Potassium Channels As A Target For Clinical Therapeutics


Potassium Channels As A Target For Clinical Therapeutics
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Potassium Channels As A Target For Clinical Therapeutics


Potassium Channels As A Target For Clinical Therapeutics
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Author : Ivan Kocić
language : en
Publisher: Bentham Science Publishers
Release Date : 2012-04-12

Potassium Channels As A Target For Clinical Therapeutics written by Ivan Kocić and has been published by Bentham Science Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-04-12 with Medical categories.


"This e-book presents an overview of the different substances capable of modulating potassium channels in relation to various clinical indications in cardiology, pulmonology, endocrinology and neurology. The possible benefits and side effects of potassium "



Potassium Channels And Their Modulators


Potassium Channels And Their Modulators
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Author : John M Evans
language : en
Publisher: CRC Press
Release Date : 2003-09-02

Potassium Channels And Their Modulators written by John M Evans and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2003-09-02 with Science categories.


Potassium ions K+ ions are vital in physiological processes, particularly with regard to the cardiovascular system. Modulators influence the channels through which these ions flow and the research into modulator drugs of these channels is the subject of rapidly-advancing research. This work is intended to be of use as a tool for those working in the pharmaceutical industry. Early chapters concentrate on the synthesis and structure-activity relationships of potassium channel modulators. These are followed by discussion on the application of these drugs to different target organs, such as the cardiovascular system and the airways. The book concludes with a broad overview of clinical experience and future prospects.; The authors show how potassium channel activators and potassium channel blockers each have a role to play as therapeutic agents for many disorders, including asthma and respiratory tract disorders, diseases of the central nervous system such as epilepsy, and vascular diseases such as angina, peripheral vascular disease and high blood pressure. This book should therefore also be of interest to those researching into this wide range of diseases.



Pharmacology Of Potassium Channels


Pharmacology Of Potassium Channels
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Author : Nikita Gamper
language : en
Publisher: Springer Nature
Release Date : 2021-09-27

Pharmacology Of Potassium Channels written by Nikita Gamper and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-09-27 with Medical categories.


The aim of the present book is to comprehensively review current advances in understanding of genetics, structural biology, pharmacology of potassium channels and their roles in disease as well as to identify current gaps in knowledge. The ultimate goal is to provide a scientific foundation for better understanding of modulatory mechanisms and pharmacology of potassium channels and to use this understanding to drive future drug discovery. This book will be a must-have for academic and industrial scientists interested in physiology, pharmacology, pathology and structure-functional relationships of ion channels. The book will also be helpful for lecturers and students in the college and university classrooms, as well as for anyone interested in the state-of-the art in modern cell biology, physiology and pharmacology.



Potassium Channels


Potassium Channels
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Author : Nigel S. Cook
language : en
Publisher: Ellis Horwood
Release Date : 1990

Potassium Channels written by Nigel S. Cook and has been published by Ellis Horwood this book supported file pdf, txt, epub, kindle and other format this book has been release on 1990 with Ion channels categories.




Ion Channels As Targets In Drug Discovery


Ion Channels As Targets In Drug Discovery
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Author : Gary Stephens
language : en
Publisher: Springer Nature
Release Date :

Ion Channels As Targets In Drug Discovery written by Gary Stephens and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on with categories.




Potassium Channel Modulators


Potassium Channel Modulators
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Author : AH Weston
language : en
Publisher: Wiley-Blackwell
Release Date : 1993-01-18

Potassium Channel Modulators written by AH Weston and has been published by Wiley-Blackwell this book supported file pdf, txt, epub, kindle and other format this book has been release on 1993-01-18 with Medical categories.


Modulation of potassium channels plays a very important part in nerve cell function in the autonomic nervous system. Compounds are now in development which can open or close potassium channels and will have numerous therapeutic applications. The major areas of clinical relevance will be hypertension, asthma and irritable bladder syndrome. The book describes the pharmacology of the channels and strategies for the design of drugs which exploit them. It consists of 17 chapters by international experts in the field which are written at a high level and will be of interest to pharmacologists and those in related clinical research disciplines



Ion Channels And Their Inhibitors


Ion Channels And Their Inhibitors
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Author : Satya Prakash Gupta
language : en
Publisher: Springer Science & Business Media
Release Date : 2011-06-21

Ion Channels And Their Inhibitors written by Satya Prakash Gupta and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-06-21 with Science categories.


Being the crucial components of living cells, ion channels are important targets of therapeutic agents. Historically, it has been challenging to develop drugs on this target class. A major issue with target based ion channel drug development is the identification of effective small chemical leads for medicinal chemistry optimization to the clinical candidate status. Thus enough attention has been paid to the study of structure and functions of ion channels and their potential inhibitors. The present book compiles important chapters authored by eminent workers in the field to cover important recent advances in the studies of the structure and functions of ion channels and their inhibitors, such as sodium ion, potassium ion, chloride ion, calcium ion channel inhibitors. The book may be of great use to the students and scientists working in the area of molecular biology, biochemistry, physiology, neurobiology, and medicinal chemistry.



Voltage Gated Ion Channels As Drug Targets


Voltage Gated Ion Channels As Drug Targets
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Author : David J. Triggle
language : en
Publisher: John Wiley & Sons
Release Date : 2006-08-21

Voltage Gated Ion Channels As Drug Targets written by David J. Triggle and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006-08-21 with Science categories.


Edited by the most prominent person in the field and top researchers at US pharmaceutical companies, this is a unique resource for drug developers and physiologists seeking a molecular-level understanding of ion channel pharmacology. After an introduction to the topic, the authors evaluate the structure and function of ion channels, as well as related drug interaction. A section on assay technologies is followed by a section each on calcium, sodium and potassium channels. Further chapters cover genetic and acquired channelopathies, before the book closes with a look at safety issues in ion channel drug development. For medicinal and pharmaceutical chemists, biochemists, molecular biologists and those working in the pharmaceutical industry.



Ion Channel Drug Discovery


Ion Channel Drug Discovery
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Author : Brian Cox
language : en
Publisher: Royal Society of Chemistry
Release Date : 2014-09-24

Ion Channel Drug Discovery written by Brian Cox and has been published by Royal Society of Chemistry this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-09-24 with Medical categories.


A rapidly growing field, this book covers the recent advances in screening technology, ion channel structure and modelling, with up-to-date case histories.



Ion Channels As Therapeutic Targets


Ion Channels As Therapeutic Targets
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Author :
language : en
Publisher: Academic Press
Release Date : 2016-03-31

Ion Channels As Therapeutic Targets written by and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-03-31 with Science categories.


This volume is the second part of the thematic on Ion Channels as Therapeutic Targets. The popular Advances in Protein Chemistry and Structural Biology series, an essential resource for protein chemists, brings forth new information about protocols and analysis of proteins, with each thematically organized volume guest edited by leading experts in a broad range of protein-related topics. Provides cutting-edge developments in protein chemistry and structural biology Discusses the use of ion channels as therapeutic targets Chapters are written by authorities in their field Targeted to a wide audience of researchers, specialists, and students