Polyamine Cell Signaling
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Polyamine Cell Signaling
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Author : Jian-Ying Wang
language : en
Publisher: Springer Science & Business Media
Release Date : 2007-11-19
Polyamine Cell Signaling written by Jian-Ying Wang and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-11-19 with Science categories.
Polyamines are organic cations found in all eukaryotic cells and intimately involved in, and required for, distinct biological functions. An increasing body of evidence indicates that the regulation of cellular polyamines is a central convergence point for the multiple signaling pathways driving various cellular functions. Over the last decade, considerable progress has been made in und- standing the molecular functions of cellular polyamines. These significant findings provide a fundamental basis to not only define the exact role of polyamines in physiology, but also to develop new therapeutic approaches for cancers and other diseases. The major objective of this book is to provide a timely and long lasting guide for investigators in the fields of polyamines, physiology, pharmacology, and cancer research. It will provide a foundation based on research and address the potential for subsequent applications in clinical practice. Polyamine Cell Signaling: Physiology, Pharmacology, and Cancer Research is divided into four main parts: Part I: Polyamines in Signal Transduction of Cell Proliferation Part II: Polyamines in Cellular Signaling of Apoptosis, Carcinogenesis, and Cancer Therapy Part III: Polyamines in Cell Motility and Cell–Cell Interactions Part IV: Polyamine Homeostasis and Transport This book not only covers the current state-of-the-art findings relevant to cellular and molecular functions of polyamines, but also provides the underlying conceptual basis and knowledge regarding potential therapeutic targeting of polyamines and polyamine metabolism. These points are addressed by int- nationally recognized experts in their contributions to this book.
Polyamines
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Author : Tomonobu Kusano
language : en
Publisher: Springer
Release Date : 2015-01-07
Polyamines written by Tomonobu Kusano and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-01-07 with Science categories.
This book covers key topics in polyamine research from a range of organisms, including plants, mammals, and prokaryotes such as bacteria and archaea. The book provides an introduction to general concepts in the field of polyamine research, as well as more detailed information. With the availability of genome sequence data from a broad range of organisms, the evolution of the genes involved in polyamine metabolism is discussed. The mode of action of polyamines has been shown to be dependent on cation channels, and this mechanism is described in the book. The origin of polyamine transporters (from bacteria, yeasts, and plants) is described. The various effects of polyamines on growth and survival are also documented. The book details the mechanisms of polyamine homeostasis and the role of polyamine molecules as precursors of secondary metabolites such as plant alkaloids and toxins derived from spiders and wasps. The role of polyamines in longevity and disease is discussed. A link between polyamine contents and cancer progression is reported, as is the use of polyamine metabolites as diagnostic markers in the initial stages of cancer. Moreover, a novel approach that utilizes the polyamine pathway of a parasite as a drug target in African sleeping sickness is described. Therefore, this book is a valuable resource, both as a textbook for undergraduate and graduate students and also as a reference book for front-line polyamine researchers.
Polyamine Metabolism In Disease And Polyamine Targeted Therapies
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Author : Tracy Murray-Stewart
language : en
Publisher: MDPI
Release Date : 2019-10-01
Polyamine Metabolism In Disease And Polyamine Targeted Therapies written by Tracy Murray-Stewart and has been published by MDPI this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-10-01 with Science categories.
Polyamines are ubiquitous polycations essential for all cellular life. The most common polyamines in eukaryotes, spermine, spermidine, and putrescine, exist in millimolar intracellular concentrations that are tightly regulated through biosynthesis, catabolism, and transport. Polyamines interact with, and regulate, negatively charged macromolecules, including nucleic acids, proteins, and ion channels. Accordingly, alterations in polyamine metabolism affect cellular proliferation and survival through changes in gene expression and transcription, translation, autophagy, oxidative stress, and apoptosis. Dysregulation of these multifaceted polyamine functions contribute to multiple disease processes, thus their metabolism and function have been targeted for preventive or therapeutic intervention. The correlation between elevated polyamine levels and cancer is well established, and ornithine decarboxylase, the rate-limiting biosynthetic enzyme in the production of putrescine, is a bona fide transcriptional target of the Myc oncogene. Furthermore, induced polyamine catabolism contributes to carcinogenesis that is associated with certain forms of chronic infection and/or inflammation through the production of reactive oxygen species. These and other characteristics specific to cancer cells have led to the development of polyamine-based agents and inhibitors aimed at exploiting the polyamine metabolic pathway for chemotherapeutic and chemopreventive benefit. In addition to cancer, polyamines are involved in the pathologies of neurodegenerative diseases including Alzheimer’s and Parkinson’s, parasitic and infectious diseases, wound healing, ischemia/reperfusion injuries, and certain age-related conditions, as polyamines are known to decrease with age. As in cancer, polyamine-based therapies for these conditions are an area of active investigation. With recent advances in immunotherapy, interest has increased regarding polyamine-associated modulation of immune responses, as well as potential immunoregulation of polyamine metabolism, the results of which could have relevance to multiple disease processes. The goal of this Special Issue of Medical Sciences is to present the most recent advances in polyamine research as it relates to health, disease, and/or therapy.
