Principles And Methods For Assessing Direct Immunotoxicity Associated With Exposure To Chemicals
DOWNLOAD
Download Principles And Methods For Assessing Direct Immunotoxicity Associated With Exposure To Chemicals PDF/ePub or read online books in Mobi eBooks. Click Download or Read Online button to get Principles And Methods For Assessing Direct Immunotoxicity Associated With Exposure To Chemicals book now. This website allows unlimited access to, at the time of writing, more than 1.5 million titles, including hundreds of thousands of titles in various foreign languages. If the content not found or just blank you must refresh this page
Principles And Methods For Assessing Autoimmunity Associated With Exposure To Chemicals
DOWNLOAD
Author : International Labour Organisation
language : en
Publisher: World Health Organization
Release Date : 2006
Principles And Methods For Assessing Autoimmunity Associated With Exposure To Chemicals written by International Labour Organisation and has been published by World Health Organization this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006 with Medical categories.
This document provides an introduction to the field of transgenic mutagenicity assays and assesses the possible role of these assays in toxicology testing and mechanistic research. Part I gives a short overview of in vivo genotoxicity testing. Part II gives an overview of the data produced by various assays. Part III discusses the use of the assays in research. Part IV evaluates the role and potential added value of transgenic mutation assays in toxicology and risk assessment. This document is directed at toxicologists, research scientists and risk assessors.--Publisher's description.
Principles And Methods For Assessing Direct Immunotoxicity Associated With Exposure To Chemicals
DOWNLOAD
Author : World Health Organization
language : en
Publisher:
Release Date : 1996
Principles And Methods For Assessing Direct Immunotoxicity Associated With Exposure To Chemicals written by World Health Organization and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1996 with Medical categories.
A comprehensive guide to general strategies and specific methods for testing the immunotoxicity of chemicals in animal models and humans. Addressed to those seeking a basic introduction to the field as well as specialist researchers the book takes its focus from growing concern in scientific and public communities about the capacity of environmental agents to disrupt normal immune functions and thus increase susceptibility to tumours and infectious diseases. Compounds known to adversely affect the immune system are numerous and include drugs pesticides solvents halogenated and aromatic hydrocarbons and metals. The book draws on considerable recent progress in understanding the immunological consequences of chemical insults as well as increasingly sophisticated methodologies for assessing such effects. Close to 1000 references are included in this authoritative guide. The book opens with a detailed basic introduction to immunotoxicology. An extensive explanation of the function histophysiology and pathophysiology of the immune system emphasizes features that can aid the understanding and interpretation of the pathological changes caused by immunotoxic insults. Chapter two on the health impact of selected immunotoxic agents gives illustrative examples for some 30 chemicals that have been shown to exert immunotoxic effects in laboratory animals and for an additional seven groups of chemicals known to disturb immune functions in humans. For each brief discussions illustrate the chemical's distinct immunosuppressive properties and the mechanisms by which it exerts its toxic effects on the immune system. Chapter three provides detailed descriptions of a number of tests used in a tiered approach to the assessment of immunotoxicity. Against this background specific nonfunctional and functional tests for the assessment of immunotoxicology in experimental animals are presented and explained in full detail. Information on individual tests includes an explanation of why the test is important the types of data it can yield and exactly how it should be performed. Also included are sections offering advice on assessments in non-rodent species in vitro approaches and approaches using biomarkers in epidemiological studies and monitoring. The chapter concludes with a discussion of good laboratory practices for immunotoxicology studies and procedures for the validation of tests. Chapter five explains the much more complicated procedures needed to assess immunotoxicity in humans. An explanation of general questions to be considered when designing epidemiological studies is followed by presentation of three recommended testing schemes proposed by WHO and other agencies for preliminary evaluation of individuals exposed to immunotoxicants. Specific assays for assessing immune status are also described. The final chapter outlines a step-by-step process of risk assessment specific to the evaluation of potentially immunotoxic chemicals.
Investigative Immunotoxicology
DOWNLOAD
Author : Helen Tryphonas
language : en
Publisher: CRC Press
Release Date : 2005-01-27
Investigative Immunotoxicology written by Helen Tryphonas and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2005-01-27 with Medical categories.
Investigative Immunotoxicology provides a critical evaluation of proposed experimental animal models and approaches, and discusses the contribution that immunotoxicity can make to the overall assessment of chemical-induced adverse health effects on humans and the ecosystem. Following a review of general concepts in immunotoxicology, the book discus
Toxicological Risk Assessment Of Chemicals
DOWNLOAD
Author : Elsa Nielsen
language : en
Publisher: CRC Press
Release Date : 2008-02-21
Toxicological Risk Assessment Of Chemicals written by Elsa Nielsen and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-02-21 with Medical categories.
Unlike many existing books on toxicology that cover either toxicity of a particular substance or toxicity of chemicals on particular organ systems, Toxicological Risk Assessment of Chemicals: A Practical Guide lays out the principle activities of conducting a toxicological risk assessment, including international approaches and methods for the risk
Oecd Guidelines For The Testing Of Chemicals Oecd Series On Testing And Assessment Descriptions Of Selected Key Generic Terms Used In Chemical Hazard Risk Assessment
DOWNLOAD
Author : OECD
language : en
Publisher: OECD Publishing
Release Date : 2004-11-01
Oecd Guidelines For The Testing Of Chemicals Oecd Series On Testing And Assessment Descriptions Of Selected Key Generic Terms Used In Chemical Hazard Risk Assessment written by OECD and has been published by OECD Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 2004-11-01 with categories.
This paper presents internationally harmonised generic and technical terms used in chemical hazard/risk assessment which will help facilitate the mutual use and acceptance of the assessment of chemicals between countries.
