Perinatal And Developmental Epigenetics
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Perinatal And Developmental Epigenetics
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Author : Garima Singh
language : en
Publisher: Academic Press
Release Date : 2022-12-02
Perinatal And Developmental Epigenetics written by Garima Singh and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-12-02 with Medical categories.
Perinatal and Developmental Epigenetics, Volume 32, a new volume in the Translational Epigenetics series, provides a thorough overview of epigenetics in the early developmental and perinatal stages, illuminating pathways for drug discovery and clinical advances. Here, over 25 international researchers examine recent steps forward in our understanding of epigenetic programming during perinatal and early development. The book opens with an in-depth introduction to known and newly discovered epigenetic marks and how they regulate various cellular processes. Later sections examine various prenatal and perinatal environmental experiences and their ability to derail the normal developmental trajectory via epigenetic reprogramming. Insights and suggestions for future research illuminate approaches for identifying individual disease susceptibility. Concluding chapters highlight preventative and targeted therapeutic pathways to improve quality of life into adulthood. - Examines disease onset stemming from epigenetic changes during the perinatal periods - Features contributions from international experts in the field, including basic biology, disease research and drug discovery - Offers intervention strategies to mitigate adverse developmental programming to improve health outcomes
In Celebration Of Women In Developmental Epigenetics
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Author : Mellissa Mann
language : en
Publisher: Frontiers Media SA
Release Date : 2024-12-18
In Celebration Of Women In Developmental Epigenetics written by Mellissa Mann and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-12-18 with Science categories.
At present, less than 30% of researchers worldwide are women. Long-standing biases and gender stereotypes are discouraging girls and women away from science-related fields, and STEM research in particular. Science and gender equality are, however, essential to ensure sustainable development as highlighted by UNESCO. In order to change traditional mindsets, gender equality must be promoted, stereotypes defeated, and girls and women should be encouraged to pursue STEM careers. Frontiers in Cell and Developmental Biology is proud to offer this platform to promote the work of women scientists, across the field of Developmental Epigenetics. The work presented here highlights the diversity of research performed across the entire breadth of Developmental Epigenetics research and presents advances in theory, experiment, and methodology with applications to compelling problems. Please note: to be considered for this collection, the first or corresponding author should identify as a woman.
Neuropsychiatric Disorders And Epigenetics
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Author : Jacob Peedicayil
language : en
Publisher: Elsevier
Release Date : 2023-09-29
Neuropsychiatric Disorders And Epigenetics written by Jacob Peedicayil and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-09-29 with Science categories.
Neuropsychiatric Disorders and Epigenetics, Second Edition is a comprehensive reference on the epigenetic basis of common neuropsychiatric disorders. The volume is organized into chapters covering individual neuropsychiatric disorders, from addiction to anxiety and autism spectrum disorders, and is contributed by leading experts in their respective fields. The epigenetic aspects of each disorder are discussed, in the context of the full range of associated epigenetic mechanisms, including DNA modification, histone post-translational modification, chromatin organization, and non-coding RNA. A particular emphasis is placed on potential epigenetic interventions, when the effects of environmental stimuli on epigenetic states is particularly relevant to disease.This new edition has been fully updated to reflect recent research advances enabled by genomic technologies, as well as therapeutic interventions for previously unmanageable disorders. Several new chapters have been added on disorders or approaches not considered in the earlier edition, including epigenetics and anxiety disorders, epigenetics and neuroimaging in neuropsychiatric disorders, genome-wide approaches to epigenetic research, and the epigenetics of spinal muscular atrophy. By helping to define epigenetics as a key player in neuropsychiatric disorders, this volume empowers new research, clinical translation, and pharmacological advances, and highlights promising directions for ongoing investigation. - Analyzes the effects of environmental stimuli on epigenetic states that correlate with neuropsychiatric disease induction - Reviews the epigenetic basis for common neuropsychiatric disorders, thereby guiding translational therapies for clinicians and mechanistic studies for scientists - Features extensive use of diagrams, illustrations, tables, and graphical abstracts for each section to reinforce understanding - - Includes chapter contributions from leading global experts
Epigenetics The Environment And Children S Health Across Lifespans
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Author : David Hollar
language : en
Publisher: Springer
Release Date : 2016-02-08
Epigenetics The Environment And Children S Health Across Lifespans written by David Hollar and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-02-08 with Medical categories.
