Proteases In Health And Disease
DOWNLOAD
Download Proteases In Health And Disease PDF/ePub or read online books in Mobi eBooks. Click Download or Read Online button to get Proteases In Health And Disease book now. This website allows unlimited access to, at the time of writing, more than 1.5 million titles, including hundreds of thousands of titles in various foreign languages. If the content not found or just blank you must refresh this page
Proteases In Health And Disease
DOWNLOAD
Author : Sajal Chakraborti
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-12-04
Proteases In Health And Disease written by Sajal Chakraborti and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-12-04 with Science categories.
In view of rapidly growing research in the deregulation of proteases and their impact in human health and diseases, this book will highlight existing and emerging research in this exciting area. In-depth critical state-of-the-art reviews will be written by established investigators on proteases dysfunctions associated with pathogenesis of different diseases that are known to occur due to deregulation of proteolytic systems. Multidisciplinary approaches demonstrating biochemical and signal transduction mechanisms associated with deregulation of proteases leading to manifestation of the diseases will be discussed. The book highlights the roles of both intracellular and extracellular proteases in health and disease.
Proteases Potential Role In Health And Disease
DOWNLOAD
Author : Walter H. Horl
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Proteases Potential Role In Health And Disease written by Walter H. Horl and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Science categories.
We are pleased to present to our readers the Proceedings of the International Symposium "Proteases: Potential Role in Health and Disease" which was held in WUrzburg (FRG) during October 17-20, 1982. The topics discussed included those dealing with the physi ology and pathophysiology of proteases and their inhibitors, the interactions of proteases and hormones, the kallikrein-kinin system, complement and the coagulation system, the function of proteases in the kidney and the intestinal tract as well as the role of proteases in lung diseases, pancreatitis, arthritis and hypercatabolic states (multiple trauma, septicemia, acute renal failure). The papers presented answered many questions, but raised many more concerning the significance of proteases and their inhibitors in clinical medicine. It was unfortunately impossible in this volume to in clude the extended, lively and extremely stimulating discussions which were enjoyed by the participants during the conference. The meeting has provided a unique framework for close inter action between scientists from various disciplines, including bio chemistry, physiology, surgery, anaesthesiology, endocrinology, hematology, pulmonology and nephrology. We would like to express our thanks and appreciation for all those who have stimulated, encouraged and supported us to hold this symposium in WUrzburg. This endeavor could not have been possible without the generous financial support of the Paul-Martini Foundation (Mainz), Bayer AG (Leverkusen), Beiersdorf AG (Hamburg).
Proteases Ii
DOWNLOAD
Author : Walter H. Hörl
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Proteases Ii written by Walter H. Hörl and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
Proteases Ii
DOWNLOAD
Author : International Symposium on Proteases: Potential Role in Health and Disease
language : en
Publisher:
Release Date : 1988
Proteases Ii written by International Symposium on Proteases: Potential Role in Health and Disease and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1988 with categories.
Serine Proteases
DOWNLOAD
Author : Anil K. Sharma
language : en
Publisher: Walter de Gruyter GmbH & Co KG
Release Date : 2023-10-23
Serine Proteases written by Anil K. Sharma and has been published by Walter de Gruyter GmbH & Co KG this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-10-23 with Science categories.
Serine proteases play significant roles in healh and human disease. Abnormal expression and activities of serine proteases have been linked to the pathogenesis of many diseases. The book presents correlation between serine proteases and human diseases. It helps the reader understand classification, catalytic mechanism and types of serine proteases and their role in human disease pathogenesis at mechanistic level. The chapters explain the role of serine proteases in various diseases including respiratory disorders and cancer. It also covers the therapeutic importance of serine proteases as drug target and explains the mechanistic insights of serine proteases inhibitors. Serine protease are known to play crucial role in biological processes but disturbance in their equilibrium can result in serious health conditions. To maintain homeostasis, serine protease inhibitors come in action and inhibit proteases. Several serine protease inhibitors have been identified and many more are being designed as novel compounds for inhibitions of proteases that provide management of comorbidities. Therefore, this book will serve as a useful reference for students and researchers to understand physiological role of serine proteases and their association with initiation and progression of human diseases. It will also help to develop some strategies to develop serine proteases inhibitors as drug target of serine proteases at cellular and molecular level.
Proteolytic Signaling In Health And Disease
DOWNLOAD
Author : Andre Zelanis
language : en
Publisher: Academic Press
Release Date : 2021-10-13
Proteolytic Signaling In Health And Disease written by Andre Zelanis and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-10-13 with Science categories.
