Pharmacological Control Of Human Nucleoside Transporters In Endothelial And Cancer Cells By Emodin
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Pharmacological Control Of Human Nucleoside Transporters In Endothelial And Cancer Cells By Emodin
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Author : Yuen-Ting Lin
language : en
Publisher: Open Dissertation Press
Release Date : 2017-01-26
Pharmacological Control Of Human Nucleoside Transporters In Endothelial And Cancer Cells By Emodin written by Yuen-Ting Lin and has been published by Open Dissertation Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-01-26 with categories.
This dissertation, "Pharmacological Control of Human Nucleoside Transporters in Endothelial and Cancer Cells by Emodin" by Yuen-ting, Lin, 林婉婷, was obtained from The University of Hong Kong (Pokfulam, Hong Kong) and is being sold pursuant to Creative Commons: Attribution 3.0 Hong Kong License. The content of this dissertation has not been altered in any way. We have altered the formatting in order to facilitate the ease of printing and reading of the dissertation. All rights not granted by the above license are retained by the author. Abstract: Nucleosides possess many physiological and pharmacological properties. Among nucleosides, adenosine is a particularly important as it regulates many physiological functions in cardiovascular system. For instance, adenosine possesses anti-inflammatory effect through its action on endothelial cells. The functions of adenosine are indirectly controlled by the human equilibrative nucleoside transporters (hENTs). These transporters mediate the uptake of adenosine, thereby reducing the amount of extracellular adenosine available for the adenosine receptors and hence reducing its vascular protective effects. Nucleoside analogs such as gemcitabine, are commonly used as anti-cancer drugs in chemotherapy. Most of the anti-cancer nucleoside drugs require human concentrative nucleoside transporters (hCNTs) for their transport into cancer cells. On the other hand, hENTs is supposed to be responsible for the efflux of anti-cancer nucleoside drugs out of the cancer cells. In theory, hENT inhibitors should reduce the removal of adenosine from extracellular compartment by endothelial cells and hence increase and prolong the cardioprotective effect of adenosine. hENT inhibitors should also inhibit the efflux of anti-cancer nucleoside drugs, that in turn increases the drug accumulation in the cancer cells, resulting in a higher efficacy. Some typical and clinically used hENT inhibitors have side effects which limit their uses. Emodin, an active ingredient in many herbs, has been proven to have cardioprotective and anti-tumor properties. However, the mechanisms are not fully understood. We hypothesized that these properties may relate to its interaction with nucleoside transporters. The aims of this study were to investigate the pharmacological effects of emodin on hENTs and its implications on vascular functions and anti-cancer therapy. Our result showed that emodin inhibited both hENT-1 and hENT-2 dose-dependently with no priority to any subtypes of hENTs. The inhibitory effect of emodin on hENTs was reversible and non-competitive, indicating that emodin may interact with the allosteric sites on hENTs. 1,8-dihdroxy-3-methyl anthraquinone, which is similar to emodin in terms of chemical structure but it lacks hydroxyl group at position 3, did not inhibit hENTs. It implied that the presence of 3-hydroxyl group was critical for the inhibitory effect of emodin. Our result also demonstrated that emodin reduced the lipopolysaccharide-induced expression of adhesion molecule in human umbilical vein endothelial cells, reflecting its anti-inflammatory effect. Emodin also enhanced the cytotoxic effect of gemcitabine in HepG2, a liver cancer cell line. Nevertheless, these effects may not be due to the inhibitory effect of emodin on hENTs and further investigation is required. DOI: 10.5353/th_b4852188 Subjects: Endothelial Nucleosides Cancer - Chemotherapy
Pharmacological Control Of Human Nucleoside Transporters In Endothelial And Cancer Cells By Emodin
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Author : Yuen-ting Lin
language : en
Publisher:
Release Date : 2012
Pharmacological Control Of Human Nucleoside Transporters In Endothelial And Cancer Cells By Emodin written by Yuen-ting Lin and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012 with Cancer categories.
