Introduction To Toxicological Screening Methods And Good Laboratory Practice
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Introduction To Toxicological Screening Methods And Good Laboratory Practice
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Author : Saravana Babu Chidambaram
language : en
Publisher: Springer Nature
Release Date : 2022-02-11
Introduction To Toxicological Screening Methods And Good Laboratory Practice written by Saravana Babu Chidambaram and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-02-11 with Medical categories.
This book focuses on the principles, methods, and interpretation involved in establishing the safety, risk, and hazard assessment of small molecules. It presents the regulatory requirements for risk and hazard identification as per the guidelines of the Organization for Economic Cooperation and Development (OECD), Paris, and the International Council for Harmonisation (ICH) of Technical Requirements for Pharmaceuticals for Human Use ICH and Schedule ‘Y’, India. It serves as reference material for undergraduate and postgraduate pharmacy degree students as well as senior researchers to learn about the principles, methods, and interpretations of systemic dosage (acute and repeated dose) and genotoxicity (in vitro and in vivo), special toxicological investigations such as reproductive and developmental toxicology, carcinogenicity, and toxicokinetics using animal models or in vitro methods, as applicable. This book is the first of its kind in providing information on the principles and methods of implementation of Good Laboratory Practice based on the guidelines of OECD. It includes detailed chapters about the regulatory requirements and guidelines in pharmaceutical products and agrochemicals. It also describes the infrastructure needed for preclinical studies, including in vivo and in vitro facilities.
Targeted Therapy For The Central Nervous System
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Author : Viral Patel
language : en
Publisher: Elsevier
Release Date : 2024-10-07
Targeted Therapy For The Central Nervous System written by Viral Patel and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-10-07 with Medical categories.
Targeted Therapy for the Central Nervous System: Formulation, Clinical Challenges, and Regulatory Strategies presents research on various delivery methods of drugs to the central nervous system and brain. This volume examines targeted therapies for neurodegenerative disorders and succinctly outlines the future of drug delivery systems, highlighting significant advancements specifically relating to central nervous system delivery. This book will be of great interest to researchers working in the field of neuroscience and pharmacology as well as clinicians (pharmacists, radiologists, psychiatrists). - Provides a current, thorough means on how drugs are delivered to the neurological system - Figures a connection amongst the physiology of drug delivery pertaining to the central nervous system, fundamentals of drug delivery, and distribution principles - Gives an accounting of clinical trials and regulatory approaches for the formulations targeting brain
Pharmacological And Toxicological Screening Methods I
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Author : Dr. Trilochan Satapathy
language : en
Publisher: JEC PUBLICATION
Release Date :
Pharmacological And Toxicological Screening Methods I written by Dr. Trilochan Satapathy and has been published by JEC PUBLICATION this book supported file pdf, txt, epub, kindle and other format this book has been release on with Medical categories.
The sciences of pharmacology and toxicology are strongly intertwined. The former focuses on how medications function in live beings, while the latter focuses on the bad effects of drugs and chemicals and how to treat them. Both fields are concerned with the behaviour of drugs and chemicals in living organisms. This book provides a detailed illustration of the most important concepts that are involved in pharmacology and the medical sciences that are related to it. The title opens with a discussion of the historical elements of drug creation, including up-to-date information about Nobel Laureates in pharmacology and toxicology and the key discoveries they made. Following this, it conducts an analysis of the fundamental concepts of pharmacology, including pharmacokinetics and pharmacodynamics, as well as providing comprehensive information on drug transporters and interactions. The subsequent chapters of the book are dedicated to covering a comprehensive assortment of subjects that provide vital knowledge on the fundamental principles of pharmacology and the manner in which these concepts are used for the clinical treatment of disorders.
Antibiotics
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Author : Peter Sass
language : en
Publisher: Springer Nature
Release Date : 2022-11-29
Antibiotics written by Peter Sass and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-11-29 with Science categories.
This second edition provides state-of-the-art and novel methods on antibiotic isolation and purification, identification of antimicrobial killing mechanisms, as well as methods for the analysis and detection of microbial responses and adaptation strategies. Antibiotics: Methods and Protocols, Second Edition, guides readers through updated and entirely new chapters on production and design, mode of action, and response and resistance. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Antibiotics: Methods and Protocols, Second Edition aims to inspire scientific work in the exciting field of antibiotic research.
High Throughput Screening Methods In Toxicity Testing
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Author : Pablo Steinberg
language : en
Publisher: John Wiley & Sons
Release Date : 2013-02-26
High Throughput Screening Methods In Toxicity Testing written by Pablo Steinberg and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-02-26 with Science categories.
