Posterior Migration Guidance In Caenorhabditis Elegans
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Posterior Migration Guidance In Caenorhabditis Elegans
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Author : Frederick William Wolf
language : en
Publisher:
Release Date : 1998
Posterior Migration Guidance In Caenorhabditis Elegans written by Frederick William Wolf and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1998 with categories.
Anterior Posterior Guidance Of Embryonic Cell Migrations In Caenorhabditis Elegans
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Author : Tinya Christina Fleming
language : en
Publisher:
Release Date : 2004
Anterior Posterior Guidance Of Embryonic Cell Migrations In Caenorhabditis Elegans written by Tinya Christina Fleming and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2004 with categories.
Wnts Are Guidance Cues In Anterior Posterior Neuronal Migration
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Author : James Endres Howell
language : en
Publisher:
Release Date : 2005
Wnts Are Guidance Cues In Anterior Posterior Neuronal Migration written by James Endres Howell and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2005 with categories.
An Investigation Of The Signaling Pathways That Control Cell Migration And Axon Guidance In Caenorhabditis Elegans
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Author : Mark Stephan Lucanic
language : en
Publisher:
Release Date : 2007
An Investigation Of The Signaling Pathways That Control Cell Migration And Axon Guidance In Caenorhabditis Elegans written by Mark Stephan Lucanic and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007 with categories.
Mig 2 A Rho Family Gtpase Involved In Cell Migration And Axon Guidance In The Nematode Caenorhabditis Elegans
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Author : Ilan David Zipkin
language : en
Publisher:
Release Date : 1997
Mig 2 A Rho Family Gtpase Involved In Cell Migration And Axon Guidance In The Nematode Caenorhabditis Elegans written by Ilan David Zipkin and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1997 with Axons categories.
The Unc 53 Mediated Interactome
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Author : Amita Pandey
language : en
Publisher: Springer
Release Date : 2014-07-05
The Unc 53 Mediated Interactome written by Amita Pandey and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-07-05 with Medical categories.
This book gives an overview of various interactomes involved in dorsal ventral (DV) and anterior posterior (AP) guidance, their mechanisms of action, subcellular localizations, and functional roles. It will provide readers a better understanding of the development of the nervous system, which in turn will help to find cures to various neural and other disorders. In nematodes there are two types of guidance systems, including DV and AP guidance. The signaling process that guides the growth cones along the DV axis has remained intact in both vertebrates and invertebrates. The adaptor protein UNC-53 appears to play a part in migration along the AP axis in both worms and their human homologs. “Neuron Navigators” (NAV) are also involved in nervous system development
Distinct Cell Guidance Pathways Control The Extension Of The Excretory Canals In C Elegans
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Author : Nancy Marcus
language : en
Publisher:
Release Date : 2012
Distinct Cell Guidance Pathways Control The Extension Of The Excretory Canals In C Elegans written by Nancy Marcus and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012 with Actin categories.
The excretory cell is the functional equivalent to the kidney in the nematode Caenorhabditis elegans, and provides an excellent in vivo model to study directional cell migration and extension. The leading edges of the growing canals resemble neuronal growth cones in that they must be able to sense and integrate directional cues in both the dorsoventral and anteroposterior axes. The cytoskeleton regulator UNC-53/NAV2 is required for both the anterior and posterior outgrowth of several neurons, as well as the excretory cell. UNC-53 and the Abelson kinase interactor (ABI-1) appear to function cell autonomously in the excretory canals to promote outgrowth, have overlapping expression patterns, and display similar cell migration phenotypes in the canals and mechanosensory neurons. Moreover, proteins known to function with abi-1 in actin dynamics, including members of the ARP2/3 complex exhibit similar excretory cell and neuronal outgrowth defects by RNAi, suggesting that UNC-53 may act as a scaffold that links ABI-1 to the ARP2/3 complex to regulate actin cytoskeleton remodelling. Genetic analysis of putative interactors of UNC-53 suggests that UNC-53 appears to function together with UNC-71/ADAM, while the kinesin-like motor VAB-8 appears to act in a separate pathway to control the posteriorly directed excretory canal outgrowth. Analysis of putative interactors of VAB-8 suggests that VAB-8, SAX-3/ROBO, SLT-1/Slit and EVA-1 are functioning together in the outgrowth of the excretory canals. The known VAB-8 interactor, the Rac/Rho GEF UNC-73/TRIO operates in both pathways, as isoform specific alleles exhibit enhancement of the phenotype in double mutant combination with either unc-53 or vab-8. Rescue experiments suggest that a cell autonomous pathway is mediated by the Rho specific GEF domain of the UNC-73E isoform in conjunction with UNC-53, UNC-71, and ABI-1, and a cell non-autonomous pathway is mediated by the Rac specific GEF domain of the UNC-73B isoform, through partnering with VAB-8 and the receptors SAX-3 and EVA-1. Taken together, my studies indicate that the migration of the excretory canals requires two or more signaling pathways, and the guidance cues involved are also essential migration molecules functioning to guide neuronal cells and axon growth cones.
