Pcr Protocols In Molecular Toxicology

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Pcr Protocols In Molecular Toxicology

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Author : John P. Vanden Heuvel
language : en
Publisher: CRC Press
Release Date : 2019-05-07

Pcr Protocols In Molecular Toxicology written by John P. Vanden Heuvel and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-05-07 with Medical categories.

Molecular toxicology is an emerging discipline that utilizes molecular and cell biology to understand how drugs and chemicals result in their unwanted effects. PCR Protocols in Molecular Toxicology is a practical guide to the use of polymerase chain reaction (PCR) to help examine, on a molecular and cellular level, how toxic responses are manifested. It offers a basic understanding of PCR and its optimization, as well as describing specific, high-impact areas of molecular toxicology and recent advances. The following techniques are described in detail: Quantitative reverse transcriptase PCR and methods to examine gene expression Differential display cloning Cloning and library screening by PCR Genotype and polymorphism analysis of drug and toxicant metabolizing enzymes Basic, non-PCR based molecular biology methods PCR Protocols in Molecular Toxicology will aid both novices and experienced PCR practitioners in using PCR to its fullest potential.

Molecular Toxicology Protocols

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Author : Phouthone Keohavong
language : en
Publisher: Springer Science & Business Media
Release Date : 2008-02-03

Molecular Toxicology Protocols written by Phouthone Keohavong and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-02-03 with Medical categories.

A collection of cutting-edge techniques for analyzing genotoxic exposure and detecting the resulting biological effects-including endogenous metabolites-up to and including the development of cancer. The authors emphasize analytical methods that can be specifically applied to human populations and patients. Among the applications detailed are the analysis of interactions between such cellular macromolecules as DNA and proteins and chemical and physical agents, the assessment of medically relevant toxicity, and the characterization of genetic alterations induced in transgenic animals by in vivo systems. There are also methods for the analysis of genotoxic exposure during gene expression, of cytotoxicity caused by the induction of apoptosis, of genetic alterations in reporter genes and oncogenes, early (premalignant) detection of altered oncogenes, and of individual variation in biotransformation and DNA repair capacity.

Regulation Of Gene Expression

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Author : Gary H. Perdew
language : en
Publisher: Springer Science & Business Media
Release Date : 2008-08-17

Regulation Of Gene Expression written by Gary H. Perdew and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-08-17 with Science categories.

The use of molecular biology and biochemistry to study the regulation of gene expression has become a major feature of research in the biological sciences. Many excellent books and reviews exist that examine the experimental methodology employed in specific areas of molecular biology and regulation of gene expression. However, we have noticed a lack of books, especially textbooks, that provide an overview of the rationale and general experimental approaches used to examine chemically or disease-mediated alterations in gene expression in mammalian systems. For example, it has been difficult to find appropriate texts that examine specific experimental goals, such as proving that an increased level of mRNA for a given gene is attributable to an increase in transcription rates. Regulation of Gene Expression: Molecular Mechanisms is intended to serve as either a textbook for graduate students or as a basic reference for laboratory personnel. Indeed, we are using this book to teach a graduate-level class at The Pennsylvania State University. For more details about this class, please visit http://moltox. cas. psu. edu and select “Courses. ” The goal for our work is to provide an overview of the various methods and approaches to characterize possible mechanisms of gene regulation. Further, we have attempted to provide a framework for students to develop an understanding of how to determine the various mechanisms that lead to altered activity of a specific protein within a cell.

Principles And Methods Of Toxicology

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Author : A. Wallace Hayes
language : en
Publisher: CRC Press
Release Date : 2007-09-25

Principles And Methods Of Toxicology written by A. Wallace Hayes and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-09-25 with Medical categories.

Founded on the paradox that all things are poisons and the difference between poison and remedy is quantity, the determination of safe dosage forms the base and focus of modern toxicology. In order to make a sound determination there must be a working knowledge of the biologic mechanisms involved and of the methods employed to define these mechanis

Information Resources In Toxicology

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Author : Philip Wexler
language : en
Publisher: Academic Press
Release Date : 2000

Information Resources In Toxicology written by Philip Wexler and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2000 with Medical categories.

History: -- K.D. Watson, P. Wexler, and J. Everitt. -- Highlights in the History of Toxicology. -- Selected References in the History of Toxicology. -- A Historical Perspective of Toxicology Information Systems. -- Books and Special Documents: -- G.L. Kennedy, Jr., P. Wexler, N.S. Selzer, and L.A. Malley. -- General Texts. -- Analytical Toxicology. -- Animals in Research. -- Biomonitoring/Biomarkers. -- Biotechnology. -- Biotoxins. -- Cancer. -- Chemical Compendia. -- Chemical--Cosmetics and Other Consumer. -- Products. -- Chemical--Drugs. -- Chemical--Dust and Fibers. -- Chemical--Metals. -- Chemicals--Pesticides -- Chemicals--Solvents. -- Chemical--Selected Chemicals. -- Clinical Toxicology. -- Developmental and Reproductive Toxicology. -- Environmental Toxicology--General. -- Environmental Toxicology-- Aquatic. -- Environmental Toxicology--Atmospheric. -- Environmental Toxicology--Hazardous Waste. -- Environmental Toxicology--Terrestrial. -- Environmental Toxicology--Wildlife. -- Ep ...

Molecular Toxicology

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Author : P. David Josephy
language : en
Publisher:
Release Date : 2006

Molecular Toxicology written by P. David Josephy and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006 with Medical categories.

