Introduction To Immunotoxicology
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Introduction To Immunotoxicology
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Author : Jacques Descotes
language : en
Publisher: CRC Press
Release Date : 2003-09-02
Introduction To Immunotoxicology written by Jacques Descotes and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2003-09-02 with Medical categories.
This text provides a concise and comprehensive introduction to key immunotoxicological issues for all those interested in, but with no prior knowledge of, this area of toxicology. The first section explores the health consequences of immunotoxicity, namely the adverse effects related to chemically-induced immunosuppression and immunostimulation, hypersensitivity reactions and autoimmune diseases, with an overview of major immunotoxicants. The second part describes the latest methods used to detect and evaluate, preclinically and clinically, the unexpected immunotoxic effects of xenobiotics. Trends in implementing strategies and recent changes to the regulatory aspects are also considered. The third section examines possible future developments, including In Vitro methods, biomarkers of immunotixicity and risk assessment.
An Introduction To Immunotoxicology
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Author :
language : en
Publisher:
Release Date : 1999
An Introduction To Immunotoxicology written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1999 with Immunopathology categories.
Immunotoxicology Strategies For Pharmaceutical Safety Assessment
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Author : Danuta J. Herzyk
language : en
Publisher: John Wiley & Sons
Release Date : 2008-11-21
Immunotoxicology Strategies For Pharmaceutical Safety Assessment written by Danuta J. Herzyk and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-11-21 with Medical categories.
An important reference which provides an overview of the current and recently introduced methodologies for testing the immunotoxic risks in drug candidates Helps readers understand the significance of the methods and approaches to immunotoxicology testing Aids drug scientists in industry and regulatory areas to consolidate approaches to immunotox testing Offers a definitive assessment of nonclinical models to study the toxic impacts (bio)pharmaceuticals can have on the immune system Includes chapter authors from across the pharma industry, bringing a real-world and applied perspective to immunotox testing
Molecular Immunotoxicology
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Author : Emanuela Corsini
language : en
Publisher: John Wiley & Sons
Release Date : 2014-11-24
Molecular Immunotoxicology written by Emanuela Corsini and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-11-24 with Science categories.
The human immune system is constantly exposed to chemical contaminants, whether from food, water or air. Some chemicals directly elicit an immune response, while others indirectly activate or deactivate components within the immune system. Thus when tracking or predicting the effect of a chemical on the immune system, many different pathways and modes of action need to be considered. Following an introduction to the various pathways and toxicity mechanisms from a systemic perspective, the main part of this comprehensive reference surveys individual molecular mechanisms of important immunotoxicants, from PAHs to biopharmaceuticals, and from receptor-mediated toxicity to nanoparticle toxicity, using analyses based on molecular effects rather than on animal models. Taken together, the knowledge presented here provides an up-to-date overview of this hot topic that can be directly applied to the prediction and characterization of immunotoxic effects in drugs, chemicals, and environmental contaminants.
Principles And Methods Of Immunotoxicology
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Author : Jacques Descotes
language : en
Publisher: Elsevier
Release Date : 2004-10-14
Principles And Methods Of Immunotoxicology written by Jacques Descotes and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2004-10-14 with Science categories.
This is a review of clinical adverse effects on the human immune system that may occur following drug treatments and chemcical exposures. Current and prospective models and assays that can be used to predict these adverse effects in animal toxicity studies or in human beings are described.
Principles And Methods For Assessing Direct Immunotoxicity Associated With Exposure To Chemicals
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Author : World Health Organization
language : en
Publisher:
Release Date : 1996
Principles And Methods For Assessing Direct Immunotoxicity Associated With Exposure To Chemicals written by World Health Organization and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1996 with Medical categories.
