Biomarkers In Liver Disease
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Biomarkers In Liver Disease
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Author : Victor R. Preedy
language : en
Publisher: Springer
Release Date : 2017-07-14
Biomarkers In Liver Disease written by Victor R. Preedy and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-07-14 with Medical categories.
In the past decade there has been a major sea change in the way disease is diagnosed and investigated due to the advent of high throughput technologies, such as microarrays, lab on a chip, proteomics, genomics, lipomics, metabolomics etc. These advances have enabled the discovery of new and novel markers of disease relating to autoimmune disorders, cancers, endocrine diseases, genetic disorders, sensory damage, intestinal diseases etc. In many instances these developments have gone hand in hand with the discovery of biomarkers elucidated via traditional or conventional methods, such as histopathology or clinical biochemistry. Together with microprocessor-based data analysis, advanced statistics and bioinformatics these markers have been used to identify individuals with active disease or pathology as well as those who are refractory or have distinguishing pathologies. New analytical methods that have been used to identify markers of disease and is suggested that there may be as many as 40 different platforms. Unfortunately techniques and methods have not been readily transferable to other disease states and sometimes diagnosis still relies on single analytes rather than a cohort of markers. There is thus a demand for a comprehensive and focused evidenced-based text and scientific literature that addresses these issues. Hence the formulation of Biomarkers in Disease The series covers a wide number of areas including for example, nutrition, cancer, endocrinology, cardiology, addictions, immunology, birth defects, genetics, and so on. The chapters are written by national or international experts and specialists.
Biomarkers In Liver Disease
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Author : Victor R. Preedy
language : en
Publisher:
Release Date :
Biomarkers In Liver Disease written by Victor R. Preedy and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on with Biochemical markers categories.
Nafld And Nash
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Author : Manuel Romero-Gomez
language : en
Publisher: Springer Nature
Release Date : 2020-02-28
Nafld And Nash written by Manuel Romero-Gomez and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-02-28 with Medical categories.
This book provides a comprehensive overview of the diagnosis and management of Non-alcoholic Fatty Liver Disease (NAFLD) and Non-Alcoholic Steatohepatis (NASH). Basic principles of disease progression, the genetic and nutritional basis of NAFLD and NASH are explained along with the proteomic principles underlying biomarker development. Chapters cover both biochemical and imaging biomarkers used in elastrography and ultrasound and discuss how these are applicable to early diagnosis and monitoring of NASH and NAFLD. This is a useful resource for hepatologists, primary care providers with an interest in metabolic disease, diabetologists and endocrinologists in their daily clinical practice.
Organ Fibrosis Pathogenesis Biomarkers And Therapeutic Targets
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Author : Henricus A. M. (Rick) Mutsaers
language : en
Publisher: Frontiers Media SA
Release Date : 2022-01-05
Organ Fibrosis Pathogenesis Biomarkers And Therapeutic Targets written by Henricus A. M. (Rick) Mutsaers and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-01-05 with Medical categories.
Diagnostic And Prognostic Markers In Liver Cirrhosis Book Edition Of Disease Markers
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Author : S. Augustin
language : en
Publisher:
Release Date : 2011
Diagnostic And Prognostic Markers In Liver Cirrhosis Book Edition Of Disease Markers written by S. Augustin and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011 with Liver categories.
Suitable for those involved in the diagnosis and treatment of liver disease, this title explores the importance of diagnostic tools and the role of different prognostic markers in the different stages and clinical complications of liver cirrhosis.
Metabolism And Metabolomics Of Liver In Health And Disease
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Author : Walter Wahli
language : en
Publisher: MDPI
Release Date : 2021-02-19
Metabolism And Metabolomics Of Liver In Health And Disease written by Walter Wahli and has been published by MDPI this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-02-19 with Science categories.
Women and men have probably never been concerned as much by their health as during this COVID-19 pandemic. In this context, lifestyle habits continue to be promoted as allies for daily prevention against diseases. This is valid also for metabolic diseases, among which many affect the liver and are risk factors for aggravating the disease course of COVID-19. In fact, liver diseases are currently a major global health problem. There is a huge range of liver diseases and non-alcoholic fatty liver disease (NAFLD) is the most common chronic hepatic condition, which in some patients progresses to cirrhosis and liver cancer. Currently, substantial efforts are being made to better understand NAFLD, especially, because there is no U.S. Food and Drug Administration (FDA)-approved pharmacological therapy. To explore this disease, metabolomics is the most recently developed omics technology after genomics, transcriptomics, and proteomics. Metabolomics is the large-scale analysis of molecules, known as metabolites that are intermediate or end products of metabolism found within cells, tissues, and biofluids. This technology has a very high potential to identify biomarker candidates for the future development of new therapeutics. The book features articles that address metabolomics technology and its use to document different liver functions and dysfunctions, with a major focus on NAFLD.
Non Invasive Characterization Of Liver Disease
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Author : Markus Karlsson
language : en
Publisher: Linköping University Electronic Press
Release Date : 2019-12-13
Non Invasive Characterization Of Liver Disease written by Markus Karlsson and has been published by Linköping University Electronic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-12-13 with categories.