The science of toxicology has progressed considerably since Molecular Toxicology was first published in 1997. New advances in biochemical and molecular biological experimental techniques have helped researchers understand the precise effects of toxins and foreign compounds on living things atthe molecular, cellular, and organismal levels. Breakthrough research has recently been completed illuminating the human genome and the role of enzymes in toxic biochemical reaction mechanisms. Toxicology now covers drug metabolism and design, carcinogenesis, programmed cell death, and DNA repair,among other subjects. The second edition captures these and other advances, and broadens its scope to address the experimental science of toxicology. The first edition of Molecular Toxicology has become an indispensable resource for graduate students in molecular and biochemical toxicology courses,as well as academic researchers and industrial researchers in toxicology. Rigorously updated and revised, the new edition commands an unrivaled authority in the field of molecular toxicology.

Pulp Paper Mill Effluent Environmental Fate Effects

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Author : Dennis L. Borton
language : en
Publisher: DEStech Publications, Inc
Release Date : 2004

Pulp Paper Mill Effluent Environmental Fate Effects written by Dennis L. Borton and has been published by DEStech Publications, Inc this book supported file pdf, txt, epub, kindle and other format this book has been release on 2004 with Science categories.

" ... 5th International Conference on Fate and Effects of Pulp and Paper Mill Effluents which was held in Seattle, Washington, June 1-4, 2003"--Acknowledgements.

Forensic Analysis

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Author : Ian Freckelton
language : en
Publisher: BoD – Books on Demand
Release Date : 2021-09-22

Forensic Analysis written by Ian Freckelton and has been published by BoD – Books on Demand this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-09-22 with Medical categories.

Forensic Analysis - Scientific and Medical Techniques and Evidence under the Microscope is an edited collection with contributions from scholars in ten countries, containing cutting-edge analyses of diverse aspects of contemporary forensic science and forensic medicine. It spans forensic gait analysis evidence, forensic analysis in wildlife investigations, mitochondrial blood-typing, DNA profiling, probabilistic genotyping, toolmark analysis, forensic osteology, obstetric markers as a diagnostic tool, salivary analysis, pharmacogenetics, and forensic analysis of herbal drugs. This book provides information about the parameters of expertise in relation to a number of areas that are being utilised as a part of criminal investigations and that are coming before courts internationally or will soon do so. Thereby, it is hoped that rigor in the evaluation of such evidence will be enhanced, a fillip for developing standards will be provided, and the incidence of miscarriages of criminal justice will be minimised.

Cellular And Molecular Toxicology

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Author : J.P. Vanden Heuvel
language : en
Publisher: Gulf Professional Publishing
Release Date : 2002-02-14

Cellular And Molecular Toxicology written by J.P. Vanden Heuvel and has been published by Gulf Professional Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 2002-02-14 with Business & Economics categories.

Volume 14 in the series Comprehensive Toxicology extends and complements the previously published 13-volume set. This volume will be available separately. Toxicology is the study of the nature and actions of chemicals on biological systems. In more primitive times, it really was the study of poisons. However, in the early 1500s, it was apparent to Paracelsus that "the dose differentiates a poison and a remedy". Clearly, the two most important tenets of toxicology were established during that time. The level of exposure (dose) and the duration of exposure (time) will determine the degree and nature of a toxicological response. Since that time the discipline of toxicology has made major advances in identifying and characterizing toxicants. The growth of toxicology as a scientific discipline has been driven to a large extent by the use of extremely powerful molecular and cell biology techniques. The overall aim of this volume is to demonstrate how these advances are being used to elucidate causal pathways (or linkages) for potential adverse health consequences of human exposure to environmental chemicals or radiation. A unique feature of this volume is its illustration of how carefully-designed studies of the molecular mechanisms of chemical action provide not only understanding of the potential toxicity of the chemical under investigation, but also new insights into the functioning of the biological system used as an experimental model. Each chapter contains a listing of major peer-reviewed articles and reviews and useful web-sites. In addition, each chapter contains a broad introductory section that outlines the subsequent sections. These Introductory and Overview sections are designed to be stand alone chapters, and may be packaged as a textbook in graduate level courses.

Plant Based Genetic Tools For Biofuels Production

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Author : Daniela Defavari do Nascimento
language : en
Publisher: Bentham Science Publishers
Release Date : 2017-06-12

Plant Based Genetic Tools For Biofuels Production written by Daniela Defavari do Nascimento and has been published by Bentham Science Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-06-12 with Science categories.

Biofuels are currently used as a viable alternative energy source in several countries. Plant-Based Genetic Tools for Biofuels Production explains biotechnological techniques and concepts that are applied to increase biofuel yield from plants and algae. Chapters of the book cover a variety of topics: the basic research techniques (cell suspension, embryogenesis, protoplast fusion), plant genetics (plant DNA mutations, new plant breeding techniques, viral genetic vectors for heterologous gene expression, sub cellular proteomes), genomic resources and bioinformatics tools, plant species with bioenergy and biofuel potential, factors influencing biomass yield, advances in cultivation technologies, fermentation of different substrates for ethanol production, and microalgae biomass technologies. Readers will gain a thorough understanding of modern biofuel production. Plant-Based Genetic Tools for Biofuels Production is a suitable reference for students in biotechnology and bioinformatics programs as well as researchers interested in information about the basics of biofuel production.