Pathway Analysis And Optimization In Metabolic Engineering
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Pathway Analysis And Optimization In Metabolic Engineering
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Author : Néstor V. Torres
language : en
Publisher: Cambridge University Press
Release Date : 2002-12-19
Pathway Analysis And Optimization In Metabolic Engineering written by Néstor V. Torres and has been published by Cambridge University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2002-12-19 with Science categories.
Facility in the targeted manipulation of the genetic and metabolic composition of organisms, combined with unprecedented computational power, is forging a niche for a new subspecialty of biotechnology called metabolic engineering. First published in 2002, this book introduces researchers and advanced students in biology and engineering to methods of optimizing biochemical systems of biotechnological relevance. It examines the development of strategies for manipulating metabolic pathways, demonstrates the need for effective systems models, and discusses their design and analysis, while placing special emphasis on optimization. The authors propose power-law models and methods of biochemical systems theory toward these ends. All concepts are derived from first principles, and the text is richly illustrated with numerous graphs and examples throughout. Special features include: nontechnical and technical introductions to models of biochemical systems; a review of basic methods of model design and analysis; concepts of optimization; and detailed case studies.
Metabolic Pathway Engineering
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Author : Jean F. Challacombe
language : en
Publisher: CRC Press
Release Date : 2021-07-14
Metabolic Pathway Engineering written by Jean F. Challacombe and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-07-14 with Medical categories.
Metabolic systems engineering combines the tools and approaches of systems biology, synthetic biology, and evolutionary engineering. This book reviews studies on metabolism, from the earliest work of Lavoisier and Buchner to current cutting-edge research in metabolic systems engineering. This technology has been used in bioengineering applications to create high-performing microbes and plants that produce important chemicals, pharmaceuticals, crops, and other natural products. Current applications include optimizing metabolic pathways to enhance degradation of biomass for biofuel production and accelerated processing of environmental waste products and contaminants. The book includes examples to illustrate the applications of this technology in the optimization of metabolic pathways to create robust industrial strains as well as in the engineering of biological processes involving health and diseases of humans, animals, and plants. Written by a seasoned computational biologist with many years of experience in genomics, bioinformatics, and systems biology, this book will appeal to anyone interested in metabolic systems analysis and metabolic pathway engineering.
The Metabolic Pathway Engineering Handbook
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Author : Christina Smolke
language : en
Publisher: CRC Press
Release Date : 2009-07-28
The Metabolic Pathway Engineering Handbook written by Christina Smolke and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-07-28 with Medical categories.
This second volume of the Metabolic Pathway Engineering Handbook delves into evolutionary tools and gene expression tools for metabolic pathway engineering. It covers applications of emerging technologies including recent research genome-wide technologies, DNA and phenotypic microarrays, and proteomics tools for experimentally determining flux thro
Metabolic Engineering
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Author : Sang Yup Lee
language : en
Publisher: John Wiley & Sons
Release Date : 2021-06-02
Metabolic Engineering written by Sang Yup Lee and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-06-02 with Science categories.
Learn more about foundational and advanced topics in metabolic engineering in this comprehensive resource edited by leaders in the field Metabolic Engineering: Concepts and Applications delivers a one-stop resource for readers seeking a complete description of the concepts, models, and applications of metabolic engineering. This guide offers practical insights into the metabolic engineering of major cell lines, including E. Coli, Bacillus and Yarrowia Lipolytica, and organisms, including human, animal, and plant). The distinguished editors also offer readers resources on microbiome engineering and the use of metabolic engineering in bioremediation. Written in two parts, Metabolic Engineering begins with the essential models and strategies of the field, like Flux Balance Analysis, Quantitative Flux Analysis, and Proteome Constrained Models. It also provides an overview of topics like Pathway Design, Metabolomics, and Genome Editing of Bacteria and Eukarya. The second part contains insightful descriptions of the practical applications of metabolic engineering, including specific examples that shed light on the topics within. In addition to subjects like the metabolic engineering of animals, humans, and plants, you’ll learn more about: Metabolic engineering concepts and a historical perspective on their development The different modes of analysis, including flux balance analysis and quantitative flux analysis An illuminating and complete discussion of the thermodynamics of metabolic pathways The Genome architecture of E. coli, as well as genome editing of both bacteria and eukarya An in-depth treatment of the application of metabolic engineering techniques to organisms including corynebacterial, bacillus, and pseudomonas, and more Perfect for students of biotechnology, bioengineers, and biotechnologists, Metabolic Engineering: Concepts and Applications also has a place on the bookshelves of research institutes, biotechnological institutes and industry labs, and university libraries. It's comprehensive treatment of all relevant metabolic engineering concepts, models, and applications will be of use to practicing biotechnologists and bioengineers who wish to solidify their understanding of the field.
The Metabolic Pathway Engineering Handbook
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Author : Christina Smolke
language : en
Publisher: CRC Press
Release Date : 2009-07-28
The Metabolic Pathway Engineering Handbook written by Christina Smolke and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-07-28 with Medical categories.
This first volume of the Metabolic Pathway Engineering Handbook provides an overview of metabolic pathway engineering with a look towards the future. It discusses cellular metabolism, including transport processes inside the cell and energy generating reactions, as well as rare metabolic conversions. This volume also explores balances and reaction
The Metabolic Pathway Engineering Handbook Two Volume Set
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Author : Christina Smolke
language : en
Publisher: CRC Press
Release Date : 2009-08-18
The Metabolic Pathway Engineering Handbook Two Volume Set written by Christina Smolke and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-08-18 with Medical categories.
