Polyamine Protocols
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Polyamine Protocols
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Author : David M. L. Morgan
language : en
Publisher: Springer Science & Business Media
Release Date : 2008-02-02
Polyamine Protocols written by David M. L. Morgan and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-02-02 with Science categories.
A unique collection of hands-on enzyme assay techniques to study polyamines and their function. The techniques range from assay methods for enzymes of polyamine biosynthesis and catabolism to measurements of polyamines, polyamine transport, and polyamine effects on cell growth. The methods are presented by leading researchers who have perfected them to a high art, and include clear, step-by-step instructions with numerous hints and tips to ensure readily reproducible results.
Polyamines
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Author : Anthony E. Pegg
language : en
Publisher: Humana Press
Release Date : 2011-04-06
Polyamines written by Anthony E. Pegg and has been published by Humana Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-04-06 with Science categories.
Recently, important new findings in the polyamine field and a variety of new experimental systems have revolutionized the study of these ubiquitous cellular components, essential for normal growth and development. In Polyamines: Methods and Protocols, leading researchers contribute an extensive collection of up-to-date laboratory techniques for the further pursuit of polyamine study. The volume delves into vital subjects such as neoplasia studies with animal models and human patients, therapeutic roles for polyamine inhibitors and analogs, polyamine metabolism and oxidative damage, polyamines as regulators of critical ion channels, as well as polyamine transport systems and polyamine-responsive genes. Written in the highly successful Methods in Molecular BiologyTM series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and expert notes on troubleshooting and avoiding known pitfalls. Comprehensive and cutting-edge, Polyamines: Methods and Protocols provides a key resource for all scientists pursuing the study of this dynamic and significant aspect of cellular biology.
Progress In Polyamine Research
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Author : V. Zappia
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Progress In Polyamine Research written by V. Zappia and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Science categories.
This book contains the scientific contributions presented at an International Symposium held in Sorrento, Italy, in June 1988 under the auspices of the University of Naples, the Italian Society of Biochemistry, and the National Research Council. The modern history of polyamines dates back to 1958 when the Tabors and Rosenthal first described the outlines of their biological synthesis. From then on, and particularly in the last ten years, a veri table explosion of Literature, characterized by thousands of papers, has witnessed the interest of the scientific community toward these molecules. Perhaps the old statement that "polyamines are molecules in search of a function" is no longer true today. A large number of effects exerted by these simple molecules are well known, and in many cases the mechanisms underlying these effects have been elucidated. The first section of the volume is entirely devoted to the enzymology and molecular biology of ornithine decarboxylase. Since its discovery by Gale more than forty years ago, this can be considered among the most widely studied enzymes in biology, and one of the most complex models in enzyme regulation. The mechanism of control of the enzyme activity at the transcriptional, post-transcriptional and post-translational levels, as well as the fine regulation by antizyme, are discussed in detail. The second group of contributions deals wi th AdoMet decarboxylase, propylamine transferase, polyamine oxidase and the other enzymes related to polyamine interconversion and regeneration.
Polyamines
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Author : Robert Anthony Casero
language : en
Publisher:
Release Date : 1995
Polyamines written by Robert Anthony Casero and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1995 with Medical categories.
Polyamine Drug Discovery
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Author : Patrick M. Woster
language : en
Publisher: Royal Society of Chemistry
Release Date : 2012
Polyamine Drug Discovery written by Patrick M. Woster and has been published by Royal Society of Chemistry this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012 with Medical categories.
This is the first comprehensive description of the discovery and therapeutic potential of polyamine drugs.
Polyamines In Biomedical Research
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Author : Joseph M. Gaugas
language : en
Publisher: John Wiley & Sons
Release Date : 1980
Polyamines In Biomedical Research written by Joseph M. Gaugas and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 1980 with Medical categories.
Advances In Polyamine Research
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Author : Advances in Polyamine Research Staff
language : en
Publisher:
Release Date :
Advances In Polyamine Research written by Advances in Polyamine Research Staff and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on with categories.
Polyamine Metabolism In Disease And Polyamine Targeted Therapies
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Author : Tracy Murray-Stewart
language : en
Publisher: MDPI
Release Date : 2019-10-01
Polyamine Metabolism In Disease And Polyamine Targeted Therapies written by Tracy Murray-Stewart and has been published by MDPI this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-10-01 with Science categories.
Polyamines are ubiquitous polycations essential for all cellular life. The most common polyamines in eukaryotes, spermine, spermidine, and putrescine, exist in millimolar intracellular concentrations that are tightly regulated through biosynthesis, catabolism, and transport. Polyamines interact with, and regulate, negatively charged macromolecules, including nucleic acids, proteins, and ion channels. Accordingly, alterations in polyamine metabolism affect cellular proliferation and survival through changes in gene expression and transcription, translation, autophagy, oxidative stress, and apoptosis. Dysregulation of these multifaceted polyamine functions contribute to multiple disease processes, thus their metabolism and function have been targeted for preventive or therapeutic intervention. The correlation between elevated polyamine levels and cancer is well established, and ornithine decarboxylase, the rate-limiting biosynthetic enzyme in the production of putrescine, is a bona fide transcriptional target of the Myc oncogene. Furthermore, induced polyamine catabolism contributes to carcinogenesis that is associated with certain forms of chronic infection and/or inflammation through the production of reactive oxygen species. These and other characteristics specific to cancer cells have led to the development of polyamine-based agents and inhibitors aimed at exploiting the polyamine metabolic pathway for chemotherapeutic and chemopreventive benefit. In addition to cancer, polyamines are involved in the pathologies of neurodegenerative diseases including Alzheimer’s and Parkinson’s, parasitic and infectious diseases, wound healing, ischemia/reperfusion injuries, and certain age-related conditions, as polyamines are known to decrease with age. As in cancer, polyamine-based therapies for these conditions are an area of active investigation. With recent advances in immunotherapy, interest has increased regarding polyamine-associated modulation of immune responses, as well as potential immunoregulation of polyamine metabolism, the results of which could have relevance to multiple disease processes. The goal of this Special Issue of Medical Sciences is to present the most recent advances in polyamine research as it relates to health, disease, and/or therapy.
Function Of Naturally Occurring Polyamines
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Author : Uriel Bachrach
language : en
Publisher:
Release Date : 1973
Function Of Naturally Occurring Polyamines written by Uriel Bachrach and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1973 with Science categories.
The Physiology Of Polyamines
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Author : Uriel Bachrach
language : en
Publisher: CRC Press
Release Date : 1989-03-31
The Physiology Of Polyamines written by Uriel Bachrach and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1989-03-31 with Science categories.
The area of polyamines is presented in this useful, two-volume publication. Basic information describing the role of polyamines in the processes of growth and differentiation is given. Also included are data on the regulation of polyamine biosynthesis and metabolism and their interactions with nucleic acids. Several chapters are devoted to the role of polyamines in various aspects of plant biology, with a special emphasis on their participation in the response of plants to extreme environments. Special attention is given to the use of inhibitors of polyamine biosynthesis as potential antitumor and antiproliferative agents. Additionally, progress in the molecular biology and genetic engineering of genes coding for polyamine biosynthetic enzymes is described. Cancer researchers, biologists, geneticists, biochemists, physiologists, and clinicians will find this volume indispensable.