Peptide Based Cancer Vaccines

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Peptide Based Cancer Vaccines

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Author : W. Martin Kast
language : en
Publisher: CRC Press
Release Date : 2000-10-01

Peptide Based Cancer Vaccines written by W. Martin Kast and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2000-10-01 with Science categories.

The field of peptide based cancer vaccines has evolved tremendously in the last decade of this century. The exploration on how to apply the peptide knowledge for vaccination purposes began when it was demonstrated that these peptides after being mixed into adjuvants actually induced T cell responses that could prevent virus infections and tumor gro

Peptide Based Cancer Vaccines

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Author :
language : en
Publisher:
Release Date : 2000

Peptide Based Cancer Vaccines written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2000 with Cancer categories.

The field of peptide based cancer vaccines has evolved tremendously in the last decade of this century. The exploration on how to apply the peptide knowledge for vaccination purposes began when it was demonstrated that these peptides after being mixed into adjuvants actually induced T cell responses that could prevent virus infections and tumor growth in experimental animal models.

Formulation Of Peptide Based Cancer Vaccines

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Author :
language : en
Publisher:
Release Date : 2022

Formulation Of Peptide Based Cancer Vaccines written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022 with categories.

Addressing Delivery And Synthesis Challenges For Peptide Based Cancer Vaccines

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Author : Rebecca Lynn Holden
language : en
Publisher:
Release Date : 2020

Addressing Delivery And Synthesis Challenges For Peptide Based Cancer Vaccines written by Rebecca Lynn Holden and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020 with categories.

Therapeutic peptide vaccines have the potential to elicit and direct an anti-cancer T cell response, but their clinical efficacy has been limited in part by poor delivery to the lymphatic system, inefficient cell uptake, and scalable synthesis in the case of personalized vaccines. The work presented in this thesis explores several approaches to address these challenges. First, we use our fast-flow automated synthesis technology to confront the synthesis bottleneck for patient-specific 'neoantigen' vaccines, which have shown early promise but are hindered by slow production. We synthesize a particularly challenging set of peptides from a previous clinical trial as a test case, demonstrating that our technology can produce the majority of sequences in sufficient quantities with comparable or higher purity than a commercial vendor in a fraction of the time. Turning towards vaccine design, we explore several approaches to address the lymphatic and intracellular delivery of peptide antigens. We demonstrate the generality and anti-tumor efficacy of vaccines containing cell-penetrating peptides (CPPs), sequences shown to enhance the cell uptake of various cargo. We characterize their mechanism and identify several unanticipated contributors, namely trafficking to the lymph nodes, serum stability, and extended presentation in vivo. We then expand on an existing approach to mediate lymphatic trafficking via binding serum albumin by exploring additional albumin binding moieties. Next, we develop a straightforward and general approach to directly quantify antigen presentation and implement this technique to explore two strategies to design more effective vaccines, including CPPs. Finally, we build on previous work using CPPs to deliver antisense oligonucleotides (ASOs), another application that we pursued in tandem with cancer vaccines. We combine amphipathic and cationic CPPs to create chimeric sequences that synergistically enhance activity of an ASO and access new routes of uptake not utilized by either parent CPP. Drawing from our experience using CPPs to deliver ASOs as well as our expertise in peptide synthesis and design, we provide insight into the rapid production of personalized vaccines and efficient delivery of vaccine antigens. This thesis represents a new area of research for our lab, one in which we will hopefully continue to apply our unique skillset and perspective.

Cancer Vaccines As Immunotherapy Of Cancer

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Author : Luigi Buonaguro
language : en
Publisher: Academic Press
Release Date : 2022-03-04

Cancer Vaccines As Immunotherapy Of Cancer written by Luigi Buonaguro and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-03-04 with Science categories.

