Pathophysiology Of The Basal Ganglia And Movement Disorders Gaining New Insights From Modeling And Experimentation To Influence The Clinic
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Pathophysiology Of The Basal Ganglia And Movement Disorders Gaining New Insights From Modeling And Experimentation To Influence The Clinic
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Author : Daniela Andres
language : en
Publisher: Frontiers Media SA
Release Date : 2017-10-31
Pathophysiology Of The Basal Ganglia And Movement Disorders Gaining New Insights From Modeling And Experimentation To Influence The Clinic written by Daniela Andres and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-10-31 with categories.
The basal ganglia constitute a group of subcortical structures, highly interconnected among themselves, as well as with the cerebral cortex, thalamus and other brain areas. These nuclei play a central role in the control of voluntary movement, and their specific pathology comprises the group of diseases known as movement disorders, including Parkinson's disease, Huntington's disease, dystonia and Gilles de la Tourette syndrome, among others. Additionally, the presence of a number of circuits within the basal ganglia related to non-motor functions has been acknowledged. Currently, the basal ganglia are thought to participate in cognitive, limbic and learning functions. Moreover, disorders related to the basal ganglia are known to involve a number of complex, non-motor symptoms and syndromes (e.g. compulsive and addictive behavior). In the light of this evidence, it is becoming clear that our knowledge about the basal ganglia needs to be revised, and that new pathophysiological models of movement disorders are needed. In this context, the study of the pathophysiology of the basal ganglia and the treatment of their pathology is becoming increasingly interdisciplinary. Nowadays, an appropriate approach to the study of these problems must necessarily involve the use of complex mathematical modeling, computer simulations, basic research (ranging from biomolecular studies to animal experimentation), and clinical research. This research topic aims to bring together the most recent advances related to the pathophysiology of the basal ganglia and movement disorders.
Compendium Of In Vivo Monitoring In Real Time Molecular Neuroscience
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Author : Adrian C. Michael
language : en
Publisher: World Scientific
Release Date : 2019
Compendium Of In Vivo Monitoring In Real Time Molecular Neuroscience written by Adrian C. Michael and has been published by World Scientific this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019 with Brain categories.
"This book is the third in a series entitled, Compendium of In-Vivo Monitoring in Real-time Molecular Neuroscience. Its purpose is to provide a cross-section of research addressing monitoring in the rodent, and in some cases, the human brain. Detailed understanding of the neurobiology of the brain is demanding and involves increasingly wider scope of talent ranging from physicists, neurobiologists, chemists, molecular biologists and bioengineers. Coming from varied backgrounds, they do not necessarily understand how to formulate functional issues in a mutually understandable way. This aim of this book is to provide information which can serve as a starting point for understanding such a complex topic. The authors provide "tutorial" writing for specialists, as well as material understandable to a wide audience including neuroscientists, those interested in drug discovery, and those using such measurements for diagnosis purposes."-
Neuroscience And The Problem Of Dual Use
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Author : Malcolm R. Dando
language : en
Publisher: Springer Nature
Release Date : 2020-08-20
Neuroscience And The Problem Of Dual Use written by Malcolm R. Dando and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-08-20 with Medical categories.
This book discusses recent brain research and the potentially dangerous dual-use applications of the findings of these research projects. The book is divided into three sections: Part I examines the rise in dual-use concerns within various state’s chemical and biological non-proliferation regime’s during this century, as well as the rapid technologically driven advances in neuroscience and the associated possible misuse considerations in the same period. Part II reviews the brain research projects in the EU, USA, Japan, China and several other countries with regard to their objectives, achievements and measures to deal with the problem of dual-use. Part III assesses the extent to which the results of this civil neuroscience work, which is intended to be benign, are being, and could be protected against future hostile applications in the development of novel chemical and biological weapons.
Non Human Primate Models Of Psychiatric Disorders
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Author : Rafael S. Maior
language : en
Publisher: Frontiers Media SA
Release Date : 2022-01-06
Non Human Primate Models Of Psychiatric Disorders written by Rafael S. Maior and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-01-06 with Science categories.
