Organometallics As Catalysts In The Fine Chemical Industry


Organometallics As Catalysts In The Fine Chemical Industry
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Organometallics As Catalysts In The Fine Chemical Industry


Organometallics As Catalysts In The Fine Chemical Industry
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Author : Matthias Beller
language : en
Publisher: Springer
Release Date : 2012-08-31

Organometallics As Catalysts In The Fine Chemical Industry written by Matthias Beller and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-08-31 with Science categories.


Johannes G. de Vries: Pd-catalyzed coupling reactions.- Gregory T. Whiteker and Christopher J. Cobley: Applications of Rhodium-Catalyzed Hydroformylation in the Pharmaceutical, Agrochemical and Fragrance Industries.- Philippe Dupau: Ruthenium-catalyzed Selective Hydrogenation for Flavor and Fragrance Applications.- Hans-Ulrich Blaser, Benoît Pugin and Felix Spindler: Asymmetric Hydrogenation.- Ioannis Houpis: Case Study: Sequential Pd-catalyzed Cross-Coupling Reactions; Challenges on Scale-up.- Adriano F. Indolese: Pilot Plant Scale Synthesis of an Aryl-Indole - Scale up of a Suzuki Coupling.- Per Ryberg: Development of a Mild and Robust Method for Palladium Catalysed Cyanation on Large Scale.- Cheng-yi Chen: Application of Ring Closing Metathesis Strategy to the Synthesis of Vaniprevir (MK-7009), a 20-Membered Macrocyclic HCV Protease Inhibitor.



Organometallics For Green Catalysis


Organometallics For Green Catalysis
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Author : Pierre H. Dixneuf
language : en
Publisher: Springer
Release Date : 2019-02-25

Organometallics For Green Catalysis written by Pierre H. Dixneuf and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-02-25 with Science categories.


This volume presents the latest developments in the use of organometallic catalysis for the formation of bulk chemicals and the production of energy, via green processes including efficient utilization of waste feedstocks from industry. The chemistry of carbon dioxide relating to its hydrogenation into methanol –an eco-friendly energy storage strategy– and its uses as C1 synthon for the formation of important building-blocks for fine chemicals industry are covered. Catalytic hydrogenations of various functional groups and hydrogen transfer reactions including the use of first row metal catalysts are presented as well as the conversion of alcohols to carboxylates via hydrogen transfer with a zero-waste strategy using water. Transformation of renewable or bio-based raw materials is surveyed through alkene metathesis and C–O bond activations and functionalizations. A green aspect for selective formation of C-C, C-O and C-N bonds involves direct regioselective C–H bond activations and functionalizations. These transformations can now be promoted under mild reaction conditions due to the use photoredox catalyts. C–H bond oxidation using visible light leads mainly to the formation of C–O and C–N bonds, whereas cross-coupled C–C bonds can be formed through the radical additions on (hetero) arenes using photoredox assisted mechanism.



Organometallic Chemistry In Industry


Organometallic Chemistry In Industry
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Author : Thomas J. Colacot
language : en
Publisher: John Wiley & Sons
Release Date : 2020-05-26

Organometallic Chemistry In Industry written by Thomas J. Colacot and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-05-26 with Science categories.


Showcases the important role of organometallic chemistry in industrial applications and includes practical examples and case studies This comprehensive book takes a practical approach to how organometallic chemistry is being used in industrial applications. It uniquely offers numerous, real-world examples and case studies that aid working R&D researchers as well as Ph.D. and postdoc students preparing to ace interviews in order to enter the workforce. Edited by two world-leading and established industrial chemists, the book covers flow chemistry (catalytic and non-catalytic organometallic chemistry), various cross-coupling reactions (C-C, C-N, and C-B) in classical batch chemistry, conjugate addition reactions, metathesis, and C-H arylation and achiral hydrogenation reactions. Beginning with an overview of the many industrial milestones within the field over the years, Organometallic Chemistry in Industry: A Practical Approach provides chapters covering: the design, development, and execution of a continuous flow enabled API manufacturing route; continuous manufacturing as an enabling technology for low temperature organometallic chemistry; the development of a nickel-catalyzed enantioselective Mizoroki-Heck coupling; and the development of iron-catalyzed Kumada cross-coupling for the large scale production of Aliskiren intermediates. The book also examines aspects of homogeneous hydrogenation from industrial research; the latest industrial uses of olefin metathesis; and more. -Includes rare industrial case studies difficult to find in current literature -Helps readers successfully carry out their own reactions -Covers topics like flow chemistry, cross-coupling reactions, and dehydrative decarbonylation -Features a foreword by Nobel Laureate R. H. Grubbs -A perfect resource for every R&D researcher in industry -Useful for PhD students and postdocs: excellent preparation for a job interview Organometallic Chemistry in Industry: A Practical Approach is an excellent resource for all chemists, including those working in the pharmaceutical industry and organometallics.



