Pathogenicity And Drug Resistance Of Human Pathogens
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Pathogenicity And Drug Resistance Of Human Pathogens
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Author : Saif Hameed
language : en
Publisher: Springer Nature
Release Date : 2020-01-23
Pathogenicity And Drug Resistance Of Human Pathogens written by Saif Hameed and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-01-23 with Medical categories.
The book comprehensively discusses the mechanisms of pathogenesis and drug resistance; current diagnostics landscape of four key human pathogens; bacterial, fungal, protozoans and viral which are the causes of major infectious diseases. It also assesses the emerging technologies for the detection and quantification of these pathogens. Further, it discusses the novel opportunities to fight against these infectious diseases and to identify pertinent drug targets with novel methodologies. It also reviews the current and future insights into the control, elimination, and eradication of these infectious diseases. Importantly, the book discusses the epidemiological characteristics and various challenges in combating Ebola and Influenza diseases. Finally, the book highlights the growing role of nanotechnology and bioinformatics resources for combating the infectious diseases. In summary, the book provides the mechanistic insight of the pathogenicity, drug-resistance, therapeutic strategies and identification of the novel drug targets of Mycobacterium tuberculosis, Plasmodium, Candida, Hepatitis C and emerging viral infections.
Pathogenicity And Drug Resistance Of Human Pathogens
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Author : Saif Hameed
language : en
Publisher:
Release Date : 2019
Pathogenicity And Drug Resistance Of Human Pathogens written by Saif Hameed and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019 with Bioinformatics categories.
The book comprehensively discusses the mechanisms of pathogenesis and drug resistance; current diagnostics landscape of four key human pathogens; bacterial, fungal, protozoans and viral which are the causes of major infectious diseases. It also assesses the emerging technologies for the detection and quantification of these pathogens. Further, it discusses the novel opportunities to fight against these infectious diseases and to identify pertinent drug targets with novel methodologies. It also reviews the current and future insights into the control, elimination, and eradication of these infectious diseases. Importantly, the book discusses the epidemiological characteristics and various challenges in combating Ebola and Influenza diseases. Finally, the book highlights the growing role of nanotechnology and bioinformatics resources for combating the infectious diseases. In summary, the book provides the mechanistic insight of the pathogenicity, drug-resistance, therapeutic strategies and identification of the novel drug targets of Mycobacterium tuberculosis, Plasmodium, Candida, Hepatitis C and emerging viral infections.
Foodborne Enterobacteriaceae Of Animal Origin Epidemic Characteristics Of Drug Resistance Pathogenic Mechanisms And Novel Control Measures
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Author : Fangkun Wang
language : en
Publisher: Frontiers Media SA
Release Date : 2021-11-25
Foodborne Enterobacteriaceae Of Animal Origin Epidemic Characteristics Of Drug Resistance Pathogenic Mechanisms And Novel Control Measures written by Fangkun Wang and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-11-25 with Science categories.
Gram Positive Pathogens
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Author : Vincent A. Fischetti
language : en
Publisher: John Wiley & Sons
Release Date : 2019-10-01
Gram Positive Pathogens written by Vincent A. Fischetti and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-10-01 with Science categories.
Gram-positive bacteria, lacking an outer membrane and related secretory systems and having a thick peptidoglycan, have developed novel approaches to pathogenesis by acquiring (among others) a unique family of surface proteins, toxins, enzymes, and prophages. For the new edition, the editors have enhanced this fully researched compendium of Gram-positive bacterial pathogens by including new data generated using genomic sequencing as well as the latest knowledge on Gram-positive structure and mechanisms of antibiotic resistance and theories on the mechanisms of Gram-positive bacterial pathogenicity. This edition emphasizes streptococci, staphylococci, listeria, and spore-forming pathogens, with chapters written by many of the leading researchers in these areas. The chapters systematically dissect these organisms biologically, genetically, and immunologically, in an attempt to understand the strategies used by these bacteria to cause human disease. “This textbook comprises a superb collection of scientific knowledge making it a must-read for any graduate student, medical doctor, or investigator studying these gram-positive bacteria and inspiring future imaginations of biological knowledge.” - William R. Jacobs, Jr., PhD, Professor Microbiology & Immunology, Albert Einstein College of Medicine
Host Pathogen Interaction
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Author : Gottfried Unden
language : en
Publisher: John Wiley & Sons
Release Date : 2016-03-11
Host Pathogen Interaction written by Gottfried Unden and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-03-11 with Science categories.