Polyamine Protocols
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Author : David M. L. Morgan
language : en
Publisher: Springer Science & Business Media
Release Date : 2008-02-02
Polyamine Protocols written by David M. L. Morgan and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-02-02 with Science categories.
A unique collection of hands-on enzyme assay techniques to study polyamines and their function. The techniques range from assay methods for enzymes of polyamine biosynthesis and catabolism to measurements of polyamines, polyamine transport, and polyamine effects on cell growth. The methods are presented by leading researchers who have perfected them to a high art, and include clear, step-by-step instructions with numerous hints and tips to ensure readily reproducible results.
Progress In Polyamine Research
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Author : V. Zappia
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Progress In Polyamine Research written by V. Zappia and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Science categories.
This book contains the scientific contributions presented at an International Symposium held in Sorrento, Italy, in June 1988 under the auspices of the University of Naples, the Italian Society of Biochemistry, and the National Research Council. The modern history of polyamines dates back to 1958 when the Tabors and Rosenthal first described the outlines of their biological synthesis. From then on, and particularly in the last ten years, a veri table explosion of Literature, characterized by thousands of papers, has witnessed the interest of the scientific community toward these molecules. Perhaps the old statement that "polyamines are molecules in search of a function" is no longer true today. A large number of effects exerted by these simple molecules are well known, and in many cases the mechanisms underlying these effects have been elucidated. The first section of the volume is entirely devoted to the enzymology and molecular biology of ornithine decarboxylase. Since its discovery by Gale more than forty years ago, this can be considered among the most widely studied enzymes in biology, and one of the most complex models in enzyme regulation. The mechanism of control of the enzyme activity at the transcriptional, post-transcriptional and post-translational levels, as well as the fine regulation by antizyme, are discussed in detail. The second group of contributions deals wi th AdoMet decarboxylase, propylamine transferase, polyamine oxidase and the other enzymes related to polyamine interconversion and regeneration.
Plant Polyamines In Stress And Development
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Author : Rubén Alcázar
language : en
Publisher: Frontiers E-books
Release Date : 2014-10-24
Plant Polyamines In Stress And Development written by Rubén Alcázar and has been published by Frontiers E-books this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-10-24 with Botany categories.
Polyamines are small aliphatic polycations which have been involved in key stress and developmental processes in plants. In the recent years, compelling genetic and molecular evidences point to polyamines as essential metabolites required for resistance to drought, freezing, salinity, oxidative stress among other type of abiotic and biotic stresses. In addition to their role as stress-protective compounds, polyamines participate in key developmental processes mediated by specific signaling pathways or in cross-regulation with other plant hormones. Our Research Topic aims to integrate the multiple stress and developmental regulatory functions of polyamines in plants under a genetic, molecular and evolutionary perspective with special focus on signaling networks, mechanisms of action and metabolism regulation.
Polyamines
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Author : Anthony E. Pegg
language : en
Publisher: Humana Press
Release Date : 2016-08-23
Polyamines written by Anthony E. Pegg and has been published by Humana Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-08-23 with Science categories.
Recently, important new findings in the polyamine field and a variety of new experimental systems have revolutionized the study of these ubiquitous cellular components, essential for normal growth and development. In Polyamines: Methods and Protocols, leading researchers contribute an extensive collection of up-to-date laboratory techniques for the further pursuit of polyamine study. The volume delves into vital subjects such as neoplasia studies with animal models and human patients, therapeutic roles for polyamine inhibitors and analogs, polyamine metabolism and oxidative damage, polyamines as regulators of critical ion channels, as well as polyamine transport systems and polyamine-responsive genes. Written in the highly successful Methods in Molecular BiologyTM series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and expert notes on troubleshooting and avoiding known pitfalls. Comprehensive and cutting-edge, Polyamines: Methods and Protocols provides a key resource for all scientists pursuing the study of this dynamic and significant aspect of cellular biology.
Polyamines In Plant Biotechnology Food Nutrition And Human Health
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Author : Rubén Alcázar
language : en
Publisher: Frontiers Media SA
Release Date : 2020-03-24
Polyamines In Plant Biotechnology Food Nutrition And Human Health written by Rubén Alcázar and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-03-24 with categories.
Plant Polyamines
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Author : Taku Takahashi
language : en
Publisher: MDPI
Release Date : 2020-06-17
Plant Polyamines written by Taku Takahashi and has been published by MDPI this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-06-17 with Science categories.
Polyamines are small organic compounds found in all living organisms. In recent years, there have been many exciting advances in our understanding of plant polyamines, such as the determination of the biosynthetic and catabolic pathways of plant polyamines and the identification of the roles that plant polyamines play in cellular processes. This Special Issue contains six original research papers and three review articles, providing valuable insights and information for future polyamine-related research.
Polyamines In Cancer
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Author : Kenji Nishioka
language : en
Publisher: Landes Bioscience
Release Date : 1996
Polyamines In Cancer written by Kenji Nishioka and has been published by Landes Bioscience this book supported file pdf, txt, epub, kindle and other format this book has been release on 1996 with Medical categories.