Perturbation Of Rna Binding Protein Regulation In Cancer
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Perturbation Of Rna Binding Protein Regulation In Cancer
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Author : Pradeep Chaluvally Raghavan
language : en
Publisher: Frontiers Media SA
Release Date : 2021-08-25
Perturbation Of Rna Binding Protein Regulation In Cancer written by Pradeep Chaluvally Raghavan and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-08-25 with Science categories.
Rna Based Mechanisms In Cancer
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Author : Gary Brewer
language : en
Publisher: World Scientific
Release Date : 2023-10-12
Rna Based Mechanisms In Cancer written by Gary Brewer and has been published by World Scientific this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-10-12 with Science categories.
The roles of gene transcription in cancer have long been appreciated. However, posttranscriptional processes also contribute significantly to alterations in gene expression that lead to tumor initiation, formation, and progression.We have known for decades that alterations in the expression of key genes, such as those involved in cell proliferation, signaling, apoptosis, and immune responses, are major molecular events in cancer. This book presents our current understanding of selected posttranscriptional control mechanisms and the RNAs that they regulate. Each chapter provides an overview of a specific RNA-directed regulatory system and the RNA/protein factors involved, then discusses major findings in the field and their relationships to the development and/or treatment of cancer and associated diseases. Future questions serve to address 'where do we go from here' and stimulate the reader's thinking about these important problems.This compendium of chapters from experts in the field is essential reading for anyone interested in the myriad ways that RNAs contribute to tumorigenesis: from graduate students, researchers, and clinical scientists interested in mRNA processing and translation, RNA-binding proteins that promote turnover/stability of specific mRNAs, how small noncoding RNAs control inflammation and signaling, roles of the epitranscriptome, and future and emerging RNA-based, anti-tumor therapeutics.
Rna And Cancer
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Author : Jane Y. Wu
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-03-12
Rna And Cancer written by Jane Y. Wu and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-03-12 with Medical categories.
Accumulating evidence supports the role of defects in post-transcriptional gene regulation in the development of cancer. RNA and Cancer examines the recent advances in our understanding of post-transcriptional gene regulation, especially RNA processing and its role in cancer development and treatment. A particular focus is mRNA splicing, but other topics such as microRNAs, mRNA stability, the perinucleolar compartment, and oligonucleotide therapeutics are also covered in detail. All chapters have been written by internationally renowned experts. The book is intended for all with an interest in gene regulation and cancer biology, and especially for those not directly working on RNA biology, including clinicians and medical students. It is hoped that it will stimulate further innovative research collaborations between RNA biologists and cancer researchers to the benefit of patients.
Posttranscriptional Gene Regulation By The Rna Binding Protein Hur In Two Disease Models
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Author : Matthew M. Gubin
language : en
Publisher:
Release Date : 2012
Posttranscriptional Gene Regulation By The Rna Binding Protein Hur In Two Disease Models written by Matthew M. Gubin and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012 with Asthma categories.
The RNA binding protein HuR binds to the AU-rich (ARE) regions of labile mRNAs, such as proto-oncogenes, stabilizing their mRNA and facilitating their translation into protein. HuR has been described to control genes in multiple areas of the acquired capabilities model of cancer and has been hypothesized to be a tumor-maintenance gene, allowing for cancers to proliferate once they are established. In additional to controlling genes involved in cancer, HuR also regulates genes involved in the immune system including. We investigated the role of HuR in two disease models: triple-negative breast cancer and allergic asthma. To understand the role of HuR in both cancer and allergic asthma we generated novel overexpression and underexpression models. Unexpectedly breast cancer tumors overexpressing HuR grew significantly slower than control tumors. Tumors overexpressing HuR had fewer blood vessels implicating HuR's role in angiogenesis. The putative mechanism seems to be an anti-angiogenic effect by increasing expression of TSP1 but also surprisingly, down-regulating VEGF, a target which HuR normally increases. Additionally, we generated and used lentiviral shRNA targeting HuR, transgenic mice overexpressing HuR in CD4+ T cells and a HuR conditional knockout (KO) mouse to understand the role of HuR in Th2 polarization. We show that the Th2 master transcription factor GATA-3, as well as IL-4 and IL-13 are regulated at the level of mRNA stability by HuR. Surprisingly, Th2 polarized cells from homozygous HuR knockout mice showed increased IL-2, IL-4 and IL-13 expression at both mRNA and protein levels but no changes in GATA-3 or IFNgamma. Despite these alterations in Th2 cytokine levels, HuR conditional KO mice have similar allergic airway inflammation as control mice.
Rna Protein Interactions
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Author : Kiyoshi Nagai
language : en
Publisher: Oxford University Press, USA
Release Date : 1994
Rna Protein Interactions written by Kiyoshi Nagai and has been published by Oxford University Press, USA this book supported file pdf, txt, epub, kindle and other format this book has been release on 1994 with Medical categories.
