Metabolic Engineering In The Post Genomic Era

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Metabolic Engineering In The Post Genomic Era

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Author : Boris N. Kholodenko
language : en
Publisher: Garland Science
Release Date : 2004

Metabolic Engineering In The Post Genomic Era written by Boris N. Kholodenko and has been published by Garland Science this book supported file pdf, txt, epub, kindle and other format this book has been release on 2004 with Medical categories.

The Horizon Scientific Press titles focus on high-level microbiology and molecular biology topics. Written by internationally renowned and highly respected leaders in the field, titles in this series comprise of review manuals, practical manuals, and reference texts for research scientists, bioscience professionals and graduate students. Engineering living cells continues to pose immense challenges to the researcher. In fact many bioengineers have only just started to appreciate the full extent of the hierarchical control used by living systems: upon attempts to increase the activity of a "rate-limiting" step, the multiple feedbacks at the metabolic, signaling and genetic levels result in the rate limiting step shifting to elsewhere in that pathway or even to elsewhere in the whole organism. The advent of full-force genomics should enable preventing this response, however, it has been difficult for researchers to know where to turn for guidance. This book aims to help the reader understand and deal with the plasticity of living cell factories and to turn the plasticity into the desired rather than the adverse direction. The book brings together all the recent, most important breakthroughs in this exciting field: Internationally renowned key scientists have reviewed each topic in detail. In the Introduction, the editors give an overview of new approaches and spell out what the engineer and the industry may now really begin to aim for; they even adapt the definition of metabolic engineering to befit the post-genomics era. Other topics included are: the experimental approaches necessary to understand cellular regulation at all of its hierarchical levels, including proteomics [Chapter 2], metabolomics [Chapter 3] and fluxomics [Chapter 4]; new tools that help metabolic engineering [Chapters 5-7]; modeling of living cells, e.g. finding metabolic pathways [Chapter 8] and comparing the actual and predicted use of these in living organisms such as E. coli and Corynebacteria [Chapters 9, 10]; the optimization of cell factories as production organisms (e.g., use of whole cell models, silicon cells, and coordinate manipulation of multiple genes [Chapters 12-15]). A chapter on future perspectives directs further developments of the field in the near future. Metabolic Engineering in the Post Genomic Erais an essential reading for everyone with an interest in engineering living cells including: Metabolic egnineers, bioengineers, biotechnologists, molecular biologists, and pharmaceutical and biotechnology companies.

Synthetic Biology Metabolic Engineering

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Author : Huimin Zhao
language : en
Publisher: Springer
Release Date : 2017-10-27

Synthetic Biology Metabolic Engineering written by Huimin Zhao and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-10-27 with Technology & Engineering categories.

This book review series presents current trends in modern biotechnology. The aim is to cover all aspects of this interdisciplinary technology where knowledge, methods and expertise are required from chemistry, biochemistry, microbiology, genetics, chemical engineering and computer science. Volumes are organized topically and provide a comprehensive discussion of developments in the respective field over the past 3-5 years. The series also discusses new discoveries and applications. Special volumes are dedicated to selected topics which focus on new biotechnological products and new processes for their synthesis and purification. In general, special volumes are edited by well-known guest editors. The series editor and publisher will however always be pleased to receive suggestions and supplementary information. Manuscripts are accepted in English.

Systems And Synthetic Metabolic Engineering

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Author : Yanfeng Liu
language : en
Publisher: Academic Press
Release Date : 2020-07-10

Systems And Synthetic Metabolic Engineering written by Yanfeng Liu and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-07-10 with Science categories.

Systems and Synthetic Metabolic Engineering provides an overview of the development of metabolic engineering within medicine that is fueled by systems and synthetic biology. These newly developed, successful strategies of metabolic engineering guide the audience on how to propose and test proper strategies for metabolic engineering research. In addition to introductory, regulatory and challenges in the field, the book also covers dynamic control and autonomous regulation to control cell metabolism, along with computational modeling and industrial applications. The book is written by leaders in the field, making it ideal for synthetic biologists, researchers, students and anyone working in this area. - Discusses the current progress of metabolic engineering, focusing on systems biology and synthetic biology - Covers introductory, regulatory, strategies, production and challenges in the field - Written technically for synthetic biologists, researchers, students, industrialists, policymakers and stakeholders

Genomics And Systems Biology Of Mammalian Cell Culture

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Author : Wei-Shou Hu
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-03-16

Genomics And Systems Biology Of Mammalian Cell Culture written by Wei-Shou Hu and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-03-16 with Science categories.

Transcriptome Analysis, by Frank Stahl, Bernd Hitzmann, Kai Mutz, Daniel Landgrebe, Miriam Lübbecke, Cornelia Kasper, Johanna Walter und Thomas Scheper Transcriptome Data Analysis for Cell Culture Processes, by Marlene Castro-Melchor, Huong Le und Wei-Shou Hu Modeling Metabolic Networks for Mammalian Cell Systems: General Considerations, Modeling Strategies, and Available Tools, by Ziomara P. Gerdtzen Metabolic Flux Analysis in Systems Biology of Mammalian Cells, by Jens Niklas und Elmar Heinzle Advancing Biopharmaceutical Process Development by System-Level Data Analysis and Integration of Omics Data, by Jochen Schaub, Christoph Clemens, Hitto Kaufmann und Torsten W. Schulz Protein Glycosylation and Its Impact on Biotechnology, by Markus Berger, Matthias Kaup und Véronique Blanchard Protein Glycosylation Control in Mammalian Cell Culture: Past Precedents and Contemporary Prospects, by Patrick Hossler Modeling of Intracellular Transport and Compartmentation, by Uwe Jandt und An-Ping Zeng Genetic Aspects of Cell Line Development from a Synthetic Biology Perspective, by L. Botezatu, S. Sievers, L. Gama-Norton, R. Schucht, H. Hauser und D. Wirth.

