Pharmaceutical Toxicology In Practice
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Pharmaceutical Toxicology In Practice
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Author : Alberto Lodola
language : en
Publisher: John Wiley & Sons
Release Date : 2011-03-31
Pharmaceutical Toxicology In Practice written by Alberto Lodola and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-03-31 with Medical categories.
This book describes, with references to key source materials, the background to, and conduct of, the principal nonclinical studies that are central to drug development. The chapters provide an understanding of the key components of the preclinical phase of drug development with a hands-on description, with core chapters addressing study conduct, types, and reporting. As such, it is a practical guide through toxicology testing and an up-to-date reference on current issues, new developments, and future directions in toxicology. Opening with a practical description of toxicology and its role in the development of pharmaceuticals, the book proceeds to detail international regulations (including the impact of the new REACH standards for chemical safety), interdisciplinary interactions among scientists in drug development, steps in toxicity testing, and risk management. Further, the book covers the methods of genetic toxicology (assays, genomics, in vivo screening) as a complement to “traditional” toxicology in the risk assessment and risk management of pharmaceuticals.
Toxicology For The Health And Pharmaceutical Sciences
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Author : Antonio Peña-Fernández
language : en
Publisher: CRC Press
Release Date : 2021-12-21
Toxicology For The Health And Pharmaceutical Sciences written by Antonio Peña-Fernández and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-12-21 with Medical categories.
There is an increasing need for knowledge of toxicology to safeguard the use of chemicals in industry and in the public and private sectors. The study of toxicology is becoming increasingly relevant in human health sciences, as future health and clinical professionals will be pivotal in addressing and managing emerging chemical threats and hazards related to modern anthropogenic activities and technological development. Comprising a series of chapters from leading toxicology, pharmacy and public health academics and experts across Europe, the United States and beyond, Toxicology for the Health and Pharmaceutical Sciences provides a concise yet comprehensive volume that can be used as a relevant textbook on toxicology for the clinical, healthcare, educational and professional sectors. Key Features: Includes cutting edge information regarding the very lastest environmental threats to public health Provides a detailed case study based on a real-world scenario that allows the reader to practice human health risk assessment Describes innovative guidance and tools to respond to chemical incidents and attacks, which enables the reader to tailor an effective protection and remediation response This book covers the fundamentals and recent developments in toxicology, to respond to local and global chemical, pharmaceutical and environmental threats. Thus, this volume has chapters specifically designed to support the understanding of the most current toxicology-related subjects for any undergraduate/postgraduate health programs as well as aid the delivery of continuing professional development training on up-to-date topics in toxicology for current practicing health professionals wishing to improve their background knowledge in toxicology. The book is also vital reading and reference for policy makers and others that influence and set regulations that have an impact on the environment and human health.
Introduction To Toxicological Screening Methods And Good Laboratory Practice
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Author : Saravana Babu Chidambaram
language : en
Publisher: Springer Nature
Release Date : 2022-02-11
Introduction To Toxicological Screening Methods And Good Laboratory Practice written by Saravana Babu Chidambaram and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-02-11 with Medical categories.
This book focuses on the principles, methods, and interpretation involved in establishing the safety, risk, and hazard assessment of small molecules. It presents the regulatory requirements for risk and hazard identification as per the guidelines of the Organization for Economic Cooperation and Development (OECD), Paris, and the International Council for Harmonisation (ICH) of Technical Requirements for Pharmaceuticals for Human Use ICH and Schedule ‘Y’, India. It serves as reference material for undergraduate and postgraduate pharmacy degree students as well as senior researchers to learn about the principles, methods, and interpretations of systemic dosage (acute and repeated dose) and genotoxicity (in vitro and in vivo), special toxicological investigations such as reproductive and developmental toxicology, carcinogenicity, and toxicokinetics using animal models or in vitro methods, as applicable. This book is the first of its kind in providing information on the principles and methods of implementation of Good Laboratory Practice based on the guidelines of OECD. It includes detailed chapters about the regulatory requirements and guidelines in pharmaceutical products and agrochemicals. It also describes the infrastructure needed for preclinical studies, including in vivo and in vitro facilities.
Drug Discovery Toxicology
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Author : Yvonne Will
language : en
Publisher: John Wiley & Sons
Release Date : 2016-04-18
Drug Discovery Toxicology written by Yvonne Will and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-04-18 with Medical categories.
As a guide for pharmaceutical professionals to the issues and practices of drug discovery toxicology, this book integrates and reviews the strategy and application of tools and methods at each step of the drug discovery process. • Guides researchers as to what drug safety experiments are both practical and useful • Covers a variety of key topics – safety lead optimization, in vitro-in vivo translation, organ toxicology, ADME, animal models, biomarkers, and –omics tools • Describes what experiments are possible and useful and offers a view into the future, indicating key areas to watch for new predictive methods • Features contributions from firsthand industry experience, giving readers insight into the strategy and execution of predictive toxicology practices
The Clinical Toxicology Laboratory
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Author : Leslie M. Shaw
language : en
Publisher: Amer. Assoc. for Clinical Chemistry
Release Date : 2001
The Clinical Toxicology Laboratory written by Leslie M. Shaw and has been published by Amer. Assoc. for Clinical Chemistry this book supported file pdf, txt, epub, kindle and other format this book has been release on 2001 with Analytical chemistry categories.
