Polymorphism In Molecular Crystals
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Polymorphism In Molecular Crystals
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Author : Joel Bernstein
language : en
Publisher: OUP Oxford
Release Date : 2002-05-17
Polymorphism In Molecular Crystals written by Joel Bernstein and has been published by OUP Oxford this book supported file pdf, txt, epub, kindle and other format this book has been release on 2002-05-17 with Science categories.
Polymorphism - the multiplicity of structures or forms - is a term that is used in many disciplines. In chemistry it refers to the existence of more than one crystal structure for a particular chemical substance. The properties of a substance are determined by its composition and by its structure. In the last two decades, there has been a sharp rise in the interest in polymorphic systems, as an intrinsically interesting phenomenon and as an increasingly important component in the development and marketing of a variety of materials based on organic molecules (e.g. pharmaceuticals, dyes and pigments, explosives, etc.). This book summarizes and brings up to date the current knowledge and understanding of polymorphism of molecular crystals, and concentrates it in one comprehensive source. The book will be an invaluable reference for students, researchers, and professionals in the field.
Polymorphism In Molecular Crystals
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Author : Barta
language : en
Publisher: Oxford University Press, USA
Release Date : 2023-04-27
Polymorphism In Molecular Crystals written by Barta and has been published by Oxford University Press, USA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-04-27 with Political Science categories.
Most people are familiar with the fact that diamond and graphite are both composed only of carbon; yet they have very different properties which result from the very different structures of the two solids - they are polymorphs of carbon. Understanding the relationship between the structures and the properties of materials is of fundamental importance in developing and producing new materials with improved or new properties. The existence of polymorphic systems allows the direct study of the connection between structures and properties. This book provides grounding on the fundamental structural and energetic basis for polymorphism, the preparation and characterization of polymorphic substances and its importance in the specific areas of pharmaceuticals, pigments and high energy (explosive) materials. The closing chapter describes the intellectual property implications and some of the precedent patent litigations in which polymorphism has played a central role. The book contains over 2500 references to provide a ready entry into the relevant literature.
Advances In Organic Crystal Chemistry
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Author : Rui Tamura
language : en
Publisher: Springer
Release Date : 2015-08-06
Advances In Organic Crystal Chemistry written by Rui Tamura and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-08-06 with Science categories.
For the last decade, the topics of organic crystal chemistry have become diversified, and each topic has been substantially advanced in concert with the rapid development of various analytical and measurement techniques for solid-state organic materials. The aim of this book is to systematically summarize and record the recent notable advances in various topics of organic crystal chemistry involving liquid crystals and organic–inorganic hybrid materials that have been achieved mainly in the last 5 years or so. The authors are invited members of the Division of Organic Crystals, The Chemical Society of Japan (CSJ), and prominent invited experts from abroad. This edited volume is planned to be published periodically, at least every 5 years, with contributions by prominent authors in Japan and from abroad.
Polymorphism In The Pharmaceutical Industry
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Author : Rolf Hilfiker
language : en
Publisher: John Wiley & Sons
Release Date : 2019-01-04
Polymorphism In The Pharmaceutical Industry written by Rolf Hilfiker and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-01-04 with Science categories.
"Polymorphism in the Pharmaceutical Industry - Solid Form and Drug Development" highlights the relevance of polymorphism in modern pharmaceutical chemistry, with a focus on quality by design (QbD) concepts. It covers all important issues by way of case studies, ranging from properties and crystallization, via thermodynamics, analytics and theoretical modelling right up to patent issues. As such, the book underscores the importance of solid-state chemistry within chemical and pharmaceutical development. It emphasizes why solid-state issues are important, the approaches needed to avoid problems and the opportunities offered by solid-state properties. The authors include true polymorphs as well as solvates and hydrates, while providing information on physicochemical properties, crystallization thermodynamics, quantum-mechanical modelling, and up-scaling. Important analytical tools to characterize solid-state forms and to quantify mixtures are summarized, and case studies on solid-state development processes in industry are also provided. Written by acknowledged experts in the field, this is a high-quality reference for researchers, project managers and quality assurance managers in pharmaceutical, agrochemical and fine chemical companies as well as for academics and newcomers to organic solid-state chemistry.
