Reactive Oxygen Species Ros Nanoparticles And Endoplasmic Reticulum Er Stress Induced Cell Death Mechanisms
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Reactive Oxygen Species Ros Nanoparticles And Endoplasmic Reticulum Er Stress Induced Cell Death Mechanisms
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Author : Loutfy H. Madkour
language : en
Publisher: Academic Press
Release Date : 2020-06-27
Reactive Oxygen Species Ros Nanoparticles And Endoplasmic Reticulum Er Stress Induced Cell Death Mechanisms written by Loutfy H. Madkour and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-06-27 with Medical categories.
Reactive Oxygen Species (ROS), Nanoparticles, and Endoplasmic Reticulum (ER) Stress-Induced Cell Death Mechanisms presents the role of ROS?mediated pathways cellular signaling stress, endoplasmic reticulum (ER) stress, oxidative stress, oxidative damage, nanomaterials, and the mechanisms by which metalloids and nanoparticles induce their toxic effects. The book covers the ecotoxicology of environmental heavy metal ions and free radicals on macromolecules cells organisms, heavy metals?induced cell responses, oxidative stress, the source of oxidants, and the roles of ROS, oxidative stress and oxidative damage mechanisms. It also examines the nanotoxicity, cytotoxicity and genotoxicity mechanisms of nanomaterials and the effects of nanoparticle interactions. Antioxidant defense therapy and strategies for treatment round out the book, making it an ideal resource for researchers and professional scientists in toxicology, environmental chemistry, environmental science, nanomaterials and the pharmaceutical sciences. - Covers the ecotoxicology of environmental heavy metal ions and the interactions between specific heavy metals?induced cell responses and oxidative stress - Provides a better understanding of the mechanism of nanomaterial-induced toxicity as a first defense for hazard prevention - Covers recent advances in new nanomedication technologies for the effects of NPs on oxidative stress, ROS and ER stress - Discusses the effects of interactions between antioxidant defense therapy, ROS and strategies for treatment
Nanoparticle Based Drug Delivery In Cancer Treatment
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Author : Loutfy H. Madkour
language : en
Publisher: CRC Press
Release Date : 2022-02-27
Nanoparticle Based Drug Delivery In Cancer Treatment written by Loutfy H. Madkour and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-02-27 with Science categories.
The careful choice of nanoparticles as targets and in drug delivery routes enhances therapeutic efficacy in cancer. Nanoparticle-Based Drug Delivery in Cancer Treatment discusses nanotechnological developments of interfering RNA-based nanoparticles, delivery vehicles, and validated therapeutic RNAi–molecular target interactions and explains the results of clinical and preclinical trials. The book also gives strategies for universal methods of constructing hybrid organic–inorganic nanomaterials that can be widely applied in the biomedical field. Key Features: Reviews recent advances of nanoparticle-mediated siRNA delivery systems and their application in clinical trials for cancer therapy Focuses on material platforms that establish NPs and both localized and controlled gene silencing Emphasizes the most promising systems for clinical application Surveys progress in nanoparticle-based nanomedicine in cancer treatment Describes the most advanced of the nonviral nanocarriers for delivery of oligonucleotides to malignant blood cancer cells This book is a valuable resource for researchers, professors, and students researching drug delivery, gene carriers, cancer therapy, nanotechnology, and nanomaterials.
Handbook Of Oxidative Stress In Cancer Therapeutic Aspects
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Author : Sajal Chakraborti
language : en
Publisher: Springer Nature
Release Date : 2022-09-28
Handbook Of Oxidative Stress In Cancer Therapeutic Aspects written by Sajal Chakraborti and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-09-28 with Medical categories.
This reference book, which is the second volume of Targeting Oxidative Stress in Cancer, explores oxidative stress as the potential therapeutic target for cancer therapy. The initial chapters discuss the molecular mechanisms of oxidative stress and its effects on different signaling pathways. Subsequently, the sections examine the impact of redox signaling on tumor cell proliferation and consider the therapeutic potential of dietary phytochemicals and nutraceuticals in reactive oxygen species (ROS)-induced cancer. In turn, it examines the evidence supporting the use of Vitamin C in cancer management, before presenting various synthetic and natural compounds that have therapeutic implications for oxidative stress-induced cancer. It also explores the correlation between non-coding RNA and oxidative stress. Furthermore, the book summarizes the role of stem cells in ROS-induced cancer therapy and reviews the therapeutic applications of nanoparticles to alter redox haemostasis in cancer cells. Lastly, it explores heat-shock proteins, ubiquitin ligases, and probiotics as potential therapeutic agents in ROS-mediated cancer. This book is a useful resource for basic and translational scientists as well as clinicians interested in the field of oxidative stress and cancer therapy.