Pharmacological Control Of Human Nucleoside Transporters In Endothelial And Cancer Cells By Emodin
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Author : Yuen-ting Lin
language : en
Publisher:
Release Date : 2012
Pharmacological Control Of Human Nucleoside Transporters In Endothelial And Cancer Cells By Emodin written by Yuen-ting Lin and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012 with Cancer categories.
Perspectives In Cellular Regulation
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Author : Judith Campisi
language : en
Publisher:
Release Date : 1991-06-06
Perspectives In Cellular Regulation written by Judith Campisi and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1991-06-06 with Science categories.
Provides excellent overviews highlighting the research results of leading scientists as well as young investigators in the field of cellular and molecular regulatory mechanisms. How each cell grows and develops at the appropriate time and place is thoroughly covered along with such issues as culturing the types of cells which represent excellent model systems for studies on tumor formation, proliferation and differentiation; cell cycle control; molecular control of DNA replication and repair and much more.
Botanical Medicine For Women S Health E Book
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Author : Aviva Romm
language : en
Publisher: Elsevier Health Sciences
Release Date : 2017-01-25
Botanical Medicine For Women S Health E Book written by Aviva Romm and has been published by Elsevier Health Sciences this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-01-25 with Medical categories.
Use herbal medicines to treat women at any stage of life! Botanical Medicine for Women’s Health, 2nd Edition provides an evidence-based, patient-centered approach to botanical interventions for many different medical conditions. More than 150 natural products are covered, showing their benefits in gynecologic health, fertility and childbearing, and menopausal health. This edition includes new full-color photos of herbal plants along with a discussion of the role of botanicals in healthy aging. Written by Aviva Romm, an experienced herbalist, midwife, and physician, this unique guide is an essential resource for everyday practice of herbal medicine. Winner of the 2010 American Botanical Council's James A. Duke Excellence in Botanical Literature Award! Current, evidence-based information covers more than 150 botanicals for over 35 different conditions. Case studies provide realistic scenarios and help you apply the content to the real world. Treatment and formula boxes summarize the most important information. Color illustrations and photographs of plants enable you to identify herbs visually as well as by substance make-up. Logical chapter organization begins with the principles of herbal medicine and then covers women’s health conditions organized chronologically by lifecycle, from teen and reproductive years to midlife and mature years. Appendices include practical, at-a-glance information on common botanical names, chemical constituents of medicinal plants, and a summary table of herbs for women's health. NEW! Updates reflect the latest research and the most current information. NEW Full-color design and detailed, professional color photos of plants make this a unique, essential resource. NEW! Coverage of the role of botanicals in healthy aging for women features phytoestrogens, Ayurvedic/Chinese herbs, and discussions of health promotion.
Drug Discovery Targeting Drug Resistant Bacteria
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Author : Prashant Kesharwani
language : en
Publisher: Academic Press
Release Date : 2020-05-29
Drug Discovery Targeting Drug Resistant Bacteria written by Prashant Kesharwani and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-05-29 with Business & Economics categories.
Drug Discovery Targeting Drug-Resistant Bacteria explores the status and possible future of developments in fighting drug-resistant bacteria. The book covers the majority of microbial diseases and the drugs targeting them. In addition, it discusses the potential targeting strategies and innovative approaches to address drug resistance. It brings together academic and industrial experts working on discovering and developing drugs targeting drug-resistant (DR) bacterial pathogens. New drugs active against drug-resistant pathogens are discussed, along with new strategies being used to discover molecules acting via new modes of action. In addition, alternative therapies such as peptides and phages are included. Pharmaceutical scientists, microbiologists, medical professionals, pathologists, researchers in the field of drug discovery, infectious diseases and microbial drug discovery both in academia and in industrial settings will find this book helpful. Written by scientists with extensive industrial experience in drug discovery Provides a balanced view of the field, including its challenges and future directions Includes a special chapter on the identification and development of drugs against pathogens which exhibit the potential to be used as weapons of war
Targeting Oral Cancer
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Author : Andrew Fribley
language : en
Publisher: Springer
Release Date : 2016-02-29
Targeting Oral Cancer written by Andrew Fribley and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-02-29 with Medical categories.