A New Understanding Of Mental Disorders
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Author : Andreas Heinz
language : en
Publisher: MIT Press
Release Date : 2017-10-06
A New Understanding Of Mental Disorders written by Andreas Heinz and has been published by MIT Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-10-06 with Medical categories.
A new computational and dimensional approach to understanding and classifying mental disorders: modeling key learning and decision-making mechanisms across different mental disorders. Even as researchers look for neurobiological correlates of mental disorders, many of these disorders are still classified solely according to the manifestation of clinical symptoms. Neurobiological findings rarely help diagnose a specific disease or predict its outcome. Although current diagnostic categories are questionable (sometimes labeling common states of human suffering as disorders), traditional neuroimaging approaches are not sophisticated enough to capture the neurobiological markers of mental disorder. In this book, Andreas Heinz proposes a computational and dimensional approach to understanding and classifying mental disorders: modeling key learning and decision-making mechanisms across different mental disorders. Such an approach focuses on the malleability and diversity of human behavior and its biological underpinnings. Heinz explains basic learning mechanisms and their effects on human behavior, focusing not on single disorders but on how such mechanisms work in a multitude of mental states. For example, he traces alterations in dopamine-reinforcement learning in psychotic, affective, and addictive disorders. He investigates to what extent these basic dimensions of mental disorders can account for such syndromes as craving and loss of control in addiction, positive and negative mood states in affective disorders, and the altered experience of self and world associated with psychotic states. Finally, Heinz explores the clinical and therapeutic implications of such accounts. He argues that a focus on learning mechanisms, with its emphasis on human creativity and resilience, should help reduce the stigma of mental disorder.
Clinical Management Of Sensorimotor Speech Disorders
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Author : Malcolm R. McNeil
language : en
Publisher: Thieme
Release Date : 2011-01-01
Clinical Management Of Sensorimotor Speech Disorders written by Malcolm R. McNeil and has been published by Thieme this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-01-01 with Medical categories.
The definitive reference for managing sensorimotor speech disorders Bringing together the expertise of leading research practitioners in the field, the second edition of Clinical Management of Sensorimotor Speech Disorders is an up-to-date reference for the underlying theory and the basic principles of assessment and treatment. This book provides a solid foundation in the conceptual framework essential for classifying and differentiating disorders according to clinical categories. It covers the theory underlying measurement strategies including acoustic, kinematic, aerodynamic, and electromyographic techniques, and guides the reader through treatments for each disorder. New in this edition is a comprehensive section with in-depth coverage of the diseases, syndromes, and pathologic conditions which are accompanied by sensorimotor speech disorders. These chapters provide concise descriptions of the disease and its signs and symptoms, neuropathology, epidemiology, and etiology. Each chapter goes on to present the speech impairment associated with the disorder and its signs and symptoms, etiology, neuropathology, associated cognitive, linguistic, and communicative signs and symptoms, special diagnostic considerations, treatment, and key references. Features: Clear articulation of theoretical issues provides a strong foundation for the clinical management of the dysarthrias, apraxia, and speech problems secondary to hearing loss New chapter on neurogenic fluency disorders Extensive discussion of neuropathologic conditions that cause sensorimotor speech disorders Authoritative and comprehensive, this expanded edition will prove to be the reference of choice for students in speech-language pathology programs as well as clinicians and researchers.
Ocular Motor And Vestibular Function In Neurometabolic Neurogenetic And Neurodegenerative Disorders
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Author : Aasef G. Shaikh
language : en
Publisher: Frontiers Media SA
Release Date : 2018-08-29
Ocular Motor And Vestibular Function In Neurometabolic Neurogenetic And Neurodegenerative Disorders written by Aasef G. Shaikh and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-08-29 with categories.