Explores the benefits and limitations of the latest high-throughput screening methods With its expert coverage of high-throughput in vitro screening methods for toxicity testing, this book makes it possible for researchers to accelerate and streamline the evaluation and risk assessment of chemicals and drugs for toxicity. Moreover, it enables them to comply with the latest standards set forth by the U.S. National Research Council's "Toxicity Testing in the 21st Century: A Vision and Strategy" and the E.U.'s REACH legislation. Readers will discover a variety of state-of-the-science, high-throughput screening methods presented by a group of leading authorities in toxicology and toxicity testing. High-Throughput Screening Methods in Toxicity Testing is divided into five parts: General aspects, including predicting the toxicity potential of chemicals and drugs via high-throughput bioactivity profiling Assessing different cytotoxicity endpoints Assessing DNA damage and carcinogenesis Assessing reproductive toxicity, cardiotoxicity, and haematotoxicity Assessing drug metabolism and receptor-related toxicity Each chapter describes method principles and includes detailed information about data generation, data analysis, and applications in risk assessment. The authors not only enumerate the advantages of each high-throughput method over comparable conventional methods, but also point out the high-throughput method's limitations and potential pitfalls. In addition, the authors describe current research efforts to make high-throughput toxicity screening even more cost effective and streamlined. Throughout the book, readers will find plenty of figures and illustrations to help them understand and perform the latest high-throughput toxicity screening methods. This book is ideal for toxicologists and other researchers who need to implement high-throughput screening methods for toxicity testing in their laboratories as well as for researchers who need to evaluate the data generated by these methods.
Histological Techniques
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Author : Robert Maynard
language : en
Publisher: Royal Society of Chemistry
Release Date : 2015-11-09
Histological Techniques written by Robert Maynard and has been published by Royal Society of Chemistry this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-11-09 with Medical categories.
Histological techniques form the basis of many areas of research, yet they can often be poorly understood. Aimed at postgraduate students and those at an early stage of their career, this title provides a detailed and comprehensive introduction to histological techniques. With detailed images and slides, this book provides a unique overview of the area while providing the reader with a guide to how to use and incorporate histological techniques within their own research. Written by experts working within the field, this book is an essential handbook for anyone wanting to learn more about histological methods and how to apply them successfully.
Toxicology And Risk Assessment
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Author : Helmut Greim
language : en
Publisher: John Wiley & Sons
Release Date : 2008-04-15
Toxicology And Risk Assessment written by Helmut Greim and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-04-15 with Science categories.
This new book, written by two outstanding scientists in the field, describes the basic principles of toxic mechanisms and organ toxicity, providing detailed information on specific mechanisms or chemicals for exemplification. The goal is to provide sufficient information that the reader becomes familiar with the basic concepts in toxicology to enable him or her to understand the basic principles in toxicology and to evaluate the risks at given exposures. With this basic understanding the reader also will be able to critically evaluate the available information on a chemical and to identify data gaps. In addition to the introductory chapters the book will offer the following systematic information, presented in six special sections: Principles in Toxicology Organ Toxicology Methods in Toxicology Risk Assessment Risk Management Toxicity of Chemicals Fulfilling a demand for such a book, this will be a welcomed introductory text for students and non-experts alike to focus on and understand the principles of hazard identification and risk assessment of toxicants. Relevant to all those studying toxicology, biochemistry, biology, medicine and chemistry, as well as toxicologists in hospitals, universities and in industry.
Introduction To Immunotoxicology
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Author : Jacques Descotes
language : en
Publisher: CRC Press
Release Date : 1998-12-09
Introduction To Immunotoxicology written by Jacques Descotes and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1998-12-09 with Medical categories.
This text provides a concise and comprehensive introduction to key immunotoxicological issues for all those interested in, but with no prior knowledge of, this area of toxicology. The first section explores the health consequences of immunotoxicity, namely the adverse effects related to chemically-induced immunosuppression and immunostimulation, hy
Good Laboratory Practice
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Author : Jürg P. Seiler
language : en
Publisher: Springer Science & Business Media
Release Date : 2006-01-16
Good Laboratory Practice written by Jürg P. Seiler and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006-01-16 with Medical categories.
After more than twenty years of use Good Laboratory Practice, or GLP, has attained a secure place in the world of testing chemicals and other “test items” with regard to their safety for humans and the environment. Gone are the days when the GLP regulations were hotly debated amongst scientists in academia and industry and were accused of stifling flexibility in, imaginative approaches to, and science-based conduct of, all kinds of studies concerned with toxic effects and other parameters important for the evaluation and assessment of products submitted for registration and permission to market. The GLP regulations have developed from rules on how to exactly document the planning, conduct and reporting of toxicity studies to a quality system for the management of a multitude of study types, from the simple determination of a physical/chemical parameter to the most complex field studies or ecotoxicology studies. At the same time the term “Good Laboratory Practice” has become somewhat ofa slogan with the aim to characterise any reliably conducted laboratory work.
Lu S Basic Toxicology
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Author : Byung-Mu Lee
language : en
Publisher: CRC Press
Release Date : 2017-09-07
Lu S Basic Toxicology written by Byung-Mu Lee and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-09-07 with Medical categories.
Continuing a long tradition, Lu‘s Basic Toxicology, Seventh Edition, provides guidance on principles of toxicology and testing procedures for toxicities as well as a concise yet detailed mechanism of both target organ and non-target organ toxicities. The book also addresses the toxic effects of chemicals and risk assessment, giving students and practicing toxicologists, the tools to enhance their practice. This edition includes new chapters on Systems Toxicology, Chemicals and Children, Toxicology of Reproductive Systems, providing the essentials of these topics in the same style as other chapters in the book. Separate subject and chemical indexes make this a useful, quick shelf reference.