Pharmaceutical Biocatalysis
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Pharmaceutical Biocatalysis
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Author : Peter Grunwald
language : en
Publisher: CRC Press
Release Date : 2020-11-26
Pharmaceutical Biocatalysis written by Peter Grunwald and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-11-26 with Medical categories.
Volume 7 of the Jenny Stanford Series on Biocatalysis deals with several different aspects of pharmaceuticals, which include not only various applications of drugs and their metabolism but also natural resources for active pharmaceutical ingredients as well as the removal of pharmaceutical pollution. In detail, novel approaches for developing microbial fermentation processes to produce vitamin B6 using microorganisms are described together with novel routes for vitamin B6 biosynthesis. The other topics discussed are new approaches for producing the successful anticancer drug Taxol from naturally occurring precursors, molecular farming through plant engineering as a cost-effective means to produce therapeutic and prophylactic proteins, and successful screening of potent microorganisms producing L-asparaginase for various chemotherapeutic applications. Furthermore, microbial biotransformations in the production and degradation of fluorinated pharmaceuticals are described. The other chapters inform the reader about the biotransformation of xenobiotics/drugs in living systems, the degradation of pharmaceuticals by white-rot fungi and their ligninolytic enzymes, and the removal of pharmaceutical pollution from municipal sewage using laccase.
Pharmaceutical Biocatalysis
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Author : Peter Grunwald
language : en
Publisher: CRC Press
Release Date : 2020-11-01
Pharmaceutical Biocatalysis written by Peter Grunwald and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-11-01 with Medical categories.
This volume of Pharmaceutical Biocatalysis starts with a discussion on the importance of biocatalytic synthesis approaches for a sustainable and environmentally friendly production of pharmaceuticals and active pharmaceutical ingredients. Among the enzymes discussed in detail with respect to their pharmaceutical relevance are cyclic nucleotide phosphodiesterases playing an important role in modulating signal transduction in various cell types; human DOPA decarboxylase, related to Parkinson's disease and aromatic amino acid decarboxylase deficiency; and phospholipase D enzymes as drug targets. Isocitrate dehydrogenase 1 and 2 mutations are novel therapeutic targets in acute myeloid leukemia. An additional chapter is devoted to the use of enzymes for prodrug activation in cancer therapy. The other topics include small-molecule inhibitors targeting receptor tyrosine kinases in cancer, β-Lactams and related compounds as antibacterials, non-vitamin K oral anticoagulants for the treatment of thromboembolic diseases, and the molecular mechanisms for statin pleiotropy and its clinical relevance in cardiovascular diseases. The last chapter is a review of lysosomal storage disorders with an overview of approved drugs for treating these disorders by enzyme replacement therapy.
Pharmaceutical Biocatalysis
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Author : Peter Grunwald
language : en
Publisher: CRC Press
Release Date : 2019-06-27
Pharmaceutical Biocatalysis written by Peter Grunwald and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-06-27 with Medical categories.
This book provides an overview of the world market of therapeutic enzymes and enzyme inhibitors, rare diseases, orphan drugs, the costs of drug development and therapies, and enzymes in downstream processing of pharmaceuticals. It discusses carbonic anhydrase inhibitors and their multiple drug interactions, carboxylesterase inhibitors for pharmaceutical applications, employment of inhibitors for the treatment of neurodegenerative diseases, use of engineered proteins, bioactive peptides, and fibrinolytic enzymes for thrombolytic therapy, and enzymes important for the design and development of new drugs/drug metabolites such as aldehyde oxidases and cytochrome P450 enzymes and the role the latter play in vascular biology and pathophysiology. The treatment of cancer is explored in connection with enzymatic amino acid deprivation therapies and new drugs that act as chemical degraders of oncogenic proteins. The book also introduces the resistance mechanisms of cancer. Furthermore, it provides an insight into the relationship between pathological conditions of cardiovascular disease and oxidative stress. The text also focuses on the potential use of nanoparticles as carriers for enzymes with medical relevance, computer-aided drug design for the identification of multi-target directed ligands, and the development of improved therapeutics through a glycan-“designer” approach. It concludes with an introduction to the chemoenzymatic synthesis of drugs.
Pharmaceutical Biocatalysis
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Author : Peter Grunwald
language : en
Publisher: CRC Press
Release Date : 2019-11-07
Pharmaceutical Biocatalysis written by Peter Grunwald and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-11-07 with Business & Economics categories.
