Physical And Biological Barriers At The Interface Between The Gut Microbiome And The Immune System
DOWNLOAD
Download Physical And Biological Barriers At The Interface Between The Gut Microbiome And The Immune System PDF/ePub or read online books in Mobi eBooks. Click Download or Read Online button to get Physical And Biological Barriers At The Interface Between The Gut Microbiome And The Immune System book now. This website allows unlimited access to, at the time of writing, more than 1.5 million titles, including hundreds of thousands of titles in various foreign languages. If the content not found or just blank you must refresh this page
Physical And Biological Barriers At The Interface Between The Gut Microbiome And The Immune System
DOWNLOAD
Author : Marika Falcone
language : en
Publisher: Springer Nature
Release Date : 2025-07-18
Physical And Biological Barriers At The Interface Between The Gut Microbiome And The Immune System written by Marika Falcone and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2025-07-18 with Medical categories.
The gut environment is fundamental to the modulation of innate and adaptive immunity, not only in the intestinal mucosa, but systemically. Immune cells constantly circulate through the intestinal tissue and gut-associated lymphoid tissue (GALT), where their phenotype and function are regulated by several factors, including but not limited to the commensal gut microbiota. The host-microbiome interaction, and the role of the gut microbiota in modulating innate and adaptive immunity in the intestinal mucosa and systemically, has been amply described in recent literature and reviews. This contributed volume instead explores the cutting-edge concept that gut microbiota composition is only one of the actors in intestinal immune regulation, and that several other factors -- both genetic and environmental -- modulate innate and adaptive immunity within the intestine. Each chapter in this volume addresses the various intestinal factors modulating immunity, including food components, endogenous metabolites, biological gut barrier components, and enteric neuroimmune circuits, individually and within the context of their integration with systemic components affecting immune cell phenotypes and function. In addition, it will more broadly address the role of the physical and biological barriers as key players in the interaction between immune cells and the intestinal environment, including coverage of cutting-edge in vivo technologies that have allowed the characterization of these interactions. The final chapters are dedicated to understanding how gut environment modifications are involved, and can be therapeutically manipulated in different diseases settings, including targeting the gut environment to regular response in anti-tumor immunity, fighting infections, and controlling autoimmune diseases.
The Role Of Physical And Biological Gut Barriers In Modulating Crosstalk Between The Microbiota And The Immune System
DOWNLOAD
Author : Marika Falcone
language : en
Publisher: Frontiers Media SA
Release Date : 2024-07-29
The Role Of Physical And Biological Gut Barriers In Modulating Crosstalk Between The Microbiota And The Immune System written by Marika Falcone and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-07-29 with Medical categories.
The intestine has several means for maintaining immune homeostasis and for avoiding inflammation despite massive antigenic stimulation by food components and by commensal bacteria residing in the gut mucosa. These mechanisms include physical and biological barriers such as (i) the intestinal epithelial barrier (IEB); (ii) the gut vascular barrier (GVB) and (iii) the mucus layer. In particular, the mucus layer does not simply act as a diffusion barrier but has important dynamic functions that regulate the type of commensal bacteria residing in the inner mucus layer, enabling the passage of food and bacterial products into the gut tissue and systemic circulation. Importantly, the mucosal layer also has key immune regulatory functions. A healthy mucus structure is fundamental for promoting the presence of beneficial commensal bacteria, such as the short-chain fatty acids (SCFA)-producing bacteria which are known to promote immune tolerance. Moreover, the mucus layer contains anti-microbial peptides (AMPs) and mucins that have key immune modulatory functions. The integrated response of these combined defense systems is fundamental for containing microbes and their products within the intestine; for avoiding their systemic spread and for suppressing their capacity to activate systemic immune and autoimmune responses.
Systems Biology In Brain Gut Axis Research
DOWNLOAD
Author : Chunhui Bao
language : en
Publisher: Frontiers Media SA
Release Date : 2023-05-31
Systems Biology In Brain Gut Axis Research written by Chunhui Bao and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-05-31 with Science categories.
Role Of Flavonoids In Chronic Metabolic Diseases
DOWNLOAD
Author : Neeraj Mishra
language : en
Publisher: John Wiley & Sons
Release Date : 2024-08-28
Role Of Flavonoids In Chronic Metabolic Diseases written by Neeraj Mishra and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-08-28 with Technology & Engineering categories.
