Pharmacogenetics Kinetics And Dynamics For Personalized Medicine
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Pharmacogenetics Kinetics And Dynamics For Personalized Medicine
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Author : David F. Kisor
language : en
Publisher: Jones & Bartlett Publishers
Release Date : 2013-02-19
Pharmacogenetics Kinetics And Dynamics For Personalized Medicine written by David F. Kisor and has been published by Jones & Bartlett Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-02-19 with Medical categories.
Pharmacogenetics, Kinetics, and Dynamics for Personalized Medicine provides a primer to understand pharmacogenetics (the study of genetic factors that influence how a drug works) in the applied context of pharmacokinetics (how the body handles a drug) and pharmacodynamics (the effects of a drug on the body). This valuable foundation illuminates how these principles and scientific advances can create optimal individual patient care, that is, "personalized medicine." Through specific drug examples, this resource explores how the genetic constitution of an individual may lead to the need for an altered dose or in some cases alternative drug therapy. Real-world cases highlight the specific relationships between genetics, drug action, and the body's response as well as adverse drug reactions, altered metabolism, and drug efficacy. Ethical issues concerning pharmacogenomics and study design are also discussed in this concise overview.
Pharmacogenomics And Personalized Medicine
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Author : Erika Cecchin
language : en
Publisher: MDPI
Release Date : 2021-01-20
Pharmacogenomics And Personalized Medicine written by Erika Cecchin and has been published by MDPI this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-01-20 with Medical categories.
Pharmacogenomics is one of the emerging approaches to precision medicine, tailoring drug selection and dosing to the patient’s genetic features. In recent years, several pharmacogenetic guidelines have been published by international scientific consortia, but the uptake in clinical practice is still poor. Many coordinated international efforts are ongoing in order to overcome the existing barriers to pharmacogenomic implementation. On the other hand, existing validated pharmacogenomic markers can explain only a minor part of the observed clinical variability in the therapeutic outcome. New investigational approaches are warranted, including a study of the pharmacogenomic role of the immune system genetics and of previously neglected rare genetic variants, reported to account for a large part of inter-individual variability in drug metabolism. In this book, we have collected a series of articles covering many aspects of pharmacogenomics. These include clinical implementation of pharmacogenomics in clinical practice, development of tools or infrastructures to support this process, research of new pharmacogenomics markers to increase drug efficacy and safety, and the impact of rare genetic variants in pharmacogenomics.
Pharmacogenetics And Individualized Therapy
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Author : Anke-Hilse Maitland-van der Zee
language : en
Publisher: John Wiley & Sons
Release Date : 2012-04-02
Pharmacogenetics And Individualized Therapy written by Anke-Hilse Maitland-van der Zee and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-04-02 with Medical categories.
This resource provides thorough coverage of pharmacogenetics and its impact on pharmaceuticals, therapeutics, and clinical practice. It opens with the basics of pharmacogenetics, including drug disposition and pharmacodynamics. The following section moves into specific disease areas, including cardiovascular, psychiatry, cancer, asthma/COPD, adverse drug reactions, transplantation, inflammatory bowel disease, and pain medication. Clinical practice and ethical issues make up the third section, with the fourth devoted to technologies like genotyping, genomics, and proteomics. In the fifth part, chapters discuss the impact of key regulatory issues on the pharmaceutical industry.
Pharmacogenomics In Clinical Therapeutics
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Author : Loralie J. Langman
language : en
Publisher: John Wiley & Sons
Release Date : 2012-01-09
Pharmacogenomics In Clinical Therapeutics written by Loralie J. Langman and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-01-09 with Medical categories.
Pharmacogenomics is the basis of personalized medicine which will be the medicine of the future. Through both reducing the numbers of adverse drug reactions and improving the use of existing drugs in targeted populations, pharmacogenomics represents a real advance on traditional therapeutic drug monitoring. Pharmacogenomics in Clinical Therapeutics provides an introduction to the principles of pharmacogenomics before addressing the pharmacogenomic aspects of key therapeutic areas such as warfarin therapy, cancer chemotherapy, therapy with immunosuppressants, antiretroviral therapy, and psychoactive drugs. It also includes methods of pharmacogenomic testing and the pharmacogenomic aspects of drug–drug interactions. From a team of expert contributors, Pharmacogenomics in Clinical Therapeutics is a comprehensive overview of the current state of pharmacogenomics in pharmacotherapy for all clinicians, pharmacologists and clinical laboratory professionals. It is also a guide for practicing clinicians and health care professionals to the basic principles of pharmacogenomics, laboratory tests currently available to aid clinicians, and the future promise of this developing field.
New Research On Pharmacogenetics
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Author : Linda P. Barnes
language : en
Publisher: Nova Publishers
Release Date : 2007
New Research On Pharmacogenetics written by Linda P. Barnes and has been published by Nova Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007 with Pharmacogenetics categories.