Information Resources In Toxicology
DOWNLOAD
Author : Philip Wexler
language : en
Publisher: Academic Press
Release Date : 2000
Information Resources In Toxicology written by Philip Wexler and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2000 with Medical categories.
History: -- K.D. Watson, P. Wexler, and J. Everitt. -- Highlights in the History of Toxicology. -- Selected References in the History of Toxicology. -- A Historical Perspective of Toxicology Information Systems. -- Books and Special Documents: -- G.L. Kennedy, Jr., P. Wexler, N.S. Selzer, and L.A. Malley. -- General Texts. -- Analytical Toxicology. -- Animals in Research. -- Biomonitoring/Biomarkers. -- Biotechnology. -- Biotoxins. -- Cancer. -- Chemical Compendia. -- Chemical--Cosmetics and Other Consumer. -- Products. -- Chemical--Drugs. -- Chemical--Dust and Fibers. -- Chemical--Metals. -- Chemicals--Pesticides -- Chemicals--Solvents. -- Chemical--Selected Chemicals. -- Clinical Toxicology. -- Developmental and Reproductive Toxicology. -- Environmental Toxicology--General. -- Environmental Toxicology-- Aquatic. -- Environmental Toxicology--Atmospheric. -- Environmental Toxicology--Hazardous Waste. -- Environmental Toxicology--Terrestrial. -- Environmental Toxicology--Wildlife. -- Ep ...
Nijkamp And Parnham S Principles Of Immunopharmacology
DOWNLOAD
Author : Michael J. Parnham
language : en
Publisher: Springer Nature
Release Date : 2019-12-10
Nijkamp And Parnham S Principles Of Immunopharmacology written by Michael J. Parnham and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-12-10 with Medical categories.
Principles of Immunopharmacology provides a unique source of essential knowledge on the immune response, its diagnosis and its modification by drugs and chemicals. The 4th edition of this internationally recognized textbook has been revised to include recent developments, but continues the established format, dealing with four related fields in a single volume, thus obviating the need to refer to several different textbooks. The first section of the book, providing a basic introduction to immunology and its relevance for human disease, has been updated to accommodate new immunological concepts, particularly the role of epigenetics and the latest understanding of cancer immunology. The second section on immunodiagnostics offers a topical description of widely used molecular techniques and a new chapter on imaging techniques. This is followed by a systematic coverage of drugs affecting the immune system, including natural products. This third section contains 15 updated chapters, covering classical immunopharmacological topics such as anti-asthmatic, anti-rheumatic and immunosuppressive drugs, but also deals with antibiotics, plant-derived and dietary agents, with new chapters on monoclonal antibodies, immunotherapy in sepsis and infection, drugs for soft-tissue autoimmunity and cell therapy. The book concludes with a chapter on immunotoxicology and drug safety tests. Aids to the reader include a two-column format, glossaries of technical terms and appendix reference tables. The emphasis on illustrations is maintained from the first three editions. The book is a valuable single reference for undergraduate and graduate medical and biomedical students, postgraduate chemistry and pharmacy students, researchers in chemistry, biochemistry and the pharmaceutical industry and researchers lacking basic immunological knowledge, who want to understand the actions of drugs on the immune system.
Who Human Health Risk Assessment Toolkit
DOWNLOAD
Author : World Health Organization
language : en
Publisher: World Health Organization
Release Date : 2021-09-30
Who Human Health Risk Assessment Toolkit written by World Health Organization and has been published by World Health Organization this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-09-30 with History categories.
Immunotoxicology And Immunopharmacology
DOWNLOAD
Author : Robert V. House
language : en
Publisher: CRC Press
Release Date : 2006-12-26
Immunotoxicology And Immunopharmacology written by Robert V. House and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006-12-26 with Medical categories.
Continuing the tradition set by the first and second editions, each a bestseller in its own right, the third edition of Immunotoxicology and Immunopharmacology provides reviews of environmental agents, updated to reflect the latest information on how these agents influence immune system function and health. For the first time in the book's history,
Toxicology And Risk Assessment
DOWNLOAD
Author : Helmut Greim
language : en
Publisher: John Wiley & Sons
Release Date : 2018-08-10
Toxicology And Risk Assessment written by Helmut Greim and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-08-10 with Science categories.
Provides a complete understanding of how our bodies respond to toxicants, and the principles used to assess the health risks of specific exposure scenarios Toxicology and Risk Assessment: A Comprehensive Introduction, Second Edition reflects recent advances in science and technology, and provides the scientific background and methodological issues to enable the reader to understand the basic principles in toxicology and to evaluate the health risks of specific exposure scenarios. Completely updated with the latest information, this book offers a concise introduction to the subject. It is divided into five sections: Principles in Toxicology, Organ Toxicology, Methods in Toxicology, Regulatory Toxicology, and Specific Toxicity. The 2nd Edition adds new chapters that cover recent scientific and technological advances and current topics including the endocrine system, alternatives to animal testing, risk assessment and thresholds for carcinogens, European and international regulation, nanomaterials, fuels, fragrances, and agrochemicals. Concentrates on the basic concepts of toxicology and provides sufficient information for the reader to become familiar with them in order to understand the principles and to evaluate the risks at given exposures 30% new chapters cover recent scientific and technological advances including alternatives to animal testing; genotoxic carcinogens; REACH regulations; nanomaterials; fuels; fragrances; PAHs; and agrochemicals Written by a team of international specialists, and edited by two outstanding scientists in the field Fully updated and expanded, Toxicology and Risk Assessment: A Comprehensive Introduction, Second Edition is an essential text for any student or researcher with an interest in toxicology and related risk assessments.