Cancer Vaccines as Immunotherapy of Cancer provides extensive and state-of-the-art information about the meaning, relevance and limitation of therapeutic cancer vaccines. It covers all the aspects involved in the vaccine research and development (identification of optimal target antigens, formulations, delivery strategies, adjuvants among others) as well as their use in combination with other immunomodulatory approaches. The book discusses topics such as identification of tumor associated and specific antigens, proteogenomic for identification of novel target tumor antigens, antigen-specific T cells, and Peptide and RNA based vaccines. Additionally, it covers oncolytic viruses for antigen delivery, cancer vaccine targeting viral antigens and combinatorial immunotherapy strategies. Written by leading experts worldwide, this is a valuable resource for cancer researchers, oncologists and members of biomedical field who wants to understand in depth the recent findings in the field of cancer vaccines. Describes the state-of-the-art of the research and development of therapeutic cancer vaccines Presents detailed diagrams to help the reader understand the functionality of each type of vaccine discussed Encompasses recent findings in the field through chapters written by leading experts worldwide

Towards The Development Of Peptide Based Cancer Vaccines

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Author : Silvia Silla
language : en
Publisher:
Release Date : 1999

Towards The Development Of Peptide Based Cancer Vaccines written by Silvia Silla and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1999 with categories.

Research Development And Clinical Trials For Peptides Based Vaccines

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Author : Shisong Jiang
language : en
Publisher: Frontiers Media SA
Release Date : 2022-05-09

Research Development And Clinical Trials For Peptides Based Vaccines written by Shisong Jiang and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-05-09 with Science categories.

Tumor Immunology And Cancer Vaccines

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Author : Samir Khleif
language : en
Publisher: Springer Science & Business Media
Release Date : 2007-07-16

Tumor Immunology And Cancer Vaccines written by Samir Khleif and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-07-16 with Medical categories.

- Volume is divided into four sections, allowing easy navagation for researchers and practicing physicians - Text includes clinical trials - Written by leaders in the field

Synthetic Peptide Vaccine Models

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Author : Mesut Karahan
language : en
Publisher: CRC Press
Release Date : 2021-02-28

Synthetic Peptide Vaccine Models written by Mesut Karahan and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-02-28 with Science categories.

A new generation of technological vaccines protect against many infectious diseases. This book describes synthetic peptide-based vaccine prototypes – the future of vaccination. Production of peptides becomes simple using automatic synthesizers. Peptides are weak immunogen and need adjuvants to provide an effective autoimmune response, which is why peptide antigens are conjugated with biopolymers and loaded with nanoparticles. The book illustrates the use of peptides vaccine systems and makes predictions of future development not only for infectious diseases, but also for cancers and brain diseases such as Alzheimer, Parkinson and psychiatric diseases. Key Features Summarizes current studies on technological vaccines Describes the uses of vaccines for the prevention of brain diseases Reviews the ways different polymers are used to enhance vaccine efficacy

Nanotherapeutics In Cancer Vaccination And Challenges

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Author : Mahfoozur Rahman
language : en
Publisher: Academic Press
Release Date : 2022-03-03

Nanotherapeutics In Cancer Vaccination And Challenges written by Mahfoozur Rahman and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-03-03 with Business & Economics categories.

Nanotherapeutics in Cancer Vaccination and Challenges consolidates the current research on cancer nanomedicine and therapeutic cancer vaccination to explore the most effective and promising avenues. The book covers cancer vaccines before exploring nanotherapeutics, DNA and mRNA vaccines in cancer treatment. Finally, it considers regulatory and industrial perspectives on cancer vaccination and nanotherapeutics. This resource will be useful for pharmaceutical scientists and researchers focused on biomedical engineering, chemical engineering, vaccine development, and cancer immunotherapy, along with advanced students in these subjects. Cancer is arguably the most complex and challenging disease known to mankind. Over the last two-decades, significant advancements have been made in new and novel concepts of cancer nanomedicines. Therapeutic cancer vaccines may be utilized to inhibit further growth of advanced cancers and/or relapsed tumors that are refractory to conventional therapies, such as surgery, radiation therapy and chemotherapy. Presents the progress made in cancer medicines from conventional to targeted therapy Covers the present state-of-the-art of cancer nanomedicines and upcoming therapeutic cancer vaccination Contains a focus on advanced nanomaterials that are utilized for encapsulation of nucleic acid, mRNA, DNA, siRNA