Eye movements provide rich source of information about brain functioning for neurologists and neuroscientists. They provide diagnostic clues, define, and localize motor and cognitive disorders. Objective eye movement assessments associated with clinical observation and genetic testing in neurodegenerative, neurometabolic, and neurogenetic diseases provide insight into their pathophysiology and disease mechanism. Finally the eye movements may be used for testing and following the response to therapies. The concrete value of studying eye movement stems from a number of advantages compared to the study of movements of axial or limb muscles. The eye movements are accessible to clinical inspection, they can be measured precisely, their interpretation is clear and therefore ocular motility examination has high localization value. There are several standardized tasks to study of each subclass of eye movements that are recognized for motor or cognitive behavior. Indeed the studies of eye movement had allowed test of motor and cognitive functions of the brain in a vast range of neurological disease. Both cortical and subcortical dysfunctions may be detected with the analysis of subclasses of eye movements and interpreted in association with other clinical, laboratory and neuroimaging features. The goal of this topic-focused volume of Frontiers in Neurology is to gather seminal studies, from well-known scientists and laboratories from across the world, delineating the features of eye movements and vestibular system in neurogenetic, neurometabolic, and neurodegenerative disorders. Such collection of articles, to our knowledge, is unique and never done in the past. The topics and the compilation will be of interest to broad groups of neuroscientists and neurologists for the reasons as follows: 1) Neurodegenerative diseases represent a large portion of neurological diseases encountered in neurological clinical practice. Eye movement changes may occur early in their course and may be specific, thus orienting the diagnosis. 2) Neurometabolic and neurogenetic conditions, although rare, show specific and characteristic eye movements that represent the hallmark of the disease. Such disorders often represent a pathologic model that helps to understand the normal functioning of specific brain regions and networks.
Encyclopedia Of The Neurological Sciences
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Author :
language : en
Publisher: Academic Press
Release Date : 2014-04-29
Encyclopedia Of The Neurological Sciences written by and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-04-29 with Medical categories.
The Encyclopedia of the Neurological Sciences, Second Edition, Four Volume Set develops from the first edition, covering all areas of neurological sciences through over 1000 entries focused on a wide variety of topics in neurology, neurosurgery, psychiatry and other related areas of neuroscience. The contributing authors represent all aspects of neurology from many viewpoints and disciplines to provide a complete overview of the field. Entries are designed to be understandable without detailed background knowledge in the subject matter, and cross-referencing and suggested further reading lead the reader from a basic knowledge of the subject to more advanced understanding. The easy-to-use 'encyclopedic-dictionary' format of the Encyclopedia of the Neurological Sciences, Second Edition features alphabetic entries, extensive cross-referencing, and a thorough index for quick reference. The wealth of information provided by these four volumes makes this reference work a trusted source of valuable information for a wide range of researchers, from undergraduate students to academic researchers. Provides comprehensive coverage of the field of neurological science in over 1,000 entries in 4 volumes "Encyclopedic-dictionary" format provides for concise, readable entries and easy searching Presents complete, up-to-date information on 32 separate areas of neurology Entries are supplemented with extensive cross-referencing, useful references to primary research articles, and an extensive index
Cumulated Index Medicus
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Author :
language : en
Publisher:
Release Date : 1985
Cumulated Index Medicus written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1985 with Medicine categories.
Parkinson S Disease And Movement Disorders
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Author : Joseph Jankovic
language : en
Publisher: Lippincott Williams & Wilkins
Release Date : 2007
Parkinson S Disease And Movement Disorders written by Joseph Jankovic and has been published by Lippincott Williams & Wilkins this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007 with Medical categories.
Written by an international group of renowned experts, the Fifth Edition of this premier reference provides comprehensive, current information on the genetics, pathophysiology, diagnosis, medical and surgical treatment, and behavioral and psychologic concomitants of all common and uncommon movement disorders. Coverage includes Parkinson's disease, other neurodegenerative diseases, tremors, dystonia, Tourette's syndrome, Huntington's disease, and ataxias. This edition features extensive updates on genetics, imaging, and therapeutics of Parkinson's disease, other parkinsonian disorders, and all hyperkinetic movement disorders. A bound-in CD-ROM, Video Atlas of Movement Disorders, demonstrates the movement and posture abnormalities and other disturbances associated with Parkinson's disease and other neurologic disorders.