This comprehensive volume covers the entire field of flavonoids by explaining their complex functions in reducing chronic metabolic illnesses, from the early stages of laboratory research to the development of therapeutic uses. Flavonoids are plant-based substances proven to have potential medical benefits in managing chronic metabolic disorders. This book explores concepts in laboratory research and therapeutic capabilities to enhance awareness of flavonoids in a medical context. The book begins with a thorough examination of the basic biochemical and molecular processes that underlie long-term metabolic disorders. It looks into these bioactive substances, from their natural origins to the synthesis of innovative derivatives. Analyzing both lab research and preclinical trials critically, it provides a solid basis for understanding the exciting opportunities flavonoids bring in treating metabolic diseases. The scope of this work extends beyond theoretical domains into clinical environments. It closes the gap between bench-side findings and bedside applications by revealing the translational potential of flavonoids. It is possible to understand the practical implications and future directions of flavonoid-based therapeutics through the synthesis of evidence-based clinical studies, therapeutic approaches, and possible healthcare issues. Readers will find the book: contains cutting-edge insights into metabolic disease research and delves into recent discoveries on the molecular mechanisms of flavonoids; facilitates a viewpoint into the findings of practical clinical implementations and the progression of flavonoid investigations from controlled experimental environments to prospective therapeutic interventions; explores the scientific effects of flavonoids on chronic metabolic disorders; presents evidence from human trials and epidemiological research on flavonoid clinical processes; encompasses various aspects of preventive measures for managing widespread metabolic diseases, containing dietary recommendations, lifestyle interventions, and the potential involvement of flavonoids; offers a comprehensive guide on how to effectively utilize flavonoids for therapeutic purposes. Audience This book is intended for researchers, scientists, clinicians/physicians, and public health professionals who work in pharmacology settings. The book is a vital tool for clinicians, nutritionists, and other healthcare professionals who are concerned about cutting-edge methods for dietary guidelines to gain an understanding of flavonoids and long-term metabolic disorders.
The Microbiome In Rheumatic Diseases And Infection
DOWNLOAD
Author : Gaafar Ragab
language : en
Publisher: Springer
Release Date : 2018-06-19
The Microbiome In Rheumatic Diseases And Infection written by Gaafar Ragab and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-06-19 with Medical categories.
This book discusses the role of the microbiome in rheumatic diseases and details its implications for patient treatment. Recently, with technological advances, there has been significant research into the microbiome. This has enabled us to more profoundly understand its role in our immune system maturation as well as the role played by microorganisms in autoimmunity and the deeply related rheumatic diseases. This book comprehensively explains the emerging microbiome research through the interrelationships of biomedical sciences, including: immunology, microbiology, bioinformatics, and, with special emphasis, the clinical aspect of rheumatology. It examines the interplay between infectious organisms and major autoimmune diseases, including rheumatoid arthritis, psoriatic arthritis, juvenile arthritis, systemic lupus erythematosus, and vasculitis, and explains how to apply that knowledge to diagnostic techniques and treatment decisions. The international team of expert authors provides insight into current therapies and future interventions specifically targeting the microbiota and explores the impact of our deeper understanding on enhancing personalized medicine. The Microbiome in Rheumatic Diseases and Infection is an essential resource for rheumatologists, pediatricians, internists, microbiologists, and critical care providers caring for children and adults with rheumatic diseases.
The Cell Biology Of Protist Parasite Host Interfaces
DOWNLOAD
Author : Carmen Faso
language : en
Publisher: Frontiers Media SA
Release Date : 2022-04-28
The Cell Biology Of Protist Parasite Host Interfaces written by Carmen Faso and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-04-28 with Science categories.
The Lung Microbiome
DOWNLOAD
Author : Michael J. Cox
language : en
Publisher: European Respiratory Society
Release Date : 2019-03-01
The Lung Microbiome written by Michael J. Cox and has been published by European Respiratory Society this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-03-01 with Medical categories.
Studying the lung microbiome requires a specialist approach to sampling, laboratory techniques and statistical analysis. This Monograph introduces the techniques used and discusses how respiratory sampling, 16S rRNA gene sequencing, metagenomics and the application of ecological theory can be used to examine the respiratory microbiome. It examines the different components of the respiratory microbiome: viruses and fungi in addition to the more frequently studied bacteria. It also considers a range of contexts from the paediatric microbiome and how this develops to disease of all ages including asthma and chronic obstructive pulmonary disease, chronic suppurative lung diseases, interstitial lung diseases, acquired pneumonias, transplantation, cancer and HIV, and the interaction of the respiratory microbiome and the environment.