This book provides research-oriented care providers with up-to-date information on the oral cancer patient population, the ways in which we are treating them, and the scientific approaches being pursued in order to improve survival and reduce treatment-related morbidity. The text is organized into three sections covering epidemiology and management, cancer development and biomarkers, and breaking developments and novel approaches for drug discovery. The first section includes discussion of the emerging role of HPV in oral cancer and explains the surgical, chemotherapy and radiation approaches to treatment. Aspects such as molecular progression, the role of cancer stem cells in tumor development, and the value of various biomarkers are then examined. The final section is devoted to the latest advances and covers, among other topics, current clinical trials, emerging drug targets, and targeting of the unfolded protein response and of mediators of coagulation.
Stockley S Herbal Medicines Interactions
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Author : Elizabeth M. Williamson
language : en
Publisher:
Release Date : 2009
Stockley S Herbal Medicines Interactions written by Elizabeth M. Williamson and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009 with Dietary supplements categories.
This is a professional level major reference work containing information, in A-Z format, on herb-drug, herb-supplement, herb -food and herb-laboratory test interactions; all of which is data referenced. Commercial herbal medicinal products are increasingly consumed on a regular basis by people in the developed world. Often such products are taken concurrently with conventional medicines, frequently without the knowledge of health care professionals. As more evidence has become available, there has been an increasing awareness of the potential and actual problems of interactions, often dangerous, between conventional medicines and herbal medicines. This proposed new major reference brings together available data on approximately 200 of the most commonly used herbal medicines in highly structured, rigorously scientific monographs. Although our texts on herbal medicines and drug interactions include the major well-known interactions, this text is able to treat the subject in considerably more detail.
Encyclopedia Of Traditional Chinese Medicines Molecular Structures Pharmacological Activities Natural Sources And Applications
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Author : Jiaju Zhou
language : en
Publisher: Springer Science & Business Media
Release Date : 2011-02-21
Encyclopedia Of Traditional Chinese Medicines Molecular Structures Pharmacological Activities Natural Sources And Applications written by Jiaju Zhou and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-02-21 with Medical categories.
This set of six volumes provides a systematic and standardized description of 23,033 chemical components isolated from 6,926 medicinal plants, collected from 5,535 books/articles published in Chinese and international journals. A chemical structure with stereo-chemistry bonds is provided for each chemical component, in addition to conventional information, such as Chinese and English names, physical and chemical properties. It includes a name list of medicinal plants from which the chemical component was isolated. Furthermore, abundant pharmacological data for nearly 8,000 chemical components are presented, including experimental method, experimental animal, cell type, quantitative data, as well as control compound data. The seven indexes allow for complete cross-indexing. Regardless whether one searches for the molecular formula of a compound, the pharmacological activity of a compound, or the English name of a plant, the information in the book can be retrieved in multiple ways.
Metabotropic Gpcrs Tgr5 And P2y Receptors In Health And Diseases
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Author : Senthilkumar Rajagopal
language : en
Publisher: Springer
Release Date : 2018-11-19
Metabotropic Gpcrs Tgr5 And P2y Receptors In Health And Diseases written by Senthilkumar Rajagopal and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-11-19 with Medical categories.
This book will provide current understandings about two ubiquitously expressed metabotropic GPCRs, G-coupled purinoreceptor type 2 (P2Y) and Takeda G-protein-coupled bile acid receptor 5 (TGR5). G protein coupled receptors (GPCRs) are the largest family of proteins implicated in majority of cellular responses. The two receptor sub-families play a central role in many physiological functions as well as in many pathological conditions. This book offers up-to-date information on the physiological functions, signaling pathways and regulatory mechanisms of P2Y and TGR5 receptors. In addition, this book provides a comprehensive overview about the abnormalities of P2Y/TGR5 receptors and their contribution in the development and progression of pathological conditions. It also covers the currently available natural, chemical and pharmacological agents targeting these two receptor families and their therapeutic implications in P2Y and TGR5 associated disorders. This book is a valuable source for beginners and researchers to follow the rapidly progressing field of these two GPCR subfamily members.