In recent years, powered by evolving technologies and experimental design, studies have better illuminated the regulating role of proteolytic enzymes across human development and pathologies. Proteolytic Signaling in Health and Disease provides an in-depth discussion of fundamental physiological and developmental processes regulated by proteases, from protein turnover and autophagy to antigen processing and presentation and major histocompatibility complex (MHC) molecules. Moving on from basic biology, international chapter authors examine a range of pathological conditions associated with proteolysis, including inflammation, wound healing, and cancer. Later chapters discuss the newly discovered network of connected events among proteases (and their inhibitors), the so-called ‘protease web’, and how best to study it. This book also empowers new research with up-to-date analytical methods and step-by-step protocols for studying proteolytic signaling events. Examines biological events triggered by proteolytic enzyme activity across human development and pathologies Discusses the role of proteolytic signaling in inflammation, wound healing, and cancer, among other disease types Features methods and protocols supporting further study of proteolytic signaling events Includes chapter contributions from international leaders in the field
Matrix Proteases In Health And Disease
DOWNLOAD
Author : Niels Behrendt
language : en
Publisher: John Wiley & Sons
Release Date : 2012-09-10
Matrix Proteases In Health And Disease written by Niels Behrendt and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-09-10 with Science categories.
Presenting a comprehensive overview of the multifaceted field of proteases in the extracellular matrix environment, this reference focuses on the recently elucidated functions of complex proteolytic systems in physiological and pathological tissue remodeling. The proteases treated include both serine proteases such as plasminogen activators and TTSPs, metalloproteases such as MMPs and ADAMS and cysteine protease cathepsins. The text specifically addresses the role of extracellular proteases in cancer cell invasion, stroke and infectious diseases, describing the basic biochemistry behind these disease states, as well as therapeutic strategies based on protease inhibition. With its trans-disciplinary scope, this reference bridges the gap between fundamental research and biomedical and pharmaceutical application, making this required reading for basic and applied scientists in the molecular life sciences.
Role Of Proteases In Cellular Dysfunction
DOWNLOAD
Author : Naranjan S. Dhalla
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-11-22
Role Of Proteases In Cellular Dysfunction written by Naranjan S. Dhalla and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-11-22 with Science categories.
It is now well known that proteases are found everywhere, in viruses and bacteria as well as in all human, animal and plant cells, and play a role in a variety of biological functions ranging from digestion, fertilization, development to senescence and death. Under physiological conditions the ability of proteases is regulated by endogenous inhibitors. However, when the activity of proteases is not regulated appropriately, disease processes can result, as seen in Alzheimer’s disease, cancer metastasis and tumor progression, inflammation and atherosclerosis. Thus it is evident that there is an absolute need for a tighter control of proteolytic activities in different cells and tissues. Aimed at graduate students and researchers with an interest in cellular proteolytic events, Role of Proteases in Cellular Dysfunctions is the second book on Proteases in this series. The book consists of three parts in specified topics based on current literatures for a better understanding for the readers with respect to their subject-wise interests. The first section of this book covers a brief idea about the neuronal disorders and the involvement of proteases such as calpains, caspases and matrix metalloproteases (MMPs). The second section covers the deadly disease cancer and its relation to ubiquitin-proteasome system, MMPs and serine proteases. The last section is about the role of proteases such as calpains, MMPs and serine protease as well as urokinase type plasminogen activator receptor (uPAR) in causing cardiovascular defects.
Matrix Metalloproteinases In Health And Disease Sculpting The Human Body
DOWNLOAD
Author : Constance E Brinckerhoff
language : en
Publisher: World Scientific
Release Date : 2017-05-05
Matrix Metalloproteinases In Health And Disease Sculpting The Human Body written by Constance E Brinckerhoff and has been published by World Scientific this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-05-05 with Science categories.
The biochemistry and cell biology of Matrix Metalloproteinases (MMPs) are not necessarily straightforward, but basic information on the history of these enzymes, their various functions that extend far beyond the cleaving of the extracellular matrix, and the complex mechanisms that control their expression are valuable to both scientists and clinicians. This volume summarizes the salient features and functions of MMPs and applies this information in a practical manner in order to understand how they contribute to normal physiology and pathology of selected diseases. Chapters by noted clinicians Jean-Michel Dayer, MD in rheumatology, Jian Cao, MD in oncology, and Peter Libby, MD in cardiology, represent important practical and clinically-oriented contributions.
Proteases In Human Diseases
DOWNLOAD
Author : Sajal Chakraborti
language : en
Publisher: Springer
Release Date : 2017-07-13
Proteases In Human Diseases written by Sajal Chakraborti and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-07-13 with Medical categories.
This book bridges the gap between fundamental research and biomedical and pharmacological applications on proteases. It represents a comprehensive overview of the multifaceted field of proteases in cellular environment and highlights the recently elucidated functions of complex proteolytic systems in different diseases. Several established investigators have elucidated the crucial role of proteases in biological processes, including how proteolytic function and regulation can be combined to develop new strategies of therapeutic interventions. Proteases form one of the largest and most diverse families of enzymes known. It is now clear that proteases are involved in every aspect of life functions of an organism. Under physiological conditions, proteases are regulated by their endogenous inhibitors; however, when the activity of proteases is not regulated appropriately, disease processes can result in. So, there is absolute need for a stringent control of proteolytic activities in cells and tissues. Dysregulation of proteases may cause derangement of cellular signalling network resulting in different pathophysiological conditions such as vascular remodelling, atherosclerotic plaque progression, ulcer and rheumatoid arthritis, Alzheimer disease, cancer metastasis, tumor progression and inflammation. Additionally, many infective microorganisms require proteases for replication or use proteases as virulence factors, which have facilitated the development of protease-targeted therapies for a variety of parasitic diseases.