Oxidative Damage To Nucleic Acids

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Oxidative Damage To Nucleic Acids

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Author : Mark D. Evans
language : en
Publisher: Springer Science & Business Media
Release Date : 2009-06-11

Oxidative Damage To Nucleic Acids written by Mark D. Evans and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-06-11 with Science categories.

This book provides up-to-date coverage of selected topics in nucleic acid oxidation. The topics have been selected to cover everything from basic chemical mechanisms, repair of damage and the biological and pathological meaning of DNA oxidation. The chapters are authored by leading, research active, international experts in the respective topics.

Biomarkers Of Oxidative Stress

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Author : Silvana Andreescu
language : en
Publisher: Springer Nature
Release Date : 2024-11-13

Biomarkers Of Oxidative Stress written by Silvana Andreescu and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-11-13 with Medical categories.

This book pinpoints one of the fastest growing, complex subjects in chemistry and medical science: the dangers of oxidative stress to human beings. It provides a solid background on the chemistry behind the generation of reactive species as well as how reactive species are involved in essential physiological processes and in almost every human disease. It also covers the most recent developments in the study of oxidative and reductive stress (redox stress), including the role of radical and reactive species, novel antioxidant therapies, and methods for assessing free radicals and redox stress. The chapters present concise, yet thorough, summaries of the state-of-the-art methods and techniques that any investigator working in the oxidative/reductive stress field needs to access. The current methodologies including the development of sensors and biosensors for the detection of ROS/RNS/RHS and of biomarkers of redox stress are thoroughly discussed. This book is a useful resource for all researchers and students interested in oxidative stress, molecular biology, and chemistry. Physicians and healthcare professionals interested in understanding the molecular mechanisms underlying the redox stress-related diseases also stand to benefit from this book.

Grappling With The Multifaceted World Of The Dna Damage Response

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Author : Antonio Porro
language : en
Publisher: Frontiers Media SA
Release Date : 2017-01-10

Grappling With The Multifaceted World Of The Dna Damage Response written by Antonio Porro and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-01-10 with categories.

DNA damage is a major threat to genomic integrity and cell survival. It can arise both spontaneously and in response to exogenous agents. DNA damage can attack most parts of the DNA structure, ranging from minor and major chemical modifications, to single-strand breaks (SSBs) and gaps, to full double-strand breaks (DSBs). If DNA injuries are mis-repaired or unrepaired, they may ultimately result in mutations or wider-scale genome aberrations that threaten cell homeostasis. Consequently, the cells elicit an elaborate signalling network, known as DNA damage response (DDR), to detect and repair these cytotoxic lesions. This Research Topic was aimed at comprehensive investigations of basic and novel mechanisms that underlie the DNA damage response in eukaryotes.

Stress Response Mechanisms In Fungi

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Author : Marek Skoneczny
language : en
Publisher: Springer
Release Date : 2018-10-16

Stress Response Mechanisms In Fungi written by Marek Skoneczny and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-10-16 with Science categories.

This book covers both the molecular basics of fungal stress response strategies as well as biotechnological applications thereof. The complex regulatory mechanisms of stress response pathways are presented in a concise and well-readable manner. Also, light will be shed on the interconnection of pathways responding to different types of stress. Profound knowledge of stress responses in yeast and filamentous fungi is crucial for further optimization of industrial processes. Applications are manifold, for example in fungicide development, for improving the resistance of crop plants to fungal pathogens, but also in medicine to help curing fungal infections. The book targets researchers from academia and industry, as well as graduate students interested in microbiology, mycology and biomedicine.

Mitochondrial Superoxide Production And Its Oxidative Damage To Proteins

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Author : Danni Li Meany
language : en
Publisher:
Release Date : 2007

Mitochondrial Superoxide Production And Its Oxidative Damage To Proteins written by Danni Li Meany and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007 with categories.

Oxidative Damage Repair

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Author : Kelvin J. A. Davies
language : en
Publisher: Elsevier
Release Date : 2013-10-22

Oxidative Damage Repair written by Kelvin J. A. Davies and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-10-22 with Health & Fitness categories.

This book was inspired by the presentations delivered at the Oxidative Damage & Repair Symposium (November, 1990). The book is organized into 20 chapters which mirror the 20 session topics of the Oxidative Damage & Repair Symposium.

Rna Damage And Repair

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Author : Ioly Kotta-Loizou
language : en
Publisher: Springer
Release Date : 2022-07-06

Rna Damage And Repair written by Ioly Kotta-Loizou and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-07-06 with Science categories.

Ribonucleic acid (RNA) is a macromolecule that plays a central role in cell physiology: RNA molecules act as intermediates between the deoxyribonucleic acid (DNA), where genetic information is stored, and proteins, which perform the necessary functions within the cell. Traditionally, the structural and functional properties of RNA are closely linked to gene expression. However, RNA-based enzymes, called ribozymes, are also involved in catalysis and small RNAs regulate key cellular processes, such as cell growth, division, differentiation, aging and death. RNA is a sensitive macromolecule that can be easily damaged by environmental conditions (ultraviolet radiation, oxidative stress) and biological factors (ribonucleases, ribotoxins, CRISPR-Cas systems). Therefore, cells have developed mechanisms to protect and/or repair RNA molecules. This book presents an overview of the biology of RNA damage, protection and repair in prokaryotes and eukaryotes. Individual chapters cover the expression regulation, enzymology and physiological role of such systems, and link them to important human diseases such as cancer and degenerative diseases.

Brain Aging

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Author : David R. Riddle
language : en
Publisher: CRC Press
Release Date : 2007-04-19

Brain Aging written by David R. Riddle and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-04-19 with Medical categories.

Recognition that aging is not the accumulation of disease, but rather comprises fundamental biological processes that are amenable to experimental study, is the basis for the recent growth of experimental biogerontology. As increasingly sophisticated studies provide greater understanding of what occurs in the aging brain and how these changes occur

Role Of Oxidative Stress In Chronic Diseases

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Author : Isaias Dichi
language : en
Publisher: CRC Press
Release Date : 2014-03-14

Role Of Oxidative Stress In Chronic Diseases written by Isaias Dichi and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-03-14 with Medical categories.

This book presents recent findings on the role of oxidative stress in chronic diseases. Understanding the mechanisms behind it enables readers to comprehend the rationale which underlies intervention in such conditions. The book places special emphasis on genetic polymorphism-an important issue related to this field of study. It covers the role of

Current Topics In Human Genetics Studies In Complex Diseases

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Author : Hong-wen Deng
language : en
Publisher: World Scientific
Release Date : 2007-11-12

Current Topics In Human Genetics Studies In Complex Diseases written by Hong-wen Deng and has been published by World Scientific this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-11-12 with Science categories.

The sequencing of the human genome has brought human genetics into a new era of study resulting in the generation of an explosive amount of information. Application of genomic, proteomic, and bioinformatics technologies to the study of human genetics has made it possible for human genetic diseases to be studied on an unprecedented scale, both in silico and in the wet lab. This volume provides up-to-date coverage of the broad range of research topics in this fascinating area. In the first part of the book, a whole spectrum of approaches to human genetics research is reviewed for both background and the latest progress. In the second, important topics related to genetic research of various complex human diseases are discussed. The robust content and diverse array of subjects allow the book to serve as both a concise “encyclopedia” that introduces basic and essential concepts of human genetics and an in-depth review of the current understanding of genetic research in human diseases.