The Crystalline States Of Organic Compounds
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Author : Angelo Gavezzotti
language : en
Publisher: Elsevier
Release Date : 2021-11-25
The Crystalline States Of Organic Compounds written by Angelo Gavezzotti and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-11-25 with Science categories.
The Crystalline States of Organic Compounds is a broad survey of the techniques by which molecular crystals are investigated, modeled, and applied, starting with the fundamentals of intra- and intermolecular bonding supplemented by a concise tutorial on present-day diffraction methods, then proceeding to an examination of crystallographic databases with their statistics and of such fundamental and fast-growing topics as intermolecular potentials, polymorphism, co-crystallization, and crystal structure prediction by computer. A substantial part of the book is devoted to the techniques of choice in modern simulation, Monte Carlo and molecular dynamics, with their most recent developments and application to formed crystals and to the concomitant phases involved in nucleation and growth. Drawing on the decades-long experience of its author in teaching and research in the field of organic solid state, The Crystalline States of Organic Compounds is an indispensable source of key insights and future directions for students and researchers at any level, in academia and in industry. Condenses theoretical information and practical methods in a single resource Provides a guide on the use of crystallographic databases, structure statistics, and molecular simulations Includes a large number of worked examples and tutorials, with extensive graphics and multimedia
Crystallization Of Lipids
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Author : Kiyotaka Sato
language : en
Publisher: John Wiley & Sons
Release Date : 2018-04-23
Crystallization Of Lipids written by Kiyotaka Sato and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-04-23 with Technology & Engineering categories.
An authoritative reference that contains the most up-to-date information knowledge, approaches, and applications of lipid crystals Crystallization of Lipids is a comprehensive resource that offers the most current and emerging knowledge, techniques and applications of lipid crystals. With contributions from noted experts in the field, the text covers the basic research of polymorphic structures, molecular interactions, nucleation and crystal growth and crystal network formation of lipid crystals which comprise main functional materials employed in food, cosmetic and pharmaceutical industry. The authors highlight trans-fat alternative and saturated-fat reduction technology to lipid crystallization. These two issues are the most significant challenges in the edible-application technology of lipids, and a key solution is lipid crystallization. The text focuses on the crystallization processes of lipids under various external influences of thermal fluctuation, ultrasound irradiation, shear, emulsification and additives. Designed to be practical, the book’s information can be applied to realistic applications of lipids to foods, cosmetic and pharmaceuticals. This authoritative and up-to-date guide: Highlights cutting-edge research tools designed to help analyse lipid crystallization with the most current and the conventional techniques Offers a thorough review of the information, techniques and applications of lipid crystals Includes contributions from noted experts in the field of lipid crystals Presents cutting-edge information on the topics of trans-fat alterative and saturated-fat reduction technology Written for research and development technologists as well as academics, this important resource contains research on lipid crystals which comprise the main functional materials employed in food, cosmetic and pharmaceutical industry.
Pharmaceutical Crystals
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Author : Tonglei Li
language : en
Publisher: John Wiley & Sons
Release Date : 2018-09-03
Pharmaceutical Crystals written by Tonglei Li and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-09-03 with Science categories.
