Pathogenesis And Mechanisms Of Liver Cell Necrosis
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Pathogenesis And Mechanisms Of Liver Cell Necrosis
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Author : D. Keppler
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Pathogenesis And Mechanisms Of Liver Cell Necrosis written by D. Keppler and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
The pathogenesis of cell death and necrosis in the liver is a central topic of research in liver disease. A molecular understanding of events and sequences leading to cellular death provides the basis for preventive and therapeutic efforts. This volume originates from a "Workshop on Experimental Liver Injury" held on November 9 and 10, 1974, in Freiburg, Germany. Recent progress in the elucidation of the mode of action includes agents inducing liver cell necrosis by a primary dis turbance of nucleotide and nucleic acid metabolism as well as hepa totoxins characterized by a primary attack on cellular membranes. I hope that this book will contribute to an increasing understanding of disease mechanisms. Freiburg im Breisgau Dietrich Keppler June 1975 Acknowledgments The generous support from Dr. H. Falk, Freiburg, has been a prereqUIsite for the organisation and publication of the meeting on "Pathogenesis and Mechanisms of Liver Cell Necrosis". I wish to express my sincere thanks for this sponsorship. I am indebted to those who acted as chairmen during the meeting: Professors H. Remmer (Tilbingen), M. Frimmer (Giessen), W. Gerok (Freiburg), H. Popper (New York), H. Schimassek (Heidelberg), and K. Decker (Freiburg).
Cellular And Molecular Mechanisms Underlying The Pathogenesis Of Hepatic Fibrosis
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Author : Ralf Weiskirchen
language : en
Publisher: MDPI
Release Date : 2020-12-29
Cellular And Molecular Mechanisms Underlying The Pathogenesis Of Hepatic Fibrosis written by Ralf Weiskirchen and has been published by MDPI this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-12-29 with Medical categories.
Worldwide, liver fibrosis is a major cause of morbidity and mortality and is associated with a high medical and economic burden. It is the common consequence of chronic liver injury due to various etiologies. During fibrogenesis, there is a progressive substitution of the liver parenchyma by scar tissue. Recent advances in the understanding of the history of liver fibrosis have shown that the pathogenesis is driven by different cell types and a large variety of soluble mediators. At present, scientists working in this field aim to increase basic knowledge, improve diagnostics, and try to translate experimental findings into new treatment modalities. This book includes 12 selected contributions from the Special Issue “Cellular and Molecular Mechanisms Underlying the Pathogenesis of Hepatic Fibrosis” that was published in Cells. These articles summarize current perspectives and findings in hepatic fibrosis research showing how scientists try to use basic scientific research to create new therapies and diagnostics.
Pathogenesis Of Liver Diseases
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Author : Emmanuel Farber
language : en
Publisher:
Release Date : 1987
Pathogenesis Of Liver Diseases written by Emmanuel Farber and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1987 with Medical categories.
Free Radicals In The Pathogenesis Of Liver Injury
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Author : Giuseppe Poli
language : en
Publisher: Pergamon
Release Date : 1989
Free Radicals In The Pathogenesis Of Liver Injury written by Giuseppe Poli and has been published by Pergamon this book supported file pdf, txt, epub, kindle and other format this book has been release on 1989 with Free radical reactions categories.
Hardbound. Since the first Congress on Free Radicals in Liver Injury took place in 1985, much research and development has taken place in this area of liver pathophysiology which is now considered to be of prime interest and importance in hepatology. In these Proceedings of the second Congress, held in Turin in June 1988, the most recent advances in the study of free radical mechanisms, from the organic to the molecular level in both acute and chronic liver injuries are discussed, in both experimental animals and man. The first section covers the remarkable advances that have been made in the clarification of biochemical mechanisms connecting oxidative insult to hepatocyte death. Stimulating new data on the role of free radicals and lipid peroxidation in the development of hepatocellular carcinoma and in liver regeneration appear in the second section. The papers in the third section investigate the involvement of oxidative species in the pathology of chr
Drug Induced Liver Injury
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Author :
language : en
Publisher: Academic Press
Release Date : 2019-07-13
Drug Induced Liver Injury written by and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-07-13 with Medical categories.
Drug-Induced Liver Injury, Volume 85, the newest volume in the Advances in Pharmacology series, presents a variety of chapters from the best authors in the field. Chapters in this new release include Cell death mechanisms in DILI, Mitochondria in DILI, Primary hepatocytes and their cultures for the testing of drug-induced liver injury, MetaHeps an alternate approach to identify IDILI, Autophagy and DILI, Biomarkers and DILI, Regeneration and DILI, Drug-induced liver injury in obesity and nonalcoholic fatty liver disease, Mechanisms of Idiosyncratic Drug-Induced Liver Injury, the Evaluation and Treatment of Acetaminophen Toxicity, and much more. Includes the authority and expertise of leading contributors in pharmacology Presents the latest release in the Advances in Pharmacology series
Mechanisms Of Hepatocyte Injury And Death
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Author : D. Keppler
language : en
Publisher: Springer
Release Date : 1984-08-31
Mechanisms Of Hepatocyte Injury And Death written by D. Keppler and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 1984-08-31 with Medical categories.