Enzyme Mixtures And Complex Biosynthesis

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Author : Sanjoy K. Bhattacharya
language : en
Publisher: CRC Press
Release Date : 2007-10-29

Enzyme Mixtures And Complex Biosynthesis written by Sanjoy K. Bhattacharya and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-10-29 with Science categories.

In this book, an ensemble of examples is provided to illustrate the diversity of approaches and applications to which the multi-enzyme catalysis is currently applied. Enzymes act in living beings as extremely complex, network mixtures that are supportive of all the biochemical transformations on which the life is based. In the biotechnological context, many of the enzymatic processes performed in vitro at both small and industrial scales lie on the enzymatic transformation of a single molecular species for the generation of a product and as catalyzed by a single enzyme. However, the number of technological applications for which cell-free enzyme mixtures are required is increasing and the science of how to combine individual reactions in complex processes is under speedy development. Obviously, any of the current in-progress multi-enzyme processes is fully mimicking the complexity of a living cell or cell community. However, the refined combination of selected enzymes and substrates is offering a new technological approach that is supporting the development of new or improved products in many fields such as food, leather and pharmaceutical industries. This book is unique and presents selective examples of each of these processes have been incorporated in this book by experts in their respective areas.

Establishing Genomic Platforms For Metabolic Engineering In Chinese Hamster Ovary Cells

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Author : Katie Fraass Wlaschin
language : en
Publisher:
Release Date : 2007

Establishing Genomic Platforms For Metabolic Engineering In Chinese Hamster Ovary Cells written by Katie Fraass Wlaschin and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007 with categories.

Postgenomics

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Author : Sarah S. Richardson
language : en
Publisher: Duke University Press
Release Date : 2015-05-29

Postgenomics written by Sarah S. Richardson and has been published by Duke University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-05-29 with Science categories.

Ten years after the Human Genome Project’s completion the life sciences stand in a moment of uncertainty, transition, and contestation. The postgenomic era has seen rapid shifts in research methodology, funding, scientific labor, and disciplinary structures. Postgenomics is transforming our understanding of disease and health, our environment, and the categories of race, class, and gender. At the same time, the gene retains its centrality and power in biological and popular discourse. The contributors to Postgenomics analyze these ruptures and continuities and place them in historical, social, and political context. Postgenomics, they argue, forces a rethinking of the genome itself, and opens new territory for conversations between the social sciences, humanities, and life sciences. Contributors. Russ Altman, Rachel A. Ankeny, Catherine Bliss, John Dupré, Michael Fortun, Evelyn Fox Keller, Sabina Leonelli, Adrian Mackenzie, Margot Moinester, Aaron Panofsky, Sarah S. Richardson, Sara Shostak, Hallam Stevens

Amino Acid Biosynthesis Pathways Regulation And Metabolic Engineering

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Author : Volker F. Wendisch
language : en
Publisher: Springer Science & Business Media
Release Date : 2007-03-24

Amino Acid Biosynthesis Pathways Regulation And Metabolic Engineering written by Volker F. Wendisch and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-03-24 with Science categories.

This book presents the current knowledge of fundamental as well as applied microbiology of amino acids. Coverage details the amino acid biosynthetic pathways, their genetic and biochemical regulation, transport of amino acids and genomics of producing microorganisms. The book also examines the metabolic engineering of microorganisms for the biotechnological production of amino acids for use as pharmaceuticals and as food and feed additives.

Pathway Analysis And Optimization In Metabolic Engineering

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Author : Néstor V. Torres
language : en
Publisher: Cambridge University Press
Release Date : 2002-12-19

Pathway Analysis And Optimization In Metabolic Engineering written by Néstor V. Torres and has been published by Cambridge University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2002-12-19 with Science categories.

Facility in the targeted manipulation of the genetic and metabolic composition of organisms, combined with unprecedented computational power, is forging a niche for a new subspecialty of biotechnology called metabolic engineering. First published in 2002, this book introduces researchers and advanced students in biology and engineering to methods of optimizing biochemical systems of biotechnological relevance. It examines the development of strategies for manipulating metabolic pathways, demonstrates the need for effective systems models, and discusses their design and analysis, while placing special emphasis on optimization. The authors propose power-law models and methods of biochemical systems theory toward these ends. All concepts are derived from first principles, and the text is richly illustrated with numerous graphs and examples throughout. Special features include: nontechnical and technical introductions to models of biochemical systems; a review of basic methods of model design and analysis; concepts of optimization; and detailed case studies.

Virtual Worlds Of Precision

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Author : Valerie Feldmann
language : en
Publisher: LIT Verlag Münster
Release Date : 2005

Virtual Worlds Of Precision written by Valerie Feldmann and has been published by LIT Verlag Münster this book supported file pdf, txt, epub, kindle and other format this book has been release on 2005 with Computers categories.

"The use of computer simulations to gain deeper understanding of complex dynamic systems has become widely accepted across scientific disciplines. Yet, the precision of results obtained in "virtual worlds" may be deceptive when they replace rather than reflect reality. The scope of this edited volume hence reaches beyond identifying areas in which computer-based simulations allow for results otherwise not possible, to include an assessment of their opportunities and limitations. Reflecting the field's interdisciplinarity, contributions range from astronomy over theoretical biology to economics."--BOOK JACKET.