Practical Handbook On The 3rs In The Context Of The Directive 2010 63 Eu
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Practical Handbook On The 3rs In The Context Of The Directive 2010 63 Eu
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Author : Gianni Dal Negro
language : en
Publisher: Academic Press
Release Date : 2021-11-18
Practical Handbook On The 3rs In The Context Of The Directive 2010 63 Eu written by Gianni Dal Negro and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-11-18 with Science categories.
Practical Handbook on the 3Rs in the Context of the Directive 2010/63/EU provides updated information on the EU Directive 2010/63/EU, which is the European Union legislation that protects animals being used in research. EU Directive 2010/63/EU is the European Union (EU) legislation 'on the protection of animals used for scientific purposes' and is one of the most stringent ethical and welfare standards worldwide. - Closes a gap in scientific literature by addressing the need for clear guidance in walking through the multifaced universe of 3Rs - Offers a useful starting point for readers and scientist who approach the 3Rs for the first-time - Gives insights into the harmonization of the animal research legislation across countries
Cancer Cell Culture
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Author : Dania Movia
language : en
Publisher: Springer Nature
Release Date : 2023-05-18
Cancer Cell Culture written by Dania Movia and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-05-18 with Medical categories.
This volume explores the latest collection of cell models that are used in preclinical cancer research, and covers both two-dimensional and three-dimensional culturing techniques. The chapters in this book are divided into two parts. Part One discusses two-dimensional cancer cell culture, cell models at the Air-Liquid Interface, and the latest advancements in three-dimensional complex spheroid models and dedicated disease animal models. Part Two contains technical chapters that illustrate step-by-step methodologies for specific cancer cell culture methods. The methods discussed range from the generation of isogenic cancer cell lines, the use of serum-free growth conditions, and three-dimensional cell cultures and their specific assays for the efficacy assessment of new anticancer therapies. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and comprehensive, Cancer Cell Culture: Methods and Protocols is a valuable tool to help researchers involved in this important field to further improve or advance their models for cancer research.
The Ufaw Handbook On The Care And Management Of Laboratory And Other Research Animals
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Author : Huw Golledge
language : en
Publisher: John Wiley & Sons
Release Date : 2024-03-12
The Ufaw Handbook On The Care And Management Of Laboratory And Other Research Animals written by Huw Golledge and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-03-12 with Medical categories.
The UFAW Handbook on The Care and Management of Laboratory and Other Research Animals The latest edition of the seminal reference on the care and management of laboratory and research animals The newly revised ninth edition of The UFAW Handbook on the Care and Management of Laboratory and Other Research Animals delivers an up-to-date and authoritative exploration on worldwide developments, current thinking, and best practices in the field of laboratory animal welfare science and technology. The gold standard in laboratory and captive animal care and management references, this latest edition continues the series’ tradition of excellence by including brand-new chapters on ethical review, the care of aged animals, and fresh guidance on the care of mole rats, corvids, zebrafish, and decapods. The book offers introductory chapters covering a variety of areas of laboratory animal use, as well as chapters on the management and care of over 30 different taxa of animals commonly utilised in scientific procedures and research around the world. It also provides: A thorough introduction to the design of animal experiments, laboratory animal genetics, and the phenotyping of genetically modified mice Comprehensive explorations of animal welfare assessment and the ethical review process Practical discussions of legislation and oversight of the conduct of research using animals from a global perspective In-depth examinations of the planning, design, and construction of efficient animal facilities, special housing arrangements, and nutrition, feeding, and animal welfare The UFAW Handbook on the Care and Management of Laboratory and Other Research Animals Ninth Edition is essential for laboratory animal scientists, veterinarians, animal care staff, animal care regulatory authorities, legislators, and professionals working in animal welfare non-governmental organizations.
Eursafe2024 Proceedings
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Author : Mona Giersberg
language : en
Publisher: BRILL
Release Date : 2024-09-10
Eursafe2024 Proceedings written by Mona Giersberg and has been published by BRILL this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-09-10 with Technology & Engineering categories.
EurSafe2024 Back to the future: Sustainable innovations for ethical food production and consumption
Handbook Of Laboratory Animal Science
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Author : Jann Hau
language : en
Publisher: CRC Press
Release Date : 2021-05-17
Handbook Of Laboratory Animal Science written by Jann Hau and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-05-17 with Medical categories.
Building upon the success of previous editions of the bestselling Handbook of Laboratory Animal Science, first published in 1994, this latest revision combines all three volumes in one definitive guide. It covers the essential principles and practices of Laboratory Animal Science as well as selected animal models in scientific disciplines where much progress has been made in recent years. Each individual chapter focuses on an important subdiscipline of laboratory animal science, and the chapters can be read and used as stand-alone texts, with only limited necessity to consult other chapters for information. With new contributors at the forefront of their fields, the book reflects the scientific and technological advances of the past decade. It also responds to advances in our understanding of animal behavior, emphasizing the importance of implementing the three Rs: replacing live animals with alternative methods, reducing the number of animals used, and refining techniques to minimize animal discomfort. This fourth edition will be useful all over the world as a textbook for laboratory animal science courses for postgraduate and undergraduate students and as a handbook for scientists who work with animals in their research, for university veterinarians, and for other specialists in laboratory animal science.
