-03-09
Organoids And Mini Organs written by Jamie Davies and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-03-09 with Science categories.
Organs and Organoids combines contributions from leading practitioners who work under the editorial control of an acclaimed researcher who also served for eight years as Editor-in-Chief of the journal Organogenesis, the first journal on this topic. The book begins with an introduction, but then delves into chapters that present advice on how to make organoids for many systems. In addition, case studies that illustrate the uses of organioids are presented, along with discussions on future directions and specific problems that need to be solved. Collects the best protocols of organoid cultures from diverse tissues Covers a wide range of organs Includes troubleshooting cases for common, but specific problems for each culture conditions Provides an entire section on the application of organoids
Human Pluripotent Stem Cell Derived Organoid Models
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Author :
language : en
Publisher: Academic Press
Release Date : 2020-06-22
Human Pluripotent Stem Cell Derived Organoid Models written by and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-06-22 with Science categories.
Human Pluripotent Stem Cell Derived Organoid Models, Volume 159 highlights recent and emerging advances that describe organoid differentiation protocols for the different organ systems that implement organoids as tools to understand complexity and maturation, high content drug screening, disease modeling, development and evolution. Specific chapters in this new release include Pluripotent stem cell derived gastric organoids, Pluripotent stem cell derived esophageal organoids, Pluripotent stem cell derived small intestinal organoids, Pluripotent stem cell derived colonic organoids, Pluripotent stem cell intestinal organoids with an Enteric Nervous System, Pluripotent stem cell derived airway organoids, Pluripotent stem cell derived alveolar organoids, and much more. Provides the first comprehensive collection of pluripotent stem cell derived organoid protocols Includes cutting-edge methods Presents methods that generate organoids from many organ systems
Organoid Technology For Disease Modelling And Personalized Treatment
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Author : Badrul Hisham Yahaya
language : en
Publisher: Springer Nature
Release Date : 2022-02-14
Organoid Technology For Disease Modelling And Personalized Treatment written by Badrul Hisham Yahaya and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-02-14 with Science categories.
Organoid Technology for Disease Modelling and Personalised Treatment provides a comprehensive overview of current knowledge of the organoid as a human-organ-in-a-dish, a powerful new technology for studying fundamental aspects of human organ development and disease progression in the search for drugs for personalised treatment. This preclinical tool is extensively being utilised as a model for studying human diseases in a dish, which is critical for accurate predictive modelling in precision medicine. The chapters in this book introduces readers to the numerous applications of organoids in various fields of study, as well as ethical considerations associated with organoids. In stem cell biology and regenerative medicine, where chimaera research, biomaterials for tissue vascularisation, gene-editing technologies, and their use in clinical procedures especially issues related to ethical concern over the use of human organoids have gotten much attention. Organoid Technology for Disease Modelling and Personalised Treatment is an excellent resource for in-depth research on one of the most interesting and significant topics in stem cell and regenerative medicine. This book's chapter collection covers a fresh viewpoint on organoid technology that scholars will require reading.
Organoids
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Author : Kursad Turksen
language : en
Publisher: Springer Nature
Release Date : 2019-09-12
Organoids written by Kursad Turksen and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-09-12 with Science categories.
This detailed volume addresses the challenge of how to instruct stem/early progenitor cells to progress through appropriate steps to generate functional 3-dimensional organs, one of the outstanding issues in regenerative medicine. The field of organoids is geared towards defining and demonstrating the in vitro conditions that achieve this goal. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Comprehensive and cutting-edge, Organoids: Stem Cells, Structure, and Function serves as an aid to researchers working in this vital area of research.
Brain Organoids In Research And Therapy
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Author : Hans-Georg Dederer
language : en
Publisher: Springer Nature
Release Date : 2022-07-09
Brain Organoids In Research And Therapy written by Hans-Georg Dederer and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-07-09 with Medical categories.
This volume elucidates the pivotal ethical and legal issues arising from the use of brain organoids for research, therapeutic and enhancement purposes. The function of the human brain is still a mystery. Until recently, only post-mortem tissue was available for a structural examination of the brain. Consequently, the examination results could only reflect the state at the end of life. However, in order to better understand the development and function of the human brain, dynamic and functional investigations of different human brain cells are necessary. This is where brain organoids, artificially grown in vitro miniature brains, provide the opportunity for more flexible research scenarios. At the same time, however, the use of brain organoids in research and therapy raises the question of how these new entities are to be treated from an ethical and legal point of view. Against this background, this volume aims at clarifying the normative implications of the use of brain organoids in research and therapy. The ethical reflections on the status of brain organoids, informed consent, human-to-animal chimeras and neuro-enhancement are mirrored by corresponding legal analyses. The ethical and legal assessments are preceded by an introduction to the scientific and medical background of the brain organoid technology. A final chapter will be devoted to the issue of whether international harmonization of normative standards for brain organoid research and therapy is feasible and advisable.
