Preventing And Treating Missing Data In Longitudinal Clinical Trials
DOWNLOAD
Download Preventing And Treating Missing Data In Longitudinal Clinical Trials PDF/ePub or read online books in Mobi eBooks. Click Download or Read Online button to get Preventing And Treating Missing Data In Longitudinal Clinical Trials book now. This website allows unlimited access to, at the time of writing, more than 1.5 million titles, including hundreds of thousands of titles in various foreign languages. If the content not found or just blank you must refresh this page
Preventing And Treating Missing Data In Longitudinal Clinical Trials
DOWNLOAD
Author : Craig H. Mallinckrodt
language : en
Publisher: Cambridge University Press
Release Date : 2013-01-28
Preventing And Treating Missing Data In Longitudinal Clinical Trials written by Craig H. Mallinckrodt and has been published by Cambridge University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-01-28 with Medical categories.
Recent decades have brought advances in statistical theory for missing data, which, combined with advances in computing ability, have allowed implementation of a wide array of analyses. In fact, so many methods are available that it can be difficult to ascertain when to use which method. This book focuses on the prevention and treatment of missing data in longitudinal clinical trials. Based on his extensive experience with missing data, the author offers advice on choosing analysis methods and on ways to prevent missing data through appropriate trial design and conduct. He offers a practical guide to key principles and explains analytic methods for the non-statistician using limited statistical notation and jargon. The book's goal is to present a comprehensive strategy for preventing and treating missing data, and to make available the programs used to conduct the analyses of the example dataset.
Preventing And Treating Missing Data In Longitudinal Clinical Trials
DOWNLOAD
Author : Craig Mallinckrodt
language : en
Publisher:
Release Date : 2013
Preventing And Treating Missing Data In Longitudinal Clinical Trials written by Craig Mallinckrodt and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013 with categories.
Preventing And Treating Missing Data In Longitudinal Clinical Trials
DOWNLOAD
Author : Craig Mallinckrodt
language : en
Publisher:
Release Date : 2013
Preventing And Treating Missing Data In Longitudinal Clinical Trials written by Craig Mallinckrodt and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013 with Clinical trials categories.
Focuses on the prevention and treatment of missing data in longitudinal clinical trials, looking at key principles and explaining analytic methods.
Preventing And Treating Missing Data In Longitudinal Clinical Trials
DOWNLOAD
Author : Craig Mallinckrodt
language : en
Publisher:
Release Date : 2013
Preventing And Treating Missing Data In Longitudinal Clinical Trials written by Craig Mallinckrodt and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013 with Clinical trials categories.
Recent decades have brought advances in statistical theory for missing data, which, combined with advances in computing ability, have allowed implementation of a wide array of analyses. In fact, so many methods are available that it can be difficult to ascertain when to use which method. This book focuses on the prevention and treatment of missing data in longitudinal clinical trials. Based on his extensive experience with missing data, the author offers advice on choosing analysis methods and on ways to prevent missing data through appropriate trial design and conduct. He offers a practical guide to key principles and explains analytic methods for the non-statistician using limited statistical notation and jargon. The book's goal is to present a comprehensive strategy for preventing and treating missing data, and to make available the programs used to conduct the analyses of the example dataset"
The Prevention And Treatment Of Missing Data In Clinical Trials
DOWNLOAD
Author : National Research Council
language : en
Publisher: National Academies Press
Release Date : 2011-01-21
The Prevention And Treatment Of Missing Data In Clinical Trials written by National Research Council and has been published by National Academies Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-01-21 with Medical categories.
Randomized clinical trials are the primary tool for evaluating new medical interventions. Randomization provides for a fair comparison between treatment and control groups, balancing out, on average, distributions of known and unknown factors among the participants. Unfortunately, these studies often lack a substantial percentage of data. This missing data reduces the benefit provided by the randomization and introduces potential biases in the comparison of the treatment groups. Missing data can arise for a variety of reasons, including the inability or unwillingness of participants to meet appointments for evaluation. And in some studies, some or all of data collection ceases when participants discontinue study treatment. Existing guidelines for the design and conduct of clinical trials, and the analysis of the resulting data, provide only limited advice on how to handle missing data. Thus, approaches to the analysis of data with an appreciable amount of missing values tend to be ad hoc and variable. The Prevention and Treatment of Missing Data in Clinical Trials concludes that a more principled approach to design and analysis in the presence of missing data is both needed and possible. Such an approach needs to focus on two critical elements: (1) careful design and conduct to limit the amount and impact of missing data and (2) analysis that makes full use of information on all randomized participants and is based on careful attention to the assumptions about the nature of the missing data underlying estimates of treatment effects. In addition to the highest priority recommendations, the book offers more detailed recommendations on the conduct of clinical trials and techniques for analysis of trial data.