Sustainable Catalysis


Sustainable Catalysis
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Author : Peter J. Dunn
language : en
Publisher: John Wiley & Sons
Release Date : 2013-04-01

Sustainable Catalysis written by Peter J. Dunn and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-04-01 with Science categories.


Opens the door to the sustainable production of pharmaceuticals and fine chemicals Driven by both public demand and government regulations, pharmaceutical and fine chemical manufacturers are increasingly seeking to replace stoichiometric reagents used in synthetic transformations with catalytic routes in order to develop greener, safer, and more cost-effective chemical processes. This book supports the discovery, development, and implementation of new catalytic methodologies on a process scale, opening the door to the sustainable production of pharmaceuticals and fine chemicals. Pairing contributions from leading academic and industrial researchers, Sustainable Catalysis focuses on key areas that are particularly important for the fine chemical and pharmaceutical industries, including chemo-, bio-, and organo-catalytic approaches to C H, C N, and C C bond-forming reactions. Chapters include academic overviews of current innovations and industrial case studies at the process scale, providing new insights into green catalytic methodologies from proof-of-concept to their applications in the synthesis of target organic molecules. Sustainable Catalysis provides the foundation needed to develop sustainable green synthetic procedures, with coverage of such emerging topics as: Catalytic reduction of amides avoiding LiAlH4 or B2H6 Synthesis of chiral amines using transaminases Industrial applications of boric acid and boronic acid catalyzed direct amidation reactions C H activation of heteroaromatics Organocatalysis for asymmetric synthesis Offering a balanced perspective on current limitations, challenges, and solutions, Sustainable Catalysis is recommended for synthetic organic chemists seeking to develop new methodologies and for industrial chemists dedicated to large-scale process development.



Non Noble Metal Catalysis


Non Noble Metal Catalysis
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Author : Robertus J. M. Klein Gebbink
language : en
Publisher: John Wiley & Sons
Release Date : 2019-04-29

Non Noble Metal Catalysis written by Robertus J. M. Klein Gebbink and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-04-29 with Technology & Engineering categories.


An expert overview of current research, applications, and economic and environmental advantages The study and development of new homogeneous catalysts based on first-row metals (Mn, Fe, Co, Ni, and Cu) has grown significantly due to the economic and environmental advantages that non-noble metals present. Base metals offer reduced cost, greater supply, and lower toxicity levels than noble metals?enabling greater opportunity for scientific investigation and increased development of practical applications. Non-Noble Metal Catalysis provides an authoritative survey of the field, from fundamental concepts and computational methods to industrial applications and reaction classes. Recognized experts in organometallic chemistry and homogeneous catalysis, the authors present a comprehensive overview of the conceptual and practical aspects of non-noble metal catalysts. Examination of topics including non-innocent ligands, proton-coupled electron transfer, and multi-nuclear complexes provide essential background information, while areas such as kinetic lability and lifetimes of intermediates reflect current research and shifting trends in the field. This timely book demonstrates the efficacy of base metal catalysts in the pharmaceutical, fine-chemical, and agrochemical industries, addressing both environmental and economic concerns. Providing essential conceptual and practical exploration, this valuable resource: -Illustrates how unravelling new reactivity patterns can lead to new catalysts and new applications -Highlights the multiple advantages of using non-noble metals in homogenous catalysis -Demonstrates how the availability of non-noble metal catalysis reduces costs and leads to immense savings for the chemical industry -Reveals how non-noble metal catalysis are more sustainable than noble metals such as palladium or platinum Non-Noble Metal Catalysis: Molecular Approaches and Reactions is an indispensable source of up-to-date information for catalytic chemists, organic chemists, industrial chemists, organometallic chemists, and those seeking to broaden their knowledge of catalytic chemistry.