This volume provides an insight into the future strategies for commercial biocatalysis with a focus on sustainable technologies, together with chemoenzymatic and biotechnological approaches to synthesize various types of approved and new active pharmaceutical ingredients (APIs) via proven and latest synthetic routes using single-step biocatalytic or enzyme cascade reactions. Many of these drugs act as enzyme inhibitors, as discussed in a chapter with a variety of examples. The targeted enzymes are involved in diseases such as different cancers, metastatic and infectious diseases, osteoporosis, and cardiovascular disorders. The biocatalysts employed for API synthesis include hydrolytic enzymes, alcohol dehydrogenases, laccases, imine reductases, reductive aminases, peroxygenases, cytochrome P450 enzymes, polyketide synthases, transaminases, and halogenases. Many of them have been improved with respect to their properties by engineering methods. The book discusses the syntheses of drugs, including alkaloids and antibiotics, non-ribosomal peptides, antimalarial and antidiabetic drugs, prenylated xanthones, antioxidants, and many important (chiral) intermediates required for the synthesis of pharmaceuticals.
Biocatalysis For The Pharmaceutical Industry
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Author : Junhua (Alex) Tao
language : en
Publisher: John Wiley & Sons
Release Date : 2009-07-23
Biocatalysis For The Pharmaceutical Industry written by Junhua (Alex) Tao and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-07-23 with Science categories.
Biocatalysis is rapidly evolving into a key technology for the discovery and production of chemicals, especially in the pharmaceutical industry, where high yielding chemo-, regio-, and enantioselective reactions are critical. Taking the latest breakthroughs in genomics and proteomics into consideration, Biocatalysis for the Pharmaceutical Industry concisely yet comprehensively discusses the modern application of biocatalysis to drug discovery, development, and manufacturing. Written by a team of leading experts, the book offers deep insight into this cutting edge field. Covers a wide range of topics in a systematic manner with an emphasis on industrial applications Provides a thorough introduction to the latest biocatalysts, modern expression hosts, state-of-the-art directed evolution, high throughput screening, and bioprocess engineering Addresses frontier subjects such as emerging enzymes, metabolite profiling, combinatorial biosynthesis, metabolic engineering, and autonomous enzymes for the synthesis and development of chiral molecules, drug metabolites, and semi-synthetic medicinal compounds and natural product analogs Highlights the impact of biocatalysis on green chemistry Contains numerous graphics to illustrate concepts and techniques Biocatalysis for the Pharmaceutical Industry is an essential resource for scientists, engineers, and R&D policy makers in the fine chemical, pharmaceutical, and biotech industries. It is also an invaluable tool for academic researchers and advanced students of organic and materials synthesis, chemical biology, and medicinal chemistry.
Biocatalysis In The Pharmaceutical And Biotechnology Industries
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Author : Ramesh N. Patel
language : en
Publisher: CRC Press
Release Date : 2006-09-26
Biocatalysis In The Pharmaceutical And Biotechnology Industries written by Ramesh N. Patel and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006-09-26 with Medical categories.
Because enzyme-catalyzed reactions exhibit higher enantioselectivity, regioselectivity, substrate specificity, and stability, they require mild conditions to react while prompting higher reaction efficiency and product yields. Biocatalysis in the Pharmaceutical and Biotechnology Industries examines the use of catalysts to produce fine chemic
Biocatalysis
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Author : Gonzalo de Gonzalo
language : en
Publisher: Royal Society of Chemistry
Release Date : 2017-11-02
Biocatalysis written by Gonzalo de Gonzalo and has been published by Royal Society of Chemistry this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-11-02 with Science categories.
Implementing biocatalytic strategies in an industrial setting at a commercial scale is a challenging task, necessitating a balance between industrial need against economic viability. With invited contributions from small and large-scale chemical and pharmaceutical companies, this book bridges the gap between academia and industry. Contributors discuss current processes, types of biocatalysts and improvements, industrial motivation and key aspects to economically succeed. With its focus on industry related issues, this book will be a useful tool for future research by both practitioners and academics.