Principles And Practice Of Toxicology In Public Health
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Author : Ira Richards
language : en
Publisher: Jones & Bartlett Learning
Release Date : 2008
Principles And Practice Of Toxicology In Public Health written by Ira Richards and has been published by Jones & Bartlett Learning this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008 with Health & Fitness categories.
In Five Sections, this reference Offers An Introduction To The Field, As WellAs The Basics Of Toxicology Principles, Chemical Toxicity, Ecotoxicology, AndToxicology Practice.
Introduction To Basics Of Pharmacology And Toxicology
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Author : Abialbon Paul
language : en
Publisher: Springer Nature
Release Date : 2021-03-13
Introduction To Basics Of Pharmacology And Toxicology written by Abialbon Paul and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-03-13 with Medical categories.
This book explains the pharmacological relationships between the various systems in the human body. It offers a comprehensive overview of the pharmacology concerning the autonomic, central, and peripheral nervous systems. Presenting up-to-date information on chemical mediators and their significance, it highlights the therapeutic aspects of several diseases affecting the cardiovascular, renal, respiratory, gastrointestinal, endocrinal, and hematopoietic systems. The book also includes drug therapy for microbial and neoplastic diseases. It also comprises sections on immunopharmacology, dermatological, and ocular pharmacology providing valuable insights into these emerging and recent topics. Covering the diverse groups of drugs acting on different systems, the book reviews their actions, clinical uses, adverse effects, interactions, and subcellular mechanisms of action. It is divided into 11 parts, subdivided into several chapters that evaluate the basic pharmacological principles that govern the different types of body systems. This book is intended for academicians, researchers, and clinicians in industry and academic institutions in pharmaceutical, pharmacological sciences, pharmacy, medical sciences, physiology, neurosciences, biochemistry, molecular biology and other allied health sciences.
Textbook Of Forensic Medicine And Toxicology Principles And Practice
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Author : Vij
language : en
Publisher: Elsevier India
Release Date : 2008
Textbook Of Forensic Medicine And Toxicology Principles And Practice written by Vij and has been published by Elsevier India this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008 with categories.
The book is a comprehensive and authoritative exposition of Forensic Medicine and Toxicology. It provides precise and useful information on relevant legal provisions and forensic anatomy, and promotes interdisciplinary understanding of issues where law an medicine converge. The text is oriented towards the practical problems ncountered during day-to-day medicollegal work. About the Author : - Krishnan Vij, MD, L.L.B. is Professor and Head, Department of Forensic Medicine and Toxicology, Government Medical College & Hospital, Chandigarh, India.
Handbook Of Toxicology Third Edition
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Author : Michael J. Derelanko
language : en
Publisher: CRC Press
Release Date : 2014-03-07
Handbook Of Toxicology Third Edition written by Michael J. Derelanko and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-03-07 with Law categories.
The Handbook of Toxicology, Third Edition provides an updated practical reference source for practicing toxicologists in the pharmaceutical and chemical industries, contract laboratories, regulatory agencies, and academia. Written by experts in their specific toxicology fields, the chapters provide both fundamental and applied information. Topics range from General Toxicology, to Genetic Toxicology, Human Clinical Toxicology, Histopathology, Clinical Pathology, Metabolism and Toxicokinetics, Risk Assessment, and more. New to this edition: Completely rewritten chapters covering immunotoxicology, endocrine toxicology, and reproductive and developmental toxicology, providing a fresh perspective on these topics Addition of new chapters on Chemical Toxicology, Pharmaceutical Toxicology, Juvenile Toxicology, and Safety Pharmacology Updated information dealing with Inhalation Toxicology, Neurotoxicology, and Regulatory Toxicology, which has been consolidated into single chapters for each specialty A separate glossary with toxicological terms presented both alphabetically and by toxicological subspecialty For nearly 20 years, this handbook has remained the only reference book of its kind, designed to facilitate easy access to information related to the various toxicology specialties. This updated edition of a popular reference book reflects current practices and the state of the science of toxicology.
Pediatric Non Clinical Drug Testing
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Author : Alan M. Hoberman
language : en
Publisher: John Wiley & Sons
Release Date : 2011-12-28
Pediatric Non Clinical Drug Testing written by Alan M. Hoberman and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-12-28 with Medical categories.
This book explains the importance and practice of pediatric drug testing for pharmaceutical and toxicology professionals. It describes the practical and ethical issues regarding non-clinical testing to meet US FDA Guidelines, differences resulting from the new European EMEA legislation, and how to develop appropriate information for submission to both agencies. It also provides practical study designs and approaches that can be used to meet international requirements. Covering the full scope of non-clinical testing, regulations, models, practice, and relation to clinical trials, this text offers a comprehensive and up-to-date resource.