Particle Lung Interactions
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Particle Lung Interactions
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Author : Peter Gehr
language : en
Publisher: CRC Press
Release Date : 2000-02-18
Particle Lung Interactions written by Peter Gehr and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2000-02-18 with Medical categories.
This wide-ranging, comprehensive reference presents the latest developments in aerosol science and interactions between particles and the respiratory tract-utilizing an inter-disciplinary approach that integrates advances in physics, chemistry, and engineering with the epidemiological and biomedical sciences, and focusing on the dynamics of particl
Particle Lung Interactions Second Edition
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Author : Peter Gehr
language : en
Publisher: CRC Press
Release Date : 2009-09-25
Particle Lung Interactions Second Edition written by Peter Gehr and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-09-25 with Medical categories.
Written by an expanded team of leading international scientists, the second edition thoroughly investigates research and therapies for managing adverse physiological effects of air-borne particles on the respiratory tract. The book examines the lung as the gateway for particle damage to organs outside the respiratory system and provide the information needed to understand and combat the numerous and varied ailments caused by inhaled particles.
Particulate Interactions In Dry Powder Formulation For Inhalation
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Author : Xian Ming Zeng
language : en
Publisher: CRC Press
Release Date : 2000-10-26
Particulate Interactions In Dry Powder Formulation For Inhalation written by Xian Ming Zeng and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2000-10-26 with Medical categories.
Interactions between drug particulates are crucial in determining drug dispersion and deaggregation, and ultimately delivery efficiency. This book combines principles established in surface and colloidal chemistry with pharmaceutical powder technology. It discusses some of the factors affecting particulate interactions, and particle-fluid interaction in the respiratory tract. It review some of the studies carried out in dry powder formulation development, and proposes possible strategies in improving DPI efficiency. The majority of these principles are applicable to other pharmaceutical solid dosage forms (e.g. tablets and capsules).
Nanoparticles In The Lung
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Author : Akira Tsuda
language : en
Publisher: CRC Press
Release Date : 2014-12-19
Nanoparticles In The Lung written by Akira Tsuda and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-12-19 with Medical categories.
Nanoparticles have a physical dimension comparable to the size of molecular structures on the cell surface. Therefore, nanoparticles, compared to larger (e.g., micrometer) particles, are considered to behave differently when they interact with cells. Nanoparticles in the Lung: Environmental Exposure and Drug Delivery provides a better understanding
Pulmonary Drug Delivery
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Author : Ali Nokhodchi
language : en
Publisher: John Wiley & Sons
Release Date : 2015-08-03
Pulmonary Drug Delivery written by Ali Nokhodchi and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-08-03 with Science categories.
Drug therapy via inhalation route is at the cutting edge of modern drug delivery research. There has been significant progress on the understanding of drug therapy via inhalation products. However, there are still problems associated with their formulation design, including the interaction between the active pharmaceutical ingredient(s) (APIs), excipients and devices. This book seeks to cover some of the most pertinent issues and challenges of such formulation design associated with industrial production and desirable clinical outcome. The chapter topics have been selected with a view to integrating the factors that require consideration in the selection and design of device and formulation components which impact upon patient usability and clinical effectiveness. The challenges involved with the delivery of macromolecules by inhalation to both adult and pediatric patients are also covered. Written by leading international experts from both academia and industry, the book will help readers (formulation design scientists, researchers and post-graduate and specialized undergraduate students) develop a deep understanding of key aspects of inhalation formulations as well as detail ongoing challenges and advances associated with their development.
Particle Toxicology
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Author : Ken Donaldson
language : en
Publisher: CRC Press
Release Date : 2019-08-30
Particle Toxicology written by Ken Donaldson and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-08-30 with categories.