Rna Delivery Function For Anticancer Therapeutics
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Author : Loutfy H. Madkour
language : en
Publisher: CRC Press
Release Date : 2022-01-25
Rna Delivery Function For Anticancer Therapeutics written by Loutfy H. Madkour and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-01-25 with Science categories.
This book presents an overview of the current status of translating the RNAi cancer therapeutics in the clinic, a brief description of the biological barriers in drug delivery, and the roles of imaging in aspects of administration route, systemic circulation, and cellular barriers for the clinical translation of RNAi cancer therapeutics, and with partial content for discussing the safety concerns. It then focuses on imaging-guided delivery of RNAi therapeutics in preclinical development, including the basic principles of different imaging modalities, and their advantages and limitations for biological imaging. With growing number of RNAi therapeutics entering the clinic, various imaging methods will play an important role in facilitating the translation of RNAi cancer therapeutics from bench to bedside. RNAi technique has become a powerful tool for basic research to selectively knock down gene expression in vitro and in vivo. Our scientific and industrial communities have started to develop RNAi therapeutics as the next class of drugs for treating a variety of genetic disorders, such as cancer and other diseases that are particularly hard to address with current treatment strategies. Key Features Provides insight into the current advances and hurdles of RNAi therapeutics. Accelerates RNAi, miRNAs, and siRNA drug development for cancer therapy from bench to bedside. Addresses various modifications and novel delivery strategies for miRNAs, piRNAs and siRNA delivery in anticancer therapeutics. Explores the need for the interaction of hematologists,cell biologists, immunologists, and material scientists in the development of novel cancer therapies. Describes the current status of clinical trials related to miRNA and siRNA-based cancer therapy Presents remaining issues that need to be overcome to establish successful therapies.
Emerging Nanomaterials For Advanced Technologies
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Author : Anand Krishnan
language : en
Publisher: Springer Nature
Release Date : 2022-02-22
Emerging Nanomaterials For Advanced Technologies written by Anand Krishnan and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-02-22 with Science categories.
Over the past decade the world has seen the rise of the fascinating and diverse field currently recognized as nanotechnology. This book covers a broad spectrum of topics within nanotechnology, including synthesis techniques, various innovative characterization techniques, growth mechanisms of nanomaterials, the physics and chemistry of nanomaterials, diverse functionalization methods, and the various applications of nanomaterials in biology, therapeutics, energy, food science, and environmental science. It also discusses applications of nanostructured materials, integrative applications such as nano- and micro-electronic sensor devices, as well as agricultural and environmental remediation applications. The book also includes a discussion of advances in functionalized nanomaterials (0D, 1D, 2D and 3D) and covers the early stages of the development of functionalized nanostructures, considering the future for 2D nanomaterials and 3D objects. Additionally, it includes a chapter on nanomaterial research development that highlights work on the life-cycle analysis of nanostructured materials and toxicity aspects. This book proves useful for researchers and professionals working in the field of nanomaterials and green technology, as well as in the field of nanotechnology. It should be useful to students and specialized researchers in a number of disciplines ranging from biology, chemistry, and materials science to engineering and manufacturing in both academia and industry.
Bioremediation Of Environmental Toxicants
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Author : Chandra Shekhar Yadav
language : en
Publisher: CRC Press
Release Date : 2024-12-06
Bioremediation Of Environmental Toxicants written by Chandra Shekhar Yadav and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-12-06 with Medical categories.
Bioremediation of Environmental Toxicants: Toxicants, Sources, Mechanism, Impact on Human Health, and Bioremediation Approaches provides insight into the nature of environmental toxicants, the impact on human health, and their bioremediation approaches, viz. nanotechnology, microorganism, and phytoremediation. Various environmental toxicants such as pesticides, heavy metals, plastic and microplastic waste, dyes used in industries, colorants, corrosive agents, and biomedical waste show different levels of mechanism of toxicity, possessing a significant threat to human health as well as the stability of ecosystems. To decontaminate the environment from these toxic compounds a low-cost effective technique is required. Bioremediation is a sustainable approach by which hazardous pollutants are converted into less harmful or non-toxic compounds using effective techniques to detoxify contaminated soil and water. In recent years, research has steadily concentrated on the various bioremediation approaches, viz. nanoparticle, microorganism, and phytoremediation. KEY FEATURES Showcases contributions from high-profile experts in the field Highlights the current state and importance of environmental bioremediation Provides detailed knowledge about the mechanism, toxicity, and action of environmental toxicants Furnishes a deep understanding of environment–human interaction and the after effects Outlines the state-of-the-art bioremediation technologies, viz. nanotechnology, microbial- and plant-based mitigation of environmental toxicants
Biology And Biotechnology Of Environmental Stress Tolerance In Plants
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Author : Aryadeep Roychoudhury
language : en
Publisher: CRC Press
Release Date : 2023-07-21
Biology And Biotechnology Of Environmental Stress Tolerance In Plants written by Aryadeep Roychoudhury and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-07-21 with Science categories.