Liver Diseases
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Author : Shakir Ali
language : en
Publisher:
Release Date : 2006
Liver Diseases written by Shakir Ali and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006 with Liver categories.
Twenty-nine articles by a richly international group of specialists offer new insights into many areas of liver disease. The first volume contains articles on mediators and regulation of liver disease and the immunological basis of liver injury, with individual topics that include the role of chemokines in liver pathophysiology, the basis for immune recognition of cellular targets in primary biliary cirrhosis, and the role of nitric oxide in liver disorders. Volume Two contains articles on pathophysiology, therapy, and diagnosis and includes chapters on molecular virology and therapeutic targets for the Hepatitis C virus, and new therapeutic approaches for hepatic fibrosis. The three editors are Ali (biochemistry, Deemed U., New Delhi, India), Scott L. Friedman (division of liver diseases, Mount Sinai School of Medicine, New York), and Derek A. Mann (molecular biology, Southampton U. Hospital, UK). Distributed in the US by Enfield. Annotation :2006 Book News, Inc., Portland, OR (booknews.com).
Liver Pathophysiology
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Author : Pablo Muriel
language : en
Publisher: Academic Press
Release Date : 2017-03-02
Liver Pathophysiology written by Pablo Muriel and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-03-02 with Medical categories.
Liver Pathophysiology: Therapies and Antioxidants is a complete volume on morphology, physiology, biochemistry, molecular biology and treatment of liver diseases. It uses an integral approach towards the role of free radicals in the pathogenesis of hepatic injury, and how their deleterious effects may be abrogated by the use of antioxidants. Written by the most prominent authors in the field, this book will be of use to basic and clinical scientists and clinicians working in the biological sciences, especially those dedicated to the study and treatment of liver pathologies. Presents the most recent advances in hepatology, with a special focus on the role of oxidative stress in liver injury. Provides in vivo and in vitro models to study human liver pathology. Explains the beneficial effects of antioxidants on liver diseases. Contains the most recent and modern treatments of hepatic pathologies, including, but not limited to, stem cells repopulation, gene therapy and liver transplantation.
Cellular And Molecular Mechanisms Underlying The Pathogenesis Of Hepatic Fibrosis
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Author : Ralf Weiskirchen
language : en
Publisher:
Release Date : 2020
Cellular And Molecular Mechanisms Underlying The Pathogenesis Of Hepatic Fibrosis written by Ralf Weiskirchen and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020 with categories.
Worldwide, liver fibrosis is a major cause of morbidity and mortality and is associated with a high medical and economic burden. It is the common consequence of chronic liver injury due to various etiologies. During fibrogenesis, there is a progressive substitution of the liver parenchyma by scar tissue. Recent advances in the understanding of the history of liver fibrosis have shown that the pathogenesis is driven by different cell types and a large variety of soluble mediators. At present, scientists working in this field aim to increase basic knowledge, improve diagnostics, and try to translate experimental findings into new treatment modalities. This book includes 12 selected contributions from the Special Issue “Cellular and Molecular Mechanisms Underlying the Pathogenesis of Hepatic Fibrosis” that was published in Cells. These articles summarize current perspectives and findings in hepatic fibrosis research showing how scientists try to use basic scientific research to create new therapies and diagnostics.
Biomarkers In Liver Disease
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Author : Victor R. Preedy
language : en
Publisher: Springer
Release Date : 2017-07-14
Biomarkers In Liver Disease written by Victor R. Preedy and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-07-14 with Medical categories.
In the past decade there has been a major sea change in the way disease is diagnosed and investigated due to the advent of high throughput technologies, such as microarrays, lab on a chip, proteomics, genomics, lipomics, metabolomics etc. These advances have enabled the discovery of new and novel markers of disease relating to autoimmune disorders, cancers, endocrine diseases, genetic disorders, sensory damage, intestinal diseases etc. In many instances these developments have gone hand in hand with the discovery of biomarkers elucidated via traditional or conventional methods, such as histopathology or clinical biochemistry. Together with microprocessor-based data analysis, advanced statistics and bioinformatics these markers have been used to identify individuals with active disease or pathology as well as those who are refractory or have distinguishing pathologies. New analytical methods that have been used to identify markers of disease and is suggested that there may be as many as 40 different platforms. Unfortunately techniques and methods have not been readily transferable to other disease states and sometimes diagnosis still relies on single analytes rather than a cohort of markers. There is thus a demand for a comprehensive and focused evidenced-based text and scientific literature that addresses these issues. Hence the formulation of Biomarkers in Disease The series covers a wide number of areas including for example, nutrition, cancer, endocrinology, cardiology, addictions, immunology, birth defects, genetics, and so on. The chapters are written by national or international experts and specialists.