C Elegans Ii
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Author : Donald L. Riddle
language : en
Publisher: Firefly Books
Release Date : 1997
C Elegans Ii written by Donald L. Riddle and has been published by Firefly Books this book supported file pdf, txt, epub, kindle and other format this book has been release on 1997 with Medical categories.
Defines the current status of research in the genetics, anatomy, and development of the nematode C. elegans, providing a detailed molecular explanation of how development is regulated and how the nervous system specifies varied aspects of behavior. Contains sections on the genome, development, neural networks and behavior, and life history and evolution. Appendices offer genetic nomenclature, a list of laboratory strain and allele designations, skeleton genetic maps, a list of characterized genes, a table of neurotransmitter assignments for specific neurons, and information on codon usage. Includes bandw photos. For researchers in worm studies, as well as the wider community of researchers in cell and molecular biology. Annotation copyrighted by Book News, Inc., Portland, OR
Building Brains
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Author : David J. Price
language : en
Publisher: John Wiley & Sons
Release Date : 2011-07-22
Building Brains written by David J. Price and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-07-22 with Medical categories.
The development of a brain from its simple beginnings in the embryo to the extraordinarily complex fully-functional adult structure is a truly remarkable process. Understanding how it occurs remains a formidable challenge despite enormous advances over the last century and current intense world-wide scientific research. A greater knowledge of how nervous systems construct themselves will bring huge benefits for human health and future technologies. Unravelling the mechanisms that lead to the development of healthy brains should help scientists tackle currently incurable diseases of the nervous system such as autism, epilepsy and schizophrenia (to name but a few), discover more about the processes that cause the uncontrolled growth associated with cancer and develop possible treatments. Building Brains provides a highly visual and readily accessible introduction to the main events that occur during neural development and the mechanisms by which they occur. Aimed at undergraduate students and postgraduates new to the field, who may not have a background in neuroscience and/or molecular genetics, it explains how cells in the early embryo first become neural, how their proliferation is controlled, what regulates the types of neural cells they become, how neurons connect to each other, how these connections are later refined under the influence of neural activity including that arising from experience, and why some neurons normally die. Key Features: A concise illustrated guide focusing on the core elements of current understanding of neural development, emphasising common principles underlying developmental mechanisms and supplemented by suggestions for further reading. Text boxes throughout provide further detail on selected major advances, issues of particular uncertainty or controversy and examples of human diseases that result from abnormal development. A balanced mammalian/non-mammalian perspective, drawing on examples from model organisms including the fruit fly, nematode worm, frog, zebrafish, chick, mouse, ferret, cat, monkey and human, and emphasising mechanisms that are conserved across species. Introduces the methods for studying neural development including genetics, transgenic technologies, advanced microscopy and computational modeling, allowing the reader to understand the main evidence underlying research advances. Student-friendly, full colour artwork reinforces important concepts; an extensive glossary and definitions in page margins help readers from different backgrounds; chapter summaries stress important points and aid revision. Associated Website includes a complete set of figures from the textbook.
Axon Growth And Guidance
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Author : Dominique Bagnard
language : en
Publisher: Springer Science & Business Media
Release Date : 2008-12-10
Axon Growth And Guidance written by Dominique Bagnard and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-12-10 with Medical categories.
This book proposes an updated view of the current knowledge of the molecular and cellular mechanisms ensuring axon growth and guidance. The introductory chapter will remind the readers of all the features of a growth cone and the mechanisms controlling its growth. From there, one enters a fabulous journey with a growth cone, a Tom Thumb story filled with molecular encounters and complex interactions leading to one of the most fantastic developmental achievements: the nervous system wiring.