Phospholipids Cellular Regulation

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Phospholipids Cellular Regulation

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Author : Jyh-Fa Kuo
language : en
Publisher: Springer
Release Date : 1985-01-29

Phospholipids Cellular Regulation written by Jyh-Fa Kuo and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 1985-01-29 with Medical categories.

Phospholipids And Cellular Regulation

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Author :
language : en
Publisher:
Release Date : 1985

Phospholipids And Cellular Regulation written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1985 with Cell membranes categories.

Cellular Regulation By Calcium Phospholipids And Cyclic Amp

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Author : American Society for Cell Biology
language : en
Publisher:
Release Date :

Cellular Regulation By Calcium Phospholipids And Cyclic Amp written by American Society for Cell Biology and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on with categories.

Molecular Mechanisms For The Cellular Regulation Of Ethanolamine Phospholipids By Ctp

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Author : University of Guelph. Department of Human Biology and Nutritional Sciences
language : en
Publisher:
Release Date : 2008

Molecular Mechanisms For The Cellular Regulation Of Ethanolamine Phospholipids By Ctp written by University of Guelph. Department of Human Biology and Nutritional Sciences and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008 with categories.

Chemical And Enzymatic Methods To Regulate Phospholipid Membrane Formation And Manipulate Cellular Mrna

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Author : Eric Cunyu Zhou
language : en
Publisher:
Release Date : 2020

Chemical And Enzymatic Methods To Regulate Phospholipid Membrane Formation And Manipulate Cellular Mrna written by Eric Cunyu Zhou and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020 with categories.

This dissertation first explores the use of photo-activated thiol-yne click chemistry methodology to gain access to phospho- and glycolipid analogs. Phospholipids and glycolipids constitute an essential part of biological membranes, and are of tremendous fundamental and practical interest. Unfortunately, the preparation of functional phospholipids, or synthetic analogs, is often synthetically challenging. We utilized thiol-yne click chemistry methodology to assemble the alkynyl hydrophilic head groups with numerous thiol modified lipid tails to yield the appropriate dithioether phospho- or glycolipids. The resulting structures closely resemble the structure and function of native diacylglycerolipids. Dithioether phosphatidylcholines (PCs) are suitable for forming giant unilamellar vesicles (GUV), which can be used as vessels for cell-free expression systems. The unnatural thioether linkages render the lipids resistant to phospholipase A2 hydrolysis. We utilized the improved stability of these lipids to control the shrinkage of GUVs composed of a mixture of 1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPC) and dioleyl-dithioether PC, and concentrating encapsulated nanoparticles. We imagine that these readily accessible lipids could find a number of applications as natural lipid substitutes. In the second investigation, this dissertation reports the development of a wash-free cellular mRNA imaging technology utilizing RNA-TAG (transglycosylation at guanine) methodology. The many roles of RNA in cellular regulation and function increasingly demand for tools to explore RNA tracking and localization within cells. Our recently reported RNA-TAG approach uses an RNA-modifying enzyme, tRNA-guanine transglycosylase, to accomplish covalent labeling of an RNA of interest with fluorescent tracking agents in a highly selective and efficient manner. Unfortunately, labeling by this method suffers from a high nonspecific fluorescent background and is unsuitable for imaging RNA within complex cellular environments. We designed and synthesized novel fluorogenic thiazole orange probes that significantly lower nonspecific binding and background fluorescence and, as a result, provide up to a 100-fold fluorescence intensity increase after labeling. Using these fluorogenic labeling agents, we were able to image mRNA expressed in Chinese Hamster Ovary cells in a wash-free manner. RNA-TAG methodology was also applied to the modification of therapeutically relevant modified mRNA (mod-mRNA). Mod-mRNA has recently been widely studied as the form of RNA useful for therapeutic applications due to its high stability and lowered immune response. As a proof of concept, we covalently attached a fluorescent probe to mCherry encoding mod-mRNA transcripts bearing 5-methylcytidine and/or pseudouridine substitutions with high labeling efficiencies. To provide a versatile labeling methodology with a wide range of possible applications, we employed a two-step strategy for functionalization of the mod-mRNA to highlight the therapeutic potential of this new methodology. We envision that this novel and facile labeling methodology of mod-RNA will have great potential in decorating both coding and noncoding therapeutic RNAs with a variety of diagnostic and functional moieties.

Phospholipid Metabolism In Cellular Signaling

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Author : Jose M. Mato
language : en
Publisher: CRC Press
Release Date : 2018-01-18

Phospholipid Metabolism In Cellular Signaling written by Jose M. Mato and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-01-18 with Medical categories.

Phospholipids are no longer considered exclusively as the building blocks of biomembranes, but are now regarded to be exceptionally important to cellular signalling.Another conclusion resulting from studies over the past several years is that no single general scheme for the role of phospholipids during cell activation can be drawn as representative of all cells. This book presents a comprehensive view of the recent advances made in certain major research areas within the field of phospholipid metabolism in cellular signalling. Topics discussed within this volume include lipid composition of cellular membranes and their organization in biological systems, the dynamic aspects of phospholipid metabolism and its regulation by extracellular stimuli, and the role of newly discovered glycosyl-phosphatidylinositols in insulin action . The book also discusses two biologically active phospholipids: the sphingolipids, and ether-linked glycerophospholipids (the platelet activating factor). Phospholipid Metabolism in Cellular Signaling is an important research reference that should be considered required reading by all scientists and graduate students working on cell activation (e.g., growth factors, hormones, and oncogenes).

Molecular Biology Of The Cell

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Author : Bruce Alberts
language : en
Publisher:
Release Date : 2002

Molecular Biology Of The Cell written by Bruce Alberts and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2002 with Cytology categories.

Epilipidome As A New Level Of Cellular Regulation

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Author : Maria Fedorova
language : en
Publisher: Frontiers Media SA
Release Date : 2022-04-27

Epilipidome As A New Level Of Cellular Regulation written by Maria Fedorova and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-04-27 with Medical categories.

Membrane Fluidity

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Author : Morris Kates
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06

Membrane Fluidity written by Morris Kates and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Science categories.

This book represents the proceedings of a Satellite Symposium of the XIth International Congress of Biochemistry on "Control of Membrane Fluidity" which was held on July 7, 1979 at the Charles H. Best Institute, University of Toronto, Toronto, Canada. The meeting was organized by M. Kates and A. Kuksis and was supported by the International Congress of Biochemistry. The purpose of the meeting was to review recent progress in many different areas of investigation bearing on the role of lipids in the structural and functional property of the cell membrane commonly referred to as fluidity. The aim was to emphasize the factors controlling membrane fluidity as studied in appropriate in vitro and in vivo experiments. The Symposium included invited review papers and short papers offered by discussants. In assem· bling the book no distinction has been made between the two types of presentations, nor has any significance been attached to the chronological order of their presentation in the Symposium. As a result it was possible to provide a much more coherent and continuous presentation than that available at the meeting.

Biochemistry Of Cellular Regulation The Cell Surface

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Author : Michael J. Clemens
language : en
Publisher:
Release Date : 1980

Biochemistry Of Cellular Regulation The Cell Surface written by Michael J. Clemens and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1980 with Cell physiology categories.