This stimulating volume addresses vital questions about gene/environment interactions as they affect cell health from the prenatal period through later life. Beginning with a tour of epigenetic processes in the human body, the book assembles current theoretical and empirical developments across the discipline, among them transgenerational epigenetic inheritance, the effects of maternal nutrition on epigenetic change, and possible links between epigenetics and childhood obesity. Public health and policy aspects of the field are discussed in depth, with the understanding that much can be done to improve our epigenetic health as a species. And in this vein, contributors consider future possibilities, such as the reprogramming of genes to reverse cancer and other diseases. Included in the coverage: The role of environmental epigenetics in perinatal and neonatal development The epigenetic biomarker γH2AX: from bench science to clinical trials What’s the risk? Dental amalgam, mercury exposure, and human health risks throughout the lifespan Post-traumatic stress disorder: neurological, genetic, and epigenetic bases Children’s exposure to alcohol, tobacco, and drugs: long-term outcomes Ethical implications of epigenetics Epigenetics, the Environment, and Children’s Health Across Lifespans brings real-world knowledge and applications of this increasingly important field to public health practitioners, maternal and child health researchers, and environmental health experts.
Epigenetics In Human Disease
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Author : Trygve O. Tollefsbol
language : en
Publisher: Elsevier
Release Date : 2023-10-09
Epigenetics In Human Disease written by Trygve O. Tollefsbol and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-10-09 with Medical categories.
Epigenetics in Human Disease, Third Edition examines the diseases and conditions on which we have advanced knowledge of epigenetic mechanisms, such as cancer, autoimmune disorders, aging, metabolic disorders, neurobiological disorders and cardiovascular disease. From molecular mechanisms and epigenetic technology to clinical translation of recent research, the nature and applications of the science is presented for those with interests ranging from the fundamental basis of epigenetics to therapeutic interventions for epigenetic-based disorders, with an emphasis throughout on understanding and application of key concepts in new research and clinical practice. Fully revised and up-to-date, this Third Edition discusses topics of current interest in epigenetic disease research, including stem cell epigenetic therapy, bioinformatic analysis of NGS data, epigenetic mechanisms of imprinting disorders, microRNA in cancer, epigenetic approaches to control obesity, epigenetics and airway disease, and epigenetics in cardiovascular disease. Further sections explore online epigenetic tools and datasets; early-life programming of epigenetics in age-related diseases; the epigenetics of addiction and suicide, and epigenetic approaches to regulating and preventing diabetes, cardiac disease, allergic disorders, Alzheimer's disease, respiratory diseases, and many other human maladies. In addition, each chapter now includes chapter summaries, definitions, and vibrant imagery and figures to reinforce understanding, as well as step-by-step methods and disease research case studies. - Includes contributions from leading international investigators involved in translational epigenetic research and therapeutic applications - Integrates methods and applications with fundamental chapters on epigenetics in human disease, along with an evaluation of recent clinical breakthroughs - Presents side-by-side coverage of the basis of epigenetic diseases and treatment pathways - Each chapter updated to include summaries, definitions, and vibrant imagery and figures to reinforce understanding - Features step-by-step methods and disease research case studies to put book concepts into practice
Epigenetics In Biological Communication
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Author : Guenther Witzany
language : en
Publisher: Springer Nature
Release Date : 2024-06-19
Epigenetics In Biological Communication written by Guenther Witzany and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-06-19 with Science categories.
Every cell, tissue, organ and organism is competent to use signs to exchange information reaching common coordinations and organisations of both single cell and group behavior. These sign-mediated interactions we term biological communication. The regulatory system that works in development, morphology, cell fate and identity, physiology, genetic instructions, immunity, memory/learning, physical and mental disease depends on epigenetic marks. The communication of cells, persistent viruses and their defectives such as mobile genetic elements and RNA networks ensures both the transport of regulatory instructions and the reprogramming of these instructions. But how are the different states of the epigenome orchestrated? The epigenetic pathways respond to various signaling cues such as DNA methylation, histone variants, histone modifications, chromatin structure, nucleosome remodeling, and epigenetic interactions. Epigenetic signals are responsible for the establishment, maintenance and reversal of transcriptional states that are fundamental for the cell's ability to memorize past events, such as changes in the external environment, socio-sphere or developmental cues. External signals trigger changes in the epigenome, allowing cells to respond dynamically. Internal signals direct activities that are necessary for body maintenance, and repairing damaged tissues and organs. With the emergence of epigenetic memory, organisms can fix historical and context dependent impressive experiences. Evolution from now on learnt to learn. Learning means organisms can avoid reproduction of always the same. This is key to adaptation. However, inheritance of acquired characteristics is only one of the many examples of the explanatory power of epigenetics. Behavioral epigenetics demonstrates the way in which environmental and social experiences produce individual differences in behaviour, cognition, personality, and mental health. This book assembles experts to outline the various motifs of all kinds of epigenetic regulation of cells throughout their lives.