Organometallics In Process Chemistry


Organometallics In Process Chemistry
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Author : Ahmed F. Abdel-Magid
language : en
Publisher: Springer Science & Business Media
Release Date : 2004-06-15

Organometallics In Process Chemistry written by Ahmed F. Abdel-Magid and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2004-06-15 with Science categories.


The design of efficient syntheses of medicinal agents is one of the prime goals of the process chemist in the pharmaceutical industry. The expanding list of metal-mediated reactions has had a major impact on this endeavor over the last two decades. This volume will highlight some of the areas of organometallic chemistry that have played a particularly important role in development. The chapters are written by chemists who work in the process groups of major pharmaceutical companies and fine chemical manufacturers. Having demonstrated the power of organometallics in their processes the authors herein expand upon their experiences with examples from the literature as reported by process groups within the industry. The chapters are organized either by the application of a particular metal or reaction class. Removal of the residual metal(s) from the isolated active pharmaceutical ingredient (API) is key to the release of the material for human consumption, and hence, is reviewed here as well. This volume of Topics in Organometallic Chemistry is presented to offer a representative cross section of organometallic applications in the pharmaceutical industry as well as to give an appreciation for the creativity possible in process chemistry.



Organometallic Oxidation Catalysis


Organometallic Oxidation Catalysis
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Author : Franc Meyer
language : en
Publisher: Springer
Release Date : 2007-01-30

Organometallic Oxidation Catalysis written by Franc Meyer and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-01-30 with Science categories.


In many of the processes of oxidation catalysis, species with metal-carbon bonds are formed as key intermediates, and these processes represent the primary focus of this volume. An important aspect covered by some of the contributors is the use of organic ligands to achieve efficient oxidation catalysis. Each volume of "Topics in Organometallic Chemistry" provides a comprehensive summary and critical overview of a specific topic in organometallic chemistry.



Aqueous Phase Organometallic Catalysis


Aqueous Phase Organometallic Catalysis
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Author : Boy Cornils
language : en
Publisher: John Wiley & Sons
Release Date : 2004

Aqueous Phase Organometallic Catalysis written by Boy Cornils and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2004 with Science categories.


Now in its second completely revised and expanded edition. Written by the renowned editors B. Cornils and W. A. Herrmann, this book presents every important aspect of aqueous-phase organometallic catalysis, a method which saves time, waste and money. The large-scale application of this "green" technology in chemical industry clearly underlines its practical use outside of academia. New chapters (for example "Organic Chemistry in Water"), 20% more content and fully updated contributions from a plethora of international authors make this book a "must-have" for everyone working in this field. From the reviews of the first edition: "This overview will be extremely useful for everyone active in this field [...]" Angewandte Chemie "This book is an essential in any chemical research library and I strongly recommend it to all synthetic research and teaching chemists. [...]" The Alchemist "The editors are to be congratulated on assembling such a wide range of contributors who have described the industrial as well as the academic aspects of the subject." [...] Journal of Organometallic Chemistry



Ruthenium Catalysts And Fine Chemistry


Ruthenium Catalysts And Fine Chemistry
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Author : Christian Bruneau
language : en
Publisher: Springer Science & Business Media
Release Date : 2004-06-30

Ruthenium Catalysts And Fine Chemistry written by Christian Bruneau and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2004-06-30 with Science categories.


With contributions by numerous experts



Regulated Systems For Multiphase Catalysis


Regulated Systems For Multiphase Catalysis
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Author : Walter Leitner
language : en
Publisher: Springer
Release Date : 2008-08-20

Regulated Systems For Multiphase Catalysis written by Walter Leitner and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-08-20 with Science categories.


Multiphase catalysis is a key technology for the competitive and sustainable production of fine chemicals in coming decades. A joint academic and industry consortium has developed tools for considering complex chemical and process-based requirements when setting up a catalytic system. This book shows how the resulting competence covers such supercritical fluid (SCF) technology in catalysis, ionic liquids (Il), ligand design for SFCs and Ils, thermomorphic solvent systems, reactor design and more.