There is a large and unmet need for diagnostic tool that can be used to characterize chronic liver diseases (CLD). In the earlier stages of CLD, much of the diagnostics involves performing biopsies, which are evaluated by a histopathologist for the presence of e.g. fat, iron, inflammation, and fibrosis. Performing biopsies, however, have two downsides: i) biopsies are invasive and carries a small but non-negligible risk for serious complications, ii) biopsies only represents a tiny portion of the liver and are thus prone to sampling error. Moreover, in the later stages of CLD, when the disease has progressed far enough, the ability of the liver to perform its basic function will be compromised. In this stage, there is a need for better methods for accurately measuring liver function. Additionally, measures of liver function can also be used when developing new drugs, as biomarkers for drug-induced liver injury (DILI), which is a serious drug-safety issue. Magnetic resonance imaging (MRI) is a non-invasive medical imaging modality, which have shown much promise with regards to characterizing liver disease in all of the abovementioned aspects. The aim of this PhD project was to develop and validate MR-based methods that can be used to non-invasively characterize liver disease. Paper I investigated if R2* mapping, a MR-method for measuring liver iron content, can be confounded by liver fat. The results show fat does affect R2*. The conclusion was therefore that fat must be taken into account when measuring small amounts of liver iron, as a small increase in R2* could be due to either small amounts of iron or large amounts of fat. Paper II examined whether T1 mapping, which is another MR-method, can be used for staging liver fibrosis. The results of previous research have been mixed; some studies have been very promising, whereas other studies have been less promising. Unfortunately, the results in Paper II belongs to the less promising studies. Paper III focused on measuring liver function by dynamic contrast-enhanced MRI (DCEMRI) using a liver specific contrast agent, which is taken up the hepatocytes and excreted to the bile. The purpose of the paper was to extend and validate a method for estimating uptake and efflux rates of the contrast agent. The method had previously only been applied in health volunteers. Paper II showed that the method can be applied to CLD patients and that the uptake of the contrast agent is lower in patients with advanced fibrosis. Paper IV also used studied liver function with DCE-MRI in patients with primary sclerosing cholangitis (PSC). PSC is a CLD where the bile ducts are attacked by the immune system. When diagnosing PSC patients, it is common to use magnetic resonance cholangiopancreatography (MRCP), which is a method for imaging the bile ducts. Paper IV examined if there was any correlation between number and severity of the morphological changes, seen on MRCP, and measures of liver function derived using DCE-MRI. However, the results showed no such correlation. The conclusion was that the results indicates that MRCP should not be used to predict parenchymal function. Paper V developed a method for translating DCE-MRI liver function parameters from rats to humans. This translation could be of value when developing new drugs, as a tool for predicting which drugs might cause drug-induced liver injury. In summary, this thesis has shown that multimodal quantitative MR has a bright future for characterizing liver disease from a range of different aspects.
Nafld And Nash
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Author :
language : en
Publisher:
Release Date : 2020
Nafld And Nash written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020 with Biochemical markers categories.
This book provides a comprehensive overview of the diagnosis and management of Non-alcoholic Fatty Liver Disease (NAFLD) and Non-Alcoholic Steatohepatis (NASH). Basic principles of disease progression, the genetic and nutritional basis of NAFLD and NASH are explained along with the proteomic principles underlying biomarker development. Chapters cover both biochemical and imaging biomarkers used in elastrography and ultrasound and discuss how these are applicable to early diagnosis and monitoring of NASH and NAFLD. This is a useful resource for hepatologists, primary care providers with an interest in metabolic disease, diabetologists and endocrinologists in their daily clinical practice.
Surrogate Markers To Assess Efficacy Of Treatment In Chronic Liver Diseases
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Author : J. Reichen
language : en
Publisher: Springer
Release Date : 1996-06-30
Surrogate Markers To Assess Efficacy Of Treatment In Chronic Liver Diseases written by J. Reichen and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 1996-06-30 with Medical categories.
Therefore, surrogate markers for the different conditions are sorely needed in order to assess the value of these novel treatment modalities.
Consultations In Liver Disease An Issue Of Clinics In Liver Disease E Book
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Author : Steven L. Flamm
language : en
Publisher: Elsevier Health Sciences
Release Date : 2022-11-18
Consultations In Liver Disease An Issue Of Clinics In Liver Disease E Book written by Steven L. Flamm and has been published by Elsevier Health Sciences this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-11-18 with Medical categories.
In this issue of Clinics in Liver Disease, guest editor Dr. Steven L. Flamm brings his considerable expertise to the topic of Updates in Consultations in Liver Disease. Many disease entities are uncommon and complicated in scope, and liver disease may occur in the setting of other chronic medical conditions and involve other organ systems. In this issue, top experts provide a up-to-date framework for approaching consultation for common liver-related problems for the gastroenterology and hepatology practitioner. Contains 12 practice-oriented topics including clinical pearls in evaluation and treatment of patients with liver disease; evaluation of patients with markedly elevated liver enzymes; evaluation of liver disease in pregnancy; COVID and implications on the liver; and more. Provides in-depth clinical reviews on consultations in liver disease, offering actionable insights for clinical practice. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.