Transgenerational Epigenetics
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Author : Trygve Tollefsbol
language : en
Publisher: Elsevier
Release Date : 2014-05-02
Transgenerational Epigenetics written by Trygve Tollefsbol and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-05-02 with Science categories.
Transgenerational Epigenetics provides a comprehensive analysis of the inheritance of epigenetic phenomena between generations. Recent research points to the existence of biological phenomena that are controlled not through gene mutations, but rather through reversible and heritable epigenetic processes. Epidemiological studies have suggested that environmental factors may be heritable. In fact, environmental factors often play a role in transgenerational epigenetics, which may have selective or adverse effects on the offspring. This epigenetic information can be transferred through a number of mechanisms including DNA methylation, histone modifications or RNA and the effects can persist for multiple generations. This book examines the evolution of epigenetic inheritance, its expression in animal and plant models, and how human diseases, such as metabolic disorders and cardiovascular diseases, appear to be affected by transgenerational epigenetic inheritance. It discusses clinical interventions in transgenerational epigenetic inheritance that may be on the horizon to help prevent diseases before the offspring are born, or to reduce the severity of diseases at the very earliest stages of development in utero, and current controversies in this area of study, as well as future directions for research. Focused discussion of metabolic disorders, cardiovascular diseases and longevity, which appear most affected by reversible and heritable epigenetic processes Encompasses both foundational and clinical aspects including discussions of preventative in utero therapies Covers history, future outlook, disease management and current controversies
Epigenetics And Neuroendocrinology
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Author : Dietmar Spengler
language : en
Publisher: Springer
Release Date : 2016-04-02
Epigenetics And Neuroendocrinology written by Dietmar Spengler and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-04-02 with Medical categories.
The field of neuroendocrinology has extended from the initial interest in the hypothalamic control of pituitary secretion to embrace multiple reciprocal interactions between the central nervous system and endocrine systems in the coordination of homeostasis and various physiological responses from adaptation to disease. Most recently, epigenetic mechanisms were recognized for their role in the development of the neuroendocrine axes as well as in the mediation of gene-environment interactions in stress-related psychiatry disorders.
Epigenetics Development Ecology And Evolution
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Author : Luis María Vaschetto
language : en
Publisher: Springer Nature
Release Date : 2022-10-13
Epigenetics Development Ecology And Evolution written by Luis María Vaschetto and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-10-13 with Science categories.
Epigenetic modifications comprise heritable gene expression changes that occur without alteration of the DNA sequence and 'co-act' with genetic factors to shape development processes and evolutionary trajectories. Multicellular organisms receive different types of environmental stimuli/stresses that trigger epigenetic modifications during development. These environmentally driven mechanisms represent an underlying cause of phenotypic diversity, especially in metazoans. This book aims to present some of the latest epigenetic insights into the development of metazoans (including humans) as an intersection between their ecology and evolution.
Developmental Human Behavioral Epigenetics
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Author : Livio Provenzi
language : en
Publisher: Academic Press
Release Date : 2020-11-12
Developmental Human Behavioral Epigenetics written by Livio Provenzi and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-11-12 with Science categories.
Developmental Human Behavioral Epigenetics: Principles, Methods, Evidence, and Future Directions, Volume 23, a new volume in the Translational Epigenetics series, offers the first systematic account of theoretical G79 frameworks, methodological approaches, findings, and future directions in the field of human behavioral epigenetics. Featuring contributions from leading scientists and international researchers, this book provides a comprehensive overview of human behavioral epigenetics, with a close examination of evidence gathered to-date from animal models, challenges of human-based research and clinical translation, pathways towards drug discovery, and next steps in research. Areas of focus include prenatal stress exposures, preterm behavioral epigenetics, intergenerational exposures, trauma and neglect, socio-economic conditions, maternal caregiving and attachment, study design, and epigenetics and psychotherapy. - Enables more effective study design and methods application in behavioral epigenetics research across human and animal models - Examines findings in human behavioral epigenetics to-date - Features contributions from leading international researchers in behavioral epigenetics