An important resource that puts the focus on understanding and handling of organic crystals in drug development Since a majority of pharmaceutical solid-state materials are organic crystals, their handling and processing are critical aspects of drug development. Pharmaceutical Crystals: Science and Engineering offers an introduction to and thorough coverage of organic crystals, and explores the essential role they play in drug development and manufacturing. Written contributions from leading researchers and practitioners in the field, this vital resource provides the fundamental knowledge and explains the connection between pharmaceutically relevant properties and the structure of a crystal. Comprehensive in scope, the text covers a range of topics including: crystallization, molecular interactions, polymorphism, analytical methods, processing, and chemical stability. The authors clearly show how to find solutions for pharmaceutical form selection and crystallization processes. Designed to be an accessible guide, this book represents a valuable resource for improving the drug development process of small drug molecules. This important text: Includes the most important aspects of solid-state organic chemistry and its role in drug development Offers solutions for pharmaceutical form selection and crystallization processes Contains a balance between the scientific fundamental and pharmaceutical applications Presents coverage of crystallography, molecular interactions, polymorphism, analytical methods, processing, and chemical stability Written for both practicing pharmaceutical scientists, engineers, and senior undergraduate and graduate students studying pharmaceutical solid-state materials, Pharmaceutical Crystals: Science and Engineering is a reference and textbook for understanding, producing, analyzing, and designing organic crystals which is an imperative skill to master for anyone working in the field.
Polymorphism In Molecular Crystals 2e
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Author : Joel Bernstein
language : en
Publisher: International Union of Crystal
Release Date : 2020-05-14
Polymorphism In Molecular Crystals 2e written by Joel Bernstein and has been published by International Union of Crystal this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-05-14 with Science categories.
Most people are familiar with the fact that diamond and graphite are both composed only of carbon; yet they have very different properties which result from the very different structures of the two solids - they are polymorphs of carbon. Understanding the relationship between the structures and the properties of materials is of fundamental importance in developing and producing new materials with improved or new properties. The existence of polymorphic systems allows the direct study of the connection between structures and properties. This book provides grounding on the fundamental structural and energetic basis for polymorphism, the preparation and characterization of polymorphic substances and its importance in the specific areas of pharmaceuticals, pigments and high energy (explosive) materials. The closing chapter describes the intellectual property implications and some of the precedent patent litigations in which polymorphism has played a central role. The book contains over 2500 references to provide a ready entry into the relevant literature.
Strength From Weakness Structural Consequences Of Weak Interactions In Molecules Supermolecules And Crystals
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Author : Aldo Domenicano
language : en
Publisher: Springer Science & Business Media
Release Date : 2002-06-30
Strength From Weakness Structural Consequences Of Weak Interactions In Molecules Supermolecules And Crystals written by Aldo Domenicano and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2002-06-30 with Science categories.
Proceedings of the NATO Advanced Research Workshop on Physical-Chemical Properties from Weak Interactions, held in Erice, Italy, from 23 to 29 May 2001
Molecular Networks
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Author : Mir Wais Hosseini
language : en
Publisher: Springer Science & Business Media
Release Date : 2009-06-29
Molecular Networks written by Mir Wais Hosseini and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-06-29 with Science categories.
In the future, many modern materials will be increasingly based on the assembly of preformed molecular entities. Their structural characteristics and functional prop- ties will be programmed at the molecular level and their formation as a completed entity will be achieved by self-assembly processes. This in essence is a bottom-up approach and its success will require a deep understanding not only of the chemistry of intermolecular interactions and associations but also of self-assembly processes in the condensed phase. Among various interesting innovations brought about by the development of supramolecular chemistry, supramolecular synthesis is a part- ularly powerful approach for the design and generation of molecular architectures displaying both structural and functional complexity. The combination of mol- ular synthesis (which allows chemists to design and prepare extremely sophis- cated biotic and abiotic molecules through the interconnection of atoms or group of atoms by strong covalent bonds) and supramolecular synthesis (which orch- trates the association of molecules by recognition processes through the use of weak and reversible interactions) opens up endless structural and functional possibilities. Following the perceptive observation by Dunitz that "A crystal is, in a sense, the supramolecule par excellence", molecular crystals may be seen as in'nite periodic architectures resulting from the interconnection of building blocks or tectons ca- ble of self-assembling through speci'c recognising events.