The terms pharmacogenomics and pharmacogenetics tend to be used interchangeably, and a precise, consensus definition of either remains elusive. Pharmacogenetics is generally regarded as the study of genetic variation that gives rise to differing response to drugs, while pharmacogenomics is the broader application of genomic technologies to new drug discovery and further characterization of older drugs. Pharmacogenetics considers one or at most a few genes of interest, while pharmacogenomics considers the entire genome. Much of current clinical interest is at the level of pharmacogenetics, involving variation in genes involved in drug metabolism with a particular emphasis on improving drug safety. This new book presents leading-edge research in this dynamic field.
10 Years Of Pharmacogenetics And Pharmacogenomics
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Author : Jose Agundez
language : en
Publisher: Frontiers Media SA
Release Date : 2020-07-08
10 Years Of Pharmacogenetics And Pharmacogenomics written by Jose Agundez and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-07-08 with categories.
The Specialty Section “Pharmacogenetics and Pharmacogenomics” makes part of two different Journals: Frontiers in Pharmacology and Frontiers in Genetics. This Specialty Section focuses on the mechanisms by which genetic variations influence drug effects and adverse drug events, and cover basic research, clinical translation, applications in drug development and regulatory issues related to this field. Also, studies addressing the role of other factors such as epigenetics, phenotypic factors or drug-drug interactions on drug pharmacokinetics or pharmacodynamics are welcome. The editorial board is composed of 34 Associate Editors which, together with the Guest Associate Editors and the Reviewer Editors, constitute a team of nearly 340 leading experts in the field of Pharmacogenetics and Pharmacogenomics. This guarantees high quality in the reviewing process as well as short review times. A look back: 10 years of Frontiers in Pharmacogenetics & Pharmacogenomics (Continued in eBook)
Concepts In Pharmacogenomics
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Author : Martin M. Zdanowicz
language : en
Publisher:
Release Date : 2017
Concepts In Pharmacogenomics written by Martin M. Zdanowicz and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017 with Pharmacogenetics categories.
As the growing field of pharmacogenomics continues to impact daily practice and offer promising new drug therapies, understanding this complex science is critical for all pharmacists. To meet this need, ASHP's Concepts in Pharmacogenomics has been completely updated for the second edition, covering both the fundamentals of pharmacogenomics and the latest genomic technologies.
Clinical Applications Of Pharmacogenetics
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Author : Despina Sanoudou
language : en
Publisher: BoD – Books on Demand
Release Date : 2012-03-21
Clinical Applications Of Pharmacogenetics written by Despina Sanoudou and has been published by BoD – Books on Demand this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-03-21 with Medical categories.
The rapidly evolving field of Pharmacogenetics aims at identifying the genetic factors implicated in the inter-individual variation of drug response. These factors could enable patient sub-classification based on their treatment needs thus expediting drug development and promoting personalized, safer and more effective treatments. This book presents Pharmacogenetic examples from a broad spectrum of different drugs, for different diseases, which are representative of different stages of evaluation or application. It has been designed so as to serve both the unfamiliar reader through explanations of basic Pharmacogenetic concepts, the clinician with presentation of the latest developments and international guidelines, and the research scientist with examples of Pharmacogenetic applications, discussions on the limitations and an outlook on the new scientific trends in this field.
Pharmacogenomics And Proteomics
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Author : Steven How-Yan Wong
language : en
Publisher: AACC Press
Release Date : 2006
Pharmacogenomics And Proteomics written by Steven How-Yan Wong and has been published by AACC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006 with Medical categories.
Reviews the fundamentals of molecular biology and general clinical implications important in understanding fundamental concepts, a general review of ethical considerations, methods of predicting response using artificial networks, regulatory issues, reimbursement, quality assurance considerations, and future market analysis; methodologies that merge the disciplines of pharmacogenetics with those of proteomics, metabolomics, and metabonomics; specific clinical applications of pharmacogenetics of major drug groups, specialties, and diseases, and how they are linked to potential clinical management; and selected biotechnologies relevant to the application of clinical pharmacogenomics and proteomics to clinical practice.
Pharmacogenomics A Primer For Clinicians
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Author : Jerika T. Lam
language : en
Publisher: McGraw Hill Professional
Release Date : 2020-12-22
Pharmacogenomics A Primer For Clinicians written by Jerika T. Lam and has been published by McGraw Hill Professional this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-12-22 with Medical categories.
An invaluable resource to the rapidly emerging field of pharmacogenomics—complete with case studies, clinical pearls, and treatment recommendations The aim of pharmacogenomics is to improve personalized medicine by taking into account how genes affect an individual’s tolerability and response to drugs. Approaching pharmacogenomics from the current clinical, scientific, and implementation perspectives, this guide serves as an invaluable evidence-based resource to the subject. Reflecting the shift from genetics to genomics in the pharmaceutical sphere, the book covers pharmacogenomics fundamentals; genotyping tests and evidence; clinical implementation; ethical, legal, and social issues; and more. You’ll also find illuminating case scenarios, clinical pearls, and evidence-based recommendations for treatments and alternatives based on CPIC, PharmGKB, and FDA guidelines.