The study of RNA-protein interactions is crucial to understanding the mechanisms and control of gene expression and protein synthesis. The realization that RNAs are often far more biologically active than was previously appreciated has stimulated a great deal of new research in this field. Uniquely, in this book, the world's leading researchers have collaborated to produce a comprehensive and current review of RNA-protein interactions for all scientists working in this area. Timely, comprehensive, and authoritative, this new Frontiers title will be invaluable for all researchers in molecular biology, biochemistry and structural biology.
Introduction To Epigenetics
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Author : Renato Paro
language : en
Publisher: Springer Nature
Release Date : 2021-03-23
Introduction To Epigenetics written by Renato Paro and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-03-23 with Science categories.
This open access textbook leads the reader from basic concepts of chromatin structure and function and RNA mechanisms to the understanding of epigenetics, imprinting, regeneration and reprogramming. The textbook treats epigenetic phenomena in animals, as well as plants. Written by four internationally known experts and senior lecturers in this field, it provides a valuable tool for Master- and PhD- students who need to comprehend the principles of epigenetics, or wish to gain a deeper knowledge in this field. After reading this book, the student will: Have an understanding of the basic toolbox of epigenetic regulation Know how genetic and epigenetic information layers are interconnected Be able to explain complex epigenetic phenomena by understanding the structures and principles of the underlying molecular mechanisms Understand how misregulated epigenetic mechanisms can lead to disease
Extracellular Matrix Degradation
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Author : William C. Parks
language : en
Publisher: Springer Science & Business Media
Release Date : 2011-04-07
Extracellular Matrix Degradation written by William C. Parks and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-04-07 with Science categories.
Regulated turnover of extracellular matrix (ECM) is an important component of tissue homeostasis. In recent years, the enzymes that participate in, and control ECM turnover have been the focus of research that touches on development, tissue remodeling, inflammation and disease. This volume in the Biology of Extracellular Matrix series provides a review of the known classes of proteases that degrade ECM both outside and inside the cell. The specific EMC proteases that are discussed include cathepsins, bacterial collagenases, matrix metalloproteinases, meprins, serine proteases, and elastases. The volume also discusses the domains responsible for specific biochemical characteristics of the proteases and the physical interactions that occur when the protease interacts with substrate. The topics covered in this volume provide an important context for understanding the role that matrix-degrading proteases play in normal tissue remodeling and in diseases such as cancer and lung disease.
Rna Tagging
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Author : Manfred Heinlein
language : en
Publisher: Humana
Release Date : 2021-08-08
Rna Tagging written by Manfred Heinlein and has been published by Humana this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-08-08 with Science categories.
This book provides a compendium of state-of-the-art methods for the labeling, detection, and purification of RNA and RNA-protein complexes and thereby constitutes an important toolbox for researchers interested in understanding the complex roles of RNA molecules in development, signaling, and disease. Beginning with a section on in situ detection of RNA molecules using FISH techniques, the volume continues with parts exploring in vivo imaging of RNA transport and localization, imaging and analysis of RNA uptake and transport between cells, identification and analysis of RNA-binding proteins, guide RNAs in genome editing, as well as other specific analytical techniques. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, RNA Tagging: Methods and Protocols serves as a vital reference for researchers looking to further the increasingly important research in RNA biology.
Systems Biology Of Cancer
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Author : Sam Thiagalingam
language : en
Publisher: Cambridge University Press
Release Date : 2015-04-09
Systems Biology Of Cancer written by Sam Thiagalingam and has been published by Cambridge University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-04-09 with Mathematics categories.
An overview of the current systems biology-based knowledge and the experimental approaches for deciphering the biological basis of cancer.
Microrna In Regenerative Medicine
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Author : Chandan K. Sen
language : en
Publisher: Academic Press
Release Date : 2023-05-08
Microrna In Regenerative Medicine written by Chandan K. Sen and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-05-08 with Science categories.
Regulating virtually all biological processes, the genome’s 2,654 newly discovered variants of mature microRNAs – short ribonucleic acid molecules found in eukaryotic cells – hold a key role in the body’s toolkit of regenerative and reparative capacities. Identifying how to activate and deliver these specialist molecules may aid in the repair and regeneration of major tissue and organ damage in future therapies. In MicroRNA and Regenerative Medicine, Second Edition, over 50 leading experts address foundational and emerging topics in the field. Concisely summarizing and evaluating key findings from new research and their translational application, contributors examine current and future significance of clinical research in the miRNA area. Coverage encompasses all major aspects of fundamental stem cell and developmental biology, including the uses of miRNA in cell and tissue plasticity, developmental biology, tissue repair, and regeneration. In particular, contributors provide focused coverage of methodologies for regenerative intervention and tissue engineering. Topics new to this edition include proteomic changes during tissue repair and regeneration, horizontal transfer of miRNAs in tissue regeneration, tissue stemness, peripheral nerve regeneration, miRNA as biomarkers, microRNA in pregnancy and embryo development, exogenous and diet derived microRNA in tissue development, ocular microRNA, mitochondrial microRNA, sensory hair cell death and regeneration, and microRNA in senescence. Features chapter contributions from international leaders in the field, covering the spectrum from bench to bedside Includes short, applied chapters offering focused discussion and practical examples Incorporates multi-color text layout with more than 150 color figures to illustrate important findings