Missing Data In Longitudinal Studies
DOWNLOAD
Author : Michael J. Daniels
language : en
Publisher: CRC Press
Release Date : 2008-03-11
Missing Data In Longitudinal Studies written by Michael J. Daniels and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-03-11 with Mathematics categories.
Drawing from the authors' own work and from the most recent developments in the field, Missing Data in Longitudinal Studies: Strategies for Bayesian Modeling and Sensitivity Analysis describes a comprehensive Bayesian approach for drawing inference from incomplete data in longitudinal studies. To illustrate these methods, the authors employ
Missing Data In Clinical Studies
DOWNLOAD
Author : Geert Molenberghs
language : en
Publisher: John Wiley & Sons
Release Date : 2007-04-04
Missing Data In Clinical Studies written by Geert Molenberghs and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-04-04 with Medical categories.
Missing Data in Clinical Studies provides a comprehensive account of the problems arising when data from clinical and related studies are incomplete, and presents the reader with approaches to effectively address them. The text provides a critique of conventional and simple methods before moving on to discuss more advanced approaches. The authors focus on practical and modeling concepts, providing an extensive set of case studies to illustrate the problems described. Provides a practical guide to the analysis of clinical trials and related studies with missing data. Examines the problems caused by missing data, enabling a complete understanding of how to overcome them. Presents conventional, simple methods to tackle these problems, before addressing more advanced approaches, including sensitivity analysis, and the MAR missingness mechanism. Illustrated throughout with real-life case studies and worked examples from clinical trials. Details the use and implementation of the necessary statistical software, primarily SAS. Missing Data in Clinical Studies has been developed through a series of courses and lectures. Its practical approach will appeal to applied statisticians and biomedical researchers, in particular those in the biopharmaceutical industry, medical and public health organisations. Graduate students of biostatistics will also find much of benefit.
Missing Data
DOWNLOAD
Author : Paul D. Allison
language : en
Publisher: SAGE Publications
Release Date : 2024-05-08
Missing Data written by Paul D. Allison and has been published by SAGE Publications this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-05-08 with Social Science categories.
Sooner or later anyone who does statistical analysis runs into problems with missing data in which information for some variables is missing for some cases. Why is this a problem? Because most statistical methods presume that every case has information on all the variables to be included in the analysis. Using numerous examples and practical tips, this book offers a nontechnical explanation of the standard methods for missing data (such as listwise or casewise deletion) as well as two newer (and, better) methods, maximum likelihood and multiple imputation. Anyone who has been relying on ad-hoc methods that are statistically inefficient or biased will find this book a welcome and accessible solution to their problems with handling missing data.
Clinical Trials With Missing Data
DOWNLOAD
Author : Michael O'Kelly
language : en
Publisher: John Wiley & Sons
Release Date : 2014-02-14
Clinical Trials With Missing Data written by Michael O'Kelly and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-02-14 with Medical categories.
This book provides practical guidance for statisticians, clinicians, and researchers involved in clinical trials in the biopharmaceutical industry, medical and public health organisations. Academics and students needing an introduction to handling missing data will also find this book invaluable. The authors describe how missing data can affect the outcome and credibility of a clinical trial, show by examples how a clinical team can work to prevent missing data, and present the reader with approaches to address missing data effectively. The book is illustrated throughout with realistic case studies and worked examples, and presents clear and concise guidelines to enable good planning for missing data. The authors show how to handle missing data in a way that is transparent and easy to understand for clinicians, regulators and patients. New developments are presented to improve the choice and implementation of primary and sensitivity analyses for missing data. Many SAS code examples are included – the reader is given a toolbox for implementing analyses under a variety of assumptions.
Handbook Of Missing Data Methodology
DOWNLOAD
Author : Geert Molenberghs
language : en
Publisher: CRC Press
Release Date : 2014-11-06
Handbook Of Missing Data Methodology written by Geert Molenberghs and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-11-06 with Mathematics categories.
Missing data affect nearly every discipline by complicating the statistical analysis of collected data. But since the 1990s, there have been important developments in the statistical methodology for handling missing data. Written by renowned statisticians in this area, Handbook of Missing Data Methodology presents many methodological advances and t