A comprehensive guide to general strategies and specific methods for testing the immunotoxicity of chemicals in animal models and humans. Addressed to those seeking a basic introduction to the field as well as specialist researchers the book takes its focus from growing concern in scientific and public communities about the capacity of environmental agents to disrupt normal immune functions and thus increase susceptibility to tumours and infectious diseases. Compounds known to adversely affect the immune system are numerous and include drugs pesticides solvents halogenated and aromatic hydrocarbons and metals. The book draws on considerable recent progress in understanding the immunological consequences of chemical insults as well as increasingly sophisticated methodologies for assessing such effects. Close to 1000 references are included in this authoritative guide. The book opens with a detailed basic introduction to immunotoxicology. An extensive explanation of the function histophysiology and pathophysiology of the immune system emphasizes features that can aid the understanding and interpretation of the pathological changes caused by immunotoxic insults. Chapter two on the health impact of selected immunotoxic agents gives illustrative examples for some 30 chemicals that have been shown to exert immunotoxic effects in laboratory animals and for an additional seven groups of chemicals known to disturb immune functions in humans. For each brief discussions illustrate the chemical's distinct immunosuppressive properties and the mechanisms by which it exerts its toxic effects on the immune system. Chapter three provides detailed descriptions of a number of tests used in a tiered approach to the assessment of immunotoxicity. Against this background specific nonfunctional and functional tests for the assessment of immunotoxicology in experimental animals are presented and explained in full detail. Information on individual tests includes an explanation of why the test is important the types of data it can yield and exactly how it should be performed. Also included are sections offering advice on assessments in non-rodent species in vitro approaches and approaches using biomarkers in epidemiological studies and monitoring. The chapter concludes with a discussion of good laboratory practices for immunotoxicology studies and procedures for the validation of tests. Chapter five explains the much more complicated procedures needed to assess immunotoxicity in humans. An explanation of general questions to be considered when designing epidemiological studies is followed by presentation of three recommended testing schemes proposed by WHO and other agencies for preliminary evaluation of individuals exposed to immunotoxicants. Specific assays for assessing immune status are also described. The final chapter outlines a step-by-step process of risk assessment specific to the evaluation of potentially immunotoxic chemicals.
Immunotoxicity Testing
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Author : Rodney R. Dietert
language : en
Publisher: Humana
Release Date : 2016-08-23
Immunotoxicity Testing written by Rodney R. Dietert and has been published by Humana this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-08-23 with Medical categories.
Recent critical advances in the field of immunotoxicology have led to incredible contributions to basic science, including crucial improvements in human risk assessment. In Immunotoxicity Testing: Methods and Protocols, expert researchers explore these changes, providing the reader with current, lab-ready procedures, along with the corresponding background information that is necessary to identify effective testing approaches for chemicals and drugs. Among the first volumes to meld consideration of immunotoxicity testing strategies with a comprehensive presentation of detailed laboratory protocols, chapters include a description of the evolution of immunotoxicity testing, a look at the importance of immunotoxicity testing for health risk reduction, and ideas concerning the future of the field. Composed in the highly successful Methods in Molecular Biology(tm) series format, most chapters contain a brief introduction, step-by-step methods, a list of necessary materials, and a Notes section which shares tips from the experts on troubleshooting and avoiding known pitfalls. Comprehensive and innovative, Immunotoxicity Testing: Methods and Protocols is a critical, one-stop reference resource for the most important and commonly used laboratory protocols in immunotoxicology.
Investigative Immunotoxicology
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Author : Helen Tryphonas
language : en
Publisher: CRC Press
Release Date : 2005-01-27
Investigative Immunotoxicology written by Helen Tryphonas and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2005-01-27 with Medical categories.
Investigative Immunotoxicology provides a critical evaluation of proposed experimental animal models and approaches, and discusses the contribution that immunotoxicity can make to the overall assessment of chemical-induced adverse health effects on humans and the ecosystem. Following a review of general concepts in immunotoxicology, the book discus
Methods In Immunotoxicology
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Author : Gary R. Burleson
language : en
Publisher: Wiley-Blackwell
Release Date : 1995
Methods In Immunotoxicology written by Gary R. Burleson and has been published by Wiley-Blackwell this book supported file pdf, txt, epub, kindle and other format this book has been release on 1995 with Medical categories.
This two-volume set provides comprehensive coverage of recent and novel approaches for the identification and characterization of immunotoxicants. The first work presents an overview of the field, discussion of experimental design, and methods for risk assessment and sound laboratory practice. Volume 2 covers macrophage function assays, the use of animal models with specific reference to heat resistance, and autoimmunity.
Developmental Immunotoxicology
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Author : Steven D. Holladay
language : en
Publisher: CRC Press
Release Date : 2004-11-15
Developmental Immunotoxicology written by Steven D. Holladay and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2004-11-15 with Medical categories.
Despite rapidly increasing interest in developmental immunotoxicology, there is not yet a textbook focused on this hot area of research. Developmental Immunotoxicology fills the void with overviews of immune system development in experimental animal and human models, and discusses the complex issues related to the evolution of developmental immunology and risk assessment. This text describes different models used to study developmental immunotoxicology and examples of specific developmental immunotoxic agents, including therapeutics. The text concludes with several chapters that describe the role of neuroimmune interactions as they relate to developmental immunotoxicology. Using a didactic approach, Developmental Immunotoxicology provides an explanatory overview of this cutting-edge field for toxicologists, immunologists, and developmental biologists. It provides a lucid account of this area of research-proposing answers to some questions and stimulating debate on those questions yet to be addressed by the research community.