Microbial Diversity Interventions And Scope
DOWNLOAD
Author : Shiwani Guleria Sharma
language : en
Publisher: Springer Nature
Release Date : 2020-06-25
Microbial Diversity Interventions And Scope written by Shiwani Guleria Sharma and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-06-25 with Science categories.
This book focuses on the application of microbes in all fields of biology. There is an urgent need to understand and explore new microbes, their biological activities, genetic makeup and further opportunities for utilizing them. The book is divided into sections, highlighting the application of microbes in agriculture, nanotechnology, genetic engineering, bioremediation, industry, medicine and forensic sciences, and describing potential future advances in these fields. It also explores the potential role of microbes in space and how they might support life on a different planet.
Microbial Endocrinology The Microbiota Gut Brain Axis In Health And Disease
DOWNLOAD
Author : Mark Lyte
language : en
Publisher: Springer
Release Date : 2014-07-05
Microbial Endocrinology The Microbiota Gut Brain Axis In Health And Disease written by Mark Lyte and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-07-05 with Science categories.
The field of microbial endocrinology is expressly devoted to understanding the mechanisms by which the microbiota (bacteria within the microbiome) interact with the host (“us”). This interaction is a two-way street and the driving force that governs these interactions are the neuroendocrine products of both the host and the microbiota. Chapters include neuroendocrine hormone-induced changes in gene expression and microbial endocrinology and probiotics. This is the first in a series of books dedicated to understanding how bi-directional communication between host and bacteria represents the cutting edge of translational medical research, and hopefully identifies new ways to understand the mechanisms that determine health and disease.
Nanotechnology And Regenerative Medicine
DOWNLOAD
Author : Maria H. Santana
language : en
Publisher: Academic Press
Release Date : 2022-11-24
Nanotechnology And Regenerative Medicine written by Maria H. Santana and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-11-24 with Science categories.
"Cell niches are present in several human body tissues as a dynamic microenvironment essential to modulate stem cells' behavior in health, under injury, and in regenerative processes. The interplay between stem cells and their niche is necessary for sustaining tissues. The extracellular matrix (ECM) is the crucial component of the stem cell. It defines the architectural space, physical binding to the cell membrane, and interactions with the neighborhood cells and supports physical stress. Domains with nano or micrometric sizes define the surface and topology of the ECM, mediating cell interactions and macrophage recruitment to injured sites. Over the last two decades, the integration of biomedicine with other engineering and biomaterial sciences promoted the development of nanotechnology and regenerative medicine toward mimicking the specialized stem cell niches to treat diseases with less invasive and efficient therapies. Innovative approaches in nanotechnology, such as targeting the immunological system, transporting drugs across blood–brain/BBB and blood–retinal barriers/BRB, directing active moiety to specific disease location/organs, encapsulation of multiple components, and promoting signalization and pathway-specific surfaces for cell interactions and growth, are indeed promising. On the other side, developments of biomaterial scaffolds to mimic the cell niches for interactions with stem cells in vitro or in vivo have tremendous potential. The three-dimensional printing technology offers a base for a wide array of applications, for example, developing tissue constructs, mimetic organs, organoids, and organ-on-a-chip, thus avoiding the differences between animal model species and humans. Aiming closer to the natural environments, fresh autologous products from the blood, such as platelet-rich plasma (PRP), contain platelets and leukocytes, providing growth factors, cytokines, and proteins for the resident stem cells in the stages of regeneration. PRP also provides pain relief, reducing disabilities in elderly or diseased people. This book brings thought-provoking multidisciplinary topics on the diverse aspects of basic and applied sciences. The prime focus of the compilation is to understand the challenges researchers encounter in combining nanotechnology and regenerative medicine, ultimately integrating both disciplines for the benefit of the patient and offering them a ray of hope to be cured. - Presents multi-disciplined knowledge on bench-to-bedside application of nanotechnology in regenerative medicines - Highlights the fundamentals, frontiers, limitations, and challenges faced by regenerative medicines - Exhibits synergy of biotechnology, nanomedicine, biomedicine, chemical-material engineering, pharmaceutical technology, and applied medical sciences in success of regenerative medicines