Biocatalysis And Pharmaceuticals A Smart Tool For Sustainable Development
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Author : Andres R Alcantara
language : en
Publisher: MDPI
Release Date : 2019-10-30
Biocatalysis And Pharmaceuticals A Smart Tool For Sustainable Development written by Andres R Alcantara and has been published by MDPI this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-10-30 with Science categories.
Biocatalysis, that is, the use of biological catalysts (enzymes, cells, etc.) for the preparation of highly valuable compounds is undergoing a great development, being considered an extremely sustainable approach to undertaking environmental demands. In this scenario, this book illustrates the versatility of applied biocatalysis for the preparation of drugs and other bioactive compounds through the presentation of different research articles and reviews, in which several authors describe the most recent developments in this appealing scientific area. By reading the excellent contributions gathered in this book, it is possible to have an updated idea about new advances and possibilities for a new exciting future.
Applied Biocatalysis
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Author : John Whittall
language : en
Publisher: John Wiley & Sons
Release Date : 2020-08-21
Applied Biocatalysis written by John Whittall and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-08-21 with Science categories.
Provides clear and comprehensive coverage of recently developed applied biocatalysis for synthetic organic chemists with an emphasis to promote green chemistry in pharmaceutical and process chemistry This book aims to make biocatalysis more accessible to both academic and industrial synthetic organic chemists. It focuses on current topics within the applied industrial biocatalysis field and includes short but detailed experimental methods on timely novel biocatalytic transformations using new enzymes or new methodologies using known enzymes. The book also features reactions that are “expanding and making the enzyme toolbox available to chemists”—providing readers with comprehensive methodology and detailed key sourcing information of a wide range of enzymes. Chapters in Applied Biocatalysis: The Chemist’s Enzyme Toolkit are organized by reaction type and feature a short introductory section describing the current state of the art for each example. Much of the book focuses on processes for which the enzymes are readily available so that organic chemists can synthesize appropriate quantities of chemicals with available materials in a standard chemical laboratory. Advanced methods are included to present examples of new enzymes that might encourage collaboration with suppliers or academic groups and that will educate chemists of rapidly expanding future possibilities. Focuses on current topics within the applied industrial biocatalysis field Offers experimental methods on novel biocatalytic transformations using new enzymes or new methodology using known enzymes Covers the hot topics of enzyme and chemoenzymatic cascades and biocatalysis in flow Edited by noted experts from both academia and industry with years of experience in the field of biocatalysis—particularly, the industrial applications of enzymes Written for synthetic organic chemists working in all industries but especially the pharmaceutical industry and for those in academia with an eye for biocatalysis, Applied Biocatalysis: The Chemist’s Enzyme Toolkit will also benefit academic groups in chemistry and related sciences that are using enzymes for synthetic purposes, as well as those working in the area of enzymology and molecular biology.
Pharmaceutical Applications Of Biocatalysis
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Author : R. C. Tripathi
language : en
Publisher:
Release Date : 2006
Pharmaceutical Applications Of Biocatalysis written by R. C. Tripathi and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006 with Drug development categories.
Biocatalysis Has A Large Impact In The Pharmaceutical World. It Offers Numerous Advantages For Manufacturing Pharmaceuticals With Unique And Highly Desirable Characteristics And Offers New Production Opportunities For A Wide Range Of Drugs. The Present Book Describes The Pharmaceutical Applications Of Biocatalysis In Detail. It Nicely Brings Together The Essential Of Biocatalysis Including Reactions, The Products And Processes That Utilize The Methodology, And Techniques For Improving Biocatalysis. This Book Will Be A Useful Reference Tool For Anyone Interested In The Fields Of Biocatalysis And Pharmaceuticals, Whether They Be Graduate Students Or More Experienced Practioners. Contents Chapter 1: Pharmaceuticals; Chapter 2: Biocatalysis; Chapter 3: Expression Of Biopharmaceuticals; Chapter 4: Enzymes For Efficient Biocatalysis; Chapter 5: Health Risk Of Enzymes; Chapter 6: Health Foods And Medical Biotechnology; Chapter 7: Robotics In Reproductive Medicine; Chapter 8: Application Of Magnetic Techniques; Chapter 9: Regulation Of Nutraceuticals And Pharmaceuticals; Chapter 10: Convergence Of Modern Biology And Medicine; Chapter 11: New Biocatalysts; Chapter 12: Evolution And Regulation Of Pharmaceuticals.