Practical Management Of Research Animal Care And Use Programs
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Author : Javier Guillén
language : en
Publisher: Springer Nature
Release Date : 2024-11-06
Practical Management Of Research Animal Care And Use Programs written by Javier Guillén and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-11-06 with Medical categories.
This book provides a complete guide to all the aspects to consider during planning, establishing and managing ethically and efficiently research animal care and use programs, taking into account all stakeholders involved in the process. Practical information on how to address the general and particular needs of all animal care and use program areas is provided. Consequently, the reader is supported with getting their project ethically and legally compliant, and implemented efficiently with organizing safe and appropriate facilities and equipment as well as hiring sufficiently trained personnel. Furthermore, strategies for impactful internal and external communication are outlined. Responsible use of animals in research can be nothing but teamwork. The environment and professional experience of all involved stakeholders are the key for ensuring quality science, as well as animal and personnel welfare. Research animal care and use programs represent a complex system in which animals, legislation and good practices, facility personnel and researchers interact on a daily basis. Thoughtful planning from the first step ensures animal welfare and improves the quality of in vivo experimentation. This book addresses animal program managers, veterinarians, researchers and technicians working in research animal facilities. Chapter 18 is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.
Animal Centric Care And Management
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Author : Dorte Bratbo Sørensen
language : en
Publisher: CRC Press
Release Date : 2020-10-14
Animal Centric Care And Management written by Dorte Bratbo Sørensen and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-10-14 with Medical categories.
The concept of the 3Rs (Refinement, Reduction and Replacement) has been used as a framework for improving the welfare of laboratory animals for the last half century. By establishing an animal-centric view on housing and management, Animal-centric Care and Management: Enhancing Refinement in Biomedical Research takes Russell and Burch’s definition of Refinement as "elimination of inhumanities" and goes further. Rather than fitting animals into experimental conditions, it encourages readers to adjust conditions to better meet the behavioral, emotional, physical, and physiological needs and preferences of the animals. The team of expert authors, from the fields of laboratory animal science, ethology, biology as well as animal training, provide ideas for creating housing conditions and handling procedures that induce, to the best of current abilities and knowledge, a long-term positive state of mind in the animals under our care. This book is written for animal caretakers, animal health technicians, researchers, animal facility managers, laboratory animal veterinarians, and anyone who engages in work with living experimental animals or is interested in the continuous improvement of laboratory animal welfare. This interdisciplinary guide will act as a catalyst, resulting in multiple viewpoints and fields collaborating to optimize laboratory animal welfare.
The Role Of The Study Director In Nonclinical Studies
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Author : William J. Brock
language : en
Publisher: John Wiley & Sons
Release Date : 2014-05-02
The Role Of The Study Director In Nonclinical Studies written by William J. Brock and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-05-02 with Science categories.
A single-source reference with a broad and holistic overview of nonclinical studies, this book offers critical training material and describes regulations of nonclinical testing through guidelines, models, case studies, practical examples, and worldwide perspectives. The book: Provides a complete overview of nonclinical study organization, conduct, and reporting and describes the roles and responsibilities of a Study Director to manage an effective study Covers regulatory and scientific concepts, including international testing and Good Laboratory Practice (GLP), compliance with guidelines, and animal models Features a concluding chapter that compiles case studies / lessons learned from those that have served as a Study Director for many years Addresses the entire spectrum of nonclinical testing, making it applicable to those in the government, laboratories and those actively involved in in all sectors of industry
Reactive Oxygen Species Ros Nanoparticles And Endoplasmic Reticulum Er Stress Induced Cell Death Mechanisms
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Author : Loutfy H. Madkour
language : en
Publisher: Academic Press
Release Date : 2020-06-27
Reactive Oxygen Species Ros Nanoparticles And Endoplasmic Reticulum Er Stress Induced Cell Death Mechanisms written by Loutfy H. Madkour and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-06-27 with Medical categories.
Reactive Oxygen Species (ROS), Nanoparticles, and Endoplasmic Reticulum (ER) Stress-Induced Cell Death Mechanisms presents the role of ROS?mediated pathways cellular signaling stress, endoplasmic reticulum (ER) stress, oxidative stress, oxidative damage, nanomaterials, and the mechanisms by which metalloids and nanoparticles induce their toxic effects. The book covers the ecotoxicology of environmental heavy metal ions and free radicals on macromolecules cells organisms, heavy metals?induced cell responses, oxidative stress, the source of oxidants, and the roles of ROS, oxidative stress and oxidative damage mechanisms. It also examines the nanotoxicity, cytotoxicity and genotoxicity mechanisms of nanomaterials and the effects of nanoparticle interactions. Antioxidant defense therapy and strategies for treatment round out the book, making it an ideal resource for researchers and professional scientists in toxicology, environmental chemistry, environmental science, nanomaterials and the pharmaceutical sciences. - Covers the ecotoxicology of environmental heavy metal ions and the interactions between specific heavy metals?induced cell responses and oxidative stress - Provides a better understanding of the mechanism of nanomaterial-induced toxicity as a first defense for hazard prevention - Covers recent advances in new nanomedication technologies for the effects of NPs on oxidative stress, ROS and ER stress - Discusses the effects of interactions between antioxidant defense therapy, ROS and strategies for treatment
Wildlife Welfare
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Author : Charlotte Lotta Berg
language : en
Publisher: Frontiers Media SA
Release Date : 2021-01-25
Wildlife Welfare written by Charlotte Lotta Berg and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-01-25 with Medical categories.