Christina Smolke, who recently developed a novel way to churn out large quantities of drugs from genetically modified brewer's yeast, is regarded as one of the most brilliant minds in biomedical engineering. In this handbook, she brings together pioneering scientists from dozens of disciplines to provide a complete record of accomplishment in metab
Systems And Synthetic Metabolic Engineering
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Author : Yanfeng Liu
language : en
Publisher: Academic Press
Release Date : 2020-07-10
Systems And Synthetic Metabolic Engineering written by Yanfeng Liu and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-07-10 with Science categories.
Systems and Synthetic Metabolic Engineering provides an overview of the development of metabolic engineering within medicine that is fueled by systems and synthetic biology. These newly developed, successful strategies of metabolic engineering guide the audience on how to propose and test proper strategies for metabolic engineering research. In addition to introductory, regulatory and challenges in the field, the book also covers dynamic control and autonomous regulation to control cell metabolism, along with computational modeling and industrial applications. The book is written by leaders in the field, making it ideal for synthetic biologists, researchers, students and anyone working in this area. Discusses the current progress of metabolic engineering, focusing on systems biology and synthetic biology Covers introductory, regulatory, strategies, production and challenges in the field Written technically for synthetic biologists, researchers, students, industrialists, policymakers and stakeholders
Optimization Methods In Metabolic Networks
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Author : Costas D. Maranas
language : en
Publisher: John Wiley & Sons
Release Date : 2016-01-05
Optimization Methods In Metabolic Networks written by Costas D. Maranas and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-01-05 with Science categories.
Provides a tutorial on the computational tools that use mathematical optimization concepts and representations for the curation, analysis and redesign of metabolic networks Organizes, for the first time, the fundamentals of mathematical optimization in the context of metabolic network analysis Reviews the fundamentals of different classes of optimization problems including LP, MILP, MLP and MINLP Explains the most efficient ways of formulating a biological problem using mathematical optimization Reviews a variety of relevant problems in metabolic network curation, analysis and redesign with an emphasis on details of optimization formulations Provides a detailed treatment of bilevel optimization techniques for computational strain design and other relevant problems
Metabolic Engineering In The Post Genomic Era
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Author : Boris N. Kholodenko
language : en
Publisher: Garland Science
Release Date : 2004
Metabolic Engineering In The Post Genomic Era written by Boris N. Kholodenko and has been published by Garland Science this book supported file pdf, txt, epub, kindle and other format this book has been release on 2004 with Biochemical engineering categories.
The Horizon Scientific Press titles focus on high-level microbiology and molecular biology topics. Written by internationally renowned and highly respected leaders in the field, titles in this series comprise of review manuals, practical manuals, and reference texts for research scientists, bioscience professionals and graduate students. Engineering living cells continues to pose immense challenges to the researcher. In fact many bioengineers have only just started to appreciate the full extent of the hierarchical control used by living systems: upon attempts to increase the activity of a "rate-limiting" step, the multiple feedbacks at the metabolic, signaling and genetic levels result in the rate limiting step shifting to elsewhere in that pathway or even to elsewhere in the whole organism. The advent of full-force genomics should enable preventing this response, however, it has been difficult for researchers to know where to turn for guidance. This book aims to help the reader understand and deal with the plasticity of living cell factories and to turn the plasticity into the desired rather than the adverse direction. The book brings together all the recent, most important breakthroughs in this exciting field: Internationally renowned key scientists have reviewed each topic in detail. In the Introduction, the editors give an overview of new approaches and spell out what the engineer and the industry may now really begin to aim for; they even adapt the definition of metabolic engineering to befit the post-genomics era. Other topics included are: the experimental approaches necessary to understand cellular regulation at all of its hierarchical levels, including proteomics [Chapter 2], metabolomics [Chapter 3] and fluxomics [Chapter 4]; new tools that help metabolic engineering [Chapters 5-7]; modeling of living cells, e.g. finding metabolic pathways [Chapter 8] and comparing the actual and predicted use of these in living organisms such as E. coli and Corynebacteria [Chapters 9, 10]; the optimization of cell factories as production organisms (e.g., use of whole cell models, silicon cells, and coordinate manipulation of multiple genes [Chapters 12-15]). A chapter on future perspectives directs further developments of the field in the near future. Metabolic Engineering in the Post Genomic Erais an essential reading for everyone with an interest in engineering living cells including: Metabolic egnineers, bioengineers, biotechnologists, molecular biologists, and pharmaceutical and biotechnology companies.
Metabolic Engineering
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Author : Jens Nielsen
language : en
Publisher: Springer
Release Date : 2003-07-03
Metabolic Engineering written by Jens Nielsen and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2003-07-03 with Science categories.
Metabolic engineering is a rapidly evolving field that is being applied for the optimization of many different industrial processes. In this issue of Advances in Biochemical Engineering/Biotechnology, developments in different areas of metabolic engineering are reviewed. The contributions discuss the application of metabolic engineering in the improvement of yield and productivity - illustrated by amino acid production and the production of novel compounds - in the production of polyketides and extension of the substrate range - and in the engineering of S. cerevisiae for xylose metabolism, and the improvement of a complex biotransformation process.