In light of the rapidity increasing incidence rate of bacterial and fungal infections with multi-resistant pathogens, the metabolic changes associated with host-pathogen interactions offer one of the most promising starting points for developing novel antibiotics. . Part one of this comprehensive guide describes the metabolic adaptation of pathogenic microbes in humans, while part two points to routes for the development of novel antibiotics. This is volume six of the book series on drug discovery in infectious diseases by Paul Selzer.
Antimicrobial Resistance And Virulence Common Mechanisms
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Author : Etienne Giraud
language : en
Publisher: Frontiers Media SA
Release Date : 2017-06-01
Antimicrobial Resistance And Virulence Common Mechanisms written by Etienne Giraud and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-06-01 with Electronic book categories.
Multiple relationships exist between antimicrobial resistance and bacterial virulence, and the spread of clones combining multiple antibiotic resistance and a high virulence level is an increasing problem. It was previously described how mutation-driven or horizontally acquired resistance mechanisms can also have effects on virulence. It was also reported that mobile genetic elements often carry both resistance determinants and virulence-modulating genes, which favors the co-selection of both traits. In the present volume, we present a collection of articles which document additional aspects of the interactions between antimicrobial resistance and virulence in bacteria, and describe their potential therapeutic consequences.
Exploiting Novel Combined Host And Pathogen Directed Therapies For Combating Bacterial Multidrug Resistance
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Author : Maurizio Fraziano
language : en
Publisher: Frontiers Media SA
Release Date : 2020-12-30
Exploiting Novel Combined Host And Pathogen Directed Therapies For Combating Bacterial Multidrug Resistance written by Maurizio Fraziano and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-12-30 with Science categories.
This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.
Antibiotic Resistance
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Author : Anthony R.M. Coates
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-10-22
Antibiotic Resistance written by Anthony R.M. Coates and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-10-22 with Medical categories.
This book describes antibiotic resistance amongst pathogenic bacteria. It starts with an overview of the erosion of the efficacy of antibiotics by resistance and the decrease in the rate of replacement of redundant compounds. The origins of antibiotic resistance are then described. It is proposed that there is a large bacterial resistome which is a collection of all resistance genes and their precursors in both pathogenic and non-pathogenic bacteria. Ongoing resistance surveillance programs are also discussed, together with the perspective of a clinical microbiologist. The book then turns to specific themes such as the most serious area of resistance in pathogens, namely in Gram-negative organisms. The role of combinations of antibiotics in combating resistance emergence is discussed, particularly in the tuberculosis field, and then the importance of non-multiplying and persistent bacteria which are phenotypically resistant to antibiotics and prolong the duration of therapy of antibiotics which leads to poor compliance and resistance emergence. The role of anti-microbial compounds in textiles is covered, with its potential to exacerbate the spread of resistance. Then, efflux pumps are discussed. The final chapter describes the compounds which are in late stage clinical development, illustrating the paucity of the antibiotic pipeline, especially for Gram-negative bacteria.
Molecular Biology Of The Cell
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Author : Bruce Alberts
language : en
Publisher:
Release Date : 2002
Molecular Biology Of The Cell written by Bruce Alberts and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2002 with Cytology categories.
Bacterial Zoonoses
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Author : Gamal Wareth
language : de
Publisher:
Release Date : 2023
Bacterial Zoonoses written by Gamal Wareth and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023 with categories.
The extensive use of broad-spectrum antibiotics in human medicine, farm animals, and the food industry has led to multidrug-resistant bacteria. The studies carried out within the scope of this Habilitation work aimed at resistance profiling and better understanding the mechanisms of resistance development and pathogenicity in the leading multiple drug resistance (MDR) bacterial pathogens known to cause nosocomial infections, such as ESKAPE pathogens, i.e. Acinetobacter baumannii, Klebsiella pneumoniae and methicillin-resistant Staphylococcus aureus (MRSA), as well as bacteria causing neglected zoonoses such as Brucella. Combined in-vitro phenotyping with in-silico molecular analysis using Illumina MiSeq Next-Generation-Sequencing (NGS) technology and BioIT pipelines on a large number of clinical and non-clinical strains collected from Europe, Asia, and Africa were applied to achieve the goal of the One-Health approach. Antimicrobial resistance is a growing concern in veterinary medicine, the food chain, and the environment as in human medicine. However, data on animals, foods and environmental sources are still scarce. The emergence and dissemination of certain ESKAPE pathogens such as A. baumannii and K. pneumonia were reported since the late 20th century and increased over time in developed and developing countries. Whole-genome sequencing (WGS) is a powerful tool for rapidly identifying antimicrobial resistance (AMR) genes and can define resistance-associated determinants with much greater precision compared to conventional phenotypic tools. Continuous susceptibility testing, updating breakpoints, and assessing mutations that lead to resistance are needed for fastidious bacteria.