Organoids As Model Systems For Human Development Disease And Clinical Applications
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Author : Eumorphia Remboutsika
language : en
Publisher: Frontiers Media SA
Release Date : 2021-11-23
Organoids As Model Systems For Human Development Disease And Clinical Applications written by Eumorphia Remboutsika and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-11-23 with Science categories.
From Single Stem Cells To Organoids Organ Repair And Public Health
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Author : Lon J. Van Winkle
language : en
Publisher: Frontiers Media SA
Release Date : 2022-03-09
From Single Stem Cells To Organoids Organ Repair And Public Health written by Lon J. Van Winkle and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-03-09 with Science categories.
Brain Organoid Research
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Author : Jay Gopalakrishnan
language : en
Publisher: Springer Nature
Release Date : 2022-09-22
Brain Organoid Research written by Jay Gopalakrishnan and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-09-22 with Medical categories.
This volume explores multiple methods and approaches used to generate human brain and neuroretinal organoids to address fundamental questions in human brain research. The chapters in this book cover topics such as self-organizing brain organoids with ventricles amenable to injection and electroporation; visualization of 3D organoids though the latest advancements in microscopy; generation of 3D retinal tissue with physiologically competent, light-sensitive photoreceptors; modeling brain tumors using genetically edited brain organoids; and brain organoids as a model to study Zika virus and SARS-CoV-2 infections. In the Neuromethods series style, chapters include the kind of detail and key advice from the specialists needed to get successful results in your laboratory. Comprehensive and cutting-edge, Brain Organoid Research is a valuable resource for researchers at various levels of learning, ranging from undergraduate students, early researchers, and advanced laboratories. This book aims to be instrumental in moving this developing field forward.
Organoids
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Author :
language : en
Publisher:
Release Date : 2018
Organoids written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018 with categories.
Producing miniature versions of organs in a dish may sound like science-fiction, but thanks to advances in stem cell technology and bioengineering scientists are now able to artificially grow a mass of cells into organoids with similar properties to organs. Organoids represent cells grown in specific three-dimensional (3D) environments, creating mini, simplified organs that retain some physiological function. They are derived from one or a few cells, from a tissue, embryonic stem cells or induced pluripotent stem cells, which can self-organise in 3D cultures. Following the observation that cells do not behave in 2D cultures as they do in vivo, 3D cultures of organoids have emerged as promising model systems for studying tissue development and generating new therapies. With recent technological breakthroughs, 3D culture models have come to represent a more physiologically relevant approximation of the in vivo environment. Hence, researchers in the fields of the physical sciences and engineering are seeking to improve the 3D culture conditions to grow mini organs in a dish. Organoids are increasing in complexity as researchers begin probing more deeply the mechanisms behind stem cell lineage and differentiation. Models have now been grown for many organs, including brain, liver, kidney, breast, retina, and organs of the gastrointestinal tract, among others. This CORDIS Results Pack presents the first results from EU/ERC-funded research in the organoid field. It sheds light on five projects and their scientific advances in organoid technology and how they can be used as in vivo-like models. The Mini Brains project generated brain organoids to study the mechanisms of various neurological disorders and discover novel drugs to treat them. TOXANOID proved that their technology can outperform current in vitro systems and replace a significant portion of animal-based toxicology studies. The team successfully developed organoid systems for several organs including small intestine, colon and liver. ColonCan developed novel ex vivo 3D organoid cultures that replicate genetic events in colorectal cancer (CRC), the second most common cause of cancer-related deaths, and used them to test novel therapeutics. COMIET created a new cell culture platform for epithelial tissues to advance the in vitro modelling of diseases, preclinical screening for drug efficacy and toxicity, as well as the understanding of organ development. The CLOC project produced liver organoids in vitro using hepatocytes cultured on 3D scaffolds as novel models for studying liver development and disease, and potential treatment of inherited cholestatic disorders.
Organoids
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Author : Kursad Turksen
language : en
Publisher: Humana
Release Date : 2019-09-13
Organoids written by Kursad Turksen and has been published by Humana this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-09-13 with Science categories.
This detailed volume addresses the challenge of how to instruct stem/early progenitor cells to progress through appropriate steps to generate functional 3-dimensional organs, one of the outstanding issues in regenerative medicine. The field of organoids is geared towards defining and demonstrating the in vitro conditions that achieve this goal. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Comprehensive and cutting-edge, Organoids: Stem Cells, Structure, and Function serves as an aid to researchers working in this vital area of research.