Exposure to particles in industry and mining and from accidental anthropogenic sources constitutes an ongoing threat. Most recently nanoparticles arising from advances in technology are exposing a wider population to pathogenic stimuli. The effects of inhaled particles are no longer confined to the lung as nanoparticles have the potential to translocate to the bloodstream, the brain, and other target sites. The new questions posed by nanoparticles underscore the importance of interdisciplinary research and exchange and highlight the need for new collaborations among disciplines in medicine, toxicology, chemistry, and material sciences. Particle Toxicology brings together the state of the science in particle physico-chemistry, cell biology, and toxicology in a single volume. While organized around the classical toxicology paradigm of exposure - dose - response, the book is unique in its emphasis on mechanistic toxicology. Preparing the reader with a brief historical overview and a conceptual framework for particle research, the book provides reviews on the mechanisms and properties of pathogenic particles and their effects on target cells at various sites in the body. The text describes how adverse effects are a consequence of deposition, translocation, and the complex issue of "dose" dominates. Contributions from leading researchers address particle-associated pro-inflammatory effects and inflammatory signaling, cellular and extracellular oxidative and nitrosative stress, particulate interactions in the pulmonary, cardiovascular, and central nervous systems, as well as genotoxic effects. Exemplar particles include quartz, asbestos, particulate material and nanoparticles. The book also covers mathematical modeling and human studies as avenues for future research. Responding to the evolving trend of consumer applications for particulate matter, Particle Toxicology provides the comprehensive resource for current knowledge from which to develop ne
Biologic Markers In Pulmonary Toxicology
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Author : National Research Council
language : en
Publisher: National Academies Press
Release Date : 1989-02-01
Biologic Markers In Pulmonary Toxicology written by National Research Council and has been published by National Academies Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1989-02-01 with Science categories.
Biologic markersâ€"indicators of biological exposure or changeâ€"offer the promise of early detection of disease caused by environmental exposure. Researchers have used these markers to discover indications of pulmonary damage from low-level ozone, a finding with serious implications for health professionals and environmental regulators. Biologic Markers in Pulmonary Toxicology is a comprehensive study of this use of biologic markers. Focusing on the respiratory tract as an entryway for airborne pollutants, this volume reviews new ways of measuring markers, the need for markers to indicate dose or exposure levels, noninvasive respiratory function tests for use with healthy humans to detect sensitivity to inhaled pollutants, approaches to evaluating markers down to the cellular and biochemical levels, and more.
Handbook Of Nanotoxicology Nanomedicine And Stem Cell Use In Toxicology
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Author : Saura C. Sahu
language : en
Publisher: John Wiley & Sons
Release Date : 2014-04-22
Handbook Of Nanotoxicology Nanomedicine And Stem Cell Use In Toxicology written by Saura C. Sahu and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-04-22 with Science categories.
The Handbook of Nanotoxicology, Nanomedicine and Stem Cell Use in Toxicology provides an insight into the current trends and future directions of research in these rapidly developing scientific fields. Written by leading scientists and experts, the Handbook will be of interest to various scientific disciplines including toxicology, medicine, and pharmacology, as well as food, drug, and other regulatory sciences.
Comparative Biology Of The Normal Lung
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Author : Richard A. Parent
language : en
Publisher: Academic Press
Release Date : 2015-03-13
Comparative Biology Of The Normal Lung written by Richard A. Parent and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-03-13 with Science categories.
Comparative Biology of the Normal Lung, 2nd Edition, offers a rigorous and comprehensive reference for all those involved in pulmonary research. This fully updated work is divided into sections on anatomy and morphology, physiology, biochemistry, and immunological response. It continues to provide a unique comparative perspective on the mammalian lung. This edition includes several new chapters and expanded content, including aging and development of the normal lung, mechanical properties of the lung, genetic polymorphisms, the comparative effect of stress of pulmonary immune function, oxygen signaling in the mammalian lung and much more. By addressing scientific advances and critical issues in lung research, this 2nd edition is a timely and valuable work on comparative data for the interpretation of studies of animal models as compared to the human lung. Edited and authored by experts in the field to provide an excellent and timely review of cross-species comparisons that will help you interpret and compare data from animal studies to human findings Incorporates lung anatomy and physiology, cell specific interactions and immunological responses to provide you with a single and unique multidisciplinary source on the comparative biology of the normal lung Includes new and expanded content on neonatal and aged lungs, developmental processes, cell signaling, antioxidants, airway cells, safety pharmacology and much more Section IV on Physical and Immunological Defenses has been significantly updated with 9 new chapters and an increased focus on the pulmonary immunological system
Air Pollution The Automobile And Public Health
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Author : Sponsored by The Health Effects Institute
language : en
Publisher: National Academies Press
Release Date : 1988-01-01
Air Pollution The Automobile And Public Health written by Sponsored by The Health Effects Institute and has been published by National Academies Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1988-01-01 with Science categories.
"The combination of scientific and institutional integrity represented by this book is unusual. It should be a model for future endeavors to help quantify environmental risk as a basis for good decisionmaking." â€"William D. Ruckelshaus, from the foreword. This volume, prepared under the auspices of the Health Effects Institute, an independent research organization created and funded jointly by the Environmental Protection Agency and the automobile industry, brings together experts on atmospheric exposure and on the biological effects of toxic substances to examine what is knownâ€"and not knownâ€"about the human health risks of automotive emissions.