Abiotic stresses such as drought, high salt, cold, heat, UV radiation, heavy metal pollution, etc., are increasingly responsible for restricting plant growth and agricultural production and are becoming more alarming due to threats from global climate change. To combat these threats, this new 3-volume set provides a comprehensive understanding of the mechanisms that mediate biosynthesis, accumulation, and degradation of plant metabolites to improve crop production and enhance abiotic stress tolerance in plants. Volume 1: Secondary Metabolites in Environmental Stress Tolerance focuses exclusively on the diverse secondary metabolites that play a major role in the adaptation of plants to the environment and in overcoming stress conditions as well as their implications in enhancing tolerance mechanisms. The book presents information on the protective roles rendered by a wide array of antioxidative secondary metabolites and their regulation during diverse environmental stress. Volume 2: Trace Elements in Environmental Stress Tolerance throws light on the different inorganic trace elements, including metal nanoparticles, that help to deal with various environmental stresses. While these elements at high level create considerable phytotoxicity and halt metabolic and enzymatic activity, they also promote growth and development in limited quantity, so that they have significant potential in revamping plant morphology and physiology under stressed conditions. Hence, optimum concentration management of these elements can help to mitigate world hunger and contribute toward sustainable agriculture and food security under challenging environments. Volume 3: Sustainable Approaches for Enhancing Environmental Stress Tolerance focuses on agronomic and biochemical approaches as well as biotechnological and high-throughput technologies, including the prospects of genetic engineering, epigenetics and the latest CRISPR/Cas technology in generating stress-tolerant plants. The volume provides a clear roadmap for the implementation of techniques for improving abiotic stress tolerance in plants for better sustenance.
Emerging Engineering Technologies And Industrial Applications
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Author : El Kacimi, Younes
language : en
Publisher: IGI Global
Release Date : 2024-05-06
Emerging Engineering Technologies And Industrial Applications written by El Kacimi, Younes and has been published by IGI Global this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-05-06 with Science categories.
Engineers have long been architects of progress, erecting massive buildings that touch the skies and designing technologies that redefine realms of known possibility. In this era of rapid change, keeping pace with innovation is the main challenge. Emerging Engineering Technologies and Industrial Applications is a comprehensive research book that delves deep into the heart of a relentless technological revolution within modern industry. From the limitless potential of the Internet of Things (IoT) to the cognitive wonders of Artificial Intelligence (AI), from the microscopic marvels of Nanotechnology to the precision and agility of Robotics, and from the revolutionary advancements in 3D Printing to the transformative capabilities of blockchain, this book explores emerging technologies. This book is an indispensable resource for professionals and researchers working in the field of emerging engineering technologies and their industrial applications. It caters to a diverse range of disciplines, including computer science and information technology, environmental, agricultural, and physical sciences, medical, healthcare, and life sciences, as well as science and engineering, and anyone seeking to navigate the current technological progress in the 21st century.
Nanotoxicology And Nanosafety 2 0
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Author : Ying-Jan Wang
language : en
Publisher: MDPI
Release Date : 2020-12-29
Nanotoxicology And Nanosafety 2 0 written by Ying-Jan Wang and has been published by MDPI this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-12-29 with Science categories.
With the rapid development of nanotechnology, nanomaterials have been widely applied in many industrial sectors, including medicine, consumer products, and electronics. While such technology has brought benefits and convenience to our daily lives, it may also potentially threaten human health. In some cases, nanomaterials present unexpected risks to both humans and the environment. Assessments of the potential hazards associated with nanotechnology have been emerging, but substantial challenges remain, because the large number of different nanomaterials cannot be effectively evaluated in a timely manner. The development of a good strategy for a nanomaterials hazard assessment not only promotes the more widespread adoption of non-rodent or 3Rs principles, but also makes nanotoxicology testing more ethical, relevant, and cost- and time-efficient. A thorough understanding of the mechanisms by which nanomaterials perturb biological systems is critical for a more comprehensive elucidation of their nanotoxicity, and this will also facilitate the development of prevention and intervention policies against adverse outcomes induced by them. We hope that the articles included in this eBook can provide updated knowledge on nanotoxicology and nanosafety, from the point of view of both toxicology and ecotoxicology.
Toxicity Mechanisms Exposure Toxicokinetic And Risk Assessment Aspects Of Metals Toxic For Animals And Humans
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Author : Yanzhu Zhu
language : en
Publisher: Frontiers Media SA
Release Date : 2022-03-10
Toxicity Mechanisms Exposure Toxicokinetic And Risk Assessment Aspects Of Metals Toxic For Animals And Humans written by Yanzhu Zhu and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-03-10 with Science categories.